{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:14:52Z","timestamp":1773004492934,"version":"3.50.1"},"reference-count":35,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    A 4 yr old spayed female Labrador retriever was examined 4 hr after ingesting an overdose of phenylpropanolamine (PPA). Clinical signs included anxiety, piloerection, mucosal ulceration, cardiac arrhythmia, mydriasis, and hyphema. Clinicopathologic abnormalities included elevated creatine kinase (CK) and aspartate aminotransferase (AST), proteinuria, and pigmenturia. Ventricular tachycardia and severe systemic hypertension were documented. Hyphema and retinal detachment were documented\n                    <jats:italic>oculus uterque<\/jats:italic>\n                    (OU). Phenoxybenzamine, sotalol, and esmolol resolved the ventricular tachycardia, and blood pressure was controlled with nitroprusside. All clinicopathologic and cardiac abnormalities resolved within 7 days, and ocular changes resolved within 1 mo. Monitoring of blood pressure and rapid pharmacologic intervention were successful in controlling hypertension secondary to PPA overdose and minimizing retinal damage.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-5692","type":"journal-article","created":{"date-parts":[[2012,11,13]],"date-time":"2012-11-13T07:27:21Z","timestamp":1352791641000},"page":"46-53","source":"Crossref","is-referenced-by-count":15,"title":["Systemic Hypertension and Hypertensive Retinopathy Following PPA Overdose in a Dog"],"prefix":"10.5326","volume":"49","author":[{"given":"Jennifer A.","family":"Ginn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellison","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Stepien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Veterinary drug handbook","first-page":"726","year":"2008","unstructured":"Phenylpropanolamine HCl. In: PlumbDC, ed. Veterinary drug handbook. 6th ed. Stockholm (WI): Pharma Vet Inc.; 2008:726\u20137."},{"issue":"6 Pt 2","key":"bib2","series-title":"Pharmacotherapy","first-page":"S116","article-title":"Pharmacokinetics of oral decongestants","volume":"13","author":"Kanfer","year":"1993","unstructured":"Kanfer\n              I\n            , DowseR, VumaV. Pharmacokinetics of oral decongestants. Pharmacotherapy1993;13(6 Pt 2):S116\u201328[discussion: S143\u20136]."},{"issue":"2","key":"bib3","series-title":"Res Commun Chem Pathol Pharmacol","first-page":"163","article-title":"Inhibition of monoamine oxidase activity by phenylpropanolamine, anorectic agent","volume":"51","author":"Yu","year":"1986","unstructured":"Yu\n              PH\n            \n          . Inhibition of monoamine oxidase activity by phenylpropanolamine, anorectic agent. Res Commun Chem Pathol Pharmacol1986;51(2):163\u201371."},{"issue":"25","key":"bib4","series-title":"N Engl J Med","first-page":"1826","article-title":"Phenylpropanolamine and the risk of hemorrhagic stroke","volume":"343","author":"Kernan","year":"2000","unstructured":"Kernan\n              WN\n            , ViscoliCM, BrassLM. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med2000;343(25):1826\u201332."},{"key":"bib5","unstructured":"US Food and Drug Administration Phenylpropanolamine Information Page. Available at: www.fda.gov\/Drugs\/DrugSafety\/InformationbyDrugClass\/ucm150738.htm.Accessed October 2, 2011."},{"issue":"2","key":"bib6","series-title":"Curr Opin Pediatr","first-page":"184","article-title":"Efficacy, abuse, and toxicity of over-the-counter cough and cold medicines in the pediatric population","volume":"18","author":"Carr","year":"2006","unstructured":"Carr\n              BC\n            \n          . Efficacy, abuse, and toxicity of over-the-counter cough and cold medicines in the pediatric population. Curr Opin Pediatr2006;18(2):184\u20138."},{"issue":"14","key":"bib7","series-title":"JAMA","first-page":"1898","article-title":"Toxicity of over-the-counter stimulants","volume":"252","author":"Pentel","year":"1984","unstructured":"Pentel\n              P\n            \n          . Toxicity of over-the-counter stimulants. JAMA1984;252(14):1898\u2013903."