{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:36:19Z","timestamp":1774546579846,"version":"3.50.1"},"reference-count":44,"publisher":"American Animal Hospital Association","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>An \u223c12 yr old castrated mixed-breed dog was evaluated for a 7 wk progressive history of intermittent hyporexia, lethargy, and erosive dermatitis. Initial examination revealed disseminated papules and macules coalescing to irregularly shaped and serpiginous plaques with widespread erosion progressing to ulceration. Skin histopathology revealed transepidermal keratinocyte apoptosis with lymphocyte satellitosis and lymphocytic and histiocytic interface infiltrate. Histopathology combined with clinical signs and history were compatible with the diagnosis of erythema multiforme major. Treatment was initiated with multidrug immunosuppression. Following 36 hr with no improvement, intravenous human immunoglobulin (0.45 mg\/kg IV) was administered resulting in notable improvement in the dog\u2019s attitude and appetite within 2 hr and the dog\u2019s skin lesions within 48 hr. Following discharge, the dog improved daily with near complete resolution of dermatologic disease achieved 1 mo postdischarge. All immunosuppressive medications were ultimately discontinued 5 mo following presentation. This is the first report of a dog with erythema multiforme major that has been successfully treated with a combination of intravenous immunoglobulin and immunosuppression.<\/jats:p>","DOI":"10.5326\/jaaha-ms-6896","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T11:17:56Z","timestamp":1579605476000},"page":"133-138","source":"Crossref","is-referenced-by-count":8,"title":["Erythema Multiforme Major in a Dog Treated with Intravenous Human Immunoglobulin and Immunosuppressive Therapy"],"prefix":"10.5326","volume":"56","author":[{"given":"Sara J.","family":"Ramos","sequence":"first","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences (S.J.R., V.M.B., M.C.W.), and Department of Pathobiological Sciences (I.M.L.), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria M.","family":"Beale","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences (S.J.R., V.M.B., M.C.W.), and Department of Pathobiological Sciences (I.M.L.), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg M.","family":"Langohr","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences (S.J.R., V.M.B., M.C.W.), and Department of Pathobiological Sciences (I.M.L.), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle C.","family":"Woodward","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Clinical Sciences (S.J.R., V.M.B., M.C.W.), and Department of Pathobiological Sciences (I.M.L.), School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"bib1","first-page":"572","article-title":"Acute exantheme und hautkrankheiten. 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Vol 1. 2nd ed.Amsterdam: Mosby Elsevier; 2008: 287."},{"key":"bib3","series-title":"Vet Dermatol","first-page":"406","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review","volume":"25","author":"Yager\n              JA","year":"2014","unstructured":"Yager\n              JA\n            \n          . Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review. Vet Dermatol2014;25:406\u2013e464."},{"key":"bib4","series-title":"Vet Dermatol","first-page":"297","article-title":"Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u20131996)","author":"Scott\n              M.","year":"1999","unstructured":"Scott\n              M.\n            \n          \n          Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u20131996). Vet Dermatol1999:297\u2013309."},{"key":"bib5","series-title":"J Vet Allergy Clin Immunol","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog: clinical classification","volume":"13\u201320","author":"Hinn\n              AC","year":"1998","unstructured":"Hinn\n              AC\n            , OlivryT, LutherPB. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog: clinical classification. J Vet Allergy Clin Immunol1998:13\u201320."},{"issue":"1","key":"bib6","series-title":"Arch Dermatol","first-page":"92","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin\n              S","year":"1993","unstructured":"Bastuji-Garin\n              S\n            , RzanyB, SternRS, ShearNH, NaldiL, RoujeauJC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993;129(1):92-96."},{"key":"bib7","series-title":"Muller and Kirk\u2019s Small Animal Dermatology","first-page":"472","article-title":"Autoimmune and immune-mediated dermatoses","author":"Miller\n              WH, Jr.","year":"2013","unstructured":"Miller\n              WH, Jr., GriffinCE, CampbellKL. Autoimmune and immune-mediated dermatoses. In: Muller and Kirk\u2019s Small Animal Dermatology. 7th ed.St. Louis: Elsevier; 2013:472\u20139."},{"key":"bib8","series-title":"J Vet Emerg Crit Care","first-page":"471","article-title":"A review of current indications, adverse effects, and administration recommendations for intravenous immunoglobulin","volume":"21","author":"Spurlock\n              NK","year":"2011","unstructured":"Spurlock\n              NK\n            , PrittieJE. A review of current indications, adverse effects, and administration recommendations for intravenous immunoglobulin. J Vet Emerg Crit Care2011;21:471\u201383."