{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:16:02Z","timestamp":1763741762029,"version":"3.45.0"},"reference-count":19,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinically relevant hypocalcemia is a well-documented complication of glucocorticoid administration in people with hypoparathyroidism. The current report describes the phenomenon in a dog. A 7 yr old neutered male Pomeranian was diagnosed with immune-mediated thrombocytopenia, immune-mediated hemolytic anemia, and primary hypoparathyroidism. This dog required long-term parenteral calcium gluconate to prevent clinical hypocalcemia despite appropriate doses of oral calcitriol and calcium carbonate. This is the first description of clinically significant presumptive glucocorticoid induced hypocalcemia in a dog with primary hypoparathyroidism.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6705","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T12:36:55Z","timestamp":1542199015000},"page":"e551-04","source":"Crossref","is-referenced-by-count":0,"title":["Presumptive Glucocorticoid-Induced Refractory Hypocalcemia in a Dog with Idiopathic Immune-Mediated Hypoparathyroidism, Thrombocytopenia, and Hemolytic Anemia"],"prefix":"10.5326","volume":"55","author":[{"given":"Jared","family":"Jaffey","sequence":"first","affiliation":[{"name":"From the Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri (J.J., A.D.); Lauderdale Veterinary Specialists, Fort Lauderdale, Florida (A.C., L.T.); and Bronson Animal Disease Diagnostic Laboratory, Kissimmee, Florida (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"DeClue","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri (J.J., A.D.); Lauderdale Veterinary Specialists, Fort Lauderdale, Florida (A.C., L.T.); and Bronson Animal Disease Diagnostic Laboratory, Kissimmee, Florida (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Cannon","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri (J.J., A.D.); Lauderdale Veterinary Specialists, Fort Lauderdale, Florida (A.C., L.T.); and Bronson Animal Disease Diagnostic Laboratory, Kissimmee, Florida (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynel","family":"Tocci","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri (J.J., A.D.); Lauderdale Veterinary Specialists, Fort Lauderdale, Florida (A.C., L.T.); and Bronson Animal Disease Diagnostic Laboratory, Kissimmee, Florida (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Hyland","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri (J.J., A.D.); Lauderdale Veterinary Specialists, Fort Lauderdale, Florida (A.C., L.T.); and Bronson Animal Disease Diagnostic Laboratory, Kissimmee, Florida (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"6","key":"bib1","series-title":"Pediatrics","first-page":"e1720","article-title":"Recalcitrant hypocalcemia in autoimmune enteropathy","volume":"134","author":"Geyer\n              M","year":"2014","unstructured":"Geyer\n              M\n            , FairchildJ, MooreD, et al. Recalcitrant hypocalcemia in autoimmune enteropathy. Pediatrics2014;134(6):e1720\u20136."},{"issue":"2","key":"bib2","series-title":"Ann Emerg Med","first-page":"241","article-title":"Corticosteroids precipitating hypocalcemic encephalopathy in hypoparathyroidism","volume":"26","author":"Handa\n              R","year":"1995","unstructured":"Handa\n              R\n            , WaliJP, SinghRI, et al. Corticosteroids precipitating hypocalcemic encephalopathy in hypoparathyroidism. Ann Emerg Med1995;26(2):241\u20132."},{"key":"bib3","series-title":"BMJ Case Rep","first-page":"1","article-title":"Steroid-induced hypocalcemia with tetany in a patient with hypoparathyroidism","author":"Oikonomou\n              D","year":"Nov 2014","unstructured":"Oikonomou\n              D\n            , LainaA, XydakiA, et al. Steroid-induced hypocalcemia with tetany in a patient with hypoparathyroidism. BMJ Case RepNov 2014:1\u20133."},{"issue":"3","key":"bib4","series-title":"Euro J Pediatr","first-page":"280","article-title":"Hypocalcemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3","volume":"144","author":"Vardi\n              P","year":"1985","unstructured":"Vardi\n              P\n            , BenderlyA, EtzioniJ, et al. Hypocalcemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3. Euro J Pediatr1985;144(3):280\u20132."},{"key":"bib5","series-title":"Canine and Feline Endocrinology","first-page":"625","article-title":"Hypocalcemia and primary hypoparathyroidism","author":"Feldman\n              EC","year":"2015","unstructured":"Feldman\n              EC\n            \n          . Hypocalcemia and primary hypoparathyroidism. In: FeldmanEC, NelsonRW, ReuschCE, Scott-MoncrieffJCR, BehrendEN, eds. Canine and Feline Endocrinology. 4th ed.St Louis: Elsevier\/Saunders; 2015:625\u201348."},{"issue":"8","key":"bib6","series-title":"Aust Vet J","first-page":"285","article-title":"Primary hypoparathyroidism in dogs: a retrospective study of 17 cases","volume":"84","author":"Russel\n              NJ","year":"2006","unstructured":"Russel\n              NJ\n            , BondKA, RobertsonID, et al. Primary hypoparathyroidism in dogs: a retrospective study of 17 cases. Aust Vet J2006;84(8):285\u201390."},{"issue":"1","key":"bib7","series-title":"J Vet Intern Med","first-page":"400","article-title":"Apparent resolution of canine primary hypoparathyroidism with immunosuppressive treatment","volume":"29","author":"Warland\n              J","year":"2015","unstructured":"Warland\n              J\n            , SkellyB, KnudsenC, et al. Apparent resolution of canine primary hypoparathyroidism with immunosuppressive treatment. J Vet Intern Med2015;29(1):400\u20134."