{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:04:33Z","timestamp":1788959073607,"version":"build-2803163510"},"reference-count":8,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 6 yr old female spayed Chihuahua was presented for evaluation of intermittent vulvar discharge, stranguria, and vomiting. This dog had an ovariohysterectomy as a puppy and did not experience any evidence of estrous until 4.5 yr later. The owner had been using a topical hormone replacement therapy (estradiol spray) twice daily for the duration of the dog\u2019s clinical signs of 1 yr. On presentation, the dog had truncal alopecia, comedones, enlarged vulva with a malodorous, and purulent discharge. Bloodwork showed a leukocytosis with a neutrophilia, d\u00f6hle bodies, and moderate toxic changes. An abdominal ultrasound revealed an enlarged uterine stump with a thickened wall, ovoid projection cranially, and echogenic luminal contents. An exploratory laparotomy identified an enlarged cervical stump. Histopathology revealed chronic suppurative vaginitis with endometritis, necrosis, and intraluminal coccoid bacteria. The dog recovered well from surgery. A baseline estrogen level post operatively was measured at 56.4 pg\/mL (&lt;50.0 pg\/mL for a spayed bitch), at this time, the dog had been separated from the owner for 7 days. After surgery, the clinical signs disappeared, and the dog\u2019s dermatologic changes improved. This is the first reported case of stump pyometra following exposure to the owner\u2019s topical estradiol replacement medication.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6744","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T12:37:23Z","timestamp":1568637443000},"page":"e556-04","source":"Crossref","is-referenced-by-count":7,"title":["Stump Pyometra Secondary to Human Topical Estrogen Hormone Exposure in a Spayed Female Chihuahua"],"prefix":"10.5326","volume":"55","author":[{"given":"Allyson A.","family":"Sterman","sequence":"first","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, Texas A&M University College of Veterinary and Biomedical Sciences, College Station, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley Thieman","family":"Mankin","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, Texas A&M University College of Veterinary and Biomedical Sciences, College Station, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia L.","family":"Barton","sequence":"additional","affiliation":[{"name":"From the Department of Small Animal Clinical Sciences, Texas A&M University College of Veterinary and Biomedical Sciences, College Station, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Current Techniques in Small Animal Surgery","first-page":"516","article-title":"Ovariohysterectomy","author":"Fingland\n              R","year":"2014","unstructured":"Fingland\n              R\n            , WaldronD. Ovariohysterectomy. In BojrabJ, WaldronDR, ToombsJ, eds. Current Techniques in Small Animal Surgery. 5th ed.Jackson (WY): Tenton NewMedia; 2014:516\u201321."},{"issue":"23","key":"bib2","series-title":"Vet Rec","first-page":"746","article-title":"Risk of pyometra in bitches treated for mismating with low doses of oestradiol benzoate","volume":"162","author":"Whitehead\n              M","year":"2008","unstructured":"Whitehead\n              M\n            \n          . Risk of pyometra in bitches treated for mismating with low doses of oestradiol benzoate. Vet Rec2008;162(23):746\u20139."},{"issue":"3","key":"bib3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"501","article-title":"The ovarian remnant syndrome in the bitch and queen","volume":"21","author":"Wallace\n              M.","year":"1991","unstructured":"Wallace\n              M.\n            \n          \n          The ovarian remnant syndrome in the bitch and queen. Vet Clin North Am Small Anim Pract1991;21(3):501\u20137."},{"issue":"5","key":"bib4","series-title":"J Am Vet Med Assoc","first-page":"548","article-title":"Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007)","volume":"236","author":"Ball\n              R","year":"2010","unstructured":"Ball\n              R\n            , BirchardS, MayL, et al.\n          Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007). J Am Vet Med Assoc2010;236(5):548\u201353."},{"issue":"2","key":"bib5","series-title":"J Am Anim Hosp Assoc","first-page":"136","article-title":"Canine alopecia secondary to human topical hormone replacement therapy in six dogs","volume":"51","author":"Berger\n              D","year":"2015","unstructured":"Berger\n              D\n            , LewisT, SchickA, et al.\n          Canine alopecia secondary to human topical hormone replacement therapy in six dogs. J Am Anim Hosp Assoc2015;51(2):136\u201342."},{"issue":"5","key":"bib6","series-title":"Vet Dermatol","first-page":"393","article-title":"Estradiol-induced alopecia in five dogs after contact with a transdermal gel used for the treatment of postmenopausal symptoms in women","volume":"26","author":"Wiener\n              D","year":"2015","unstructured":"Wiener\n              D\n            , RufenachtS, KochH, et al.\n          Estradiol-induced alopecia in five dogs after contact with a transdermal gel used for the treatment of postmenopausal symptoms in women. Vet Dermatol2015;26(5):393\u20136."},{"issue":"5","key":"bib7","series-title":"Vet Dermatol","first-page":"490","article-title":"BW Variability of estradiol concentration in normal dogs","volume":"21","author":"Frank\n              LA","year":"2010","unstructured":"Frank\n              LA\n            , MullinsR, Rohrbach, BW Variability of estradiol concentration in normal dogs. Vet Dermatol2010;21(5):490\u20133."},{"issue":"4","key":"bib8","series-title":"J S Afr Vet Assoc","first-page":"363","article-title":"Oestrogen-induced bone marrow aplasia in a dog","volume":"49","author":"Bland-van den Berg\n              P","year":"1978","unstructured":"Bland-van den Berg\n              P\n            , BomzonL, LurieA. Oestrogen-induced bone marrow aplasia in a dog. J S Afr Vet Assoc1978;49(4):363\u20135."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/6\/article-pe556-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/doi\/10.5326\/JAAHA-MS-6744\/2481862\/jaaha-ms-6744.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/6\/article-pe556-04.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/6\/article-pe556-04.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:43:25Z","timestamp":1784425405000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/6\/article-pe556-04.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":8,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6744","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}