{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:09:33Z","timestamp":1782497373889,"version":"3.54.5"},"reference-count":50,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"ABSTRACT<\/jats:title>\n Squamous cell carcinoma of the penis was diagnosed by incisional biopsy of a penile mass in a 12 yr old intact male beagle dog presenting with hemorrhagic discharge from the prepuce. Penile amputation, orchiectomy with scrotal ablation, and scrotal urethrostomy were performed. Hypertrophic osteopathy secondary to pulmonary metastatic disease occurred 10 mo after the surgery. Palliative treatment with piroxicam was administered and led to complete resolution of the clinical signs of the pain. Sixteen months following surgery, the dog presented with significant dyspnea and anorexia and was euthanized due to poor prognosis. This case report describes a rare penile tumor, squamous cell carcinoma. Consequent paraneoplastic hypertrophic osteopathy and its palliative treatment are also reviewed.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6425","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T16:58:55Z","timestamp":1502297935000},"page":"277-280","source":"Crossref","is-referenced-by-count":4,"title":["Squamous Cell Carcinoma of the Penis with Pulmonary Metastasis and Paraneoplastic Hypertrophic Osteopathy in a Dog"],"prefix":"10.5326","volume":"53","author":[{"given":"Victoria","family":"Jenkins","sequence":"first","affiliation":[{"name":"From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); H\u00f4pital V\u00e9t\u00e9rinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Henrique de Mello Souza","sequence":"additional","affiliation":[{"name":"From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); H\u00f4pital V\u00e9t\u00e9rinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Phillippe","family":"de Lorimier","sequence":"additional","affiliation":[{"name":"From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); H\u00f4pital V\u00e9t\u00e9rinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro","family":"de Toledo-Piza","sequence":"additional","affiliation":[{"name":"From the University of Florida, Gainesville, Florida (V.J., C.H.d.M.S.); H\u00f4pital V\u00e9t\u00e9rinaire Rive-Sud, Brossard, Quebec, Canada (L-P.d.L.); IPEV, Rio de Janeiro, Brazil (E.d.T-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Vet Pathol","first-page":"543","article-title":"Testicular epidermoid cyst and penile squamous cell carcinoma in a dog","volume":"29","author":"Wakui\n S","year":"1992","unstructured":"Wakui\n S\n , FurusatoM, NomuraY, et al. Testicular epidermoid cyst and penile squamous cell carcinoma in a dog. Vet Pathol1992;29:543\u20135."},{"key":"bib2","series-title":"Small Animal Clinical Oncology","first-page":"233","article-title":"Tumors of the skin and subcutaneous tissues","author":"Vail\n DM","year":"2001","unstructured":"Vail\n DM\n , WithrowSJ. Tumors of the skin and subcutaneous tissues. In: WithrowSJ, MacEwenEG, eds. Small Animal Clinical Oncology. 3rd ed. Philadelphia: WB Saunders Co; 2001:233\u201360."},{"key":"bib3","series-title":"J Am Vet Med Assoc","first-page":"759","article-title":"Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987\u20131988)","volume":"201","author":"O\u2019Brien\n MG","year":"1992","unstructured":"O\u2019Brien\n MG\n , BergJ, EnglerSJ. Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987\u20131988). J Am Vet Med Assoc1992;201:759\u201361."},{"key":"bib4","series-title":"Vet Radiol","first-page":"133","article-title":"Canine oral nontonsillar squamous cell carcinomas: prognostic factors for recurrence and survival following orthovoltage radiation therapy","volume":"29","author":"Evans\n SM","year":"1988","unstructured":"Evans\n SM\n , ShoferF. Canine oral nontonsillar squamous cell carcinomas: prognostic factors for recurrence and survival following orthovoltage radiation therapy. Vet Radiol1988;29:133\u20137."