},{"issue":"2","key":"bib8","series-title":"J Clin Endocrinol Metab","first-page":"548","article-title":"Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism","volume":"89","author":"Kifor\n              O","year":"2004","unstructured":"Kifor\n              O\n            , McElduffA, LeBoffMS, et al. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab2004;89(2):548\u201356."},{"issue":"1","key":"bib9","series-title":"J Clin Endocrinol Metab","first-page":"152","article-title":"Effect of glucocorticoids on function of parathyroid glands in man","volume":"40","author":"Fucik\n              RF","year":"1975","unstructured":"Fucik\n              RF\n            , KukrejaSC, HargisGK, et al. Effect of glucocorticoids on function of parathyroid glands in man. J Clin Endocrinol Metab1975;40(1):152\u20135."},{"issue":"3","key":"bib10","series-title":"Joint Bone Spine","first-page":"282","article-title":"Hypoparathyroidism in systemic lupus erythematosus","volume":"74","author":"Attout\n              H","year":"2007","unstructured":"Attout\n              H\n            , GuezS, DurandJ, et al. Hypoparathyroidism in systemic lupus erythematosus. Joint Bone Spine2007;74(3):282\u20134."},{"issue":"2","key":"bib11","series-title":"Lupus","first-page":"164","article-title":"Hypoparathyroidism in systemic lupus erythematous","volume":"14","author":"Nashi\n              E","year":"2005","unstructured":"Nashi\n              E\n            , BanerjeeD, CrelinstenG. Hypoparathyroidism in systemic lupus erythematous. Lupus2005;14(2):164\u20135."},{"key":"bib12","series-title":"Principles and Practice of Endocrinology and Metabolism","first-page":"586","article-title":"Hypoparathyroidism and other causes of Hypocalcemia","author":"Jan de Beur\n              SM","year":"2001","unstructured":"Jan de Beur\n              SM\n            , StreetenEA, LevineMA. Hypoparathyroidism and other causes of Hypocalcemia. In: BeckerKL, ed. Principles and Practice of Endocrinology and Metabolism. 3rd ed.Philadelphia: Lippincott Williams & Wilkins; 2001:586\u2013603."},{"key":"bib13","series-title":"Stiehm\u2019s Immune Deficiencies","first-page":"221","article-title":"Defects in thymic development: DiGeorge\/CHARGE\/chromosome 22q11.2 deletion","author":"Markert\n              LM","year":"2014","unstructured":"Markert\n              LM\n            \n          . Defects in thymic development: DiGeorge\/CHARGE\/chromosome 22q11.2 deletion. In: SullivanKE, StiehmRE, eds. Stiehm\u2019s Immune Deficiencies. 3rd ed.Amsterdam: Elsevier; 2014:221\u201342."},{"issue":"6","key":"bib14","series-title":"J Small Anim Pract","first-page":"330","article-title":"Treatment of five haemodynamically stable dogs with immune-mediated thrombocytopenia using mycophenolate mofetil as a single agent","volume":"55","author":"Yau\n              VK","year":"2014","unstructured":"Yau\n              VK\n            , BiancoD. Treatment of five haemodynamically stable dogs with immune-mediated thrombocytopenia using mycophenolate mofetil as a single agent. J Small Anim Pract2014;55(6):330\u20133."},{"issue":"4","key":"bib15","series-title":"J Am Anim Hosp Assoc","first-page":"364","article-title":"Severe calcinosis cutis associated with treatment of hypoparathyroidism in a dog","volume":"37","author":"Schaer\n              M","year":"2001","unstructured":"Schaer\n              M\n            , GinnPE, FoxLE, et al. Severe calcinosis cutis associated with treatment of hypoparathyroidism in a dog. J Am Anim Hosp Assoc2001;37(4):364\u20139."},{"issue":"3","key":"bib16","series-title":"Vet Dermatol","first-page":"355","article-title":"Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases","volume":"24","author":"Doerr\n              KA","year":"2013","unstructured":"Doerr\n              KA\n            , OuterbridgeCA, WhiteSD, et al. Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases. Vet Dermatol2013;24(3):355\u201361."},{"issue":"4 Pt 1","key":"bib17","series-title":"J Am Acad Dermatol","first-page":"527","article-title":"Cutaneous deposition diseases. Part II","volume":"39","author":"Touart\n              DM","year":"1998","unstructured":"Touart\n              DM\n            , SauP. Cutaneous deposition diseases. Part II. J Am Acad Dermatol1998;39(4 Pt 1):527\u201346."},{"issue":"3","key":"bib18","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"123","article-title":"The integumentary changes of hyperadrenocorticism","volume":"9","author":"Stewart\n              LJ","year":"1994","unstructured":"Stewart\n              LJ\n            \n          . The integumentary changes of hyperadrenocorticism. Semin Vet Med Surg (Small Anim)1994;9(3):123\u20136."},{"issue":"1","key":"bib19","series-title":"Cancer Chemother Pharmacol","first-page":"165","article-title":"Oral bioavailability of DN101, a concentrated formulation of calcitriol, in tumor-bearing dogs","volume":"67","author":"Rassnick\n              KM","year":"2011","unstructured":"Rassnick\n              KM\n            , MuindiJR, JohnsonCS, et al. Oral bioavailability of DN101, a concentrated formulation of calcitriol, in tumor-bearing dogs. Cancer Chemother Pharmacol2011;67(1):165\u201371."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/1\/article-pe551-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/doi\/10.5326\/JAAHA-MS-6705\/2377192\/jaaha-ms-6705.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/1\/article-pe551-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/1\/article-pe551-04.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:03:21Z","timestamp":1763741001000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/1\/article-pe551-04.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":19,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6705","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"type":"print","value":"0587-2871"},{"type":"electronic","value":"1547-3317"}],"subject":[],"published":{"date-parts":[[2019]]}}}