{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:12:58Z","timestamp":1763741578127,"version":"3.45.0"},"reference-count":31,"publisher":"American Animal Hospital Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    A 4 yr old spayed female Labrador retriever with clinical signs of blindness, cutaneous lesions, coughing, inappetence, and lethargy was diagnosed with disseminated blastomycosis based on cytologic (skin and lymph node aspirates) and histopathologic (skin biopsy) examinations of tissue samples. The dog deteriorated clinically during hospitalization and developed sustained ventricular tachycardia. Echocardiography revealed pericardial effusion, a nodule associated with the left ventricular papillary muscle, and a right atrial mural lesion. Therapy for myocardial performance and glaucoma was initiated. A combination of itraconazole and fluconazole successfully treated the dog. The dog regained vision in the left eye (\n                    <jats:italic>oculus sinister<\/jats:italic>\n                    [OS]) and had no residual cardiac disease detectable by either electrocardiography or echocardiography. This report is unique in documenting survival from intracardiac blastomycosis and in the use of combination azole therapy for treating disseminated disease with intraocular involvement.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-5874","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:56:39Z","timestamp":1369097799000},"page":"273-280","source":"Crossref","is-referenced-by-count":4,"title":["Successful Treatment of Intracardiac and Intraocular Blastomycosis in a Dog with Combination Azole Therapy"],"prefix":"10.5326","volume":"49","author":[{"given":"Daniel K.","family":"Langlois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusta","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Kruger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"6","key":"bib1","series-title":"Am J Vet Res","first-page":"954","article-title":"Clinical, clinicopathologic, and parasitologic observations of trypanosomiasis in dogs infected with North American Trypanosoma cruzi isolates","volume":"52","author":"Barr","year":"1991","unstructured":"Barr\n              SC\n            , GossettKA, KleiTR. Clinical, clinicopathologic, and parasitologic observations of trypanosomiasis in dogs infected with North American Trypanosoma cruzi isolates. Am J Vet Res1991;52(6):954\u201360."},{"key":"bib2","series-title":"Infectious diseases of the dog and cat","first-page":"841","article-title":"Cardiovascular infections","author":"Calvert","year":"2006","unstructured":"Calvert\n              CA\n            , WallM. Cardiovascular infections. In: GreeneCE, ed. Infectious diseases of the dog and cat. 3rd ed. St. Louis (MO): Saunders Elsevier; 2006:841\u201365."},{"issue":"5","key":"bib3","series-title":"J Vet Intern Med","first-page":"1219","article-title":"Acute encephalitis, polyarthritis, and myocarditis associated with West Nile virus infection in a dog","volume":"20","author":"Cannon","year":"2006","unstructured":"Cannon\n              AB\n            , LuffJA, BraultAC. Acute encephalitis, polyarthritis, and myocarditis associated with West Nile virus infection in a dog. J Vet Intern Med2006;20(5):1219\u201323."},{"issue":"6","key":"bib4","series-title":"J Vet Diagn Invest","first-page":"565","article-title":"Use of a multiplex polymerase chain reaction to rapidly differentiate Neospora caninum from Toxoplasma gondii in an adult dog with necrotizing myocarditis and myocardial infarct","volume":"17","author":"Meseck","year":"2005","unstructured":"Meseck\n              EK\n            , NjaaBL, HaleyNJ. Use of a multiplex polymerase chain reaction to rapidly differentiate Neospora caninum from Toxoplasma gondii in an adult dog with necrotizing myocarditis and myocardial infarct. J Vet Diagn Invest2005;17(6):565\u20138."