{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:35Z","timestamp":1772327015202,"version":"3.50.1"},"reference-count":54,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors\u2019 knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature. In this case series, seven dogs are described to have experienced injuries following a suspected carboplatin extravasation resembling vesicant injuries a median of 7 days after carboplatin administration (range 4\u201315 days). Wounds healed with a variety of treatments, including medical management and\/or surgical debridement, a median of 25.5 days (range 7\u201349 days) after observation of the suspected extravasation injury. There were no obvious similarities involving carboplatin administration among patients to explain why these reactions occurred. Extravasation injury should be considered a possible local complication associated with carboplatin chemotherapy.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6773","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T10:54:03Z","timestamp":1538391243000},"page":"360-367","source":"Crossref","is-referenced-by-count":5,"title":["Suspected Carboplatin Extravasation Reactions in Seven Dogs"],"prefix":"10.5326","volume":"54","author":[{"given":"Kristina Bowles","family":"Miller","sequence":"first","affiliation":[{"name":"From the Oncology Service, Dogwood Veterinary Emergency and Specialty Care, Richmond, Virginia (K.B.M.); College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.L., A.S.); SAGE Centers for Veterinary Specialty and Emergency Care, Campbell, California (R.R.); and IVG (InTown Veterinary Group by Ethos), Portsmouth, New Hampshire (K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Lejeune","sequence":"additional","affiliation":[{"name":"From the Oncology Service, Dogwood Veterinary Emergency and Specialty Care, Richmond, Virginia (K.B.M.); College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.L., A.S.); SAGE Centers for Veterinary Specialty and Emergency Care, Campbell, California (R.R.); and IVG (InTown Veterinary Group by Ethos), Portsmouth, New Hampshire (K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Regan","sequence":"additional","affiliation":[{"name":"From the Oncology Service, Dogwood Veterinary Emergency and Specialty Care, Richmond, Virginia (K.B.M.); College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.L., A.S.); SAGE Centers for Veterinary Specialty and Emergency Care, Campbell, California (R.R.); and IVG (InTown Veterinary Group by Ethos), Portsmouth, New Hampshire (K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Szivek","sequence":"additional","affiliation":[{"name":"From the Oncology Service, Dogwood Veterinary Emergency and Specialty Care, Richmond, Virginia (K.B.M.); College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.L., A.S.); SAGE Centers for Veterinary Specialty and Emergency Care, Campbell, California (R.R.); and IVG (InTown Veterinary Group by Ethos), Portsmouth, New Hampshire (K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kow","sequence":"additional","affiliation":[{"name":"From the Oncology Service, Dogwood Veterinary Emergency and Specialty Care, Richmond, Virginia (K.B.M.); College of Veterinary Medicine, University of Florida, Gainesville, Florida (A.L., A.S.); SAGE Centers for Veterinary Specialty and Emergency Care, Campbell, California (R.R.); and IVG (InTown Veterinary Group by Ethos), Portsmouth, New Hampshire (K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"bib1","series-title":"Withrow and MacEwen\u2019s Small Animal Clinical Oncology","author":"Winthrow\n              S","year":"2012","unstructured":"Winthrow\n              S\n            , VailD, PageR. In: VailD, ed. Withrow and MacEwen\u2019s Small Animal Clinical Oncology. 5th ed. Elsevier: St. Louis; 2012."},{"issue":"4","key":"bib2","series-title":"J Vet Intern Med","first-page":"235","article-title":"Pharmacokinetic and phase I evaluation of carboplatin in dogs","volume":"7","author":"Page\n              RL","year":"1993","unstructured":"Page\n              RL\n            , McEnteeMC, GeorgeSL, et al. Pharmacokinetic and phase I evaluation of carboplatin in dogs. J Vet Intern Med1993;7(4):235\u201340."