{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:21Z","timestamp":1772327001023,"version":"3.50.1"},"reference-count":34,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"ABSTRACT<\/jats:title>\n A 9 mo old female intact golden retriever presented for evaluation of chronic lethargy and decreased appetite. The serum biochemistry profile revealed increased liver enzymes consistent with a mixed hepatocellular and cholestatic pattern. A multiphase computed tomography angiography was performed to evaluate for a portosystemic shunt. Numerous hyperattenuating nodules were identified throughout the liver on the noncontrast-enhanced series. Histologic evaluation of percutaneous needle biopsy samples of a liver nodule showed a rare form of hepatitis called lobular dissecting hepatitis. Lobular dissecting hepatitis should be considered as a differential in young dogs with precontrast hyperattenuating hepatic nodules on noncontrast-enhanced computed tomography.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6867","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T16:31:30Z","timestamp":1547742690000},"page":"e552-03","source":"Crossref","is-referenced-by-count":2,"title":["Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever"],"prefix":"10.5326","volume":"55","author":[{"given":"Eric T.","family":"Hostnik","sequence":"first","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio (E.T.H., V.J.P.); and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (J.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie J.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio (E.T.H., V.J.P.); and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (J.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Cullen","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio (E.T.H., V.J.P.); and Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina (J.M.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"2","key":"bib1","series-title":"Vet Pathol","first-page":"179","article-title":"Lobular dissecting hepatitis in the dog","volume":"20","author":"Bennett\n AM","year":"1983","unstructured":"Bennett\n AM\n , DaviesJD, GaskellCJ, et al. Lobular dissecting hepatitis in the dog. Vet Pathol1983;20(2):179\u201388."},{"issue":"5","key":"bib2","series-title":"J Vet Med Sci","first-page":"597","article-title":"Histological and immunohistochemical evaluations of lobular dissecting hepatitis in American cocker spaniel dogs","volume":"75","author":"Mizooku\n H","year":"2013","unstructured":"Mizooku\n H\n , KagawaY, MatsudaK, et al. Histological and immunohistochemical evaluations of lobular dissecting hepatitis in American cocker spaniel dogs. J Vet Med Sci2013;75(5):597\u2013603."},{"issue":"1","key":"bib3","series-title":"J Vet Intern Med","first-page":"72","article-title":"Primary hepatitis in dogs: a retrospective review (2002\u20132006)","volume":"23","author":"Poldervaart\n JH","year":"2009","unstructured":"Poldervaart\n JH\n , FavierRP, PenningLC, et al. Primary hepatitis in dogs: a retrospective review (2002\u20132006). J Vet Intern Med2009;23(1):72\u201380."},{"issue":"3","key":"bib4","series-title":"J Vet Intern Med","first-page":"217","article-title":"Lobular dissecting hepatitis in juvenile and young adult dogs","volume":"8","author":"van den Ingh\n TS","year":"1994","unstructured":"van den Ingh\n TS\n , RothuizenJ. Lobular dissecting hepatitis in juvenile and young adult dogs. J Vet Intern Med1994;8(3):217\u201320."},{"issue":"4","key":"bib5","series-title":"J Vet Intern Med","first-page":"794","article-title":"Soy protein isolate versus meat-based low-protein diet for dogs with congenital portosystemic shunts","volume":"23","author":"Proot\n S","year":"2009","unstructured":"Proot\n S\n , BiourgeV, TeskeE, et al. Soy protein isolate versus meat-based low-protein diet for dogs with congenital portosystemic shunts. J Vet Intern Med2009;23(4):794\u2013800."},{"issue":"2","key":"bib6","series-title":"Vet Radiol Ultrasound","first-page":"144","article-title":"Associations between dual-phase computed tomography features and histopathologic diagnoses in 52 dogs with hepatic or splenic masses","volume":"57","author":"Jones\n ID","year":"2016","unstructured":"Jones\n ID\n , LambCR, DreesR, et al. Associations between dual-phase computed tomography features and histopathologic diagnoses in 52 dogs with hepatic or splenic masses. Vet Radiol Ultrasound2016;57(2):144\u201353."},{"issue":"3","key":"bib7","series-title":"Vet Radiol Ultrasound","first-page":"252","article-title":"CT characteristics of primary hepatic mass lesions in dogs","volume":"53","author":"Fukushima\n K","year":"2012","unstructured":"Fukushima\n K\n , KanemotoH, OhnoK, et al. CT characteristics of primary hepatic mass lesions in dogs. Vet Radiol Ultrasound2012;53(3):252\u20137."