},{"issue":"6","key":"bib8","series-title":"Clin Pharm","first-page":"529","article-title":"Managing acute toxicity from nonprescription stimulants","volume":"1","author":"Sawyer","year":"1982","unstructured":"Sawyer\n              DR\n            , ConnerCS, RumackBH. Managing acute toxicity from nonprescription stimulants. Clin Pharm1982;1(6):529\u201333."},{"issue":"7","key":"bib9","series-title":"Stroke","first-page":"1667","article-title":"Stroke associated with sympathomimetics contained in over-the-counter colugh and cold drugs","volume":"34","author":"Cantu","year":"2003","unstructured":"Cantu\n              C\n            , ArauzA, Murillo-BonillaLM. Stroke associated with sympathomimetics contained in over-the-counter colugh and cold drugs. Stroke2003;34(7):1667\u201372."},{"issue":"13","key":"bib10","series-title":"Vet Rec","first-page":"373","article-title":"Treatment of urethral sphincter mechanism incompetence in 11 bitches with a sustained-release formulation of phenylpropanolamine hydrochloride","volume":"151","author":"Bacon","year":"2002","unstructured":"Bacon\n              NJ\n            , OniO, WhiteRA. Treatment of urethral sphincter mechanism incompetence in 11 bitches with a sustained-release formulation of phenylpropanolamine hydrochloride. Vet Rec2002;151(13):373\u20136."},{"issue":"1","key":"bib11","series-title":"J Vet Intern Med","first-page":"47","article-title":"Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs","volume":"21","author":"Byron","year":"2007","unstructured":"Byron\n              JK\n            , MarchPA, ChewDJ. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. J Vet Intern Med2007;21(1):47\u201353."},{"issue":"5","key":"bib12","series-title":"Am J Vet Res","first-page":"901","article-title":"Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs","volume":"67","author":"Hamaide","year":"2006","unstructured":"Hamaide\n              AJ\n            , GrandJ-G, FarnirF. Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. Am J Vet Res2006;67(5):901\u20138."},{"issue":"11","key":"bib13","series-title":"J Small Anim Pract","first-page":"493","article-title":"Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch","volume":"43","author":"Scott","year":"2002","unstructured":"Scott\n              L\n            , LeddyM, BernayF. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. J Small Anim Pract2002;43(11):493\u20136."},{"issue":"4","key":"bib14","series-title":"Am J Vet Res","first-page":"723","article-title":"Evaluation of the urodynamic and hemodynamic effects of orally administered phenylpropanolamine and ephedrine in female dogs","volume":"67","author":"Carofiglio","year":"2006","unstructured":"Carofiglio\n              F\n            , HamaideAJ, FarnirF. Evaluation of the urodynamic and hemodynamic effects of orally administered phenylpropanolamine and ephedrine in female dogs. Am J Vet Res2006;67(4):723\u201330."},{"issue":"6","key":"bib15","series-title":"J Am Anim Hosp Assoc","first-page":"413","article-title":"Cardiac toxicity from phenylpropanolamine overdose in a dog","volume":"41","author":"Crandell","year":"2005","unstructured":"Crandell\n              JM\n            , WareWA. Cardiac toxicity from phenylpropanolamine overdose in a dog. J Am Anim Hosp Assoc2005;41(6):413\u201320."},{"issue":"1","key":"bib16","series-title":"J Pharmacol Exp Ther","first-page":"432","article-title":"Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha 2-adrenoceptors","volume":"313","author":"Flavahan","year":"2005","unstructured":"Flavahan\n              NA\n            \n          . Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha 2-adrenoceptors. J Pharmacol Exp Ther2005;313(1):432\u20139."