},{"issue":"3","key":"bib5","series-title":"J Am Vet Med Assoc","first-page":"435","article-title":"Subtotal pericardectomy and epicardial excision for treatment of coccidioidomycosis-induced effusive-constrictive pericarditis in dogs: 17 cases (1999\u20132003)","volume":"227","author":"Heinritz","year":"2005","unstructured":"Heinritz\n              CK\n            , GilsonSD, SoderstromMJ. Subtotal pericardectomy and epicardial excision for treatment of coccidioidomycosis-induced effusive-constrictive pericarditis in dogs: 17 cases (1999\u20132003). J Am Vet Med Assoc2005;227(3):435\u201340."},{"issue":"6","key":"bib6","series-title":"J Vet Intern Med","first-page":"1351","article-title":"Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infection","volume":"20","author":"Schmiedt","year":"2006","unstructured":"Schmiedt\n              C\n            , KellumH, LegendreAM. Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infection. J Vet Intern Med2006;20(6):1351\u20134."},{"issue":"1","key":"bib7","series-title":"Clin Tech Small Anim Pract","first-page":"71","article-title":"Medical and surgical management of the glaucoma patient","volume":"16","author":"Abrams","year":"2001","unstructured":"Abrams\n              KL\n            \n          . Medical and surgical management of the glaucoma patient. Clin Tech Small Anim Pract2001;16(1):71\u20136."},{"issue":"1","key":"bib8","series-title":"Vet Ophthalmol","first-page":"9","article-title":"Advances in topical glaucoma therapy","volume":"5","author":"Willis","year":"2002","unstructured":"Willis\n              AM\n            , DiehlKA, RobbinTE. Advances in topical glaucoma therapy. Vet Ophthalmol2002;5(1):9\u201317."},{"issue":"2","key":"bib9","series-title":"Vet Clin North Am Small Anim Pract","first-page":"323","article-title":"Canine and feline uveitis","volume":"38","author":"Townsend","year":"2008","unstructured":"Townsend\n              WM\n            \n          . Canine and feline uveitis. Vet Clin North Am Small Anim Pract2008;38(2):323\u201346, vii."},{"issue":"6","key":"bib10","series-title":"J Vet Intern Med","first-page":"365","article-title":"Treatment of blastomycosis with itraconazole in 112 dogs","volume":"10","author":"Legendre","year":"1996","unstructured":"Legendre\n              AM\n            , RohrbachBW, ToalRL. Treatment of blastomycosis with itraconazole in 112 dogs. J Vet Intern Med1996;10(6):365\u201371."},{"key":"bib11","series-title":"Infectious diseases of the dog and cat","first-page":"542","article-title":"Antifungal chemotherapy","author":"Greene","year":"2006","unstructured":"Greene\n              CE\n            \n          . Antifungal chemotherapy. In: GreenCE, ed. Infectious diseases of the dog and cat. 3rd ed. St. Louis (MO): Saunders Elsevier; 2006:542\u201350."},{"key":"bib12","series-title":"Textbook of veterinary internal medicine","first-page":"415","article-title":"Echocardiography","volume":"1","author":"B\u00e9langer","year":"2010","unstructured":"B\u00e9langer\n              MC\n            \n          . Echocardiography. In: EttingerSJ, ed. Textbook of veterinary internal medicine. 7th ed. St. Louis (MO): Saunders Elsevier; 2010;1:415\u201331."},{"key":"bib13","series-title":"Infectious diseases of the dog and cat","first-page":"569","article-title":"Blastomycosis","author":"Legendre","year":"2006","unstructured":"Legendre\n              AM\n            \n          . Blastomycosis. In: GreeneCE, ed. Infectious diseases of the dog and cat. 3rd ed. St. Louis (MO): Saunders Elsevier; 2006:569\u201376."