},{"key":"bib5","series-title":"J Am Anim Hosp Assoc","first-page":"981","article-title":"Tumors of the canine genital system","volume":"19","author":"Herron\n MA","year":"1993","unstructured":"Herron\n MA\n \n . Tumors of the canine genital system. J Am Anim Hosp Assoc1993;19:981\u201393."},{"key":"bib6","series-title":"J Am Anim Hosp Assoc","first-page":"403","article-title":"Two cases of penile neoplasm: Squamous cell carcinoma and mesenchymal chondrosarcoma","volume":"24","author":"Patnaik\n AK","year":"1988","unstructured":"Patnaik\n AK\n , MatthiesenDT, ZawieDA. Two cases of penile neoplasm: Squamous cell carcinoma and mesenchymal chondrosarcoma. J Am Anim Hosp Assoc1988:24:403\u20136."},{"key":"bib7","series-title":"J Am Anim Hosp Assoc","first-page":"474","article-title":"Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog","volume":"37","author":"Michels\n GM","year":"2001","unstructured":"Michels\n GM\n , KnappDW, DavidM, et al. Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog. J Am Anim Hosp Assoc2001;37:474\u20137."},{"key":"bib8","series-title":"Can Vet J","first-page":"547","article-title":"Priapism secondary to penile metastasis in a dog","volume":"43","author":"Rogers\n L","year":"2002","unstructured":"Rogers\n L\n , LopezA, GillisA. Priapism secondary to penile metastasis in a dog. Can Vet J2002;43:547\u20139."},{"key":"bib9","series-title":"J Am Vet Med Assoc","first-page":"1242","article-title":"Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases","volume":"159","author":"Brodey\n RS","year":"1971","unstructured":"Brodey\n RS\n \n . Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases. J Am Vet Med Assoc1971;159:1242\u201356."},{"issue":"3","key":"bib10","series-title":"Vet Comp Oncol","first-page":"157","article-title":"Paraneoplastic hypertrophic osteopathy in 30 dogs","volume":"13","author":"Withers\n SS","year":"2015","unstructured":"Withers\n SS\n , JohnsonEG, CulpWT, et al. Paraneoplastic hypertrophic osteopathy in 30 dogs. Vet Comp Oncol2015;13(3):157\u201365."},{"key":"bib11","series-title":"J Am Anim Hosp Assoc","first-page":"76","article-title":"Treatment of renal nephroblastoma in an adult dog","volume":"39","author":"Seaman\n RL","year":"2003","unstructured":"Seaman\n RL\n , PattonCS. Treatment of renal nephroblastoma in an adult dog. J Am Anim Hosp Assoc2003;39:76\u20139."},{"issue":"10","key":"bib12","series-title":"J Am Vet Med Assoc","first-page":"911","article-title":"Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog","volume":"165","author":"Halliwell\n WH","year":"1974","unstructured":"Halliwell\n WH\n , AckermanN. Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. J Am Vet Med Assoc. 1974;165(10):911\u20133."},{"issue":"2","key":"bib13","series-title":"J Small Anim Pract","first-page":"99","article-title":"Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog","volume":"48","author":"Dunn\n ME","year":"2007","unstructured":"Dunn\n ME\n , BlondL, LetardD, et al. Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog. J Small Anim Pract2007;48(2):99\u2013103."},{"key":"bib14","series-title":"Thorax","first-page":"545","article-title":"Plasma growth hormone and digital clubbing in carcinoma of the bronchus","volume":"45","author":"Gosney\n MA","year":"1990","unstructured":"Gosney\n MA\n , GosneyJR, LyeM. Plasma growth hormone and digital clubbing in carcinoma of the bronchus. Thorax1990;45:545\u20137."},{"key":"bib15","series-title":"Sem Hop","first-page":"529","article-title":"Hypertrophic pulmonary osteoarthropathy with paraneoplastic secretion of four hormones. 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Circulation2013;127:1997\u20139."