{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:13:46Z","timestamp":1767665626465,"version":"3.45.0"},"reference-count":21,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>This report describes multiple endocrine neoplasia in a dog, which is a rare hereditary disorder characterized by the presence of two or more neoplasms of different endocrine tissues within a patient. A 14 yr old dog was evaluated for polyuria\/polydipsia, polyphagia, and abdominal enlargement. Adrenal-dependent hyperadrenocorticism with concomitant left thyroid enlargement and a presumed abdominal metastatic lesion were diagnosed by an adrenocorticotropic hormone stimulation test, ultrasonography, and computed tomography. Trilostane therapy was initiated and resolved the clinical signs for 2 yr at which time the dog presented with left testicular enlargement. The dog was euthanized and was diagnosed with adrenocortical carcinoma, thyroid carcinoma, an abdominal mass compatible with a metastatic lymph node, and bilateral interstitial cell testicular adenomas. To the authors\u2019 knowledge, this is the first report to describe the concomitant association of these types of endocrine neoplasms in a dog. The concomitant presence of these neoplasms could represent a potential variant of multiple endocrine neoplasia; however, the presence of the interstitial cell testicular adenomas may have only been an incidental finding. If any of these tumors are diagnosed, veterinarians should perform a thorough clinical assessment to evaluate for the presence of additional endocrine neoplasms or hyperplasia.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5708","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T02:09:11Z","timestamp":1327025351000},"page":"132-138","source":"Crossref","is-referenced-by-count":12,"title":["Potential Variant of Multiple Endocrine Neoplasia in a Dog"],"prefix":"10.5326","volume":"48","author":[{"given":"Daniela","family":"Proverbio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Spada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Perego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Lodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Di Giancamillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"5","key":"bib1","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1083","article-title":"Endocrine tumors","volume":"31","author":"Lurye","year":"2001","unstructured":"Lurye\n              JC\n            , BehrendEN. Endocrine tumors. Vet Clin North Am Small Anim Pract2001;31(5):1083\u2013110, ix\u2013x."},{"key":"bib2","series-title":"Canine and feline endocrinology and reproduction","first-page":"440","article-title":"Pheochromocytoma and multiple endocrine neoplasia","author":"Feldman","year":"2004","unstructured":"Feldman\n              EC\n            , NelsonRW. Pheochromocytoma and multiple endocrine neoplasia. In: FeldmanEC, NelsonRW, eds. Canine and feline endocrinology and reproduction. 3rd ed. St. Louis (MO): Saunders; 2004:440\u201363."},{"key":"bib3","series-title":"Adv Intern Med","first-page":"597","article-title":"Recent advances in multiple endocrine neoplasia syndromes","volume":"42","author":"Gardner","year":"1997","unstructured":"Gardner\n              DG\n            \n          . Recent advances in multiple endocrine neoplasia syndromes. 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