{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:45:38Z","timestamp":1775094338105,"version":"3.50.1"},"reference-count":25,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title\/>\n                  <jats:p>A 5 yr old, male, neutered mixed-breed dog was referred for persistent vomiting 2 wk following a pyloric biopsy for a pyloric outflow obstruction. Histopathology at the time of initial surgery was suggestive of pythiosis. Following referral, the dog underwent radical surgical treatment with a Billroth II procedure, partial pancreatectomy, and cholecystoduodenostomy. Histopathology and serology confirmed the diagnosis of pythiosis and medical treatment consisting of itraconazole and terbinafine was started postoperatively. Serology titers were checked again at 8, 12, and 24 wk postoperatively revealing a positive response to treatment and no reoccurrence of pythiosis. Since surgery, the patient experienced waxing and waning elevations of liver values and laparoscopic liver biopsies 10 mo postoperatively revealed hepatic cirrhosis with fibrosis, bile duct hyperplasia, and chronic inflammation. This report documents successful treatment of pyloric\/duodenal pythiosis and the long-term (17 mo) consequences associated with the Billroth II, partial pancreatectomy, and biliary rerouting in the dog.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6217","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T14:49:10Z","timestamp":1446648550000},"page":"385-391","source":"Crossref","is-referenced-by-count":9,"title":["Surgical and Medical Treatment of Pyloric and Duodenal Pythiosis in a Dog"],"prefix":"10.5326","volume":"51","author":[{"given":"David Lee","family":"Dycus","sequence":"first","affiliation":[{"name":"From the Department Orthopedic Surgery, Veterinary Orthopedic and Sports Medicine Group (VOSM), Annapolis Junction, MD (D.L.D.); and Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS (D.L.D., C.F., R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory","family":"Fisher","sequence":"additional","affiliation":[{"name":"From the Department Orthopedic Surgery, Veterinary Orthopedic and Sports Medicine Group (VOSM), Annapolis Junction, MD (D.L.D.); and Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS (D.L.D., C.F., R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Butler","sequence":"additional","affiliation":[{"name":"From the Department Orthopedic Surgery, Veterinary Orthopedic and Sports Medicine Group (VOSM), Annapolis Junction, MD (D.L.D.); and Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS (D.L.D., C.F., R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-51-6-385-b01","series-title":"Vet Clin North Am Small Anim Pract","first-page":"695","article-title":"Pythiosis, lagenidiosis, and zygomycosis in small animals","volume":"33","author":"Grooters\n              AM.","year":"2003","unstructured":"Grooters\n              AM.\n            \n          \n          Pythiosis, lagenidiosis, and zygomycosis in small animals. 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J Am Vet Med Assoc2012;241:358\u2013363."},{"key":"i1547-3317-51-6-385-b03","series-title":"J Vet Intern Med","first-page":"1065","article-title":"Gastrointestinal pythiosis in 10 dogs from California","volume":"22","author":"Berryessa\n              NA,","year":"2008","unstructured":"Berryessa\n              NA, \n            \n              Marks\n              SL, \n            \n              Pesavento\n              PA, \n            et al\n          . Gastrointestinal pythiosis in 10 dogs from California. J Vet Intern Med2008;22:1065\u20131069."},{"key":"i1547-3317-51-6-385-b04","series-title":"Vet Res Commun","first-page":"301","article-title":"Cutaneous and gastrointestinal pythiosis in a dog in Brazil","volume":"34","author":"Pereira\n              DI,","year":"2010","unstructured":"Pereira\n              DI, \n            \n              Schild\n              AL, \n            \n              Motta\n              MA, \n            et al\n          . 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Prostatic Pythiosis in a Dog","volume":"16","author":"Jaeger, GH,","year":"2002","unstructured":"Jaeger, GH, \n            \n              Rotstein\n              DS, \n          \n          McHugh Law J. Prostatic Pythiosis in a Dog. J Vet Inern Med2002;16:598\u2013602."},{"key":"i1547-3317-51-6-385-b18","series-title":"J Vet Diagn Invest","first-page":"380","article-title":"Gastrointestinal pythiosis in Missouri dogs: eleven cases","volume":"6","author":"Fisher\n              JR,","year":"1994","unstructured":"Fisher\n              JR, \n            \n              Pace\n              LW, \n            \n              Turk\n              JR, \n            et al\n          . Gastrointestinal pythiosis in Missouri dogs: eleven cases. 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J Am Vet Med Assoc1985;186:473\u2013478."},{"key":"i1547-3317-51-6-385-b21","series-title":"J Am Anim Hosp Aooc","first-page":"959","article-title":"A report of subcutaneous pythiosis in five dogs and a review of the etiologic agent Phythium spp","volume":"20","author":"Foil\n              CSO,","year":"1984","unstructured":"Foil\n              CSO, \n            \n              Short\n              BG, \n            \n              Fadok\n              VA, \n            et al\n          . 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J Vet Intern Med2002;16:147\u2013152."},{"key":"i1547-3317-51-6-385-b23","series-title":"Vet Dermatol","first-page":"187","article-title":"PCR-based detection of Pythium and Lagenidum DNA in frozen and ethanol-fixed animal tissues","volume":"13","author":"Znajda\n              NR,","year":"2002","unstructured":"Znajda\n              NR, \n            \n              Grooters\n              AM, \n            \n              Marsella\n              R.\n            \n          \n          PCR-based detection of Pythium and Lagenidum DNA in frozen and ethanol-fixed animal tissues. Vet Dermatol2002;13:187\u2013194."},{"key":"i1547-3317-51-6-385-b24","series-title":"J Vet Intern Med","first-page":"142","article-title":"Development and evaluation of an enzyme-linked immunosorbent assay for the serodiagnosis of Pythiosis in dogs","volume":"16","author":"Grooters\n              AM,","year":"2002","unstructured":"Grooters\n              AM, \n            \n              Leise\n              BS, \n            \n              Lopez\n              MK, \n            et al\n          . Development and evaluation of an enzyme-linked immunosorbent assay for the serodiagnosis of Pythiosis in dogs. J Vet Intern Med2002;16:142\u2013146."},{"key":"i1547-3317-51-6-385-b25","series-title":"Vaccine","first-page":"2797","article-title":"An improved Pythium insidiosum-vaccine formulation with enhanced immunotherapeutic properties in horses and dogs with pythiosis","volume":"21","author":"Mendoza\n              L,","year":"2003","unstructured":"Mendoza\n              L, \n            \n              Mandy\n              W, \n            \n              Glass\n              R.\n            \n          \n          An improved Pythium insidiosum-vaccine formulation with enhanced immunotherapeutic properties in horses and dogs with pythiosis. Vaccine2003;21:2797\u20132804."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/6\/article-p385.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/51\/6\/385\/1589704\/jaaha-ms-6217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/6\/article-p385.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/6\/article-p385.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:01:19Z","timestamp":1763740879000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/6\/article-p385.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6217","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}