{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:43:52Z","timestamp":1790257432259,"version":"4.1.0"},"reference-count":25,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Twenty-two cases of feline histoplasmosis seen at the Virginia-Maryland Regional College of Veterinary Medicine Teaching Hospital between 1986 and 2009 were reviewed. The median age of affected cats was 9 yr (mean, 8.8 yr). Female domestic shorthairs were more commonly affected. The clinical presentation of most cases was nonspecific. The most common presenting complaints included weakness, lymphadenopathy, weight loss, and anorexia. Less frequent clinical signs included vomiting, diarrhea, blindness, and lameness. Less than half of the cats had clinical evidence of pulmonary disease on admission. Anemia and hypoalbuminemia were common laboratory abnormalities. An interstitial pattern was the most common radiographic pattern observed with pulmonary disease. Diagnosis was based on identification of the organism on cytology or histopathology. Fifteen of the 22 cats were treated, and itraconazole was the most common antifungal agent prescribed. Median duration of the antifungal treatment was 5 mo for cats that survived to discharge. Overall survival at time of discharge for cats in this study was 55%.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5758","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T02:01:28Z","timestamp":1333504888000},"page":"182-187","source":"Crossref","is-referenced-by-count":51,"title":["Feline Histoplasmosis: A Retrospective Study of 22 Cases (1986\u20132009)"],"prefix":"10.5326","volume":"48","author":[{"given":"Harmeet K.","family":"Aulakh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karanvir S.","family":"Aulakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory C.","family":"Troy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"1","key":"bib1","series-title":"Texas. J Med Vet Mycol","first-page":"41","article-title":"Endemic canine and feline histoplasmosis in El Paso","volume":"24","author":"Kabli","year":"1986","unstructured":"Kabli\n              S\n            , KoschmannJR, RobertstadGW. Endemic canine and feline histoplasmosis in El Paso, Texas. J Med Vet Mycol1986;24(1):41\u201350."},{"key":"bib2","series-title":"Infectious diseases of the dog and cat","first-page":"577","article-title":"Histoplasmosis","author":"Green","year":"2006","unstructured":"Green\n              CE\n            \n          . Histoplasmosis. In: GreenCE, ed. Infectious diseases of the dog and cat. 3rd ed. Philadelphia (PA): WB Saunders; 2006:577\u201384."},{"issue":"5","key":"bib3","series-title":"J Am Anim Hosp Assoc","first-page":"380","article-title":"Deep mycotic infections in cats","volume":"32","author":"Davies","year":"1996","unstructured":"Davies\n              C\n            , TroyGC. Deep mycotic infections in cats. J Am Anim Hosp Assoc1996;32(5):380\u201391."},{"issue":"3","key":"bib4","series-title":"Can Vet J","first-page":"95","article-title":"Disseminated canine histoplasmosis: a clinical survey of 24 cases in Texas","volume":"21","author":"Mitchell","year":"1980","unstructured":"Mitchell\n              M\n            , StarkDR. Disseminated canine histoplasmosis: a clinical survey of 24 cases in Texas. Can Vet J1980;21(3):95\u2013100."},{"key":"bib5","series-title":"J Am Anim Hosp Assoc","first-page":"154","article-title":"Primary gastrointestinal histoplasmosis in a cat","volume":"18","author":"Stark","year":"1982","unstructured":"Stark\n              DR\n            \n          . Primary gastrointestinal histoplasmosis in a cat. J Am Anim Hosp Assoc1982;18:154\u20136."},{"issue":"4","key":"bib6","series-title":"Clin Tech Small Anim Pract","first-page":"227","article-title":"Histoplasmosis in dogs and cats","volume":"20","author":"Br\u00f6mel","year":"2005","unstructured":"Br\u00f6mel\n              C\n            , SykesJE. Histoplasmosis in dogs and cats. Clin Tech Small Anim Pract2005;20(4):227\u201332."