{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:13:06Z","timestamp":1763741586326,"version":"3.45.0"},"reference-count":15,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Canine cryptococcosis cases are typically reported as neurologic, disseminated, or both. There have been few reports of other parenchymal organ involvement. Dogs infected with\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    spp. are likely to develop central nervous system involvement, and those that are severely affected are treated aggressively with surgery and\/or amphotericin B. This report describes two cases of canine abdominal cryptococcosis: one boxer with primary alimentary cryptococcosis alone and one miniature schnauzer with pancreatic and disseminated cryptococcosis. The boxer is unique in that the dog suffered from primary alimentary cryptococcosis without dissemination, secondary anemia due to gastrointestinal losses, and is the second case to have\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    spp. identified on fecal examination as part of the diagnostic workup. Unlike previous reports, surgery was not performed in either case, and both dogs were treated with fluconazole alone. Currently, both dogs are free from clinical signs, and\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    spp. antigen titers are negative at 17 and 15 mo after initial presentation. These cases suggest fluconazole may be effective therapy alone for canine abdominal cryptococcosis, negating the need for high-risk therapy options such as surgery and\/or amphotericin B in some cases.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6100","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T15:28:38Z","timestamp":1424359718000},"page":"107-113","source":"Crossref","is-referenced-by-count":7,"title":["Abdominal Cryptococcosis in Two Dogs: Diagnosis and Medical Management"],"prefix":"10.5326","volume":"51","author":[{"given":"Lindsay","family":"Tangeman","sequence":"first","affiliation":[{"name":"L. Tangeman's updated credentials since acceptence are DVM, DACVIM."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Davignon","sequence":"additional","affiliation":[{"name":"D. Davignon's present affiliation is Cornell University Hospital for Animals, Ithaca, NY."},{"name":"From the Department of Pathobiology (R.P.) and Department of Clinical Studies (M.L.), University of Pennsylvania, Philadelphia, PA (L.T.); and Angell Animal Medical Center (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Department of Pathobiology (R.P.) and Department of Clinical Studies (M.L.), University of Pennsylvania, Philadelphia, PA (L.T.); and Angell Animal Medical Center (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryl","family":"Littman","sequence":"additional","affiliation":[{"name":"From the Department of Pathobiology (R.P.) and Department of Clinical Studies (M.L.), University of Pennsylvania, Philadelphia, PA (L.T.); and Angell Animal Medical Center (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-51-2-107-b01","series-title":"Infectious diseases of the dog and cat. 4th ed","first-page":"621","article-title":"Cryptococcosis","author":"Malik\n              R,","year":"2012","unstructured":"Malik\n              R, \n            \n              Krockenberger\n              M, \n            \n              O'Brien\n              C, \n            et al\n          . Cryptococcosis. In: GreeneCE, ed. Infectious diseases of the dog and cat. 4th ed. St. Louis (MO): Elsevier Saunders;2012:621\u201334."},{"issue":"1","key":"i1547-3317-51-2-107-b02","series-title":"Vet Clin Path","first-page":"4","article-title":"Cryptococcosis: update and emergence of Cryptococcus gattii","volume":"40","author":"Lester\n              SJ,","year":"2011","unstructured":"Lester\n              SJ, \n            \n              Malik\n              R, \n            \n              Bartlett\n              KH, \n            et al\n          . Cryptococcosis: update and emergence of Cryptococcus gattii. Vet Clin Path2011;40(1):4\u201317."},{"issue":"3","key":"i1547-3317-51-2-107-b03","series-title":"J Am Vet Med Assoc","first-page":"357","article-title":"Clinical features and epidemiology of cryptococcosis in cats and dogs in California: 93 cases (1988\u20132010)","volume":"239","author":"Trivedi\n              SR,","year":"2011","unstructured":"Trivedi\n              SR, \n            \n              Sykes\n              JE, \n            \n              Cannon\n              MS, \n            et al\n          . Clinical features and epidemiology of cryptococcosis in cats and dogs in California: 93 cases (1988\u20132010). J Am Vet Med Assoc2011;239(3):357\u201369."},{"key":"i1547-3317-51-2-107-b04","series-title":"Prog Vet Neurol","first-page":"88","article-title":"Cryptococcus of the nervous system in dogs. Part 1: Epidemiologic, clinical and neuropathologic features","volume":"5","author":"Berthlin\n              CF,","year":"1994","unstructured":"Berthlin\n              CF, \n            \n              Bailey\n              CS, \n            \n              Kass\n              PH, \n            et al\n          . Cryptococcus of the nervous system in dogs. Part 1: Epidemiologic, clinical and neuropathologic features. Prog Vet Neurol1994;5:88\u201397."},{"issue":"4","key":"i1547-3317-51-2-107-b05","series-title":"Vet Q","first-page":"185","article-title":"Gastric granulomatous cryptococcosis mimicking gastric carcinoma in a dog","volume":"13","author":"Van der Gaag\n              I,","year":"1991","unstructured":"Van der Gaag\n              I, \n            \n              Van Niel\n              MHF, \n            \n              Belshaw\n              BE, \n            et al\n          . Gastric granulomatous cryptococcosis mimicking gastric carcinoma in a dog. Vet Q1991;13(4):185\u201390."