},{"issue":"2","key":"bib3","series-title":"J Vet Intern Med","first-page":"76","article-title":"Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993)","volume":"10","author":"Bergman\n              PJ","year":"1996","unstructured":"Bergman\n              PJ\n            , MacEwenEG, KurzmanID, et al. Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993). J Vet Intern Med1996;10(2):76\u201381."},{"key":"bib4","series-title":"J Vet Intern Med","first-page":"279","article-title":"Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder","volume":"11","author":"Chun\n              R","year":"1997","unstructured":"Chun\n              R\n            , KnappDW, WidmerWR, et al. Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder. J Vet Intern Med1997;11:279\u201383."},{"issue":"9","key":"bib5","series-title":"J Am Vet Med Assoc","first-page":"1444","article-title":"Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989\u20132000)","volume":"218","author":"Rassnick\n              KM","year":"2001","unstructured":"Rassnick\n              KM\n            , RuslanderDM, CotterSM, et al. Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989\u20132000). J Am Vet Med Assoc2001;218(9):1444\u20138."},{"key":"bib6","series-title":"Cancer Chemotherapy and Biotherapy: Principles and Practice","author":"Chabner\n              BA","year":"2010","unstructured":"Chabner\n              BA\n            , LongoDL.. Cancer Chemotherapy and Biotherapy: Principles and Practice. 5th ed. Philadelphia: Wolters Kluwer; 2010."},{"issue":"6","key":"bib7","series-title":"Oncol Nurs Forum","first-page":"1134","article-title":"Vesicant extravasation part I: Mechanisms, pathogenesis, and nursing care to reduce risk","volume":"33","author":"Sauerland\n              C","year":"2006","unstructured":"Sauerland\n              C\n            , EngelkingC, WickhamR, et al. Vesicant extravasation part I: Mechanisms, pathogenesis, and nursing care to reduce risk. Oncol Nurs Forum2006;33(6):1134\u201341."},{"issue":"5","key":"bib8","series-title":"Support Care Cancer","first-page":"1459","article-title":"Comit\u00e9 de l'\u00e9volution de la pratique des soins pharmaceutiques; Comit\u00e9 de l'\u00e9volution des pratiques en oncologie. Management of the extravasation of anti-neoplastic agents","volume":"23","author":"Boulanger\n              J","year":"2015","unstructured":"Boulanger\n              J\n            , DucharmeA, DufourA, et al.; Comit\u00e9 de l'\u00e9volution de la pratique des soins pharmaceutiques; Comit\u00e9 de l'\u00e9volution des pratiques en oncologie. Management of the extravasation of anti-neoplastic agents. Support Care Cancer2015;23(5):1459\u201371."},{"issue":"3","key":"bib9","series-title":"Metallomics","first-page":"508","article-title":"Extravasation of Pt-based chemotherapeutics \u2013 bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)","volume":"7","author":"Egger\n              AE","year":"2015","unstructured":"Egger\n              AE\n            , KornauthC, HaslikW, et al. Extravasation of Pt-based chemotherapeutics \u2013 bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Metallomics2015;7(3):508\u201315."},{"issue":"7","key":"bib10","series-title":"J Clin Oncol","first-page":"1116","article-title":"Etiology and treatment of chemotherapeutic agent extravasation injuries: a review","volume":"5","author":"Rudolph\n              R","year":"1987","unstructured":"Rudolph\n              R\n            , LarsonDL. Etiology and treatment of chemotherapeutic agent extravasation injuries: a review. J Clin Oncol1987;5(7):1116\u201326."},{"issue":"6","key":"bib11","series-title":"Support Care Cancer","first-page":"1741","article-title":"Outcome of chemotherapy extravasation in a large patient series using a standardised management protocol","volume":"23","author":"Pluschnig\n              U","year":"2015","unstructured":"Pluschnig\n              U\n            , HaslikW, BayerG, et al. Outcome of chemotherapy extravasation in a large patient series using a standardised management protocol. Support Care Cancer2015;23(6):1741\u20138."},{"issue":"3","key":"bib12","series-title":"J Am Vet Med Assoc","first-page":"304","article-title":"Dexrazoxane treatment of doxorubicin extravasation injury in four dogs","volume":"240","author":"Venable\n              RO","year":"2012","unstructured":"Venable\n              RO\n            , SabaCF, EndicottMM, et al. Dexrazoxane treatment of doxorubicin extravasation injury in four dogs. J Am Vet Med Assoc2012;240(3):304\u20137."