{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:13:51Z","timestamp":1763741631933,"version":"3.45.0"},"reference-count":19,"publisher":"American Animal Hospital Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Medical records for 79 dogs with confirmed splenic hemangiosarcoma (HSA) following splenectomy were reviewed for information regarding either the presence or absence of macroscopic liver lesions and the histopathological characteristics of the liver. Only 29 of 58 dogs (50%) with grossly abnormal livers had HSA metastasis. No dogs with grossly normal livers had metastasis detected on liver pathology. Gross lesions in the liver such as multiple nodules, dark-colored nodules, and active bleeding nodules were highly associated with malignancy. For the dogs in this study, performing biopsy in a grossly normal liver was a low-yield procedure in dogs with splenic HSA.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6059","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T17:53:20Z","timestamp":1404755600000},"page":"e6-e10","source":"Crossref","is-referenced-by-count":19,"title":["Association Between Macroscopic Appearance of Liver Lesions and Liver Histology in Dogs With Splenic Hemangiosarcoma: 79 Cases (2004\u20132009)"],"prefix":"10.5326","volume":"50","author":[{"given":"Daphne C.","family":"Clendaniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh K.","family":"Sivacolundhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin U.","family":"Sorenmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taryn A.","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avenelle","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Arteaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"5","key":"bib1","series-title":"J Vet Intern Med","first-page":"479","article-title":"Treatment of canine hemangiosarcoma: 2000 and beyond","volume":"14","author":"Clifford","year":"2000","unstructured":"Clifford\n              CA\n            , MackinAJ, HenryCJ. Treatment of canine hemangiosarcoma: 2000 and beyond. J Vet Intern Med2000;14(5):479\u201385."},{"issue":"3","key":"bib2","series-title":"Vet Clin North Am Small Anim Pract","first-page":"533","article-title":"Hemangiosarcoma in dogs and cats","volume":"33","author":"Smith","year":"2003","unstructured":"Smith\n              AN\n            \n          . Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract2003;33(3):533\u201352, vi."},{"issue":"5","key":"bib3","series-title":"J Am Anim Hosp Assoc","first-page":"417","article-title":"Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991\u20131993)","volume":"34","author":"Wood","year":"1998","unstructured":"Wood\n              CA\n            , MooreAS, GliattoJM, et al. Prognosis for dogs with stage I or II splenic hemangiosarcoma treated by splenectomy alone: 32 cases (1991\u20131993). 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