{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:21:12Z","timestamp":1769512872002,"version":"3.49.0"},"reference-count":19,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    This manuscript describes the extended clinical abnormalities that can occur in severe snake envenomation and the clinical signs associated with antivenom hypersensitivity in a 3 yr old dog. Treatment consisted of IV fluid therapy, analgesics, a vasopressor, cardiac antiarrhythmia drugs, and polyvalent pit viper antivenom. Following initial response to treatment, relapse of clinical signs occurred. Most interesting was the recrudescence of clinical signs on day 7 that may have been caused by the release of deposited venom during surgical debridement of necrotic skin. The resulting extensive clinical signs required multiple vials of antivenom (22 vials over a 7 day period). Both F(ab\u2032)\n                    <jats:sub>2<\/jats:sub>\n                    antivenom and antivenin (Crotalidae) polyvalent were used in this dog because of availability logistics. It is thought that this large amount of antivenom resulted in type I (anaphylaxis) and type III hypersensitivity (serum sickness) reactions. The dog made a complete clinical recovery. This description of extended, fluctuating clinical abnormalities that were associated with envenomation together with the development of hypersensitivity reactions that were presumably secondary to antivenom administration is information that can be useful for the management of patients afflicted with severe pit viper envenomation.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6234","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:57:32Z","timestamp":1441933052000},"page":"329-337","source":"Crossref","is-referenced-by-count":9,"title":["Severe Pit Viper Envenomation with Extended Clinical Signs and Treatment Complications in a Dog"],"prefix":"10.5326","volume":"51","author":[{"given":"Michael","family":"Schaer","sequence":"first","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth J.","family":"Buckley","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobbi J.","family":"Conner","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Cuddy","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."},{"name":"Laura C. Cuddy's updated credentials since article acceptance are MS, MVB, DACVS."},{"name":"Laura C. Cuddy's present affiliation is University College Dublin, Dublin, Ireland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Vigani","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."},{"name":"Alessio Vigani's updated credentials since article acceptance are PhD, DVM, DACVA, DACVECC."},{"name":"Alessio Vigani's present affiliation is North Carolina State University, Raleigh, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison E.","family":"Vansickle","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Coisman","sequence":"additional","affiliation":[{"name":"James G. Coisman's updated credentials since article acceptance are DVM, DACVS."},{"name":"James G. Coisman's present affiliation is United States Army, Fort Belvoir, VA."},{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna R.","family":"DeVuyst","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Bandt","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL (M.S., G.B., B.C., L.C., A.V., A.E.V., J.C., C.B.); and Lake Veterinary Clinic, Mt. Dora, FL (D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"1","key":"i1547-3317-51-5-329-b01","series-title":"Ann Emerg Med","first-page":"33","article-title":"Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning","volume":"30","author":"Dart\n              RC,","year":"1997","unstructured":"Dart\n              RC, \n            \n              Seifert\n              SA, \n            \n              Carroll\n              L, \n            et al\n          . 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Top Companion Anim Med2011;26(3):128\u201334."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/5\/article-p329.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/51\/5\/329\/1589345\/jaaha-ms-6234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/5\/article-p329.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/51\/5\/article-p329.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:00:41Z","timestamp":1763740841000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/51\/5\/article-p329.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6234","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}