},{"issue":"4","key":"bib13","series-title":"J Vet Intern Med","first-page":"872","article-title":"Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat","volume":"21","author":"Mahoney\n              JA","year":"2007","unstructured":"Mahoney\n              JA\n            , BergmanPJ, Camps-PalauMA, et al. Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat. J Vet Intern Med2007;21(4):872\u20133."},{"issue":"1","key":"bib14","series-title":"Ther Adv Med Oncol","first-page":"16","article-title":"Taxanes: vesicants, irritants, or just irritating?","volume":"6","author":"Barbee\n              MS","year":"2014","unstructured":"Barbee\n              MS\n            , OwonikokoTK, HarveyRD. Taxanes: vesicants, irritants, or just irritating?Ther Adv Med Oncol2014;6(1):16\u201320."},{"issue":"4","key":"bib15","series-title":"J Am Anim Hosp Assoc","first-page":"181","article-title":"2016 AAHA Oncology Guidelines for Dogs and Cats [published correction appears in J Am Anim Hosp Assoc 2016;52(6):viii]","volume":"52","author":"Biller\n              B","year":"2016","unstructured":"Biller\n              B\n            , BergJ, GarrettL, et al. 2016 AAHA Oncology Guidelines for Dogs and Cats [published correction appears in J Am Anim Hosp Assoc 2016;52(6):viii]. J Am Anim Hosp Assoc2016;52(4):181\u2013204."},{"issue":"4","key":"bib16","series-title":"Curr Oncol Rep","first-page":"242","article-title":"Extravasation of chemotherapy","volume":"12","author":"Langer\n              SW","year":"2010","unstructured":"Langer\n              SW\n            \n          . Extravasation of chemotherapy. Curr Oncol Rep2010;12(4):242\u20136."},{"issue":"5","key":"bib17","series-title":"J Am Vet Med Assoc","first-page":"608","article-title":"Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006\u20132010)","volume":"241","author":"Simcock\n              JO","year":"2012","unstructured":"Simcock\n              JO\n            , WithersSS, PrpichCY, et al. Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006\u20132010). J Am Vet Med Assoc2012;241(5):608\u201314."},{"issue":"4","key":"bib18","series-title":"Vet Comp Oncol","first-page":"171","article-title":"Evaluation of intracavitary mitoxantrone and carboplatin for treatment of carcinomatosis, sarcomatosis and mesothelioma, with or without malignant effusions: A retrospective analysis of 12 cases (1997\u20132002)*","volume":"3","author":"Charney\n              SC","year":"2005","unstructured":"Charney\n              SC\n            , BergmanPJ, McKnightJA, et al. Evaluation of intracavitary mitoxantrone and carboplatin for treatment of carcinomatosis, sarcomatosis and mesothelioma, with or without malignant effusions: A retrospective analysis of 12 cases (1997\u20132002)*. Vet Comp Oncol2005;3(4):171\u201381."},{"issue":"9","key":"bib19","series-title":"J Am Vet Med Assoc","first-page":"1302","article-title":"Epidemiologic evaluation of postoperative wound infections in dogs and cats","volume":"210","author":"Brown\n              DC","year":"1997","unstructured":"Brown\n              DC\n            , ConzemiusMG, ShoferF, et al. Epidemiologic evaluation of postoperative wound infections in dogs and cats. J Am Vet Med Assoc1997;210(9):1302\u20136."},{"issue":"2","key":"bib20","series-title":"Vet Surg","first-page":"60","article-title":"Surgical wound infection rates in dogs and cats. Data from a teaching hospital","volume":"17","author":"Vasseur\n              PB","year":"1988","unstructured":"Vasseur\n              PB\n            , LevyJ, DowdE, et al. Surgical wound infection rates in dogs and cats. Data from a teaching hospital. Vet Surg1988;17(2):60\u20134."},{"issue":"4","key":"bib21","series-title":"Cancer","first-page":"850","article-title":"Intradermal carboplatin and ifosfamide extravasation in the mouse","volume":"70","author":"Marnocha\n              RSM","year":"1992","unstructured":"Marnocha\n              RSM\n            , HutsonPR. Intradermal carboplatin and ifosfamide extravasation in the mouse. Cancer1992;70(4):850\u20133."},{"issue":"6 Pt 2","key":"bib22","series-title":"Fundam Appl Toxicol","first-page":"S134","article-title":"Molecular basis for mustard-induced vesication","volume":"5","author":"Papirmeister\n              B","year":"1985","unstructured":"Papirmeister\n              B\n            , GrossCL, MeierHL, et al. Molecular basis for mustard-induced vesication. Fundam Appl Toxicol1985;5(6 Pt 2):S134\u201349."