{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:44:12Z","timestamp":1787031852678,"version":"build-2736575974"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    A 2.5 yr old sexually intact male vizsla was admitted to the Iowa State University Veterinary Teaching Hospital for persistent diarrhea, weight loss, and panhypoproteinemia. Examination revealed an emaciated condition and melena. Two masses were palpated in the cranial abdomen. Hematology and serum biochemistry exhibited a regenerative anemia and confirmed the presence of panhypoproteinemia, suggestive of a protein-losing eneteropathy. Distinct areas of thickened intestinal wall and enlarged mesenteric lymph nodes were found on abdominal ultrasound. Cytology from those nodes showed the presence of suspected\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    spp., and infection was confirmed utilizing a cryptococcal antigen titer. Medical therapy with lipid-complexed amphotericin B and fluconazole was unsuccessful. Two surgical procedures were performed to remove the affected areas of intestine and lymph nodes, but the disease persisted as evidenced by a persistently elevated cryptococcal antigen titer. Terbinafine was prescribed, which resulted in complete resolution of clinical signs and a steadily decreasing cryptococcal antigen titer. Very few cases of intestinal cryptococcosis have been reported. In this case, infection resulted in a protein-losing enteropathy. In addition, this article describes the use of terbinafine in the treatment of intestinal cryptococcal infection in the dog, which has not been previously reported.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-5813","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T02:01:28Z","timestamp":1333504888000},"page":"216-220","source":"Crossref","is-referenced-by-count":14,"title":["Use of Terbinafine in the Treatment Protocol of Intestinal Cryptococcus neoformans in a Dog"],"prefix":"10.5326","volume":"48","author":[{"given":"Gavin L.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krysta L.","family":"Deitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R.","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Hurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Infectious diseases of the dog and cat","first-page":"584","article-title":"Cryptococcosis","author":"Malik","year":"2006","unstructured":"Malik\n              R\n            , KrockenbergerM, O'BrienCR. Cryptococcosis. In: GreeneCE, ed. Infectious diseases of the dog and cat. St. Louis (MO): Elsevier; 2006:584\u201398."},{"issue":"4","key":"bib2","series-title":"Vet Clin Pathol","first-page":"409","article-title":"Diagnosis of systemic cryptococcosis by fecal cytology in a dog","volume":"34","author":"Graves","year":"2005","unstructured":"Graves\n              TK\n            , BargerAM, AdamsB. Diagnosis of systemic cryptococcosis by fecal cytology in a dog. Vet Clin Pathol2005;34(4):409\u201312."},{"issue":"5","key":"bib3","series-title":"Aust Vet J","first-page":"358","article-title":"A latex cryptococcal antigen agglutination test for diagnosis and monitoring of therapy for cryptococcosis","volume":"74","author":"Malik","year":"1996","unstructured":"Malik\n              R\n            , McPetrieR, WigneyDI. A latex cryptococcal antigen agglutination test for diagnosis and monitoring of therapy for cryptococcosis. 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J Pharm Sci2001;90(11):1817\u201328."},{"issue":"11","key":"bib14","series-title":"Antimicrob Agents Chemother","first-page":"3087","article-title":"Comparative efficacies of terbinafine and fluconazole in treatment of experimental coccidioidal meningitis in a rabbit model","volume":"44","author":"Sorensen","year":"2000","unstructured":"Sorensen\n              KN\n            , SobelRA, ClemonsKV. Comparative efficacies of terbinafine and fluconazole in treatment of experimental coccidioidal meningitis in a rabbit model. Antimicrob Agents Chemother2000;44(11):3087\u201391."},{"issue":"5","key":"bib15","series-title":"Antimicrob Agents Chemother","first-page":"1057","article-title":"In vitro activities of terbinafine against cutaneous isolates of Candida albicans and other pathogenic yeasts","volume":"42","author":"Ryder","year":"1998","unstructured":"Ryder\n              NS\n            , WagnerS, LeitnerI. 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Vet Dermatol2011;22(6):528\u201334."},{"issue":"16","key":"bib20","series-title":"Expert Opin Pharmacother","first-page":"2723","article-title":"Terbinafine: a pharmacological and clinical review","volume":"10","author":"Krishnan-Natesan","year":"2009","unstructured":"Krishnan-Natesan\n              S\n            \n          . Terbinafine: a pharmacological and clinical review. 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