{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:28:56Z","timestamp":1775284136335,"version":"3.50.1"},"reference-count":35,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"ABSTRACT<\/jats:title>\n We evaluated the diagnostic accuracy of the contrast-enhanced ultrasonography (CEUS), using a second-generation microbubble contrast agent, in differentiating the different types of adrenal mass lesions in 24 dogs. At B-mode ultrasound, 9 lesions involved the right adrenal gland, 14 the left, and 1 was bilateral. Each dog received a bolus of the contrast agent into the cephalic vein, immediately followed by a 5-mL saline flush. The first contrast enhancement of each adrenal lesion was evaluated qualitatively to assess the degree of enhancement and its distribution during the wash-in and wash-out phases, as well as the presence of non-vascularized areas and specific vascular patterns. Pathological diagnoses were determined in all dogs by histopathology or by cytology. Combining enhancement degree and vascularity resulted in the best predictive model, allowing CEUS to differentiate adrenocortical adenoma (n=10), adenocarcinoma (n=7), and pheochromocytoma (n=7) with an accuracy of 91.7% (P < 0.001). Combining enhancement degree and vascularity, CEUS can discriminate malignant versus benign adrenal lesions with a sensitivity of 100.0%, a specificity of 80.0%, and an accuracy of 91.7% (P < 0.001). In conclusion, results of this study confirm that CEUS is useful for differentiating between the different types of adrenal tumors in dogs.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6363","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T11:01:04Z","timestamp":1458730864000},"page":"132-143","source":"Crossref","is-referenced-by-count":20,"title":["Use of Contrast-Enhanced Ultrasound in the Differential Diagnosis of Adrenal Tumors in Dogs"],"prefix":"10.5326","volume":"52","author":[{"given":"Paolo","family":"Bargellini","sequence":"first","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Orlandi","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Dentini","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Paloni","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rubini","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Fonti","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Diana","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Boiti","sequence":"additional","affiliation":[{"name":"From the Tyrus Clinica Veterinaria, Terni, Italy (P.B., R.O., A.D., C.P.); Ultravet Diagnostic, Bologna, Italy (G.R.); Centro Veterinario Specialistico, Roma, Italy (P.F.); Dipartimento di Scienze Mediche Veterinarie, Ozzano Emilia, Italy (A.D.); Animal Endocrine Clinic, New York, NY (M.E.P.); and Laboratorio di Biotecnologie Fisiologiche, Universit\u00e0 degli Studi di Perugia, Perugia, Italy (C.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-52-3-132-b01","series-title":"Vet Radiol Ultrasound","first-page":"448","article-title":"Retrospective ultrasonographic evaluation of adrenal lesions in 26 dogs","volume":"38","author":"Besso \n JG,","year":"1997","unstructured":"Besso \n JG, \n \n \n Penninck \n DG, \n \n \n Gliatto \n JM. \n \n \n Retrospective ultrasonographic evaluation of adrenal lesions in 26 dogs. 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Discov Med2010;9:24\u201333."},{"key":"i1547-3317-52-3-132-b14","series-title":"Vet Radiol Ultrasound","first-page":"560","article-title":"Contrast-enhanced ultrasonography of the normal canine adrenal gland","volume":"52","author":"Pey \n P,","year":"2011","unstructured":"Pey \n P, \n \n \n Vignoli \n M, \n \n \n Haers \n H, \n \n et al. \n Contrast-enhanced ultrasonography of the normal canine adrenal gland. Vet Radiol Ultrasound2011;52:560\u2013567."},{"key":"i1547-3317-52-3-132-b15","series-title":"Vet Radiol Ultrasound","first-page":"283","article-title":"Contrast-enhanced ultrasonography of adrenal glands in dogs with pituitary-dependent Cushing's syndrome","volume":"54","author":"Bargellini \n P,","year":"2013","unstructured":"Bargellini \n P, \n \n \n Orlandi \n R, \n \n \n Paloni \n C, \n \n et al. \n Contrast-enhanced ultrasonography of adrenal glands in dogs with pituitary-dependent Cushing's syndrome. 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Eur J Surg Oncol2003; 29: 689\u2013692."},{"key":"i1547-3317-52-3-132-b28","series-title":"Vet Radiol Ultrasound","first-page":"625","article-title":"Contrast-enhanced computed tomography as a preoperative indicator of vascular invasion from adrenal masses in dogs","volume":"50","author":"Schultz \n RM,","year":"2009","unstructured":"Schultz \n RM, \n \n \n Wisner \n ER, \n \n \n Johnson \n EG, \n \n et al. \n Contrast-enhanced computed tomography as a preoperative indicator of vascular invasion from adrenal masses in dogs. Vet Radiol Ultrasound2009;50:625\u2013629."},{"key":"i1547-3317-52-3-132-b29","series-title":"Vet Radiol Ultrasound","first-page":"534","article-title":"Imaging diagnosis-metastatic adrenal pheochromocytoma in a dog","volume":"52","author":"Spall \n B,","year":"2011","unstructured":"Spall \n B, \n \n \n Chen \n AV, \n \n \n Tucker \n RL, \n \n et al. \n Imaging diagnosis-metastatic adrenal pheochromocytoma in a dog. 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