},{"issue":"6","key":"bib17","series-title":"Ann Acad Med Singapore","first-page":"719","article-title":"Transaminitis in Duchenne's muscular dystrophy","volume":"29","author":"Tay","year":"2000","unstructured":"Tay\n              SK\n            , OngHT, LowPS. Transaminitis in Duchenne's muscular dystrophy. Ann Acad Med Singapore2000;29(6):719\u201322."},{"issue":"1","key":"bib18","series-title":"Circulation","first-page":"101","article-title":"Cardiac troponin I. A marker with high specificity for cardiac injury","volume":"88","author":"Adams","year":"1993","unstructured":"Adams\n              JE\n              III\n            , BodorGS, Davila-RomanVG. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation1993;88(1):101\u20136."},{"issue":"10","key":"bib19","series-title":"CMAJ","first-page":"1191","article-title":"Troponin: the biomarker of choice for detection of cardiac injury","volume":"173","author":"Babuin","year":"2005","unstructured":"Babuin\n              L\n            , JaffeAS. Troponin: the biomarker of choice for detection of cardiac injury. CMAJ2005;173(10):1191\u2013202."},{"issue":"1","key":"bib20","series-title":"J S Afr Vet Assoc","first-page":"4","article-title":"Cardiac involvement in canine babesiosis","volume":"76","author":"Lobetti","year":"2005","unstructured":"Lobetti\n              RG\n            \n          . Cardiac involvement in canine babesiosis. J S Afr Vet Assoc2005;76(1):4\u20138."},{"issue":"3","key":"bib21","series-title":"Clin Chem","first-page":"338","article-title":"Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology","volume":"46","author":"Ooi","year":"2000","unstructured":"Ooi\n              DS\n            , IsotaloPA, VeinotJP. Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology. Clin Chem2000;46(3):338\u201344."},{"issue":"3","key":"bib22","series-title":"J Vet Intern Med","first-page":"322","article-title":"Cardiac troponins I and T in dogs with pericardial effusion","volume":"18","author":"Shaw","year":"2004","unstructured":"Shaw\n              SP\n            , RozanskiEA, RushJE. Cardiac troponins I and T in dogs with pericardial effusion. J Vet Intern Med2004;18(3):322\u20134."},{"issue":"8","key":"bib23","series-title":"J Hum Hypertens","first-page":"643","article-title":"The impact of oral phenylpropanolamine on blood pressure: a meta-analysis and review of the literature","volume":"19","author":"Salerno","year":"2005","unstructured":"Salerno\n              SM\n            , JacksonJL, BerbanoEP. The impact of oral phenylpropanolamine on blood pressure: a meta-analysis and review of the literature. J Hum Hypertens2005;19(8):643\u201352."},{"issue":"1","key":"bib24","series-title":"Arch Int Pharmacodyn Ther","first-page":"13","article-title":"Cardiovascular studies of phenylpropanolamine","volume":"327","author":"Vick","year":"1994","unstructured":"Vick\n              J\n            , WeissL, EllisS. Cardiovascular studies of phenylpropanolamine. Arch Int Pharmacodyn Ther1994;327(1):13\u201324."},{"issue":"3","key":"bib25","series-title":"J Vet Intern Med","first-page":"542","article-title":"Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats","volume":"21","author":"Brown","year":"2007","unstructured":"Brown\n              S\n            , AtkinsC, BagleyR. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med2007;21(3):542\u201358."},{"issue":"4","key":"bib26","series-title":"J Am Vet Med Assoc","first-page":"486","article-title":"Spontaneous systemic hypertension in dogs: five cases (1981\u20131983)","volume":"193","author":"Littman","year":"1988","unstructured":"Littman\n              MP\n            , RobertsonJL, BoveeKC. Spontaneous systemic hypertension in dogs: five cases (1981\u20131983). J Am Vet Med Assoc1988;193(4):486\u201394."},{"issue":"23","key":"bib27","series-title":"Vet Rec","first-page":"593","article-title":"Ocular signs in four dogs with hypertension","volume":"140","author":"Sansom","year":"1997","unstructured":"Sansom\n              J\n            , BodeyA. Ocular signs in four dogs with hypertension. Vet Rec1997;140(23):593\u20138."