{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:19Z","timestamp":1772326999440,"version":"3.50.1"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 12 yr old male neutered beagle was presented on transfer to the intensive care unit with severe anemia, thrombocytopenia, and bruising detected 1 day after undergoing tibial plateau leveling osteotomy surgery. The patient had undergone extra-capsular stifle stabilization surgery 14 wk prior to treat ligament disease in the same knee. Laboratory testing and treatment for anemia, presumptive immune-mediated thrombocytopenia, and possible hemostatic disorder was initiated. A persistent anemia, progressive thrombocytopenia, and the development of a firm swelling and neurologic impairment in the limb raised concerns for compartment syndrome (CS). A musculoskeletal ultrasound revealed a large aneurysm in the caudal thigh surrounded by abnormal muscle tissue. The patient underwent amputation of the limb and recovered without further complication. Pathology findings were consistent with the development of femoral CS secondary to a ruptured peripheral arterial aneurysm or a pseudoaneurysm. A consumptive thrombocytopenia and regenerative anemia were attributed to periodic or progressive thrombosis of the vessel and regional hemorrhage. Postoperative CS can develop in combination with peripheral arterial aneurysm or pseudoaneurysm, and screening for vascular abnormalities as well as CS should be considered in complicated recovery from orthopedic surgery with compatible clinical signs including progressive soft tissue swelling, persistent anemia, and thrombocytopenia.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6659","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T16:31:30Z","timestamp":1547742690000},"page":"e552-04","source":"Crossref","is-referenced-by-count":0,"title":["Suspected Compartment Syndrome, Consumptive Thrombocytopenia, and Anemia Secondary to a Ruptured Arterial Aneurysm or Pseudoaneurysm Following Multiple Stifle Surgeries"],"prefix":"10.5326","volume":"55","author":[{"given":"Michael","family":"Levenson","sequence":"first","affiliation":[{"name":"From Friendship Hospital for Animals, Washington, District of Columbia (M.L., J.M.C., S.K.H.); and Veterinary Pathology Services, Joint Pathology Center, Silver Spring, Maryland (J.R.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine M.","family":"Calabro","sequence":"additional","affiliation":[{"name":"From Friendship Hospital for Animals, Washington, District of Columbia (M.L., J.M.C., S.K.H.); and Veterinary Pathology Services, Joint Pathology Center, Silver Spring, Maryland (J.R.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R.","family":"Crawford","sequence":"additional","affiliation":[{"name":"From Friendship Hospital for Animals, Washington, District of Columbia (M.L., J.M.C., S.K.H.); and Veterinary Pathology Services, Joint Pathology Center, Silver Spring, Maryland (J.R.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha K.","family":"Hart","sequence":"additional","affiliation":[{"name":"From Friendship Hospital for Animals, Washington, District of Columbia (M.L., J.M.C., S.K.H.); and Veterinary Pathology Services, Joint Pathology Center, Silver Spring, Maryland (J.R.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"5","key":"bib1","series-title":"J Small Anim Pract","first-page":"286","article-title":"Femoral compartment syndrome due to haemangiosarcoma in the semimembranosus muscle in a dog","volume":"47","author":"Bar-Am\n              Y","year":"2006","unstructured":"Bar-Am\n              Y\n            , AnugM, ShaharR. Femoral compartment syndrome due to haemangiosarcoma in the semimembranosus muscle in a dog. J Small Anim Pract2006;47(5):286\u20139."},{"issue":"5","key":"bib2","series-title":"J Small Anim Pract","first-page":"281","article-title":"Acute compartment syndrome complicating an intramuscular haemangiosarcoma in a dog","volume":"47","author":"Radke\n              H","year":"2006","unstructured":"Radke\n              H\n            , SprengD, SigristN, et al. Acute compartment syndrome complicating an intramuscular haemangiosarcoma in a dog. J Small Anim Pract2006;47(5):281\u20134."