{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:22:57Z","timestamp":1784805777875,"version":"3.55.0"},"reference-count":16,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>A 10 yr old bichon frise presented with a 3 mo history of polyuria, polydipsia, and hind limb weakness. Serum biochemistry revealed persistent hypokalemia. A left adrenal gland mass with right adrenal atrophy was detected ultrasonographically. Basal serum cortisol concentration was at the low end of normal (30 nmol\/L; reference range, 30\u2013140 nmol\/L) and adrenocorticotropic hormone (ACTH)-stimulated cortisol concentration was low (199 nmol\/L; reference range, 220\u2013470 nmol\/L). Basal serum 17-\u03b1-OH progesterone concentration was also low (0.03 ng\/mL; reference range, 0.06\u20130.30 ng\/mL), but the aldosterone concentration 2 hr after the ACTH stimulation was elevated (&gt; 3,000 pmol\/L; reference range, 197\u20132,103 pmol\/L). A left adrenalectomy and nephrectomy were performed. Histopathology revealed an adrenocortical zona glomerulosa carcinoma. Surgical excision was considered incomplete; however, clinical signs resolved. Two years later, basal and ACTH-stimulated aldosterone concentrations were elevated. Computed tomography demonstrated a mass effect in the liver. The left lateral and left medial hepatic lobes were removed. Histopathology confirmed metastatic endocrine carcinoma. The patient was stable 1,353 days postsurgically (when this report was prepared). This is the first case report of a metastatic adrenal carcinoma that was successfully managed surgically for &gt; 3 yr.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5800","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T02:38:09Z","timestamp":1349145489000},"page":"417-423","source":"Crossref","is-referenced-by-count":5,"title":["Adrenocortical Carcinoma in a Dog with Incomplete Excision Managed Long-term with Metastasectomy Alone"],"prefix":"10.5326","volume":"48","author":[{"given":"Jennifer L.","family":"Frankot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen N.","family":"Behrend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sebestyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"5","key":"bib1","series-title":"Am J Vet Res","first-page":"661","article-title":"Determination of the concentrations of trilostane and ketotrilostane that inhibit ex vivo canine adrenal gland synthesis of cortisol, corticosterone, and aldosterone","volume":"72","author":"McGraw","year":"2011","unstructured":"McGraw\n              AL\n            , WhitleyEM, LeeHP. Determination of the concentrations of trilostane and ketotrilostane that inhibit ex vivo canine adrenal gland synthesis of cortisol, corticosterone, and aldosterone. Am J Vet Res2011;72(5):661\u20135."},{"issue":"10","key":"bib2","series-title":"J Am Vet Med Assoc","first-page":"1662","article-title":"Corticosterone- and aldosterone-secreting adrenocortical tumor in a dog","volume":"226","author":"Behrend","year":"2005","unstructured":"Behrend\n              EN\n            , WeigandCM, WhitleyEM. Corticosterone- and aldosterone-secreting adrenocortical tumor in a dog. J Am Vet Med Assoc2005;226(10):1662\u20136, 1659."},{"issue":"3","key":"bib3","series-title":"J Vet Med Sci","first-page":"317","article-title":"Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a.: case report","volume":"70","author":"Machida","year":"2008","unstructured":"Machida\n              T\n            , UchidaE, MatsudaK. Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a.: case report. J Vet Med Sci2008;70(3):317\u201320."},{"issue":"2","key":"bib4","series-title":"Vet Clin North Am Small Anim Pract","first-page":"381","article-title":"Adrenal incidentalomas. Diagnostic workup of the incidentally discovered adrenal mass","volume":"27","author":"Myers","year":"1997","unstructured":"Myers\n              NC\n              III\n            \n          . Adrenal incidentalomas. Diagnostic workup of the incidentally discovered adrenal mass. Vet Clin North Am Small Anim Pract1997;27(2):381\u201399."},{"issue":"1","key":"bib5","series-title":"Vet Q","first-page":"38","article-title":"Hyperaldosteronism in a cat with metastasised adrenocortical tumour","volume":"23","author":"Rijnberk","year":"2001","unstructured":"Rijnberk\n              A\n            , VoorhoutG, KooistraHS. Hyperaldosteronism in a cat with metastasised adrenocortical tumour. 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St. Louis (MO): Saunders; 2004:252\u2013357."},{"issue":"4","key":"bib10","series-title":"J Vet Intern Med","first-page":"386","article-title":"Deoxycorticosterone-secreting adrenocortical carcinoma in a dog","volume":"13","author":"Reine","year":"1999","unstructured":"Reine\n              NJ\n            , HohenhausAE, PetersonME. Deoxycorticosterone-secreting adrenocortical carcinoma in a dog. J Vet Intern Med1999;13(4):386\u201390."},{"issue":"4","key":"bib11","series-title":"Aust Vet J","first-page":"139","article-title":"Hypokalaemic paresis, hypertension, alkalosis and adrenal-dependent hyperadrenocorticism in a dog","volume":"86","author":"Davies","year":"2008","unstructured":"Davies\n              DR\n            , FosterSF, HopperBJ. Hypokalaemic paresis, hypertension, alkalosis and adrenal-dependent hyperadrenocorticism in a dog. Aust Vet J2008;86(4):139\u201346."},{"issue":"3","key":"bib12","series-title":"Vet Q","first-page":"113","article-title":"Results of adrenalectomy in 36 dogs with hyperadrenocorticism caused by adreno-cortical tumour","volume":"17","author":"van Sluijs","year":"1995","unstructured":"van Sluijs\n              FJ\n            , SjollemaBE, VoorhoutG. Results of adrenalectomy in 36 dogs with hyperadrenocorticism caused by adreno-cortical tumour. Vet Q1995;17(3):113\u20136."},{"issue":"1","key":"bib13","series-title":"J Am Anim Hosp Assoc","first-page":"93","article-title":"Surgical treatment of adrenocortical tumors: 21 cases","volume":"37","author":"Anderson","year":"1990\u20131996","unstructured":"Anderson\n              CR\n            , BirchardSJ, PowersBE. Surgical treatment of adrenocortical tumors: 21 cases (1990\u20131996). 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