{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:14:31Z","timestamp":1763741671352,"version":"3.45.0"},"reference-count":23,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary hypodipsic hypernatremia is a rarely reported disease in dogs. Reported underlying causes associated with this disease in dogs include congenital malformations, encephalitis, intracranial neoplasia, and pressure atrophy of the hypothalamus secondary to hydrocephalus. The dog in this report had an infiltrative neoplastic disorder, likely causing damage to the hypothalamic osmoreceptors responsible for the thirst generation. The neoplastic process was identified histopathologically as glioblastoma multiforme, an unusual tumor to occur in a dog this young. A tumor of the central nervous system causing physical destruction of the osmoreceptors has rarely been reported in dogs and none of the previously reported cases involved a glial cell tumor.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6382","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:16:31Z","timestamp":1470230191000},"page":"319-324","source":"Crossref","is-referenced-by-count":3,"title":["Glioblastoma Multiforme with Hypodipsic Hypernatremia in a Seven-Month-Old Golden Retriever"],"prefix":"10.5326","volume":"52","author":[{"given":"Stephanie","family":"Engel","sequence":"first","affiliation":[{"name":"From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Marie","family":"Hilling","sequence":"additional","affiliation":[{"name":"From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis Kuder","family":"Meuten","sequence":"additional","affiliation":[{"name":"From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad Brendan","family":"Frank","sequence":"additional","affiliation":[{"name":"From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela J.","family":"Marolf","sequence":"additional","affiliation":[{"name":"From the Clinical Sciences Department (S.E.); the Microbiology, Immunology and Pathology Department, College of Veterinary Medicine and Biomedical Sciences (T.K.M., C.B.F.); and the Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences (A.J.M.), Colorado State University, Fort Collins, CO; and the Animal Hospital Specialty Center, Highlands Ranch, CO (K.M.H.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-52-5-319-b01","series-title":"Aust Vet J","first-page":"14","article-title":"and hypernatraemia in a dog with focal hypothalamic granulomatous meningoencephalitis","volume":"77","author":"Mackay \n              BM,","year":"1999","unstructured":"Mackay \n              BM, \n            \n            \n              Curtis N. \n              Adipsia \n            \n          \n          and hypernatraemia in a dog with focal hypothalamic granulomatous meningoencephalitis. Aust Vet J1999;77:14\u201317."},{"key":"i1547-3317-52-5-319-b02","series-title":"J Am Vet Med Assoc","first-page":"922","article-title":"Hypodipsic hypernatremia in a dog with defective osmoregulation of antidiuretic hormone","volume":"204","author":"DiBartola \n              SP,","year":"1994","unstructured":"DiBartola \n              SP, \n            \n            \n              Johnson \n              SE, \n            \n            \n              Johnson \n              GC, \n            \n            et al. \n          Hypodipsic hypernatremia in a dog with defective osmoregulation of antidiuretic hormone. J Am Vet Med Assoc1994;204:922\u2013925."},{"key":"i1547-3317-52-5-319-b03","series-title":"J Am Anim Hosp Assoc","first-page":"267","article-title":"Hypernatremia, adipsia, and diabetes insipidus in a dog with hypothalamic dysplasia","volume":"29","author":"Bagley \n              RS,","year":"1993","unstructured":"Bagley \n              RS, \n            \n            \n              Lahunta \n              A, \n            \n            \n              Randolph \n              JF, \n            \n            et al. \n          Hypernatremia, adipsia, and diabetes insipidus in a dog with hypothalamic dysplasia. J Am Anim Hosp Assoc1993;29:267\u2013271."},{"key":"i1547-3317-52-5-319-b04","series-title":"J Am Vet Med Assoc","first-page":"1783","article-title":"Lobar holoprosencephaly in a Miniature Schnauzer with hypodipsic hypernatremia","volume":"223","author":"Sullivan \n              SA,","year":"2003","unstructured":"Sullivan \n              SA, \n            \n            \n              Harmon \n              BG, \n            \n            \n              Purinton \n              PT, \n            \n            et al. \n          Lobar holoprosencephaly in a Miniature Schnauzer with hypodipsic hypernatremia. J Am Vet Med Assoc2003;223:1783\u20131787."