},{"issue":"1","key":"bib18","series-title":"J Vet Med Sci","first-page":"133","article-title":"Regression of hypertrophic osteopathy following removal of intrathoracic neoplasia derived from vagus nerve in a dog","volume":"57","author":"Hara\n Y","year":"1995","unstructured":"Hara\n Y\n , TagawaM, EjimaH, et al. Regression of hypertrophic osteopathy following removal of intrathoracic neoplasia derived from vagus nerve in a dog. J Vet Med Sci1995;57(1):133\u20135."},{"key":"bib19","series-title":"J Vet Intern Med","first-page":"407","article-title":"Resolution of paraneoplastic leukocytosis, and hypertrophic osteopathy after resection of a renal transitional cell carcinoma producing granulocyte-macrophage colony stimulating factor in a young Bull Terrier","volume":"15","author":"Peeters\n D","year":"2001","unstructured":"Peeters\n D\n , ClercxC, ThiryA, et al. Resolution of paraneoplastic leukocytosis, and hypertrophic osteopathy after resection of a renal transitional cell carcinoma producing granulocyte-macrophage colony stimulating factor in a young Bull Terrier. J Vet Intern Med2001;15:407\u201311."},{"key":"bib20","series-title":"J Am Vet Med Assoc","first-page":"351","article-title":"Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog","volume":"195","author":"Hahn\n KA","year":"1989","unstructured":"Hahn\n KA\n , RichardsonRC. Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog. J Am Vet Med Assoc1989;195:351\u20133."},{"key":"bib21","series-title":"Am J Vet Res","first-page":"91","article-title":"Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood","volume":"63","author":"Streppa\n HK","year":"2002","unstructured":"Streppa\n HK\n , JonesCJ, BudsbergSC. Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. Am J Vet Res2002;63:91\u20134."},{"key":"bib22","series-title":"J Cancer Res Clin Oncol","first-page":"411","article-title":"Cyclooxygenase-2: a novel target for cancer chemotherapy?","volume":"127","author":"Dempke\n W","year":"2001","unstructured":"Dempke\n W\n , RieC, GrrrotheyA, et al. Cyclooxygenase-2: a novel target for cancer chemotherapy?J Cancer Res Clin Oncol2001;127:411\u20137."},{"key":"bib23","series-title":"FASEB J","first-page":"2742","article-title":"COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib","volume":"15","author":"Grosch\n S","year":"2001","unstructured":"Grosch\n S\n , TegederI, NiederbergerE, et al. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. FASEB J2001;15:2742\u20134."},{"key":"bib24","series-title":"J Cell Physiol","first-page":"279","article-title":"Many actions of cyclooxygenase-2 in cellular dynamics and in cancer","volume":"190","author":"Cao\n Y","year":"2002","unstructured":"Cao\n Y\n , PrescottSM. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol2002;190:279\u201386."},{"key":"bib25","series-title":"J Histochem Cytochem","first-page":"867","article-title":"Expression of cyclooxygenase-2 in naturally occurring squamous cell carcinoma in dogs","volume":"49","author":"Pestili de Almeida\n EM","year":"2001","unstructured":"Pestili de Almeida\n EM\n , PicheC, SiroisJ, et al. Expression of cyclooxygenase-2 in naturally occurring squamous cell carcinoma in dogs. J Histochem Cytochem2001;49:867\u201375."},{"key":"bib1","series-title":"Vet Pathol","first-page":"543","article-title":"Testicular epidermoid cyst and penile squamous cell carcinoma in a dog","volume":"29","author":"Wakui\n S","year":"1992","unstructured":"Wakui\n S\n , FurusatoM, NomuraY, et al. Testicular epidermoid cyst and penile squamous cell carcinoma in a dog. Vet Pathol1992;29:543\u20135."},{"key":"bib2","series-title":"Small Animal Clinical Oncology","first-page":"233","article-title":"Tumors of the skin and subcutaneous tissues","author":"Vail\n DM","year":"2001","unstructured":"Vail\n DM\n , WithrowSJ. Tumors of the skin and subcutaneous tissues. In: WithrowSJ, MacEwenEG, eds. Small Animal Clinical Oncology. 3rd ed. Philadelphia: WB Saunders Co; 2001:233\u201360."