{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:52:31Z","timestamp":1763747551592,"version":"3.45.0"},"reference-count":29,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinical and metabolic variables were evaluated in 13 dogs with border collie collapse (BCC) before, during, and following completion of standardized strenuous exercise protocols. Six dogs participated in a ball-retrieving protocol, and seven dogs participated in a sheep-herding protocol. Findings were compared with 16 normal border collies participating in the same exercise protocols (11 retrieving, five herding). Twelve dogs with BCC developed abnormal mentation and\/or an abnormal gait during evaluation. All dogs had post-exercise elevations in rectal temperature, pulse rate, arterial blood pH, PaO2, and lactate, and decreased PaCO2 and bicarbonate, as expected with strenuous exercise, but there were no significant differences between BCC dogs and normal dogs. Electrocardiography demonstrated sinus tachycardia in all dogs following exercise. Needle electromyography was normal, and evaluation of muscle biopsy cryosections using a standard panel of histochemical stains and reactions did not reveal a reason for collapse in 10 dogs with BCC in which these tests were performed. Genetic testing excluded the dynamin-1 related exercise-induced collapse mutation and the V547A malignant hyperthermia mutation as the cause of BCC. Common reasons for exercise intolerance were eliminated. Although a genetic basis is suspected, the cause of collapse in BCC was not determined.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6361","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:16:31Z","timestamp":1470230191000},"page":"281-290","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols"],"prefix":"10.5326","volume":"52","author":[{"given":"Susan","family":"Taylor","sequence":"first","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Shmon","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Su","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasha","family":"Epp","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Minor","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mickelson","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Patterson","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Diane","family":"Shelton","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences (S.T., C.S., L.S.) and the Department of Large Animal Clinical Sciences (T.E.), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; the University of Minnesota, Minneapolis, MN (K.M., J.M., E.P.); and the Comparative Neuromuscular Laboratory, Department of Pathology, University of California\u2013San Diego, La Jolla, CA (G.D.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-52-5-281-b01","series-title":"Agilitynet","article-title":"Exercise-induced hyperthermia","year":"2013","unstructured":"Exercise-induced hyperthermia. Agilitynet. http:\/\/www.agilitynet.co.uk\/health\/exercise-inducedhyperthermia.HTML. 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J Sm Anim Pract2011;52:26\u201331."},{"issue":"December","key":"i1547-3317-52-5-281-b05","series-title":"University of Sydney Centre for Veterinary Education Control and Therapy Series No. 5174","first-page":"33","article-title":"Preliminary investigations of an exercise intolerance syndrome in Border collies","author":"Taylor \n              SM.","year":"2011","unstructured":"Taylor \n              SM. \n            \n          \n          Preliminary investigations of an exercise intolerance syndrome in Border collies. 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The Five Minute Veterinary Consult, 5th ed. Ames Iowa, Wiley Blackwell, 2011:1344"},{"key":"i1547-3317-52-5-281-b10","series-title":"J Small An Pract","first-page":"608","article-title":"Centronuclear myopathy in a Border collie dog","volume":"53","author":"Eminaga \n              S,","year":"2012","unstructured":"Eminaga \n              S, \n            \n            \n              Cherubini \n              GB, \n            \n            \n              Shelton \n              GD. \n            \n          \n          Centronuclear myopathy in a Border collie dog. 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Vet Clin North Am Small Anim Pract2002;32:103\u2013124."},{"key":"i1547-3317-52-5-281-b12","series-title":"J Vet Int Med","first-page":"424","article-title":"Nemaline rods in canine myopathies: 4 case reports and literature review","volume":"12","author":"Delauche \n              AJ,","year":"1998","unstructured":"Delauche \n              AJ, \n            \n            \n              Cuddon \n              PA, \n            \n            \n              Podell \n              M, \n            \n            et al. \n          Nemaline rods in canine myopathies: 4 case reports and literature review. J Vet Int Med1998;12:424\u2013430."},{"key":"i1547-3317-52-5-281-b13","series-title":"J Vet Int Med","first-page":"679","article-title":"Canine inflammatory myopathies: a clinicopathologic review of 200 cases","volume":"18","author":"Evans \n              J,","year":"2004","unstructured":"Evans \n              J, \n            \n            \n              Levesque \n              D, \n            \n            \n              Shelton \n              GD. \n            \n          \n          Canine inflammatory myopathies: a clinicopathologic review of 200 cases. J Vet Int Med2004;18:679\u2013691."},{"key":"i1547-3317-52-5-281-b14","series-title":"Mol Genet Metab","first-page":"3","article-title":"Lactic acidemia and mitochondrial disease","volume":"89","author":"Robinson \n              BH.","year":"2006","unstructured":"Robinson \n              BH. \n            \n          \n          Lactic acidemia and mitochondrial disease. Mol Genet Metab2006;89:3\u201313."},{"key":"i1547-3317-52-5-281-b15","series-title":"J Vet Intern Med","first-page":"342","article-title":"Pyruvate dehydrogenase deficiency in Clumber and Sussex Spaniels in the United States","volume":"14","author":"Shelton \n              GD,","year":"2000","unstructured":"Shelton \n              GD, \n            \n            \n              van Ham \n              L, \n            \n            \n              Bhatti \n              S, \n            \n            et al. \n          Pyruvate dehydrogenase deficiency in Clumber and Sussex Spaniels in the United States. J Vet Intern Med2000;14:342."},{"key":"i1547-3317-52-5-281-b16","series-title":"J Vet Int Med","first-page":"1305","article-title":"Characterization and mode of inheritance of a paroxysmal dyskinesia in Chinook dogs","volume":"24","author":"Packer \n              RA,","year":"2010","unstructured":"Packer \n              RA, \n            \n            \n              Patterson \n              EE, \n            \n            \n              Taylor \n              JF, \n            \n            et al. \n          Characterization and mode of inheritance of a paroxysmal dyskinesia in Chinook dogs. J Vet Int Med2010;24:1305\u20131313."},{"key":"i1547-3317-52-5-281-b17","series-title":"Topics in Compan An Med","first-page":"34","article-title":"Terminology and classification of seizures and epilepsy in veterinary patients","volume":"28","author":"Mariani \n              CL.","year":"2013","unstructured":"Mariani \n              CL. \n            \n          \n          Terminology and classification of seizures and epilepsy in veterinary patients. Topics in Compan An Med2013;28:34\u201341."},{"key":"i1547-3317-52-5-281-b18","series-title":"Sem Ophthal","first-page":"255","article-title":"Neuro-ophthalmologic manifestations of epilepsy","volume":"21","author":"Bajwa \n              R,","year":"2006","unstructured":"Bajwa \n              R, \n            \n            \n              Jay \n              WM, \n            \n            \n              Asconape \n              J. \n            \n          \n          Neuro-ophthalmologic manifestations of epilepsy. Sem Ophthal2006;21:255\u2013261."},{"key":"i1547-3317-52-5-281-b19","series-title":"Dev Med Child Neurol","first-page":"1001","article-title":"Outcome of children with hyperventilation-induced high amplitude rhythmic slow activity with altered awareness","volume":"54","author":"Barker \n              A,","year":"2012","unstructured":"Barker \n              A, \n            \n            \n              Ng \n              J, \n            \n            \n              Rittey \n              CDC, \n            \n            et al. \n          Outcome of children with hyperventilation-induced high amplitude rhythmic slow activity with altered awareness. 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