},{"issue":"5","key":"bib14","series-title":"J Am Vet Med Assoc","first-page":"658","article-title":"Blastomycosis in dogs: 115 cases (1980\u20131995)","volume":"213","author":"Arceneaux","year":"1998","unstructured":"Arceneaux\n              KA\n            , TaboadaJ, HosgoodG. Blastomycosis in dogs: 115 cases (1980\u20131995). J Am Vet Med Assoc1998;213(5):658\u201364."},{"key":"bib15","series-title":"Textbook of veterinary internal medicine","first-page":"971","article-title":"Histoplasmosis, blastomycosis, sporotrichosis, candidiasis, pythiosis, and lagenidiosis","volume":"1","author":"Taboada","year":"2010","unstructured":"Taboada\n              J\n            , GrootersAM. Histoplasmosis, blastomycosis, sporotrichosis, candidiasis, pythiosis, and lagenidiosis. In: EttingerSJ, ed. Textbook of veterinary internal medicine. 7th ed. St. Louis (MO): Saunders Elsevier; 2010:1:971\u201388."},{"issue":"4","key":"bib16","series-title":"J Am Vet Med Assoc","first-page":"537","article-title":"Constrictive pericarditis secondary to Coccidioides immitis infection in a dog","volume":"218","author":"Shubitz","year":"2001","unstructured":"Shubitz\n              LF\n            , MatzME, NoonTH. Constrictive pericarditis secondary to Coccidioides immitis infection in a dog. J Am Vet Med Assoc2001;218(4):537\u201340, 526."},{"issue":"4","key":"bib17","series-title":"Vet Ophthalmol","first-page":"245","article-title":"Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs","volume":"9","author":"Plummer","year":"2006","unstructured":"Plummer\n              CE\n            , MacKayEO, GelattKN. Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. Vet Ophthalmol2006;9(4):245\u20139."},{"issue":"1","key":"bib18","series-title":"J Vet Cardiol","first-page":"67","article-title":"Oculocardiac reflex induced by zygomatic arch fracture in a crossbreed dog","volume":"11","author":"Selk Ghaffari","year":"2009","unstructured":"Selk Ghaffari\n              M\n            , MarjaniM, MasoudifardM. Oculocardiac reflex induced by zygomatic arch fracture in a crossbreed dog. J Vet Cardiol2009;11(1):67\u20139."},{"issue":"1","key":"bib19","series-title":"Ophthal Plast Reconstr Surg","first-page":"e2","article-title":"A case of delayed oculocardiac reflex induced by an intraorbital foreign body","volume":"27","author":"Yang","year":"2011","unstructured":"Yang\n              HS\n            , OhDE. A case of delayed oculocardiac reflex induced by an intraorbital foreign body. Ophthal Plast Reconstr Surg2011;27(1):e2\u20134."},{"issue":"6","key":"bib20","series-title":"J Glaucoma","first-page":"377","article-title":"Autonomic dysfunction in normal tension glaucoma: the short-term heart rate variability analysis","volume":"19","author":"Na","year":"2010","unstructured":"Na\n              KS\n            , LeeNY, ParkSH. Autonomic dysfunction in normal tension glaucoma: the short-term heart rate variability analysis. J Glaucoma2010;19(6):377\u201381."},{"issue":"10","key":"bib21","series-title":"J Am Vet Med Assoc","first-page":"1249","article-title":"Treatment of canine blastomycosis with amphotericin B and ketoconazole","volume":"184","author":"Legendre","year":"1984","unstructured":"Legendre\n              AM\n            , SelcerBA, EdwardsDF. Treatment of canine blastomycosis with amphotericin B and ketoconazole. J Am Vet Med Assoc1984;184(10):1249\u201354."},{"issue":"4","key":"bib22","series-title":"Antimicrob Agents Chemother","first-page":"978","article-title":"Susceptibilities of clinical and laboratory isolates of Blastomyces dermatitidis to ketoconazole, itraconazole, and fluconazole","volume":"42","author":"Chapman","year":"1998","unstructured":"Chapman\n              SW\n            , RogersPD, RinaldiMG. Susceptibilities of clinical and laboratory isolates of Blastomyces dermatitidis to ketoconazole, itraconazole, and fluconazole. Antimicrob Agents Chemother1998;42(4):978\u201380."