{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:08:58Z","timestamp":1785240538927,"version":"3.55.0"},"reference-count":22,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We describe an atypical case of duodenal leishmaniasis in a boxer dog presenting with chronic diarrhea and poor general condition. Antidiarrheic therapy was previously administered without success and inflammatory bowel disease localized to the small intestine was suspected, given the chronic clinical signs and by ruling out other known causes of gastrointestinal inflammation. Endoscopic biopsy of duodenum showed a moderate increase in lamina propria lymphocytes, plasma cells, and macrophages. Basophilic bodies were seen in the cytoplasm of numerous macrophages, suggestive of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    spp, confirmed by immunostaining, and a diagnosis of granulomatous duodenitis associated to\n                    <jats:italic>Leishmania<\/jats:italic>\n                    infection was made. After 7 mo of therapy, a significant clinical improvement and weight gain were observed, and endoscopic histology showed no evidence of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    . A progressive decline of anti-leishmanial antibody titer was also observed during follow-up. This report emphasizes the importance of atypical symptoms and the unusual location of visceral leishmaniasis, suggesting the need to consider leishmaniasis in the differential diagnosis of canine chronic enteritis, especially in endemic areas.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6401","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:00:33Z","timestamp":1489165233000},"page":"101-106","source":"Crossref","is-referenced-by-count":7,"title":["An Atypical Case of Leishmaniasis Associated with Chronic Duodenitis in a Dog"],"prefix":"10.5326","volume":"53","author":[{"given":"Ignacio","family":"Ayala","sequence":"first","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Jesus","family":"Bernal","sequence":"additional","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"Garcia-Martinez","sequence":"additional","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Gomez","sequence":"additional","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Navarro","sequence":"additional","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bernabe","sequence":"additional","affiliation":[{"name":"From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"11-12","key":"i1547-3317-53-2-101-b01","series-title":"Int J Parasitol","first-page":"1169","article-title":"The current status of zoonotic leishmaniases and approaches to disease control","volume":"35","author":"Gramiccia \n              M,","year":"2005","unstructured":"Gramiccia \n              M, \n            \n            \n              Gradoni \n              L. \n            \n          \n          The current status of zoonotic leishmaniases and approaches to disease control. Int J Parasitol2005;35(11-12):1169\u20131180."},{"issue":"6","key":"i1547-3317-53-2-101-b02","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1065","article-title":"Canine leishmaniasis in North America: emerging or newly recognized?","volume":"39","author":"Petersen \n              CA,","year":"2009","unstructured":"Petersen \n              CA, \n            \n            \n              Barr \n              SC. \n            \n          \n          Canine leishmaniasis in North America: emerging or newly recognized?\n          Vet Clin North Am Small Anim Pract\n          2009;39(6):1065\u20131074."},{"key":"i1547-3317-53-2-101-b03","series-title":"Leishmaniasis","first-page":"1","article-title":"Biology of leishmania and leishmaniasis","author":"Chang \n              KP,","year":"1985","unstructured":"Chang \n              KP, \n            \n            \n              Fong \n              D, \n            \n            \n              Bray \n              RS. \n            \n          \n          Biology of leishmania and leishmaniasis. 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Parasit Vectors2011;4:86."},{"key":"i1547-3317-53-2-101-b11","series-title":"Prat Med Chir An Comp","first-page":"137","article-title":"Leishmaniose canine: difficulties du diagnostic et du traitment (125 cas)","volume":"31","author":"Denerolle \n              P.","year":"1996","unstructured":"Denerolle \n              P. \n            \n          \n          Leishmaniose canine: difficulties du diagnostic et du traitment (125 cas). Prat Med Chir An Comp1996;31:137\u201345."},{"key":"i1547-3317-53-2-101-b12","series-title":"Vet Pathol","first-page":"342","article-title":"Chronic colitis due to leishmania infection in two dogs","volume":"28","author":"Ferrer \n              L,","year":"1991","unstructured":"Ferrer \n              L, \n            \n            \n              Juanola \n              B, \n            \n            \n              Ramos \n              JA, \n            \n            et al. \n          Chronic colitis due to leishmania infection in two dogs. 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BMC Immunol2013;14:22."},{"issue":"1","key":"i1547-3317-53-2-101-b17","series-title":"Acta Vet Scand","first-page":"67","article-title":"Histopathological and parasitological study of the gastrointestinal tract of dogs naturally infected with Leishmania infantum","volume":"53","author":"Pinto \n              AJ,","year":"2011","unstructured":"Pinto \n              AJ, \n            \n            \n              Figueiredo \n              MM, \n            \n            \n              Silva \n              FL, \n            \n            et al. \n          Histopathological and parasitological study of the gastrointestinal tract of dogs naturally infected with Leishmania infantum. 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Vet Record1995;136:514\u2013516."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/53\/2\/article-p101.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/53\/2\/101\/1589930\/jaaha-ms-6401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/53\/2\/article-p101.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/53\/2\/article-p101.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:01:18Z","timestamp":1763740878000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/53\/2\/article-p101.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6401","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}