{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:08Z","timestamp":1772326988812,"version":"3.50.1"},"reference-count":40,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"An 8 yr old castrated male Labrador retriever mixed-breed dog with osteosarcoma (OSA) of the left proximal humerus receiving carboplatin presented 10 days after the third chemotherapy treatment with hematuria, stranguria, and pollakiuria. A presumptive diagnosis of hemorrhagic cystitis was made based on clinical signs, urinalysis, and cytologic analysis of a traumatic catheterization sample. Carboplatin was removed from the chemotherapy treatment plan and was substituted with doxorubicin. The dog was treated with meloxicam for pain, and the cystitis signs subsided over a period of 4 wk. Carboplatin is commonly used as adjuvant chemotherapy for dogs with OSA following amputation and is not known to cause hematuria in dogs, although there are reports of this occurring in humans. To the authors\u2019 knowledge, there are no reports in the veterinary literature of this toxicity.<\/jats:p>","DOI":"10.5326\/jaaha-ms-5965","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T23:28:20Z","timestamp":1384212500000},"page":"67-70","source":"Crossref","is-referenced-by-count":1,"title":["Hemorrhagic Cystitis in a Dog Receiving Carboplatin"],"prefix":"10.5326","volume":"50","author":[{"given":"Valerie","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Cancer principles and practice of oncology","first-page":"2455","article-title":"Urologic emergencies","author":"Strope","year":"2008","unstructured":"Strope\n SA\n , HafezKS. Urologic emergencies. In: DeVitaVT, HellmanS, RosenbergSA, eds. 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In: BarakatRR, MarkmanM, RandallME, eds. Principles and practice of gynecologic oncology. 5th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2009:409\u201362."},{"issue":"6","key":"bib6","series-title":"Med Pediatr Oncol","first-page":"473","article-title":"Acute renal failure in high dose carboplatin chemotherapy","volume":"25","author":"Frenkel","year":"1995","unstructured":"Frenkel\n J\n , KoolG, de KrakerJ. Acute renal failure in high dose carboplatin chemotherapy. Med Pediatr Oncol1995;25(6):473\u20134."},{"key":"bib7","series-title":"Cancer","first-page":"917","article-title":"A phase 1 study of carboplatin in children with acute leukemia in bone marrow relapses","volume":"72","author":"Ettinger","year":"1993","unstructured":"Ettinger\n LJ\n , KrailoMD, GaynonPS. A phase 1 study of carboplatin in children with acute leukemia in bone marrow relapses. 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Philadelphia (PA): Lippincott Williams & Wilkins; 2008:2455\u201360."},{"issue":"10","key":"bib2","series-title":"J Am Vet Med Assoc","first-page":"1572","article-title":"Acute sterile hemorrhagic cystitis after a single intravenous administration of cyclophosphamide in three dogs","volume":"201","author":"Peterson","year":"1992","unstructured":"Peterson\n JL\n , CoutoCG, HammerAS. Acute sterile hemorrhagic cystitis after a single intravenous administration of cyclophosphamide in three dogs. J Am Vet Med Assoc1992;201(10):1572\u20134."},{"issue":"3","key":"bib3","series-title":"J Am Vet Med Assoc","first-page":"259","article-title":"Cyclophosphamide-induced cystitis in the dog and cat","volume":"171","author":"Crow","year":"1977","unstructured":"Crow\n SE\n , TheilenGH, MadewellBR. Cyclophosphamide-induced cystitis in the dog and cat. 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In: BarakatRR, MarkmanM, RandallME, eds. Principles and practice of gynecologic oncology. 5th ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2009:409\u201362."},{"issue":"6","key":"bib6","series-title":"Med Pediatr Oncol","first-page":"473","article-title":"Acute renal failure in high dose carboplatin chemotherapy","volume":"25","author":"Frenkel","year":"1995","unstructured":"Frenkel\n J\n , KoolG, de KrakerJ. Acute renal failure in high dose carboplatin chemotherapy. Med Pediatr Oncol1995;25(6):473\u20134."},{"key":"bib7","series-title":"Cancer","first-page":"917","article-title":"A phase 1 study of carboplatin in children with acute leukemia in bone marrow relapses","volume":"72","author":"Ettinger","year":"1993","unstructured":"Ettinger\n LJ\n , KrailoMD, GaynonPS. A phase 1 study of carboplatin in children with acute leukemia in bone marrow relapses. 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