{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:14:40Z","timestamp":1763741680808,"version":"3.45.0"},"reference-count":22,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title\/>\n                  <jats:p>A 3 mo old, female, entire Labrador retriever presented with vomiting, diarrhea, polyuria, polydipsia, polyphagia, and stunted growth. Diagnostics revealed the presence of juvenile diabetes mellitus and concurrent exocrine pancreatic insufficiency. Pancreatic histopathology showed severe pancreatic atrophy. Successful treatment was achieved with a combination of insulin and pancreatic enzymes. This report describes successful long-term treatment of juvenile diabetes mellitus and concurrent exocrine pancreatic insufficiency in a dog.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6283","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T14:49:10Z","timestamp":1446648550000},"page":"419-423","source":"Crossref","is-referenced-by-count":7,"title":["Juvenile Diabetes Mellitus and Concurrent Exocrine Pancreatic Insufficiency in a Labrador Retriever: Long-Term Management"],"prefix":"10.5326","volume":"51","author":[{"given":"Maria Saiz","family":"Alvarez","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Hospital ARS Veterinaria, Barcelona, Spain (M.S.A., V.H-B., A.F.U.); and the Histolog\u00eda y Anatom\u00eda Patol\u00f3gica Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain (J.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Herrer\u00eda-Bustillo","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Hospital ARS Veterinaria, Barcelona, Spain (M.S.A., V.H-B., A.F.U.); and the Histolog\u00eda y Anatom\u00eda Patol\u00f3gica Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain (J.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur Font","family":"Utset","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Hospital ARS Veterinaria, Barcelona, Spain (M.S.A., V.H-B., A.F.U.); and the Histolog\u00eda y Anatom\u00eda Patol\u00f3gica Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain (J.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Hospital ARS Veterinaria, Barcelona, Spain (M.S.A., V.H-B., A.F.U.); and the Histolog\u00eda y Anatom\u00eda Patol\u00f3gica Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain (J.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"1","key":"i1547-3317-51-6-419-b01","series-title":"J Vet Intern Med","first-page":"67","article-title":"Juvenile pancreatic atrophy in Greyhounds: 12 cases (1995-2000)","volume":"23","author":"Brenner\n              K,","year":"2009","unstructured":"Brenner\n              K, \n            \n              Harkin\n              KR, \n            \n              Andrews\n              GA, \n            et al\n          . Juvenile pancreatic atrophy in Greyhounds: 12 cases (1995-2000). J Vet Intern Med. 2009Jan-Feb;23(1):67\u201371."},{"issue":"12","key":"i1547-3317-51-6-419-b02","series-title":"J Vet Med Sci","first-page":"1337","article-title":"Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog","volume":"70","author":"Kang\n              JH,","year":"2008","unstructured":"Kang\n              JH, \n            \n              Na\n              KJ, \n            \n              Mo\n              IP, \n            et al\n          . Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog. J Vet Med Sci. 2008Dec;70(12):1337\u201340."},{"issue":"7","key":"i1547-3317-51-6-419-b03","series-title":"J Small Anim Pract","first-page":"344","article-title":"Exocrine pancreatic insufficiency combined with insulin-dependent diabetes mellitus in a juvenile German shepherd dog","volume":"37","author":"Neiger\n              R,","year":"1996","unstructured":"Neiger\n              R, \n            \n              Jaunin\n              VB, \n            \n              Boujon\n              CE.\n            \n          \n          Exocrine pancreatic insufficiency combined with insulin-dependent diabetes mellitus in a juvenile German shepherd dog. J Small Anim Pract. 1996Jul;37(7):344\u20139."},{"issue":"1","key":"i1547-3317-51-6-419-b04","series-title":"J Mahanakorn Vet Med","first-page":"51","article-title":"Diabetes mellitus concurrent with exocrine pancreatic insufficiency in a young golden retriever dog: a clinico-pathological report","volume":"5","author":"Mamom\n              T,","year":"2010","unstructured":"Mamom\n              T, \n            \n              Rungpupradit\n              J.\n            \n          \n          Diabetes mellitus concurrent with exocrine pancreatic insufficiency in a young golden retriever dog: a clinico-pathological report. J Mahanakorn Vet Med2010;5(1):51\u201360."},{"issue":"3","key":"i1547-3317-51-6-419-b05","series-title":"Vet Clin North Am Small Anim Pract","first-page":"549","article-title":"Pediatric endocrinology","volume":"36","author":"Greco\n              DS.","year":"2006","unstructured":"Greco\n              DS.\n            \n          \n          Pediatric endocrinology. Vet Clin North Am Small Anim Pract. 2006May;36(3):549\u201356, vi."},{"key":"i1547-3317-51-6-419-b06","series-title":"Proceedings of the 75th Western Vet Conference","article-title":"Pediatric endocrine and metabolic disorders","author":"Gelens\n              H.","year":"2003","unstructured":"Gelens\n              H.