},{"issue":"2","key":"bib23","series-title":"Toxicol In Vitro","first-page":"139","article-title":"Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: Morphological alterations and biochemical depletion of glutathione","volume":"6","author":"Gentilhomme\n              E","year":"1992","unstructured":"Gentilhomme\n              E\n            , NeveuxY, HuaA, et al. Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: Morphological alterations and biochemical depletion of glutathione. Toxicol In Vitro1992;6(2):139\u201347."},{"issue":"6","key":"bib24","series-title":"Ann Oncol","first-page":"858","article-title":"Extravasation of systemic hemato-oncological therapies","volume":"15","author":"Ener\n              RA","year":"2004","unstructured":"Ener\n              RA\n            , MeglatherySB, StylerM. Extravasation of systemic hemato-oncological therapies. Ann Oncol2004;15(6):858\u201362."},{"issue":"4","key":"bib25","series-title":"Cutan Ocul Toxicol","first-page":"298","article-title":"Correlation between experimental human and murine skin sensitization induction thresholds","volume":"34","author":"Api\n              AM","year":"2015","unstructured":"Api\n              AM\n            , BasketterD, LalkoJ. Correlation between experimental human and murine skin sensitization induction thresholds. Cutan Ocul Toxicol2015;34(4):298\u2013302."},{"issue":"2","key":"bib26","series-title":"J Vet Intern Med","first-page":"374","article-title":"Thromboelastographic tracings in retired racing greyhounds and in non-greyhound dogs","volume":"22","author":"Vilar\n              P","year":"2008","unstructured":"Vilar\n              P\n            , CoutoCG, WestendorfN, et al. Thromboelastographic tracings in retired racing greyhounds and in non-greyhound dogs. J Vet Intern Med2008;22(2):374\u20139."},{"issue":"2","key":"bib27","series-title":"J Vet Intern Med","first-page":"365","article-title":"Evaluation of platelet aggregation using a point-of-care instrument in retired racing greyhounds","volume":"20","author":"Couto\n              CG","year":"2006","unstructured":"Couto\n              CG\n            , LaraA, IazbikMC, et al. Evaluation of platelet aggregation using a point-of-care instrument in retired racing greyhounds. J Vet Intern Med2006;20(2):365\u201370."},{"key":"bib1","series-title":"Withrow and MacEwen\u2019s Small Animal Clinical Oncology","author":"Winthrow\n              S","year":"2012","unstructured":"Winthrow\n              S\n            , VailD, PageR. In: VailD, ed. Withrow and MacEwen\u2019s Small Animal Clinical Oncology. 5th ed. Elsevier: St. Louis; 2012."},{"issue":"4","key":"bib2","series-title":"J Vet Intern Med","first-page":"235","article-title":"Pharmacokinetic and phase I evaluation of carboplatin in dogs","volume":"7","author":"Page\n              RL","year":"1993","unstructured":"Page\n              RL\n            , McEnteeMC, GeorgeSL, et al. Pharmacokinetic and phase I evaluation of carboplatin in dogs. J Vet Intern Med1993;7(4):235\u201340."},{"issue":"2","key":"bib3","series-title":"J Vet Intern Med","first-page":"76","article-title":"Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993)","volume":"10","author":"Bergman\n              PJ","year":"1996","unstructured":"Bergman\n              PJ\n            , MacEwenEG, KurzmanID, et al. Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993). J Vet Intern Med1996;10(2):76\u201381."},{"key":"bib4","series-title":"J Vet Intern Med","first-page":"279","article-title":"Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder","volume":"11","author":"Chun\n              R","year":"1997","unstructured":"Chun\n              R\n            , KnappDW, WidmerWR, et al. Phase II clinical trial of carboplatin in canine transitional cell carcinoma of the urinary bladder. J Vet Intern Med1997;11:279\u201383."},{"issue":"9","key":"bib5","series-title":"J Am Vet Med Assoc","first-page":"1444","article-title":"Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989\u20132000)","volume":"218","author":"Rassnick\n              KM","year":"2001","unstructured":"Rassnick\n              KM\n            , RuslanderDM, CotterSM, et al. Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989\u20132000). J Am Vet Med Assoc2001;218(9):1444\u20138."