},{"issue":"1","key":"bib8","series-title":"Hiroshima J Med Sci","first-page":"17","article-title":"Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning","volume":"58","author":"Taniura\n T","year":"2009","unstructured":"Taniura\n T\n , MarukawaK, YamadaK, et al. Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning. Hiroshima J Med Sci2009;58(1):17\u201324."},{"key":"bib9","series-title":"Atlas of Small Animal CT and MRI","first-page":"522","article-title":"Hepatobiliary disorders","author":"Wisner\n ER","year":"2015","unstructured":"Wisner\n ER\n , ZingenbergerAL. Hepatobiliary disorders. In: Atlas of Small Animal CT and MRI. 1st ed.Ames (IA): John Wiley & Sons, Inc.; 2015:522\u201337."},{"issue":"1","key":"bib10","series-title":"Vet Radiol Ultrasound","first-page":"7","article-title":"Triple-phase helical computed tomography in dogs with hepatic masses","volume":"55","author":"Kutara\n K","year":"2014","unstructured":"Kutara\n K\n , SekiM, IshikawaC, et al. Triple-phase helical computed tomography in dogs with hepatic masses. Vet Radiol Ultrasound2014;55(1):7\u201315."},{"key":"bib11","series-title":"Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat","first-page":"1637","article-title":"Inflammatory canine heptic disease","author":"Willard\n MD","year":"2010","unstructured":"Willard\n MD\n \n . Inflammatory canine heptic disease. In: EttingerSJ, FeldmanEC, eds. Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat. 7th ed.St. Louis: Elsevier Saunders; 2010:1637\u201342."},{"issue":"1","key":"bib12","series-title":"J Vet Intern Med","first-page":"51","article-title":"A comparison of liver sampling techniques in dogs","volume":"29","author":"Kemp\n SD","year":"2015","unstructured":"Kemp\n SD\n , ZimmermanKL, PancieraDL, et al. A comparison of liver sampling techniques in dogs. J Vet Intern Med2015;29(1):51\u20137."},{"issue":"3","key":"bib13","series-title":"J Am Anim Hosp Assoc","first-page":"190","article-title":"Accuracy of US-guided FNA of focal liver lesions in dogs: 140 cases (2005\u20132008)","volume":"49","author":"Bahr\n KL","year":"2013","unstructured":"Bahr\n KL\n , SharkeyLC, MurakamiT, et al\n Accuracy of US-guided FNA of focal liver lesions in dogs: 140 cases (2005\u20132008). J Am Anim Hosp Assoc2013;49(3):190\u20136."},{"issue":"1","key":"bib14","series-title":"Vet Surg","first-page":"86","article-title":"Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs","volume":"35","author":"Vasanjee\n SC","year":"2006","unstructured":"Vasanjee\n SC\n , BubenikLJ, HosgoodG, et al. Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs. Vet Surg2006;35(1):86\u201393."},{"key":"bib15","series-title":"The Essential Physics of Medical Imaging","first-page":"312","article-title":"Computed tomography","author":"Bushberg\n JT","year":"2012","unstructured":"Bushberg\n JT\n , SeibertJA, LeidholdtEM, et al. Computed tomography. In: The Essential Physics of Medical Imaging. 3rd ed.Philadelphia: Lippincott Williams & Wilkins; 2012:312\u201366."},{"issue":"4","key":"bib16","series-title":"Scand J Gastroenterol","first-page":"461","article-title":"Liver attenuation values at computed tomography related to liver copper content","volume":"17","author":"Smevik\n B","year":"1982","unstructured":"Smevik\n B\n , RitlandS, Nilsen, et al. Liver attenuation values at computed tomography related to liver copper content. Scand J Gastroenterol1982;17(4):461\u20133."},{"issue":"6","key":"bib17","series-title":"Radiographics","first-page":"1291","article-title":"Diffuse disease of the liver: radiologic-pathologic correlation","volume":"14","author":"Mergo\n PJ","year":"1994","unstructured":"Mergo\n PJ\n , RosPR, BuetowPC, et al. Diffuse disease of the liver: radiologic-pathologic correlation. 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J Vet Med Sci2013;75(5):597\u2013603."},{"issue":"1","key":"bib3","series-title":"J Vet Intern Med","first-page":"72","article-title":"Primary hepatitis in dogs: a retrospective review (2002\u20132006)","volume":"23","author":"Poldervaart\n JH","year":"2009","unstructured":"Poldervaart\n JH\n , FavierRP, PenningLC, et al. Primary hepatitis in dogs: a retrospective review (2002\u20132006). J Vet Intern Med2009;23(1):72\u201380."},{"issue":"3","key":"bib4","series-title":"J Vet Intern Med","first-page":"217","article-title":"Lobular dissecting hepatitis in juvenile and young adult dogs","volume":"8","author":"van den Ingh\n TS","year":"1994","unstructured":"van den Ingh\n TS\n , RothuizenJ. Lobular dissecting hepatitis in juvenile and young adult dogs. J Vet Intern Med1994;8(3):217\u201320."},{"issue":"4","key":"bib5","series-title":"J Vet Intern Med","first-page":"794","article-title":"Soy protein isolate versus meat-based low-protein diet for dogs with congenital portosystemic shunts","volume":"23","author":"Proot\n S","year":"2009","unstructured":"Proot\n S\n , BiourgeV, TeskeE, et al. Soy protein isolate versus meat-based low-protein diet for dogs with congenital portosystemic shunts. J Vet Intern Med2009;23(4):794\u2013800."