{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:02Z","timestamp":1772326982783,"version":"3.50.1"},"reference-count":28,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>A 9 yr old neutered male mixed-breed dog was presented for an anal sac apocrine gland adenocarcinoma with regional nodal metastases. At presentation, ionized calcium was 1.91 mmol\/L (NOVA Stat reference range, 1.1\u20131.3 mmol\/L). Surgical excision of the primary tumor and metastatic lymph nodes was performed. Following surgery, symptomatic hypocalcemia was noted. Repeated ionized calcium measurements confirmed hypocalcemia, and hypercalcemia of malignancy panels suggested parathyroid gland suppression as the cause. The calcium normalized with parenteral calcium administration, but calcium later became elevated with tumor recurrence and an increase in the parathormone-related peptide. Disrupted calcium homeostasis is a potential complication following the treatment of long-standing humoral hypercalcemia of malignancy.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5601","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T12:29:53Z","timestamp":1320409793000},"page":"e173-e177","source":"Crossref","is-referenced-by-count":6,"title":["Hypocalcemia Following Surgical Treatment of Metastatic Anal Sac Adenocarcinoma in a Dog"],"prefix":"10.5326","volume":"47","author":[{"given":"Corey","family":"Saba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Cornell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"4","key":"bib1","series-title":"Lab Invest","first-page":"428","article-title":"Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of the anal sac. 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Aust Vet J2000;78(10):690\u20132."},{"issue":"6","key":"bib3","series-title":"J Am Vet Med Assoc","first-page":"825","article-title":"Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985\u20131995)","volume":"223","author":"Williams","year":"2003","unstructured":"Williams\n              LE\n            , GliattoJM, DodgeRK. Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985\u20131995). J Am Vet Med Assoc2003;223(6):825\u201331."},{"issue":"2","key":"bib4","series-title":"Vet Comp Oncol","first-page":"94","article-title":"Postoperative radiotherapy and mitoxantrone for anal sac adenocarcinoma in the dog: 15 cases (1991\u20132001)","volume":"1","author":"Turek","year":"2003","unstructured":"Turek\n              MM\n            , ForrestLJ, AdamsWM. Postoperative radiotherapy and mitoxantrone for anal sac adenocarcinoma in the dog: 15 cases (1991\u20132001). Vet Comp Oncol2003;1(2):94\u2013104."},{"issue":"1","key":"bib5","series-title":"J Vet Intern Med","first-page":"100","article-title":"Canine anal sac adenocarcinomas: clinical presentation and response to therapy","volume":"16","author":"Bennett","year":"2002","unstructured":"Bennett\n              PF\n            , DeNicolaDB, BonneyP. Canine anal sac adenocarcinomas: clinical presentation and response to therapy. J Vet Intern Med2002;16(1):100\u20134."},{"key":"bib6","series-title":"Withrow & MacEwen's small animal clinical oncology","first-page":"503","article-title":"Perianal tumors","author":"Turek","year":"2007","unstructured":"Turek\n              MM\n            , WithrowSJ. Perianal tumors. In: WithrowSJ, VailDM, eds. Withrow & MacEwen's small animal clinical oncology. 4th ed. 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Aust Vet J2005;83(6):340\u20133."},{"issue":"3","key":"bib9","series-title":"Vet Surg","first-page":"267","article-title":"Surgery of metastatic anal sac adenocarcinoma in five dogs","volume":"35","author":"Hobson","year":"2006","unstructured":"Hobson\n              HP\n            , BrownMR, RogersKS. Surgery of metastatic anal sac adenocarcinoma in five dogs. Vet Surg2006;35(3):267\u201370."},{"key":"bib10","series-title":"Canine and feline endocrinology and reproduction","first-page":"661","article-title":"Hypercalcemia","author":"Feldman","year":"2004","unstructured":"Feldman\n              EC\n            , NelsonRW. Hypercalcemia. In: FeldmanEC, NelsonRW, eds. Canine and feline endocrinology and reproduction. 3rd ed. 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