},{"issue":"5","key":"bib23","series-title":"Am J Med","first-page":"489","article-title":"Itraconazole therapy for blastomycosis and histoplasmosis","volume":"93","author":"Dismukes","year":"1992","unstructured":"Dismukes\n              WE\n            , BradsherRWJr, CloudGC. Itraconazole therapy for blastomycosis and histoplasmosis. Am J Med1992;93(5):489\u201397."},{"issue":"2","key":"bib24","series-title":"Clin Infect Dis","first-page":"267","article-title":"Treatment of blastomycosis with fluconazole: a pilot study","volume":"20","author":"Pappas","year":"1995","unstructured":"Pappas\n              PG\n            , BradsherRW, ChapmanSW. Treatment of blastomycosis with fluconazole: a pilot study. Clin Infect Dis1995;20(2):267\u201371."},{"issue":"2","key":"bib25","series-title":"Clin Infect Dis","first-page":"200","article-title":"The National Institute of Allergy and Infectious Diseases Mycoses Study Group. Treatment of blastomycosis with higher doses of fluconazole","volume":"25","author":"Pappas","year":"1997","unstructured":"Pappas\n              PG\n            , BradsherRW, KauffmanCA; The National Institute of Allergy and Infectious Diseases Mycoses Study Group. Treatment of blastomycosis with higher doses of fluconazole. Clin Infect Dis1997;25(2):200\u20135."},{"issue":"3","key":"bib26","series-title":"J Vet Intern Med","first-page":"440","article-title":"Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs","volume":"25","author":"Mazepa","year":"2011","unstructured":"Mazepa\n              AS\n            , TrepanierLA, FoyDS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med2011;25(3):440\u20135."},{"issue":"2","key":"bib27","series-title":"FEMS Microbiol Lett","first-page":"175","article-title":"In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi","volume":"307","author":"Nyilasi","year":"2010","unstructured":"Nyilasi\n              I\n            , Kocsub\u00e9S, Krizs\u00e1nK. In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi. FEMS Microbiol Lett2010;307(2):175\u201384."},{"issue":"3","key":"bib28","series-title":"Vet Clin North Am Small Anim Pract","first-page":"693","article-title":"The use of corticosteroids to treat ocular inflammation","volume":"34","author":"Holmberg","year":"2004","unstructured":"Holmberg\n              BJ\n            , MaggsDJ. The use of corticosteroids to treat ocular inflammation. Vet Clin North Am Small Anim Pract2004;34(3):693\u2013705."},{"issue":"7","key":"bib29","series-title":"J Am Vet Med Assoc","first-page":"1271","article-title":"Ocular blastomycosis in dogs: 73 cases, 108 eyes (1985\u20131993)","volume":"209","author":"Bloom","year":"1996","unstructured":"Bloom\n              JD\n            , HamorRE, GerdingPAJr. Ocular blastomycosis in dogs: 73 cases, 108 eyes (1985\u20131993). J Am Vet Med Assoc1996;209(7):1271\u20134."},{"issue":"5","key":"bib30","series-title":"Vet Ophthalmol","first-page":"299","article-title":"Visual outcome in a group of dogs with ocular blastomycosis treated with systemic antifungals and systemic corticosteroids","volume":"10","author":"Finn","year":"2007","unstructured":"Finn\n              MJ\n            , StilesJ, KrohneSG. Visual outcome in a group of dogs with ocular blastomycosis treated with systemic antifungals and systemic corticosteroids. Vet Ophthalmol2007;10(5):299\u2013303."},{"issue":"3","key":"bib31","series-title":"Vet Clin North Am Small Anim Pract","first-page":"707","article-title":"Nonsteroidal anti-inflammatory drugs in veterinary ophthalmology","volume":"34","author":"Giuliano","year":"2004","unstructured":"Giuliano\n              EA\n            \n          . Nonsteroidal anti-inflammatory drugs in veterinary ophthalmology. 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