\n            \n          \n          Pediatric endocrine and metabolic disorders. In: Proceedings of the 75th Western Vet Conference; 2003; Canada."},{"key":"i1547-3317-51-6-419-b07","series-title":"St. Louis: Elsevier Saunders;","first-page":"1449","article-title":"Canine diabetes mellitus. In: Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine. 7th ed","author":"Nelson\n              R.","year":"2010","unstructured":"Nelson\n              R.\n            \n          \n          Canine diabetes mellitus. In: Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine. 7th ed. 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Textbook of veterinary internal medicine. 7th ed","author":"Steiner\n              J.","year":"2010","unstructured":"Steiner\n              J.\n            \n          \n          Exocrine pancreatic insufficiency in dogs and cats. In: Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine. 7th ed. St Louis: Elsevier Saunders;2010:1311\u201315."},{"issue":"5","key":"i1547-3317-51-6-419-b10","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1165","article-title":"Exocrine pancreatic insufficiency in dogs","volume":"33","author":"Westermarck\n              E,","year":"2003","unstructured":"Westermarck\n              E, \n            \n              Wiberg\n              M.\n            \n          \n          Exocrine pancreatic insufficiency in dogs. Vet Clin North Am Small Anim Pract2003Sep;33(5):1165\u201379, viii\u2013ix."},{"issue":"3","key":"i1547-3317-51-6-419-b11","series-title":"Top Companion Anim Med","first-page":"96","article-title":"Exocrine pancreatic insufficiency in the dog: historical background, diagnosis, and treatment","volume":"27","author":"Westermarck\n              E,","year":"2012","unstructured":"Westermarck\n              E, \n            \n              Wiberg\n              M.\n            \n          \n          Exocrine pancreatic insufficiency in the dog: historical background, diagnosis, and treatment. Top Companion Anim Med2012Aug;27(3):96\u2013103."},{"issue":"2","key":"i1547-3317-51-6-419-b12","series-title":"Vet Q","first-page":"61","article-title":"Pancreatic acinar atrophy in German shepherd dogs and rough-coated collies. Etiopathogenesis, diagnosis and treatment. 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In: Hall JE, Guyton AC. Textbook of medical physiology. 11th ed. Michigan: Saunders;2006:961\u201377."},{"key":"i1547-3317-51-6-419-b16","series-title":"Feldman EC, Nelson RW. Canine and feline endocrinology and reproduction. 3rd ed","first-page":"45","article-title":"Disorders of growth hormone","author":"Feldman\n              EC,","year":"2004","unstructured":"Feldman\n              EC, \n            \n              Nelson\n              RW.\n            \n          \n          Disorders of growth hormone. In: Feldman EC, Nelson RW. Canine and feline endocrinology and reproduction. 3rd ed. Philadelphia: Saunders;2004:45\u201358."},{"key":"i1547-3317-51-6-419-b17","series-title":"Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine. 7th ed","first-page":"126","article-title":"Failure to grow","author":"Ihle\n              SL.","year":"2010","unstructured":"Ihle\n              SL.\n            \n          \n          Failure to grow. In: Ettinger SJ, Feldman EC. 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St Louis: Elsevier Saunders;2010:1326\u201333."},{"issue":"4","key":"i1547-3317-51-6-419-b19","series-title":"J Clin Endocrinol Metab","first-page":"1312","article-title":"Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus","volume":"80","author":"Bereket\n              A,","year":"1995","unstructured":"Bereket\n              A, \n            \n              Lang\n              CH, \n            \n              Blethen\n              SL, \n            et al\n          . Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J Clin Endocrinol Metab1995;80(4):1312\u201317."},{"key":"i1547-3317-51-6-419-b20","series-title":"BMC Vet Res","first-page":"127","article-title":"A blinded randomised controlled trial to determine the effect of enteric coating on enzyme treatment for canine exocrine pancreatic efficiency","volume":"8","author":"Mas\n              A,","year":"2012","unstructured":"Mas\n              A, \n            \n              Noble\n              PJ, \n            \n              Cripps\n              PJ, \n            et al\n          . A blinded randomised controlled trial to determine the effect of enteric coating on enzyme treatment for canine exocrine pancreatic efficiency. BMC Vet Res2012Jul28;8:127."},{"key":"i1547-3317-51-6-419-b21","series-title":"BSAVA Manual of Small Animal Ophtalmology. 2nd ed","first-page":"204","article-title":"The lens","author":"Petersen-Jones\n              S.","year":"2002","unstructured":"Petersen-Jones\n              S.\n            \n          \n          The lens. In: Petersen-JonesS, CrispinS, eds. BSAVA Manual of Small Animal Ophtalmology. 2nd ed. Gloucester: BSAVA;2002:204\u201319."},{"key":"i1547-3317-51-6-419-b22","series-title":"Jubb, Kennedy, and Palmer's pathology of domestic animals. 5th ed","first-page":"389","article-title":"Pancreas","author":"Charles\n              JA.","year":"2007","unstructured":"Charles\n              JA.\n            \n          \n          Pancreas. In: MaxieMG, ed. Jubb, Kennedy, and Palmer's pathology of domestic animals. 5th ed. 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