},{"issue":"1","key":"bib28","series-title":"J Am Vet Med Assoc","first-page":"81","article-title":"Essential hypertension in a dog","volume":"195","author":"Bovee","year":"1989","unstructured":"Bovee\n              KC\n            , LittmanMP, CrabtreeBJ. Essential hypertension in a dog. J Am Vet Med Assoc1989;195(1):81\u20136."},{"issue":"5","key":"bib29","series-title":"J Am Vet Med Assoc","first-page":"695","article-title":"Ocular lesions associated with systemic hypertension in cats: 69 cases (1985\u20131998)","volume":"217","author":"Maggio","year":"2000","unstructured":"Maggio\n              F\n            , DeFrancescoTC, AtkinsCE. Ocular lesions associated with systemic hypertension in cats: 69 cases (1985\u20131998). J Am Vet Med Assoc2000;217(5):695\u2013702."},{"issue":"7","key":"bib30","series-title":"J Am Vet Med Assoc","first-page":"915","article-title":"Ocular lesions associated with systemic hypertension in cats: 65 cases (2005\u20132007)","volume":"238","author":"LeBlanc","year":"2011","unstructured":"LeBlanc\n              N\n            , StepienRL, BentleyE. Ocular lesions associated with systemic hypertension in cats: 65 cases (2005\u20132007). J Am Vet Med Assoc2011;238(7):915\u201321."},{"key":"bib31","series-title":"Textbook of veterinary internal medicine","first-page":"592","article-title":"Ocular manifestations of systemic disease","author":"Maggs","year":"2005","unstructured":"Maggs\n              DJ\n            \n          . Ocular manifestations of systemic disease. In: EttingerS, FeldmanE, eds. Textbook of veterinary internal medicine. St. Louis (MO): WB Saunders; 2005:592\u20136."},{"issue":"3","key":"bib32","series-title":"Am J Vet Res","first-page":"411","article-title":"Clinical pharmacology of an etorphine-acepromazine preparation: experiments in dogs and horses","volume":"34","author":"Schlarmann","year":"1973","unstructured":"Schlarmann\n              B\n            , GorlitzBD, WintzerH. Clinical pharmacology of an etorphine-acepromazine preparation: experiments in dogs and horses. Am J Vet Res1973;34(3):411\u20135."},{"issue":"6","key":"bib33","series-title":"Aust Vet J","first-page":"260","article-title":"Respiratory and cardiovascular effects of five drugs used as sedatives in the dog","volume":"50","author":"Turner","year":"1974","unstructured":"Turner\n              DM\n            , IlkiwJE, RoseRJ. Respiratory and cardiovascular effects of five drugs used as sedatives in the dog. Aust Vet J1974;50(6):260\u20135."},{"issue":"1","key":"bib34","series-title":"Am J Vet Res","first-page":"78","article-title":"Cardiorespiratory effects of acepromazine maleate and buprenorphine hydrochloride in clinically normal dogs","volume":"56","author":"Stepien","year":"1995","unstructured":"Stepien\n              RL\n            , BonaguraJD, BednarskiRM. Cardiorespiratory effects of acepromazine maleate and buprenorphine hydrochloride in clinically normal dogs. Am J Vet Res1995;56(1):78\u201384."},{"issue":"1","key":"bib35","series-title":"Vet Anaesth Analg","first-page":"25","article-title":"Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine in dogs","volume":"36","author":"Monteiro","year":"2009","unstructured":"Monteiro\n              ER\n            , JuniorAR, AssizHM. Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine in dogs. Vet Anaesth Analg2009;36(1):25\u201333."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/49\/1\/article-p46.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/49\/1\/46\/1334974\/jaaha-ms-5692.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/49\/1\/article-p46.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/49\/1\/article-p46.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:58:17Z","timestamp":1763740697000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/49\/1\/article-p46.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":35,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-5692","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}