},{"key":"i1547-3317-52-5-319-b05","series-title":"J Vet Intern Med","first-page":"1029","article-title":"Hypernatremia and Hyperlipidemia in a Dog with Central Nervous System Lymphosarcoma","volume":"20","author":"Hanselman \n              B,","year":"2006","unstructured":"Hanselman \n              B, \n            \n            \n              Kruth \n              S, \n            \n            \n              Poma \n              R, \n            \n            et al. \n          Hypernatremia and Hyperlipidemia in a Dog with Central Nervous System Lymphosarcoma. J Vet Intern Med2006;20:1029\u20131032."},{"key":"i1547-3317-52-5-319-b06","series-title":"Vet Clin Pathol","first-page":"362","article-title":"Hypernatremia associated with intracranial B-cell lymphoma in a cat","volume":"35","author":"Morrison \n              JA,","year":"2006","unstructured":"Morrison \n              JA, \n            \n            \n              Williams \n              AF. \n            \n          \n          Hypernatremia associated with intracranial B-cell lymphoma in a cat. Vet Clin Pathol2006;35:362\u2013365."},{"key":"i1547-3317-52-5-319-b07","series-title":"J Vet Intern Med","first-page":"669","article-title":"Canine intracranial primary neoplasia: 173 cases (1986-2003)","volume":"20","author":"Snyder \n              JM,","year":"2006","unstructured":"Snyder \n              JM, \n            \n            \n              Shofer \n              FS, \n            \n            \n              Van Winkle \n              TJ, \n            \n            et al. \n          Canine intracranial primary neoplasia: 173 cases (1986-2003). J Vet Intern Med2006;20:669\u2013675."},{"key":"i1547-3317-52-5-319-b08","series-title":"Vet Pathol","first-page":"659","article-title":"Glioblastoma Multiforme: Clinical Findings, Magnetic Resonance Imaging, and Pathology in Five Dogs","volume":"40","author":"Lipsitz \n              D,","year":"2003","unstructured":"Lipsitz \n              D, \n            \n            \n              Higgins \n              RJ, \n            \n            \n              Kortz \n              GD, \n            \n            et al. \n          Glioblastoma Multiforme: Clinical Findings, Magnetic Resonance Imaging, and Pathology in Five Dogs. Vet Pathol2003;40:659\u2013669."},{"key":"i1547-3317-52-5-319-b09","series-title":"Veterinary Neuropathology","first-page":"135","author":"Vandevelde \n              M,","year":"2012","unstructured":"Vandevelde \n              M, \n            \n            \n              Higgins \n              R, \n            \n            \n              Oevermann \n              A. \n            \n          \n          Veterinary Neuropathology. West Sussex, United Kingdom: John Wiley & Sons;2012:135\u20137."},{"key":"i1547-3317-52-5-319-b10","series-title":"Child's Nerv Syst","first-page":"507","article-title":"Primary intracranial neoplasms of infancy and early childhood","volume":"13","author":"Rickert \n              CH,","year":"1997","unstructured":"Rickert \n              CH, \n            \n            \n              Probst-Cousin \n              S, \n            \n            \n              Gullotta \n              F. \n            \n          \n          Primary intracranial neoplasms of infancy and early childhood. Child's Nerv Syst1997;13:507\u201313."},{"key":"i1547-3317-52-5-319-b11","series-title":"Surg Neurol","first-page":"64","article-title":"Astrocytomas in childhood: a population-based study","volume":"23","author":"Dohrmann \n              GJ,","year":"1985","unstructured":"Dohrmann \n              GJ, \n            \n            \n              Farwell \n              JR, \n            \n            \n              Flannery \n              JT. \n            \n          \n          Astrocytomas in childhood: a population-based study. Surg Neurol1985;23:64\u20138."},{"key":"i1547-3317-52-5-319-b12","series-title":"J Am Anim Hosp Assoc","first-page":"288","article-title":"Astrocytomas in young dogs","volume":"39","author":"Kube \n              SA,","year":"2003","unstructured":"Kube \n              SA, \n            \n            \n              Bruyette \n              DS, \n            \n            \n              Hanson \n              SM. \n            \n          \n          Astrocytomas in young dogs. J Am Anim Hosp Assoc2003;39:288\u201393."},{"key":"i1547-3317-52-5-319-b13","series-title":"J Small Anim Pract","first-page":"325","article-title":"Intracranial anaplastic astrocytoma in a 19-week-old boxer dog","volume":"52","author":"Wong \n              M,","year":"2011","unstructured":"Wong \n              M, \n            \n            \n              Glass \n              E, \n            \n            \n              DeLahunta \n              A, \n            \n            et al. \n          Intracranial anaplastic astrocytoma in a 19-week-old boxer dog. J Small Anim Pract2011;52:325\u20138."},{"key":"i1547-3317-52-5-319-b14","series-title":"J Am Vet Med Assoc","first-page":"1530","article-title":"Locations and types of neoplasms in immature dogs: 69 cases (1964-1989)","volume":"200","author":"Keller \n              ET,","year":"1992","unstructured":"Keller \n              ET, \n            \n            \n              Madewell \n              BR. \n            \n          \n          Locations and types of neoplasms in immature dogs: 69 cases (1964-1989). J Am Vet Med Assoc1992;200:1530\u20132."