},{"issue":"4","key":"i1547-3317-51-2-107-b06","series-title":"Aust Vet J","first-page":"124","article-title":"Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B","volume":"73","author":"Malik\n              R,","year":"1996","unstructured":"Malik\n              R, \n            \n              Craig\n              AJ, \n            \n              Wigney\n              DI, \n            et al\n          . Combination chemotherapy of canine and feline cryptococcosis using subcutaneously administered amphotericin B. Aust Vet J1996;73(4):124\u20138."},{"key":"i1547-3317-51-2-107-b07","series-title":"J Sm Anim Pract","first-page":"387","article-title":"Intra-abdominal cryptococcosis in two dogs","volume":"40","author":"Malik\n              R,","year":"1999","unstructured":"Malik\n              R, \n            \n              Hunt\n              GB, \n            \n              Bellenger\n              CR, \n            et al\n          . Intra-abdominal cryptococcosis in two dogs. J Sm Anim Pract1999;40:387\u201391."},{"issue":"4","key":"i1547-3317-51-2-107-b08","series-title":"Vet Clin Pathol","first-page":"409","article-title":"Diagnosis of systemic cryptococcosis by fecal cytology in a dog","volume":"34","author":"Graves\n              TK,","year":"2005","unstructured":"Graves\n              TK, \n            \n              Barger\n              AM, \n            \n              Adams\n              B, \n            et al\n          . Diagnosis of systemic cryptococcosis by fecal cytology in a dog. Vet Clin Pathol2005;34(4):409\u201312."},{"key":"i1547-3317-51-2-107-b09","series-title":"Med Mycol","first-page":"449","article-title":"Retrospective study of feline and canine cryptococcosis in Australia from 1981 to 2001: 195 cases","volume":"42","author":"O'Brien\n              CR,","year":"2004","unstructured":"O'Brien\n              CR, \n            \n              Krockenberger\n              MB, \n            \n              Wigney\n              DI, \n            et al\n          . Retrospective study of feline and canine cryptococcosis in Australia from 1981 to 2001: 195 cases. Med Mycol2004;42:449\u201360."},{"key":"i1547-3317-51-2-107-b10","series-title":"J V Intern Med","first-page":"1427","article-title":"Clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from California","volume":"24","author":"Sykes\n              JE,","year":"2010","unstructured":"Sykes\n              JE, \n            \n              Sturges\n              BK, \n            \n              Cannon\n              MS, \n            et al\n          . Clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from California. J V Intern Med2010;24:1427\u201338."},{"key":"i1547-3317-51-2-107-b11","series-title":"J Vet Intern Med","first-page":"964","article-title":"Remission of histiocytic ulcerative colitis in boxer dogs correlates with eradication of invasive intramucosal Escherichia coli","volume":"23","author":"Mansfield\n              CS,","year":"2009","unstructured":"Mansfield\n              CS, \n            \n              James\n              FE, \n            \n              Craven\n              M, \n            et al\n          . Remission of histiocytic ulcerative colitis in boxer dogs correlates with eradication of invasive intramucosal Escherichia coli. J Vet Intern Med2009;23:964\u20139."},{"key":"i1547-3317-51-2-107-b12","series-title":"Vet Clin N Am-Small","first-page":"433","article-title":"Granulomatous colitis of boxer dogs","volume":"41","author":"Carven\n              M,","year":"2011","unstructured":"Carven\n              M, \n            \n              Mansfield\n              C, \n            \n              Simpson\n              K. \n          \n          Granulomatous colitis of boxer dogs. Vet Clin N Am-Small2011;41:433\u201345."},{"issue":"3","key":"i1547-3317-51-2-107-b13","series-title":"Med Mycol","first-page":"249","article-title":"Protothecosis in 17 Australian dogs and a review of the canine literature","volume":"45","author":"Stenner\n              VJ,","year":"2007","unstructured":"Stenner\n              VJ, \n            \n              Mackay\n              B, \n            \n              King\n              T, \n            et al\n          . Protothecosis in 17 Australian dogs and a review of the canine literature. Med Mycol2007;45(3):249\u201366."},{"issue":"6","key":"i1547-3317-51-2-107-b14","series-title":"Aust Vet J","first-page":"403","article-title":"Mycobacterial nodular granulomas affecting the subcutis and skin of dogs (canine leproid granuloma syndrome)","volume":"76","author":"Malik\n              R,","year":"1998","unstructured":"Malik\n              R, \n            \n              Love\n              DN, \n            \n              Wigney\n              DI, \n            et al\n          . Mycobacterial nodular granulomas affecting the subcutis and skin of dogs (canine leproid granuloma syndrome). Aust Vet J1998;76(6):403\u20137, 398."},{"key":"i1547-3317-51-2-107-b15","series-title":"Plumb's veterinary drug handbook, 5th ed","first-page":"336","author":"Plumb\n              DC.","year":"2005","unstructured":"Plumb\n              DC. \n          \n          Plumb's veterinary drug handbook, 5th ed. Ames (IA): Blackwell Publishing;2005:336\u20139."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/2\/article-p107.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/51\/2\/107\/1336014\/jaaha-ms-6100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/2\/article-p107.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/2\/article-p107.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:58:54Z","timestamp":1763740734000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/2\/article-p107.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6100","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"type":"electronic","value":"1547-3317"},{"type":"print","value":"0587-2871"}],"subject":[],"published":{"date-parts":[[2015]]}}}