},{"key":"bib3","series-title":"J Am Vet Med Assoc","first-page":"759","article-title":"Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987\u20131988)","volume":"201","author":"O\u2019Brien\n MG","year":"1992","unstructured":"O\u2019Brien\n MG\n , BergJ, EnglerSJ. Treatment by digital amputation of subungual squamous cell carcinoma in dogs: 21 cases (1987\u20131988). J Am Vet Med Assoc1992;201:759\u201361."},{"key":"bib4","series-title":"Vet Radiol","first-page":"133","article-title":"Canine oral nontonsillar squamous cell carcinomas: prognostic factors for recurrence and survival following orthovoltage radiation therapy","volume":"29","author":"Evans\n SM","year":"1988","unstructured":"Evans\n SM\n , ShoferF. Canine oral nontonsillar squamous cell carcinomas: prognostic factors for recurrence and survival following orthovoltage radiation therapy. Vet Radiol1988;29:133\u20137."},{"key":"bib5","series-title":"J Am Anim Hosp Assoc","first-page":"981","article-title":"Tumors of the canine genital system","volume":"19","author":"Herron\n MA","year":"1993","unstructured":"Herron\n MA\n \n . Tumors of the canine genital system. J Am Anim Hosp Assoc1993;19:981\u201393."},{"key":"bib6","series-title":"J Am Anim Hosp Assoc","first-page":"403","article-title":"Two cases of penile neoplasm: Squamous cell carcinoma and mesenchymal chondrosarcoma","volume":"24","author":"Patnaik\n AK","year":"1988","unstructured":"Patnaik\n AK\n , MatthiesenDT, ZawieDA. Two cases of penile neoplasm: Squamous cell carcinoma and mesenchymal chondrosarcoma. J Am Anim Hosp Assoc1988:24:403\u20136."},{"key":"bib7","series-title":"J Am Anim Hosp Assoc","first-page":"474","article-title":"Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog","volume":"37","author":"Michels\n GM","year":"2001","unstructured":"Michels\n GM\n , KnappDW, DavidM, et al. Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog. J Am Anim Hosp Assoc2001;37:474\u20137."},{"key":"bib8","series-title":"Can Vet J","first-page":"547","article-title":"Priapism secondary to penile metastasis in a dog","volume":"43","author":"Rogers\n L","year":"2002","unstructured":"Rogers\n L\n , LopezA, GillisA. Priapism secondary to penile metastasis in a dog. Can Vet J2002;43:547\u20139."},{"key":"bib9","series-title":"J Am Vet Med Assoc","first-page":"1242","article-title":"Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases","volume":"159","author":"Brodey\n RS","year":"1971","unstructured":"Brodey\n RS\n \n . Hypertrophic osteoarthropathy in the dog: a clinicopathologic survey of 60 cases. J Am Vet Med Assoc1971;159:1242\u201356."},{"issue":"3","key":"bib10","series-title":"Vet Comp Oncol","first-page":"157","article-title":"Paraneoplastic hypertrophic osteopathy in 30 dogs","volume":"13","author":"Withers\n SS","year":"2015","unstructured":"Withers\n SS\n , JohnsonEG, CulpWT, et al. Paraneoplastic hypertrophic osteopathy in 30 dogs. Vet Comp Oncol2015;13(3):157\u201365."},{"key":"bib11","series-title":"J Am Anim Hosp Assoc","first-page":"76","article-title":"Treatment of renal nephroblastoma in an adult dog","volume":"39","author":"Seaman\n RL","year":"2003","unstructured":"Seaman\n RL\n , PattonCS. Treatment of renal nephroblastoma in an adult dog. J Am Anim Hosp Assoc2003;39:76\u20139."},{"issue":"10","key":"bib12","series-title":"J Am Vet Med Assoc","first-page":"911","article-title":"Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog","volume":"165","author":"Halliwell\n WH","year":"1974","unstructured":"Halliwell\n WH\n , AckermanN. Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. J Am Vet Med Assoc. 1974;165(10):911\u20133."},{"issue":"2","key":"bib13","series-title":"J Small Anim Pract","first-page":"99","article-title":"Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog","volume":"48","author":"Dunn\n ME","year":"2007","unstructured":"Dunn\n ME\n , BlondL, LetardD, et al. Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog. J Small Anim Pract2007;48(2):99\u2013103."