},{"key":"i1547-3317-52-5-319-b15","series-title":"Vet Clin North Am Small Anim Pract","first-page":"535","article-title":"Therapeutic Approach to Chronic Electrolyte Disorders","volume":"38","author":"Willard \n              M.","year":"2008","unstructured":"Willard \n              M. \n            \n          \n          Therapeutic Approach to Chronic Electrolyte Disorders. Vet Clin North Am Small Anim Pract2008;38:535\u201341."},{"key":"i1547-3317-52-5-319-b16","series-title":"Vet Clin North Am Small Anim Pract","first-page":"513","article-title":"Therapeutic Approach to Electrolyte Emergencies","volume":"38","author":"Schaer \n              M.","year":"2008","unstructured":"Schaer \n              M. \n            \n          \n          Therapeutic Approach to Electrolyte Emergencies. Vet Clin North Am Small Anim Pract2008;38:513\u201333."},{"key":"i1547-3317-52-5-319-b17","series-title":"Textbook of Veterinary Internal Medicine. 7th ed","first-page":"299","author":"Ettinger \n              SJ,","year":"2007","unstructured":"Ettinger \n              SJ, \n            \n            \n              Feldman \n              EC. \n            \n          \n          Textbook of Veterinary Internal Medicine. 7th ed. Saint Louis: Saunders;2007:299\u2013300."},{"key":"i1547-3317-52-5-319-b18","series-title":"Vet Clin North Am Small Anim Pract","first-page":"231","article-title":"Hypernatremia","volume":"19","author":"Hardy \n              RM.","year":"1989","unstructured":"Hardy \n              RM. \n            \n          \n          Hypernatremia. Vet Clin North Am Small Anim Pract1989;19:231\u201340."},{"key":"i1547-3317-52-5-319-b19","series-title":"Veterinary Neuropathology","first-page":"362","author":"Summers \n              BA,","year":"1995","unstructured":"Summers \n              BA, \n            \n            \n              Cummings \n              JF, \n            \n            \n              De Lahunta \n              A. \n            \n          \n          Veterinary Neuropathology. Philadelphia: Mosby;1995:362\u201370."},{"key":"i1547-3317-52-5-319-b20","series-title":"Tumors in Domestic Animals. 4th ed","first-page":"701","author":"Meuten \n              DJ,","year":"2008","unstructured":"Meuten \n              DJ, \n            \n          \n          ed. Tumors in Domestic Animals. 4th ed. Ames (IA): John Wiley & Sons;2008:701\u20133."},{"key":"i1547-3317-52-5-319-b21","series-title":"Brain","first-page":"3336","article-title":"Serum GFAP is a diagnostic marker for glioblastoma multiforme","volume":"130","author":"Jung \n              CS,","year":"2007","unstructured":"Jung \n              CS, \n            \n            \n              Foerch \n              C, \n            \n            \n              Schanzer \n              A, \n            \n            et al. \n          Serum GFAP is a diagnostic marker for glioblastoma multiforme. Brain2007;130:3336\u201341."},{"key":"i1547-3317-52-5-319-b22","series-title":"J Am Vet Med Assoc","first-page":"986","article-title":"Oligodendroglioma in a 15-month-old dog","volume":"205","author":"Triolo \n              AJ,","year":"1994","unstructured":"Triolo \n              AJ, \n            \n            \n              Howard \n              MO, \n            \n            \n              Miles \n              KG. \n            \n          \n          Oligodendroglioma in a 15-month-old dog. J Am Vet Med Assoc1994;205:986\u201388."},{"key":"i1547-3317-52-5-319-b23","series-title":"J Am Anim Hosp Assoc","first-page":"353","article-title":"Brainstem oligodendroglioma in a puppy","volume":"49","author":"Mateo \n              I,","year":"2013","unstructured":"Mateo \n              I, \n            \n            \n              Orlandi \n              R, \n            \n            \n              Vazquez \n              F, \n            \n            et al. \n          Brainstem oligodendroglioma in a puppy. J Am Anim Hosp Assoc2013;49:353\u20136."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/52\/5\/article-p319.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/52\/5\/319\/1589581\/jaaha-ms-6382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/52\/5\/article-p319.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/52\/5\/article-p319.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:01:21Z","timestamp":1763740881000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/52\/5\/article-p319.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6382","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"type":"electronic","value":"1547-3317"},{"type":"print","value":"0587-2871"}],"subject":[],"published":{"date-parts":[[2016]]}}}