{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:33:22Z","timestamp":1784763202898,"version":"3.55.0"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title\/>\n                  <jats:p>\n                    An 8 yr old, intact male Shiba Inu was presented with loose stool, polydipsia, hematuria, vomiting, and anorexia. On abdominal ultrasonography, numerous nodules were detected in the hepatic parenchyma distributed diffusely throughout all lobes. Excisional biopsy of one of the nodules was performed via exploratory laparotomy. A histopathological diagnosis of the lesion was carcinoid, and the tumor cells stained positive to chromogranin A and gastrin. The serum gastrin level of the dog was 45,613 pg\/mL (reference range: 160\u2013284). In addition to medical treatment with omeprazolec and famotidinee, suppression of gastrin secretion was attempted with octreotide acetate. A test dose of octreotide acetate significantly decreased the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular,\n                    <jats:italic>q<\/jats:italic>\n                    4 wk) was initiated. The serum gastrin concentration gradually decreased over 32 days and then progressively increased in parallel with the progression of the hepatic nodules. The dog gradually developed recurrence of initial clinical signs, and was lost to follow-up on day 510.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6270","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T14:49:10Z","timestamp":1446648550000},"page":"407-412","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog"],"prefix":"10.5326","volume":"51","author":[{"given":"Sangho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"6","key":"i1547-3317-51-6-407-b01","series-title":"J Vet Intern Med","first-page":"379","article-title":"Omeprazole in a dog with gastrinoma","volume":"11","author":"Brooks\n              D,","year":"1997","unstructured":"Brooks\n              D, \n            \n              Watson\n              GL.\n            \n          \n          Omeprazole in a dog with gastrinoma. J Vet Intern Med1997;11(6):379\u201381."},{"issue":"4","key":"i1547-3317-51-6-407-b02","series-title":"Clin Oncol","first-page":"282","article-title":"The management of neuroendocrine tumours: Current and future medical therapy options","volume":"24","author":"Oberg\n              KE.","year":"2012","unstructured":"Oberg\n              KE.\n            \n          \n          The management of neuroendocrine tumours: Current and future medical therapy options. Clin Oncol2012;24(4):282\u201393."},{"issue":"19\u201320","key":"i1547-3317-51-6-407-b03","series-title":"Wien Klin Wochenschr","first-page":"609","article-title":"Medical treatment of gastrinoma","volume":"119","author":"Auernhammer\n              CJ,","year":"2007","unstructured":"Auernhammer\n              CJ, \n            \n              G\u00f6ke\n              B.\n            \n          \n          Medical treatment of gastrinoma. Wien Klin Wochenschr2007;119(19\u201320):609\u201315."},{"issue":"15","key":"i1547-3317-51-6-407-b04","series-title":"Intern Med","first-page":"1557","article-title":"Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up","volume":"49","author":"Yamaguchi\n              M,","year":"2010","unstructured":"Yamaguchi\n              M, \n            \n              Yamada\n              Y, \n            \n              Hosokawa\n              Y, \n            et al\n          . Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up. 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