{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:44:12Z","timestamp":1787031852058,"version":"build-2736575974"},"reference-count":34,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    A 6 yr old female Labrador retriever was evaluated for an acute onset of difficulty walking and a head tilt. Initial physical examination revealed bilateral retinal detachment, a left-sided head tilt, positional rotary nystagmus, and lumbar hyperpathia. Pertinent preliminary diagnostic findings included systemic hypertension, bony lysis and adjacent sclerosis of the vertebral endplates of the first and second lumbar vertebrae, and positive urine and blood cultures for a yeast identified as\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. Concerned about disseminated candidiasis after subsequent subretinal aspirates confirmed the presence of a yeast-like organism, therapy with voriconazole was initiated. Because of progressive clinical deterioration and the poor prognosis for recovery, the dog was eventually euthanized. Postmortem histological examination of tissues, including the affected vertebral endplates, revealed numerous intralesional algae compatible with\n                    <jats:italic>Prototheca<\/jats:italic>\n                    spp. To the authors' knowledge, this report is the first to document a case of protothecal diskospondylitis with possible concurrent candidiasis in a dog. Although typically associated with signs referable to the gastrointestinal tract, this report underscores the importance of not excluding protothecosis as a differential diagnosis when such signs are absent. Lastly, the use of voriconazole appears ineffective for reversing the clinical course of late-stage disseminated protothecosis.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6083","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T09:40:55Z","timestamp":1411551655000},"page":"429-435","source":"Crossref","is-referenced-by-count":13,"title":["Disseminated Protothecosis Associated With Diskospondylitis in a Dog"],"prefix":"10.5326","volume":"50","author":[{"given":"Paul M.","family":"Manino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ficken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Swinford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Burney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-50-6-429-bib1","series-title":"Infectious diseases of the dog and cat","first-page":"659","article-title":"Protothecosis","author":"Greene","year":"2006","unstructured":"Greene\n              CE\n            , RakichPM, LatimerKS. Protothecosis. In: GreeneCE, ed. Infectious diseases of the dog and cat. 3rd ed. Philadelphia (PA): WB Saunders Co.; 2006:659\u201365."},{"issue":"2","key":"i1547-3317-50-6-429-bib2","series-title":"Protothecosis. Med Mycol","first-page":"95","volume":"42","author":"Leimann","year":"2004","unstructured":"Leimann\n              BC\n            , MonteiroPC, Laz\u00e9raM. Protothecosis. Med Mycol2004;42(2):95\u2013106."},{"key":"i1547-3317-50-6-429-bib3","series-title":"Compend Contin Educ Pract Vet","first-page":"96","article-title":"Canine protothecosis","volume":"26","author":"Strunck","year":"2004","unstructured":"Strunck\n              E\n            , BillupsL, AvgerisS. Canine protothecosis. Compend Contin Educ Pract Vet2004;26:96\u2013102."},{"issue":"5","key":"i1547-3317-50-6-429-bib4","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1091","article-title":"Canine protothecosis","volume":"30","author":"Hollingsworth","year":"2000","unstructured":"Hollingsworth\n              SR\n            \n          . Canine protothecosis. Vet Clin North Am Small Anim Pract2000;30(5):1091\u2013101."},{"issue":"2","key":"i1547-3317-50-6-429-bib5","series-title":"Clin Microbiol Rev","first-page":"230","article-title":"Human protothecosis","volume":"20","author":"Lass-Fl\u00f6rl","year":"2007","unstructured":"Lass-Fl\u00f6rl\n              C\n            , MayrA. Human protothecosis. 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J Am Vet Med Assoc1984;185(6):681\u20133."},{"issue":"1","key":"i1547-3317-50-6-429-bib8","series-title":"Aust Vet J","first-page":"25","article-title":"Generalised protothecosis in a collie dog","volume":"67","author":"Thomas","year":"1990","unstructured":"Thomas\n              JB\n            , PrestonN. Generalised protothecosis in a collie dog. Aust Vet J1990;67(1):25\u20137."},{"issue":"3","key":"i1547-3317-50-6-429-bib9","series-title":"Med Mycol","first-page":"249","article-title":"Protothecosis in 17 Australian dogs and a review of the canine literature","volume":"45","author":"Stenner","year":"2007","unstructured":"Stenner\n              VJ\n            , MackayB, KingT. Protothecosis in 17 Australian dogs and a review of the canine literature. 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