},{"key":"bib7","series-title":"Compend Contin Educ Pract Vet","first-page":"1223","article-title":"Feline disseminated histoplasmosis","volume":"11","author":"Clinkenbeard","year":"1989","unstructured":"Clinkenbeard\n              KD\n            , WolfAM, CrowellRL. Feline disseminated histoplasmosis. Compend Contin Educ Pract Vet1989;11:1223\u201333."},{"key":"bib8","series-title":"Feline Pract","first-page":"32","article-title":"Osseous histoplasmosis in a cat","volume":"13","author":"Goad","year":"1983","unstructured":"Goad\n              ME\n            , RoenickWJ. Osseous histoplasmosis in a cat. Feline Pract1983;13:32\u20136."},{"key":"bib9","series-title":"J Am Anim Hosp Assoc","first-page":"995","article-title":"Feline histoplasmosis: A literature review and retrospective study of 20 new cases","volume":"20","author":"Wolf","year":"1984","unstructured":"Wolf\n              AM\n            , BeldenMN. Feline histoplasmosis: A literature review and retrospective study of 20 new cases. J Am Anim Hosp Assoc1984;20:995\u20138."},{"issue":"6","key":"bib10","series-title":"J Vet Intern Med","first-page":"409","article-title":"Itraconazole for the treatment of histoplasmosis in cats","volume":"8","author":"Hodges","year":"1994","unstructured":"Hodges\n              RD\n            , LegendreAM, AdamsLG. Itraconazole for the treatment of histoplasmosis in cats. J Vet Intern Med1994;8(6):409\u201313."},{"issue":"8","key":"bib11","series-title":"J Am Vet Med Assoc","first-page":"817","article-title":"Disseminated histoplasmosis in a cat: successful treatment with ketoconazole","volume":"181","author":"Noxon","year":"1982","unstructured":"Noxon\n              JO\n            , DigilioK, SchmidtDA. Disseminated histoplasmosis in a cat: successful treatment with ketoconazole. J Am Vet Med Assoc1982;181(8):817\u201320."},{"key":"bib12","series-title":"J Am Anim Hosp Assoc","first-page":"119","article-title":"Pancytopenia associated with disseminated histoplasmosis in a cat","volume":"20","author":"Gabbert","year":"1984","unstructured":"Gabbert\n              NH\n            , CambellTW, BeiermannRL. Pancytopenia associated with disseminated histoplasmosis in a cat. J Am Anim Hosp Assoc1984;20:119\u201322."},{"issue":"11","key":"bib13","series-title":"J Am Vet Med Assoc","first-page":"1445","article-title":"Disseminated histoplasmosis in cats: 12 cases (1981\u20131986)","volume":"190","author":"Clinkenbeard","year":"1987","unstructured":"Clinkenbeard\n              KD\n            , CowellRL, TylerRD. Disseminated histoplasmosis in cats: 12 cases (1981\u20131986). J Am Vet Med Assoc1987;190(11):1445\u20138."},{"issue":"1","key":"bib14","series-title":"Vet Radiology","first-page":"34","article-title":"The radiographic appearance of pulmonary histoplasmosis in the cat","volume":"28","author":"Wolf","year":"1987","unstructured":"Wolf\n              AM\n            , GreenRW. The radiographic appearance of pulmonary histoplasmosis in the cat. Vet Radiology1987;28(1):34\u20137."},{"key":"bib15","series-title":"J Am Anim Hosp Assoc","first-page":"468","article-title":"Histoplasmosis in a cat","volume":"18","author":"Blass","year":"1982","unstructured":"Blass\n              C\n            \n          . Histoplasmosis in a cat. J Am Anim Hosp Assoc1982;18:468\u201370."},{"issue":"4","key":"bib16","series-title":"Vet Clin Pathol","first-page":"113","article-title":"What is your diagnosis? Peripheral blood from a 15-year-old male domestic shorthair cat","volume":"25","author":"Blischok","year":"1996","unstructured":"Blischok\n              D\n            , BenderH. What is your diagnosis? Peripheral blood from a 15-year-old male domestic shorthair cat. Vet Clin Pathol1996;25(4):113."},{"issue":"3","key":"bib17","series-title":"J Am Vet Med Assoc","first-page":"303","article-title":"Ketoconazole: clinical pharmacology and therapeutic recommendations","volume":"188","author":"Moriello","year":"1986","unstructured":"Moriello\n              KA\n            \n          . Ketoconazole: clinical pharmacology and therapeutic recommendations. J Am Vet Med Assoc1986;188(3):303\u20136."