},{"issue":"4","key":"bib3","series-title":"Vet Radiol Ultrasound","first-page":"244","article-title":"Compartment syndrome in a Labrador retriever","volume":"34","author":"Williams\n              J","year":"1993","unstructured":"Williams\n              J\n            , BaileyMQ, SchertelER, et al. Compartment syndrome in a Labrador retriever. Vet Radiol Ultrasound1993;34(4):244\u20138."},{"issue":"10000","key":"bib4","series-title":"Lancet","first-page":"1299","article-title":"Diagnosis and treatment of acute extremity compartment syndrome","volume":"386","author":"von Keudell, AG","unstructured":"von Keudell, AG, WeaverMJ, AppletonPT, et al. Diagnosis and treatment of acute extremity compartment syndrome. Lancet386(10000):1299\u2013310."},{"issue":"4","key":"bib5","series-title":"Canine Pract","first-page":"10","article-title":"Development and validation of a body condition score system for dogs","volume":"22","author":"Laflamme\n              D","year":"1997","unstructured":"Laflamme\n              D\n            \n          . Development and validation of a body condition score system for dogs. Canine Pract1997;22(4):10\u20135."},{"issue":"12","key":"bib6","series-title":"Am J Vet Res","first-page":"1700","article-title":"Effect of desmopressin acetate administration on primary hemostasis in Doberman Pinschers with type-1 von Willebrand disease as assessed by a point-of-care instrument","volume":"63","author":"Callan\n              MB","year":"2002","unstructured":"Callan\n              MB\n            , GigerU. Effect of desmopressin acetate administration on primary hemostasis in Doberman Pinschers with type-1 von Willebrand disease as assessed by a point-of-care instrument. Am J Vet Res2002; 63(12):1700\u20136."},{"issue":"6","key":"bib7","series-title":"Vet Surg","first-page":"427","article-title":"Osteofascial compartment syndrome in the dog","volume":"16","author":"Basinger\n              RR","year":"1987","unstructured":"Basinger\n              RR\n            , AronDN, CroweDT, et al. Osteofascial compartment syndrome in the dog. Vet Surg1987;16(6):427\u201334."},{"issue":"4","key":"bib8","series-title":"Orthopedics","first-page":"e486","article-title":"Treatment of compartment syndrome of the thigh associated with acute renal failure after the Wenchuan earthquake","volume":"35","author":"Duan\n              X","year":"2012","unstructured":"Duan\n              X\n            , ZhangK, ZhongG, et al. Treatment of compartment syndrome of the thigh associated with acute renal failure after the Wenchuan earthquake. Orthopedics2012;35(4):e486\u201390."},{"issue":"2","key":"bib9","series-title":"J Arthroplasty","first-page":"355","article-title":"Fasciotomy following total knee arthroplasty: beware of terrible outcome","volume":"29","author":"Vegari\n              DN","year":"2014","unstructured":"Vegari\n              DN\n            , RangavajjulaAV, DiiorioTM, et al. Fasciotomy following total knee arthroplasty: beware of terrible outcome. J Arthroplasty2014;29(2):355\u20139."},{"issue":"2","key":"bib10","series-title":"J Trauma","first-page":"393","article-title":"Thigh compartment syndrome as a result of a false aneurysm of the profunda femoris artery complicating fixation of an intertrochanteric fracture","volume":"47","author":"Karkos\n              CD","year":"1999","unstructured":"Karkos\n              CD\n            , HughesR, PrasadV, et al. Thigh compartment syndrome as a result of a false aneurysm of the profunda femoris artery complicating fixation of an intertrochanteric fracture. J Trauma1999;47(2):393\u20135."},{"issue":"5","key":"bib1","series-title":"J Small Anim Pract","first-page":"286","article-title":"Femoral compartment syndrome due to haemangiosarcoma in the semimembranosus muscle in a dog","volume":"47","author":"Bar-Am\n              Y","year":"2006","unstructured":"Bar-Am\n              Y\n            , AnugM, ShaharR. Femoral compartment syndrome due to haemangiosarcoma in the semimembranosus muscle in a dog. J Small Anim Pract2006;47(5):286\u20139."},{"issue":"5","key":"bib2","series-title":"J Small Anim Pract","first-page":"281","article-title":"Acute compartment syndrome complicating an intramuscular haemangiosarcoma in a dog","volume":"47","author":"Radke\n              H","year":"2006","unstructured":"Radke\n              H\n            , SprengD, SigristN, et al. Acute compartment syndrome complicating an intramuscular haemangiosarcoma in a dog. J Small Anim Pract2006;47(5):281\u20134."