},{"key":"bib9","series-title":"Transfus Med","first-page":"403","article-title":"Use of intravenous immune globulin in the ICU: a retrospective review of prescribing practices and patient outcomes","volume":"20","author":"Foster\n              R","year":"2010","unstructured":"Foster\n              R\n            , SuriA, FilateW, et al.\n          Use of intravenous immune globulin in the ICU: a retrospective review of prescribing practices and patient outcomes. Transfus Med2010;20:403\u20138."},{"key":"bib10","series-title":"J Am Vet Med Assoc","first-page":"197","article-title":"Use of human immunoglobulin for treatment of severe erythema multiforme in a cat","volume":"220","author":"Byrne\n              KP","year":"2002","unstructured":"Byrne\n              KP\n            , GigerU. Use of human immunoglobulin for treatment of severe erythema multiforme in a cat. J Am Vet Med Assoc2002;220:197\u2013201, 183\u201394."},{"key":"bib11","series-title":"Am J Surg","first-page":"71","article-title":"Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses","volume":"163","author":"Phillips\n              JD","year":"1992","unstructured":"Phillips\n              JD\n            , KimCS, FonkalsrudEW, et al.\n          Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses. Am J Surg1992;163:71\u20137."},{"key":"bib12","series-title":"Advances in Veterinary Dermatology","article-title":"Immunohistochemical characterization of canine acute graft-versus-host disease and erythema multiforme","volume":"Vol 3","author":"Affolter\n              V","year":"1998","unstructured":"Affolter\n              V\n            , MooreP, SandmaierB. Immunohistochemical characterization of canine acute graft-versus-host disease and erythema multiforme. In: KwochkaKW, WillemseT, von TscharnerC, eds. Advances in Veterinary Dermatology. Vol 3. Boston (MA): Butterworth-Heinemann; 1998."},{"key":"bib13","series-title":"J Small Anim Pract","first-page":"357","article-title":"Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog","volume":"45","author":"Nuttall\n              TJ","year":"2004","unstructured":"Nuttall\n              TJ\n            , MalhamT. Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog. J Small Anim Pract2004;45:357\u201361."},{"key":"bib14","series-title":"Vet Pathol","first-page":"321","article-title":"Clinical and microscopic characteristics of canine toxic epidermal necrolysis","volume":"52","author":"Banovic\n              F","year":"2015","unstructured":"Banovic\n              F\n            , OlivryT, BazzleL, et al.\n          Clinical and microscopic characteristics of canine toxic epidermal necrolysis. Vet Pathol2015;52:321\u201330."},{"key":"bib15","series-title":"Vet Pathol","first-page":"249","article-title":"Apoptosis as a mechanism for keratinocyte death in canine toxic epidermal necrolysis","volume":"54","author":"Banovic\n              F","year":"2017","unstructured":"Banovic\n              F\n            , DunstonS, LinderKE, et al.\n          Apoptosis as a mechanism for keratinocyte death in canine toxic epidermal necrolysis. Vet Pathol2017;54:249\u201353."},{"key":"bib16","series-title":"Skin Diseases of the Dog and Cat","first-page":"75","article-title":"Interface disease of the dermal-epidermal junction","volume":"67\u20138","author":"Gross\n              TL","year":"2005","unstructured":"Gross\n              TL\n            , IhrkePJ, WalderEJ, et al.\n          Interface disease of the dermal-epidermal junction. Skin Diseases of the Dog and Cat. 2nd ed.Oxford: Blackwell Science, Ltd. 2005:67\u20138; 75\u20139."},{"key":"bib17","series-title":"Today's Vet Pract","first-page":"32","article-title":"Diagnosis of immune-mediated hemolytic anemia","volume":"3","author":"Archer\n              TMA","year":"2013","unstructured":"Archer\n              TMA\n            \n          . Diagnosis of immune-mediated hemolytic anemia. Today's Vet Pract2013;3:32\u20136."},{"key":"bib18","series-title":"Vet Dermatol","first-page":"391","article-title":"Erythema multiforme associated with zonisamide in a dog","volume":"26","author":"Ackermann\n              AL","year":"2015","unstructured":"Ackermann\n              AL\n            , FrankLA, McEnteeMF, et al.\n          Erythema multiforme associated with zonisamide in a dog. Vet Dermatol2015;26:391\u20132, e389."},{"key":"bib19","series-title":"Vet Pathol","first-page":"647","article-title":"Parvovirus infection of keratinocytes as a cause of canine erythema multiforme","volume":"37","author":"Favrot\n              COT","year":"2000","unstructured":"Favrot\n              COT\n            , DunstonSM, Degorce-RubialesF, et al.\n          Parvovirus infection of keratinocytes as a cause of canine erythema multiforme. Vet Pathol2000;37:647\u20139."},{"key":"bib20","series-title":"J Vet Med Sci","first-page":"869","article-title":"Erythema multiforme possibly triggered by food substances in a dog","volume":"68","author":"Itoh\n              T","year":"2006","unstructured":"Itoh\n              T\n            , NibeK, KojimotoA, et al.