},{"key":"bib6","series-title":"Cancer Chemotherapy and Biotherapy: Principles and Practice","author":"Chabner\n              BA","year":"2010","unstructured":"Chabner\n              BA\n            , LongoDL.. Cancer Chemotherapy and Biotherapy: Principles and Practice. 5th ed. Philadelphia: Wolters Kluwer; 2010."},{"issue":"6","key":"bib7","series-title":"Oncol Nurs Forum","first-page":"1134","article-title":"Vesicant extravasation part I: Mechanisms, pathogenesis, and nursing care to reduce risk","volume":"33","author":"Sauerland\n              C","year":"2006","unstructured":"Sauerland\n              C\n            , EngelkingC, WickhamR, et al. Vesicant extravasation part I: Mechanisms, pathogenesis, and nursing care to reduce risk. Oncol Nurs Forum2006;33(6):1134\u201341."},{"issue":"5","key":"bib8","series-title":"Support Care Cancer","first-page":"1459","article-title":"Comit\u00e9 de l'\u00e9volution de la pratique des soins pharmaceutiques; Comit\u00e9 de l'\u00e9volution des pratiques en oncologie. Management of the extravasation of anti-neoplastic agents","volume":"23","author":"Boulanger\n              J","year":"2015","unstructured":"Boulanger\n              J\n            , DucharmeA, DufourA, et al.; Comit\u00e9 de l'\u00e9volution de la pratique des soins pharmaceutiques; Comit\u00e9 de l'\u00e9volution des pratiques en oncologie. Management of the extravasation of anti-neoplastic agents. Support Care Cancer2015;23(5):1459\u201371."},{"issue":"3","key":"bib9","series-title":"Metallomics","first-page":"508","article-title":"Extravasation of Pt-based chemotherapeutics \u2013 bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)","volume":"7","author":"Egger\n              AE","year":"2015","unstructured":"Egger\n              AE\n            , KornauthC, HaslikW, et al. Extravasation of Pt-based chemotherapeutics \u2013 bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Metallomics2015;7(3):508\u201315."},{"issue":"7","key":"bib10","series-title":"J Clin Oncol","first-page":"1116","article-title":"Etiology and treatment of chemotherapeutic agent extravasation injuries: a review","volume":"5","author":"Rudolph\n              R","year":"1987","unstructured":"Rudolph\n              R\n            , LarsonDL. Etiology and treatment of chemotherapeutic agent extravasation injuries: a review. J Clin Oncol1987;5(7):1116\u201326."},{"issue":"6","key":"bib11","series-title":"Support Care Cancer","first-page":"1741","article-title":"Outcome of chemotherapy extravasation in a large patient series using a standardised management protocol","volume":"23","author":"Pluschnig\n              U","year":"2015","unstructured":"Pluschnig\n              U\n            , HaslikW, BayerG, et al. Outcome of chemotherapy extravasation in a large patient series using a standardised management protocol. Support Care Cancer2015;23(6):1741\u20138."},{"issue":"3","key":"bib12","series-title":"J Am Vet Med Assoc","first-page":"304","article-title":"Dexrazoxane treatment of doxorubicin extravasation injury in four dogs","volume":"240","author":"Venable\n              RO","year":"2012","unstructured":"Venable\n              RO\n            , SabaCF, EndicottMM, et al. Dexrazoxane treatment of doxorubicin extravasation injury in four dogs. J Am Vet Med Assoc2012;240(3):304\u20137."},{"issue":"4","key":"bib13","series-title":"J Vet Intern Med","first-page":"872","article-title":"Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat","volume":"21","author":"Mahoney\n              JA","year":"2007","unstructured":"Mahoney\n              JA\n            , BergmanPJ, Camps-PalauMA, et al. Treatment of doxorubicin extravasation with intravenous dexrazoxane in a cat. J Vet Intern Med2007;21(4):872\u20133."},{"issue":"1","key":"bib14","series-title":"Ther Adv Med Oncol","first-page":"16","article-title":"Taxanes: vesicants, irritants, or just irritating?","volume":"6","author":"Barbee\n              MS","year":"2014","unstructured":"Barbee\n              MS\n            , OwonikokoTK, HarveyRD. Taxanes: vesicants, irritants, or just irritating?Ther Adv Med Oncol2014;6(1):16\u201320."},{"issue":"4","key":"bib15","series-title":"J Am Anim Hosp Assoc","first-page":"181","article-title":"2016 AAHA Oncology Guidelines for Dogs and Cats [published correction appears in J Am Anim Hosp Assoc 2016;52(6):viii]","volume":"52","author":"Biller\n              B","year":"2016","unstructured":"Biller\n              B\n            , BergJ, GarrettL, et al. 2016 AAHA Oncology Guidelines for Dogs and Cats [published correction appears in J Am Anim Hosp Assoc 2016;52(6):viii]. J Am Anim Hosp Assoc2016;52(4):181\u2013204."