},{"issue":"4","key":"bib3","series-title":"Vet Radiol Ultrasound","first-page":"244","article-title":"Compartment syndrome in a Labrador retriever","volume":"34","author":"Williams\n              J","year":"1993","unstructured":"Williams\n              J\n            , BaileyMQ, SchertelER, et al. Compartment syndrome in a Labrador retriever. Vet Radiol Ultrasound1993;34(4):244\u20138."},{"issue":"10000","key":"bib4","series-title":"Lancet","first-page":"1299","article-title":"Diagnosis and treatment of acute extremity compartment syndrome","volume":"386","author":"von Keudell, AG","unstructured":"von Keudell, AG, WeaverMJ, AppletonPT, et al. Diagnosis and treatment of acute extremity compartment syndrome. Lancet386(10000):1299\u2013310."},{"issue":"4","key":"bib5","series-title":"Canine Pract","first-page":"10","article-title":"Development and validation of a body condition score system for dogs","volume":"22","author":"Laflamme\n              D","year":"1997","unstructured":"Laflamme\n              D\n            \n          . Development and validation of a body condition score system for dogs. Canine Pract1997;22(4):10\u20135."},{"issue":"12","key":"bib6","series-title":"Am J Vet Res","first-page":"1700","article-title":"Effect of desmopressin acetate administration on primary hemostasis in Doberman Pinschers with type-1 von Willebrand disease as assessed by a point-of-care instrument","volume":"63","author":"Callan\n              MB","year":"2002","unstructured":"Callan\n              MB\n            , GigerU. Effect of desmopressin acetate administration on primary hemostasis in Doberman Pinschers with type-1 von Willebrand disease as assessed by a point-of-care instrument. Am J Vet Res2002; 63(12):1700\u20136."},{"issue":"6","key":"bib7","series-title":"Vet Surg","first-page":"427","article-title":"Osteofascial compartment syndrome in the dog","volume":"16","author":"Basinger\n              RR","year":"1987","unstructured":"Basinger\n              RR\n            , AronDN, CroweDT, et al. Osteofascial compartment syndrome in the dog. Vet Surg1987;16(6):427\u201334."},{"issue":"4","key":"bib8","series-title":"Orthopedics","first-page":"e486","article-title":"Treatment of compartment syndrome of the thigh associated with acute renal failure after the Wenchuan earthquake","volume":"35","author":"Duan\n              X","year":"2012","unstructured":"Duan\n              X\n            , ZhangK, ZhongG, et al. Treatment of compartment syndrome of the thigh associated with acute renal failure after the Wenchuan earthquake. Orthopedics2012;35(4):e486\u201390."},{"issue":"2","key":"bib9","series-title":"J Arthroplasty","first-page":"355","article-title":"Fasciotomy following total knee arthroplasty: beware of terrible outcome","volume":"29","author":"Vegari\n              DN","year":"2014","unstructured":"Vegari\n              DN\n            , RangavajjulaAV, DiiorioTM, et al. Fasciotomy following total knee arthroplasty: beware of terrible outcome. J Arthroplasty2014;29(2):355\u20139."},{"issue":"2","key":"bib10","series-title":"J Trauma","first-page":"393","article-title":"Thigh compartment syndrome as a result of a false aneurysm of the profunda femoris artery complicating fixation of an intertrochanteric fracture","volume":"47","author":"Karkos\n              CD","year":"1999","unstructured":"Karkos\n              CD\n            , HughesR, PrasadV, et al. Thigh compartment syndrome as a result of a false aneurysm of the profunda femoris artery complicating fixation of an intertrochanteric fracture. J Trauma1999;47(2):393\u20135."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/2\/article-pe552-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/doi\/10.5326\/JAAHA-MS-6659\/1590070\/jaaha-ms-6659.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/2\/article-pe552-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/2\/article-pe552-04.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:31:20Z","timestamp":1772325080000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/2\/article-pe552-04.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6659","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}