{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:03:32Z","timestamp":1784887412669,"version":"3.55.0"},"reference-count":29,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Hemangiosarcomas (HSAs) are aggressive tumors with a high rate of metastasis. Clinical stage has been considered a negative prognostic factor for survival. The study authors hypothesized that the median survival time (MST) of dogs with metastatic (stage III) HSA treated with a vincristine, doxorubicin, and cyclophosphamide (VAC) chemotherapy protocol would not be different than those with stage I\/II HSA. Sixty-seven dogs with HSA in different anatomic locations were evaluated retrospectively. All dogs received the VAC protocol as an adjuvant to surgery (n = 50), neoadjuvant (n = 3), or as the sole treatment modality (n = 14). There was no significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.97) between the MST of dogs with stage III and stage I\/II HSA. For dogs presenting with splenic HSA alone, there was no significant difference between the MST of dogs with stage III and stage I\/II disease (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.12). The overall response rate (complete response [CR] and partial response [PR]) was 86%). No unacceptable toxicities were observed. Dogs with stage III HSA treated with the VAC protocol have a similar prognosis to dogs with stage I\/II HSA. Dogs with HSA and evidence of metastases at the time of diagnosis should not be denied treatment.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-5954","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T04:21:16Z","timestamp":1379650876000},"page":"370-377","source":"Crossref","is-referenced-by-count":32,"title":["VAC Protocol for Treatment of Dogs with Stage III Hemangiosarcoma"],"prefix":"10.5326","volume":"49","author":[{"given":"Francisco J.","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hosoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lara-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kisseberth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"3","key":"bib1","series-title":"J Vet Intern Med","first-page":"160","article-title":"Efficacy and toxicity of VAC chemotherapy (vincristine, doxorubicin, and cyclophosphamide) in dogs with hemangiosarcoma","volume":"5","author":"Hammer","year":"1991","unstructured":"Hammer\n              AS\n            , CoutoCG, FilppiJ. Efficacy and toxicity of VAC chemotherapy (vincristine, doxorubicin, and cyclophosphamide) in dogs with hemangiosarcoma. J Vet Intern Med1991;5(3):160\u20136."},{"issue":"1","key":"bib2","series-title":"J Am Vet Med Assoc","first-page":"56","article-title":"Canine hemangiosarcoma: retrospective analysis of 104 cases","volume":"186","author":"Brown","year":"1985","unstructured":"Brown\n              NO\n            , PatnaikAK, MacEwenEG. Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc1985;186(1):56\u20138."},{"issue":"6","key":"bib3","series-title":"J Vet Intern Med","first-page":"370","article-title":"Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide","volume":"7","author":"Sorenmo","year":"1993","unstructured":"Sorenmo\n              KU\n            , JeglumKA, HelfandSC. Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. 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Risk factors for sterile hemorrhagic cystitis in dogs with lymphoma receiving cyclophosphamide with or without concurrent administration of furosemide: 216 cases (1990\u20131996). 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