},{"issue":"4","key":"bib16","series-title":"Curr Oncol Rep","first-page":"242","article-title":"Extravasation of chemotherapy","volume":"12","author":"Langer\n              SW","year":"2010","unstructured":"Langer\n              SW\n            \n          . Extravasation of chemotherapy. Curr Oncol Rep2010;12(4):242\u20136."},{"issue":"5","key":"bib17","series-title":"J Am Vet Med Assoc","first-page":"608","article-title":"Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006\u20132010)","volume":"241","author":"Simcock\n              JO","year":"2012","unstructured":"Simcock\n              JO\n            , WithersSS, PrpichCY, et al. Evaluation of a single subcutaneous infusion of carboplatin as adjuvant chemotherapy for dogs with osteosarcoma: 17 cases (2006\u20132010). J Am Vet Med Assoc2012;241(5):608\u201314."},{"issue":"4","key":"bib18","series-title":"Vet Comp Oncol","first-page":"171","article-title":"Evaluation of intracavitary mitoxantrone and carboplatin for treatment of carcinomatosis, sarcomatosis and mesothelioma, with or without malignant effusions: A retrospective analysis of 12 cases (1997\u20132002)*","volume":"3","author":"Charney\n              SC","year":"2005","unstructured":"Charney\n              SC\n            , BergmanPJ, McKnightJA, et al. Evaluation of intracavitary mitoxantrone and carboplatin for treatment of carcinomatosis, sarcomatosis and mesothelioma, with or without malignant effusions: A retrospective analysis of 12 cases (1997\u20132002)*. Vet Comp Oncol2005;3(4):171\u201381."},{"issue":"9","key":"bib19","series-title":"J Am Vet Med Assoc","first-page":"1302","article-title":"Epidemiologic evaluation of postoperative wound infections in dogs and cats","volume":"210","author":"Brown\n              DC","year":"1997","unstructured":"Brown\n              DC\n            , ConzemiusMG, ShoferF, et al. Epidemiologic evaluation of postoperative wound infections in dogs and cats. J Am Vet Med Assoc1997;210(9):1302\u20136."},{"issue":"2","key":"bib20","series-title":"Vet Surg","first-page":"60","article-title":"Surgical wound infection rates in dogs and cats. Data from a teaching hospital","volume":"17","author":"Vasseur\n              PB","year":"1988","unstructured":"Vasseur\n              PB\n            , LevyJ, DowdE, et al. Surgical wound infection rates in dogs and cats. Data from a teaching hospital. Vet Surg1988;17(2):60\u20134."},{"issue":"4","key":"bib21","series-title":"Cancer","first-page":"850","article-title":"Intradermal carboplatin and ifosfamide extravasation in the mouse","volume":"70","author":"Marnocha\n              RSM","year":"1992","unstructured":"Marnocha\n              RSM\n            , HutsonPR. Intradermal carboplatin and ifosfamide extravasation in the mouse. Cancer1992;70(4):850\u20133."},{"issue":"6 Pt 2","key":"bib22","series-title":"Fundam Appl Toxicol","first-page":"S134","article-title":"Molecular basis for mustard-induced vesication","volume":"5","author":"Papirmeister\n              B","year":"1985","unstructured":"Papirmeister\n              B\n            , GrossCL, MeierHL, et al. Molecular basis for mustard-induced vesication. Fundam Appl Toxicol1985;5(6 Pt 2):S134\u201349."},{"issue":"2","key":"bib23","series-title":"Toxicol In Vitro","first-page":"139","article-title":"Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: Morphological alterations and biochemical depletion of glutathione","volume":"6","author":"Gentilhomme\n              E","year":"1992","unstructured":"Gentilhomme\n              E\n            , NeveuxY, HuaA, et al. Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: Morphological alterations and biochemical depletion of glutathione. Toxicol In Vitro1992;6(2):139\u201347."},{"issue":"6","key":"bib24","series-title":"Ann Oncol","first-page":"858","article-title":"Extravasation of systemic hemato-oncological therapies","volume":"15","author":"Ener\n              RA","year":"2004","unstructured":"Ener\n              RA\n            , MeglatherySB, StylerM. Extravasation of systemic hemato-oncological therapies. 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