},{"issue":"4","key":"bib18","series-title":"Rev Infect Dis","first-page":"551","article-title":"Combination therapy of experimental histoplasmosis and cryptococcosis with amphotericin B and ketoconazole","volume":"2","author":"Graybill","year":"1980","unstructured":"Graybill\n              JR\n            , WilliamsDM, Van CutsemE. Combination therapy of experimental histoplasmosis and cryptococcosis with amphotericin B and ketoconazole. Rev Infect Dis1980;2(4):551\u20138."},{"issue":"5","key":"bib19","series-title":"Vet Med","first-page":"412","article-title":"Diagnosing pulmonary histoplasmosis despite nonspecific signs","volume":"81","author":"Lenarduzzi","year":"1986","unstructured":"Lenarduzzi\n              RF\n            , JonesL. Diagnosing pulmonary histoplasmosis despite nonspecific signs. Vet Med1986;81(5):412\u20138."},{"key":"bib20","series-title":"J Am Anim Hosp Assoc","first-page":"216","article-title":"Feline Histoplasmosis","volume":"13","author":"Breitschwerdt","year":"1977","unstructured":"Breitschwerdt\n              EB\n            , HalliwellWH, BurkRL. Feline Histoplasmosis. J Am Anim Hosp Assoc1977;13:216\u201322."},{"key":"bib21","series-title":"J Am Anim Hosp Assoc","first-page":"511","article-title":"Successful treatment of disseminated histoplasmosis with osseous involvement in two cats","volume":"24","author":"Wolf","year":"1988","unstructured":"Wolf\n              AM\n            \n          . Successful treatment of disseminated histoplasmosis with osseous involvement in two cats. J Am Anim Hosp Assoc1988;24:511\u20136."},{"issue":"3","key":"bib22","series-title":"Vet Microbiol","first-page":"219","article-title":"Diagnosis of histoplasmosis by detection of the internal transcribed spacer region of fungal rRNA gene from a paraffin-embedded skin sample from a dog in Japan","volume":"94","author":"Ueda","year":"2003","unstructured":"Ueda\n              Y\n            , SanoA, TamuraM. Diagnosis of histoplasmosis by detection of the internal transcribed spacer region of fungal rRNA gene from a paraffin-embedded skin sample from a dog in Japan. Vet Microbiol2003;94(3):219\u201324."},{"key":"bib23","first-page":"1","article-title":"Histoplasmosis in Veterinary Medicine","author":"Wheat","year":"2004","unstructured":"Wheat\n              LJ\n            \n          . Histoplasmosis in Veterinary Medicine. 2004:1\u20139. Available at: http:\/\/www.miravistalabs.com\/Files\/pdf\/Histo_Vet_Review_2010%20final.pdf. Accessed February 2, 2012."},{"issue":"1","key":"bib24","series-title":"Vet Radiology","first-page":"2","article-title":"The radiographic appearance of pulmonary histoplasmosis in the dog and cat. A review of 37 case histories","volume":"19","author":"Burk","year":"1978","unstructured":"Burk\n              RL\n            , CorleyEA, CorwinLAJr. The radiographic appearance of pulmonary histoplasmosis in the dog and cat. A review of 37 case histories. Vet Radiology1978;19(1):2\u20137."},{"issue":"2","key":"bib25","series-title":"J Am Anim Hosp Assoc","first-page":"165","article-title":"Histoplasmosis infection in two cats from California","volume":"40","author":"Johnson","year":"2004","unstructured":"Johnson\n              LR\n            , FryMM, AnezKL. Histoplasmosis infection in two cats from California. J Am Anim Hosp Assoc2004;40(2):165\u20139."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/48\/3\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/48\/3\/182\/1335514\/jaaha-ms-5758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/48\/3\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/48\/3\/article-p182.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:59:06Z","timestamp":1763740746000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/48\/3\/article-p182.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-5758","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}