{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:11:50Z","timestamp":1785247910808,"version":"3.55.0"},"reference-count":100,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"abstract":"ABSTRACT<\/jats:title>\n Systemic inflammation is known to cause WBC abnormalities, specifically neutrophilia and lymphopenia. The neutrophil-to-lymphocyte ratio (NLR) is a simple and affordable biomarker that has been used in human clinical settings of sepsis but has not been investigated in veterinary species. We evaluated NLR in dogs with septic and nonseptic systemic inflammatory diseases and compared with a healthy dog population. An NLR \u22656 had an 84.39% sensitivity and 86.95% specificity to identify dogs with systemic inflammatory states; however, no ratio distinguished septic and nonseptic causes. The NLR was not associated with length of hospitalization, morbidity based on the acute patient physiologic laboratory evaluation scoring system, or mortality. The disassociation may be due to the retrospective nature of the study, including a restricted population size and acquisition of only a one-time blood sample. NLR is currently of limited use for diagnosis and prognosis in systemic inflammatory states in dogs, and larger, prospective studies are necessary to further evaluate NLR.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6808","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T10:54:03Z","timestamp":1538391243000},"page":"351-359","source":"Crossref","is-referenced-by-count":58,"title":["Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis"],"prefix":"10.5326","volume":"54","author":[{"given":"Natasha","family":"Hodgson","sequence":"first","affiliation":[{"name":"From the College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efa A.","family":"Llewellyn","sequence":"additional","affiliation":[{"name":"From the College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"From the College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"8","key":"bib1","series-title":"J Am Med Assoc","first-page":"801","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer\n M","year":"2016","unstructured":"Singer\n M\n , DeutschmanCS, SeymourCW, et al. 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J Am Vet Med Assoc1994;204(3):407\u201314."},{"issue":"2","key":"bib3","series-title":"Vet Surg","first-page":"174","article-title":"Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993-1999)","volume":"31","author":"Staatz\n AJ","year":"2002","unstructured":"Staatz\n AJ\n , MonnetE, SeimHBIII. Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993-1999). Vet Surg2002;31(2):174\u201380."},{"issue":"5","key":"bib4","series-title":"J Vet Intern Med","first-page":"674","article-title":"Hemostatic changes in dogs with naturally occurring sepsis","volume":"17","author":"de Laforcade\n AM","year":"2003","unstructured":"de Laforcade\n AM\n , FreemanLM, ShawSP, et al. Hemostatic changes in dogs with naturally occurring sepsis. 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