{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:01:55Z","timestamp":1783728115937,"version":"3.55.0"},"reference-count":28,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The emergence of methicillin-resistant\n                    <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                    has increased the interest in topical therapy for treating canine pyoderma. Shampooing with chlorhexidine followed by dilute bleach rinses are often recommended, but household bleach can dry the skin and is unpleasant to use. A shampoo formulated with sodium hypochlorite and salicylic acid was evaluated as sole therapy for dogs with superficial pyoderma associated with\n                    <jats:italic>S. pseudintermedius<\/jats:italic>\n                    , including methicillin-resistant strains. Client-owned dogs were recruited based on positive culture for methicillin-resistant staphylococci or prior failure of pyoderma to respond to antibiotics. This prospective, open-label pilot study assessed the efficacy of the shampoo when used three times weekly for 4 wk. Dogs were evaluated at baseline and at 2 and 4 wk by cytology, clinical examination, and owner assessment. Digital images were also obtained. Baseline bacterial counts, clinical assessments and owner scores were significantly improved at 2 and 4 wk. Clients completing the study reported excellent lathering and dispersion, reduction in odor, and brightening of white and light coats. No owners reported skin dryness or other adverse events during the study. We conclude that this shampoo containing sodium hypochlorite in a vehicle that avoids skin drying is an effective treatment for canine pyoderma.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6628","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T17:03:11Z","timestamp":1552582991000},"page":"117-123","source":"Crossref","is-referenced-by-count":9,"title":["Sodium Hypochlorite\/Salicylic Acid Shampoo for Treatment of Canine Staphylococcal Pyoderma"],"prefix":"10.5326","volume":"55","author":[{"given":"Valerie A.","family":"Fadok","sequence":"first","affiliation":[{"name":"From Zoetis, Inc., Bellaire, Texas (V.A.F.); and ACVD Dermatology for Animals, Omaha, Nebraska (K.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Irwin","sequence":"additional","affiliation":[{"name":"From Zoetis, Inc., Bellaire, Texas (V.A.F.); and ACVD Dermatology for Animals, Omaha, Nebraska (K.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"3\u20134","key":"bib1","series-title":"Vet Microbiol","first-page":"418","article-title":"Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine","volume":"140","author":"Weese\n              JS","year":"2010","unstructured":"Weese\n              JS\n            , van DuijkerenE. Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine. Vet Microbiol2010;140(3\u20134):418\u201329."},{"issue":"12","key":"bib2","series-title":"J Antimicrob Chemother","first-page":"2705","article-title":"Review on methicillin-resistant Staphylococcus pseudintermedius","volume":"66","author":"van Duijkeren\n              E","year":"2011","unstructured":"van Duijkeren\n              E\n            , CatryB, GrekoC, et al. Review on methicillin-resistant Staphylococcus pseudintermedius. J Antimicrob Chemother2011;66(12):2705\u201314."},{"issue":"3","key":"bib3","series-title":"J Small Anim Pract","first-page":"147","article-title":"What's happened to Staphylococcus intermedius? Taxonomic revision and emergence of multi-drug resistance","volume":"53","author":"Bond\n              R","year":"2012","unstructured":"Bond\n              R\n            , LoefflerA. What's happened to Staphylococcus intermedius? 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September 8\u201310, 2011; Brussels, Belgium."},{"issue":"4","key":"bib23","series-title":"Burns","first-page":"529","article-title":"The use of topical, un-buffered sodium hypochlorite in the management of burn wound infection","volume":"38","author":"Coetzee\n              E","year":"2012","unstructured":"Coetzee\n              E\n            , WhitelawA, KahnD, et al. The use of topical, un-buffered sodium hypochlorite in the management of burn wound infection. Burns2012;38(4):529\u201333."},{"issue":"3","key":"bib24","series-title":"Pediatr Dermatol","first-page":"308","article-title":"Novel sodium hypochlorite cleanser shows clinical response and excellent acceptability in the treatment of atopic dermatitis","volume":"30","author":"Ryan\n              C","year":"2013","unstructured":"Ryan\n              C\n            , ShawRE, CockerillCJ, et al. Novel sodium hypochlorite cleanser shows clinical response and excellent acceptability in the treatment of atopic dermatitis. 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Endod Dent Traumatol1992;8(6):223\u20139."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/3\/article-p117.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/55\/3\/117\/2473524\/jaaha-ms-6628.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/3\/article-p117.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/3\/article-p117.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:02:54Z","timestamp":1763740974000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/3\/article-p117.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":28,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6628","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}