},{"issue":"2","key":"bib6","series-title":"Vet Radiol Ultrasound","first-page":"144","article-title":"Associations between dual-phase computed tomography features and histopathologic diagnoses in 52 dogs with hepatic or splenic masses","volume":"57","author":"Jones\n ID","year":"2016","unstructured":"Jones\n ID\n , LambCR, DreesR, et al. Associations between dual-phase computed tomography features and histopathologic diagnoses in 52 dogs with hepatic or splenic masses. Vet Radiol Ultrasound2016;57(2):144\u201353."},{"issue":"3","key":"bib7","series-title":"Vet Radiol Ultrasound","first-page":"252","article-title":"CT characteristics of primary hepatic mass lesions in dogs","volume":"53","author":"Fukushima\n K","year":"2012","unstructured":"Fukushima\n K\n , KanemotoH, OhnoK, et al. CT characteristics of primary hepatic mass lesions in dogs. Vet Radiol Ultrasound2012;53(3):252\u20137."},{"issue":"1","key":"bib8","series-title":"Hiroshima J Med Sci","first-page":"17","article-title":"Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning","volume":"58","author":"Taniura\n T","year":"2009","unstructured":"Taniura\n T\n , MarukawaK, YamadaK, et al. Differential diagnosis of hepatic tumor-like lesions in dog by using dynamic CT scanning. Hiroshima J Med Sci2009;58(1):17\u201324."},{"key":"bib9","series-title":"Atlas of Small Animal CT and MRI","first-page":"522","article-title":"Hepatobiliary disorders","author":"Wisner\n ER","year":"2015","unstructured":"Wisner\n ER\n , ZingenbergerAL. Hepatobiliary disorders. In: Atlas of Small Animal CT and MRI. 1st ed.Ames (IA): John Wiley & Sons, Inc.; 2015:522\u201337."},{"issue":"1","key":"bib10","series-title":"Vet Radiol Ultrasound","first-page":"7","article-title":"Triple-phase helical computed tomography in dogs with hepatic masses","volume":"55","author":"Kutara\n K","year":"2014","unstructured":"Kutara\n K\n , SekiM, IshikawaC, et al. Triple-phase helical computed tomography in dogs with hepatic masses. Vet Radiol Ultrasound2014;55(1):7\u201315."},{"key":"bib11","series-title":"Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat","first-page":"1637","article-title":"Inflammatory canine heptic disease","author":"Willard\n MD","year":"2010","unstructured":"Willard\n MD\n \n . Inflammatory canine heptic disease. In: EttingerSJ, FeldmanEC, eds. Textbook of Veterinary Internal Medicine: Disease of the Dog and the Cat. 7th ed.St. Louis: Elsevier Saunders; 2010:1637\u201342."},{"issue":"1","key":"bib12","series-title":"J Vet Intern Med","first-page":"51","article-title":"A comparison of liver sampling techniques in dogs","volume":"29","author":"Kemp\n SD","year":"2015","unstructured":"Kemp\n SD\n , ZimmermanKL, PancieraDL, et al. A comparison of liver sampling techniques in dogs. J Vet Intern Med2015;29(1):51\u20137."},{"issue":"3","key":"bib13","series-title":"J Am Anim Hosp Assoc","first-page":"190","article-title":"Accuracy of US-guided FNA of focal liver lesions in dogs: 140 cases (2005\u20132008)","volume":"49","author":"Bahr\n KL","year":"2013","unstructured":"Bahr\n KL\n , SharkeyLC, MurakamiT, et al\n Accuracy of US-guided FNA of focal liver lesions in dogs: 140 cases (2005\u20132008). J Am Anim Hosp Assoc2013;49(3):190\u20136."},{"issue":"1","key":"bib14","series-title":"Vet Surg","first-page":"86","article-title":"Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs","volume":"35","author":"Vasanjee\n SC","year":"2006","unstructured":"Vasanjee\n SC\n , BubenikLJ, HosgoodG, et al. Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs. Vet Surg2006;35(1):86\u201393."},{"key":"bib15","series-title":"The Essential Physics of Medical Imaging","first-page":"312","article-title":"Computed tomography","author":"Bushberg\n JT","year":"2012","unstructured":"Bushberg\n JT\n , SeibertJA, LeidholdtEM, et al. Computed tomography. In: The Essential Physics of Medical Imaging. 3rd ed.Philadelphia: Lippincott Williams & Wilkins; 2012:312\u201366."},{"issue":"4","key":"bib16","series-title":"Scand J Gastroenterol","first-page":"461","article-title":"Liver attenuation values at computed tomography related to liver copper content","volume":"17","author":"Smevik\n B","year":"1982","unstructured":"Smevik\n B\n , RitlandS, Nilsen, et al. Liver attenuation values at computed tomography related to liver copper content. Scand J Gastroenterol1982;17(4):461\u20133."},{"issue":"6","key":"bib17","series-title":"Radiographics","first-page":"1291","article-title":"Diffuse disease of the liver: radiologic-pathologic correlation","volume":"14","author":"Mergo\n PJ","year":"1994","unstructured":"Mergo\n PJ\n , RosPR, BuetowPC, et al. Diffuse disease of the liver: radiologic-pathologic correlation. 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