},{"key":"bib14","series-title":"Thorax","first-page":"545","article-title":"Plasma growth hormone and digital clubbing in carcinoma of the bronchus","volume":"45","author":"Gosney\n MA","year":"1990","unstructured":"Gosney\n MA\n , GosneyJR, LyeM. Plasma growth hormone and digital clubbing in carcinoma of the bronchus. Thorax1990;45:545\u20137."},{"key":"bib15","series-title":"Sem Hop","first-page":"529","article-title":"Hypertrophic pulmonary osteoarthropathy with paraneoplastic secretion of four hormones. Consideration on pathogenesis","volume":"58","author":"Audebert\n AA","year":"1982","unstructured":"Audebert\n AA\n , AubriotA, KurlikM, et al. Hypertrophic pulmonary osteoarthropathy with paraneoplastic secretion of four hormones. Consideration on pathogenesis. Sem Hop1982;58:529\u201330."},{"key":"bib16","series-title":"Clin Rheumatol","first-page":"435","article-title":"Hypertrophic osteoarthropathy: Endothelium and platelet function","volume":"15","author":"Silveri\n F","year":"1996","unstructured":"Silveri\n F\n , De AngelisR, ArgentatiF, et al. Hypertrophic osteoarthropathy: Endothelium and platelet function. Clin Rheumatol1996;15:435\u20139."},{"key":"bib17","series-title":"Circulation","first-page":"1997","article-title":"Digital clubbing","volume":"127","author":"Rutherford\n JD","year":"2013","unstructured":"Rutherford\n JD\n \n . Digital clubbing. Circulation2013;127:1997\u20139."},{"issue":"1","key":"bib18","series-title":"J Vet Med Sci","first-page":"133","article-title":"Regression of hypertrophic osteopathy following removal of intrathoracic neoplasia derived from vagus nerve in a dog","volume":"57","author":"Hara\n Y","year":"1995","unstructured":"Hara\n Y\n , TagawaM, EjimaH, et al. Regression of hypertrophic osteopathy following removal of intrathoracic neoplasia derived from vagus nerve in a dog. J Vet Med Sci1995;57(1):133\u20135."},{"key":"bib19","series-title":"J Vet Intern Med","first-page":"407","article-title":"Resolution of paraneoplastic leukocytosis, and hypertrophic osteopathy after resection of a renal transitional cell carcinoma producing granulocyte-macrophage colony stimulating factor in a young Bull Terrier","volume":"15","author":"Peeters\n D","year":"2001","unstructured":"Peeters\n D\n , ClercxC, ThiryA, et al. Resolution of paraneoplastic leukocytosis, and hypertrophic osteopathy after resection of a renal transitional cell carcinoma producing granulocyte-macrophage colony stimulating factor in a young Bull Terrier. J Vet Intern Med2001;15:407\u201311."},{"key":"bib20","series-title":"J Am Vet Med Assoc","first-page":"351","article-title":"Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog","volume":"195","author":"Hahn\n KA","year":"1989","unstructured":"Hahn\n KA\n , RichardsonRC. Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog. J Am Vet Med Assoc1989;195:351\u20133."},{"key":"bib21","series-title":"Am J Vet Res","first-page":"91","article-title":"Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood","volume":"63","author":"Streppa\n HK","year":"2002","unstructured":"Streppa\n HK\n , JonesCJ, BudsbergSC. Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. Am J Vet Res2002;63:91\u20134."},{"key":"bib22","series-title":"J Cancer Res Clin Oncol","first-page":"411","article-title":"Cyclooxygenase-2: a novel target for cancer chemotherapy?","volume":"127","author":"Dempke\n W","year":"2001","unstructured":"Dempke\n W\n , RieC, GrrrotheyA, et al. Cyclooxygenase-2: a novel target for cancer chemotherapy?J Cancer Res Clin Oncol2001;127:411\u20137."},{"key":"bib23","series-title":"FASEB J","first-page":"2742","article-title":"COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib","volume":"15","author":"Grosch\n S","year":"2001","unstructured":"Grosch\n S\n , TegederI, NiederbergerE, et al. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. 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