{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:45:32Z","timestamp":1763747132450,"version":"3.45.0"},"reference-count":14,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Three dogs were examined for clinical signs ultimately attributed to systemic fungal infections. One dog was evaluated for chronic, ulcerated dermal lesions and lymphadenomegaly; one dog was examined for acute onset of unilateral blepharospasm; and one dog had diarrhea and hematochezia. Two of the dogs were diagnosed with blastomycosis (one with disseminated disease and the other with the disease localized to the left eye). The third dog was diagnosed with disseminated histoplasmosis. None of the dogs originated from, or had traveled to, typical regions endemic for these fungal diseases. All diagnoses were established from histopathology and either polymerase chain reaction (PCR) or cytology and culture. The two dogs diagnosed with blastomycosis were treated with either itraconazole or ketoconazole with apparent resolution of the infections. The dog with ocular involvement had an enucleation prior to beginning therapy. The dog diagnosed with histoplasmosis was euthanized without treatment. In patients with characteristic clinical features, systemic fungal infections should still be considered as differential diagnoses regardless of their travel history.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5799","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T02:38:09Z","timestamp":1349145489000},"page":"411-416","source":"Crossref","is-referenced-by-count":5,"title":["Systemic Mycosis in Three Dogs from Nonendemic Regions"],"prefix":"10.5326","volume":"48","author":[{"given":"Carmela L.","family":"Pratt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rance K.","family":"Sellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick S.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ty W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Righter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"Suppl 2","key":"bib1","series-title":"Clin Infect Dis","first-page":"S102","article-title":"Histoplasmosis and blastomycosis","volume":"22","author":"Bradsher","year":"1996","unstructured":"Bradsher\n              RW\n            \n          . Histoplasmosis and blastomycosis. Clin Infect Dis1996;22(Suppl 2):S102\u201311."},{"issue":"4","key":"bib2","series-title":"Vet Clin North Am Small Anim Pract","first-page":"721","article-title":"Update on canine and feline fungal diseases","volume":"33","author":"Kerl","year":"2003","unstructured":"Kerl\n              ME\n            \n          . Update on canine and feline fungal diseases. Vet Clin North Am Small Anim Pract2003;33(4):721\u201347."},{"issue":"4","key":"bib3","series-title":"Clin Tech Small Anim Pract","first-page":"233","article-title":"Epidemiology, diagnosis, and treatment of blastomycosis in dogs and cats","volume":"20","author":"Br\u00f6mel","year":"2005","unstructured":"Br\u00f6mel\n              C\n            , SykesJE. Epidemiology, diagnosis, and treatment of blastomycosis in dogs and cats. Clin Tech Small Anim Pract2005;20(4):233\u20139."},{"issue":"4","key":"bib4","series-title":"Clin Tech Small Anim Pract","first-page":"227","article-title":"Histoplasmosis in dogs and cats","volume":"20","author":"Br\u00f6mel","year":"2005","unstructured":"Br\u00f6mel\n              C\n            , SykesJE. Histoplasmosis in dogs and cats. Clin Tech Small Anim Pract2005;20(4):227\u201332."},{"issue":"2","key":"bib5","series-title":"J Am Anim Hosp Assoc","first-page":"165","article-title":"Histoplasmosis infection in two cats from California","volume":"40","author":"Johnson","year":"2004","unstructured":"Johnson\n              LR\n            , FryMM, AnezKL. Histoplasmosis infection in two cats from California. J Am Anim Hosp Assoc2004;40(2):165\u20139."},{"issue":"7","key":"bib6","series-title":"Can Vet J","first-page":"734","article-title":"Histoplasmosis in a dog from New Brunswick","volume":"48","author":"Tyre","year":"2007","unstructured":"Tyre\n              E\n            , EisenbartD, FoleyP. Histoplasmosis in a dog from New Brunswick. Can Vet J2007;48(7):734\u20136."},{"issue":"8","key":"bib7","series-title":"Emerg Infect Dis","first-page":"1185","article-title":"Cryptococcus gattii Working Group of the Pacific Northwest. Spread of Cryptococcus gattii into Pacific Northwest region of the United States","volume":"15","author":"Datta","year":"2009","unstructured":"Datta\n              K\n            , BartlettKH, BaerR; Cryptococcus gattii Working Group of the Pacific Northwest. Spread of Cryptococcus gattii into Pacific Northwest region of the United States. Emerg Infect Dis2009;15(8):1185\u201391."},{"issue":"28","key":"bib8","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"865","article-title":"Emergence of Cryptococcus gattii\u2014 Pacific Northwest, 2004\u20132010","volume":"59","year":"2010","unstructured":"Centers for Disease Control and Prevention (CDC). Emergence of Cryptococcus gattii\u2014 Pacific Northwest, 2004\u20132010. MMWR Morb Mortal Wkly Rep2010;59(28):865\u20138."},{"issue":"1","key":"bib9","series-title":"Am J Orthop","first-page":"29","article-title":"Blastomyces dermatitidis osteomyelitis of the tibia","volume":"36","author":"Weber","year":"2007","unstructured":"Weber\n              CL\n            , BartleyD, Al-ThaqafiA. Blastomyces dermatitidis osteomyelitis of the tibia. Am J Orthop2007;36(1):29\u201332."},{"issue":"2","key":"bib10","series-title":"Fungal Genet Biol","first-page":"81","article-title":"Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment","volume":"35","author":"Woods","year":"2002","unstructured":"Woods\n              JP\n            \n          . Histoplasma capsulatum molecular genetics, pathogenesis, and responsiveness to its environment. Fungal Genet Biol2002;35(2):81\u201397."},{"issue":"4","key":"bib11","series-title":"J Vet Intern Med","first-page":"839","article-title":"Antigen and antibody testing for the diagnosis of blastomycosis in dogs","volume":"22","author":"Spector","year":"2008","unstructured":"Spector\n              D\n            , LegendreAM, WheatJ. Antigen and antibody testing for the diagnosis of blastomycosis in dogs. J Vet Intern Med2008;22(4):839\u201343."},{"issue":"5","key":"bib12","series-title":"Am J Vet Res","first-page":"554","article-title":"Canine antibody response to Blastomyces dermatitidis WI-1 antigen","volume":"61","author":"Klein","year":"2000","unstructured":"Klein\n              BS\n            , SquiresRA, LloydJK. Canine antibody response to Blastomyces dermatitidis WI-1 antigen. Am J Vet Res2000;61(5):554\u20138."},{"issue":"2","key":"bib13","series-title":"Vet Clin North Am Small Anim Pract","first-page":"373","article-title":"Fungal diagnostics: current techniques and future trends","volume":"37","author":"Dial","year":"2007","unstructured":"Dial\n              SM\n            \n          . Fungal diagnostics: current techniques and future trends. Vet Clin North Am Small Anim Pract2007;37(2):373\u201392, viii."},{"issue":"8","key":"bib14","series-title":"J Histochem Cytochem","first-page":"1217","article-title":"Immunomycology: rapid and specific immunocytochemical identification of fungi in formalin-fixed, paraffin-embedded material","volume":"41","author":"Reed","year":"1993","unstructured":"Reed\n              JA\n            , HemannBA, AlexanderJL. Immunomycology: rapid and specific immunocytochemical identification of fungi in formalin-fixed, paraffin-embedded material. 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