\n          Erythema multiforme possibly triggered by food substances in a dog. J Vet Med Sci2006;68:869\u201371."},{"key":"bib21","series-title":"J Am Anim Hosp Assoc","first-page":"312","article-title":"Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs","volume":"42","author":"Trotman\n              TK","year":"2006","unstructured":"Trotman\n              TK\n            , PhillipsH, FordyceH, et al.\n          Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs. J Am Anim Hosp Assoc2006;42:312\u201320."},{"key":"bib22","series-title":"J Vet Intern Med","first-page":"504","article-title":"Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs","volume":"16","author":"Carr\n              AP","year":"2002","unstructured":"Carr\n              AP\n            , PancieraDL, KiddL. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs. J Vet Intern Med2002;16:504\u20139."},{"key":"bib1","first-page":"572","article-title":"Acute exantheme und hautkrankheiten. Handbuch der Speciellen Pathologie und Therapie. Erlangen (Germany)","author":"Hebra\n              F.","year":"1860","unstructured":"Hebra\n              F.\n            \n          \n          Acute exantheme und hautkrankheiten. Handbuch der Speciellen Pathologie und Therapie. Erlangen (Germany): F. Enke; 1860:572\u2013601."},{"key":"bib2","series-title":"Dermatology","first-page":"287","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"Vol 1","author":"French\n              LE","year":"2008","unstructured":"French\n              LE\n            , PrinsC. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. In: BolognaJL, JorizzoJL, RapiniRP eds. Dermatology. Vol 1. 2nd ed.Amsterdam: Mosby Elsevier; 2008: 287."},{"key":"bib3","series-title":"Vet Dermatol","first-page":"406","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review","volume":"25","author":"Yager\n              JA","year":"2014","unstructured":"Yager\n              JA\n            \n          . Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review. Vet Dermatol2014;25:406\u2013e464."},{"key":"bib4","series-title":"Vet Dermatol","first-page":"297","article-title":"Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u20131996)","author":"Scott\n              M.","year":"1999","unstructured":"Scott\n              M.\n            \n          \n          Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988\u20131996). Vet Dermatol1999:297\u2013309."},{"key":"bib5","series-title":"J Vet Allergy Clin Immunol","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog: clinical classification","volume":"13\u201320","author":"Hinn\n              AC","year":"1998","unstructured":"Hinn\n              AC\n            , OlivryT, LutherPB. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis in the dog: clinical classification. J Vet Allergy Clin Immunol1998:13\u201320."},{"issue":"1","key":"bib6","series-title":"Arch Dermatol","first-page":"92","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin\n              S","year":"1993","unstructured":"Bastuji-Garin\n              S\n            , RzanyB, SternRS, ShearNH, NaldiL, RoujeauJC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993;129(1):92-96."},{"key":"bib7","series-title":"Muller and Kirk\u2019s Small Animal Dermatology","first-page":"472","article-title":"Autoimmune and immune-mediated dermatoses","author":"Miller\n              WH, Jr.","year":"2013","unstructured":"Miller\n              WH, Jr., GriffinCE, CampbellKL. Autoimmune and immune-mediated dermatoses. In: Muller and Kirk\u2019s Small Animal Dermatology. 7th ed.St. Louis: Elsevier; 2013:472\u20139."},{"key":"bib8","series-title":"J Vet Emerg Crit Care","first-page":"471","article-title":"A review of current indications, adverse effects, and administration recommendations for intravenous immunoglobulin","volume":"21","author":"Spurlock\n              NK","year":"2011","unstructured":"Spurlock\n              NK\n            , PrittieJE. A review of current indications, adverse effects, and administration recommendations for intravenous immunoglobulin. J Vet Emerg Crit Care2011;21:471\u201383."},{"key":"bib9","series-title":"Transfus Med","first-page":"403","article-title":"Use of intravenous immune globulin in the ICU: a retrospective review of prescribing practices and patient outcomes","volume":"20","author":"Foster\n              R","year":"2010","unstructured":"Foster\n              R\n            , SuriA, FilateW, et al.\n          Use of intravenous immune globulin in the ICU: a retrospective review of prescribing practices and patient outcomes. Transfus Med2010;20:403\u20138."},{"key":"bib10","series-title":"J Am Vet Med Assoc","first-page":"197","article-title":"Use of human immunoglobulin for treatment of severe erythema multiforme in a cat","volume":"220","author":"Byrne\n              KP","year":"2002","unstructured":"Byrne\n              KP\n            , GigerU. Use of human immunoglobulin for treatment of severe erythema multiforme in a cat. J Am Vet Med Assoc2002;220:197\u2013201, 183\u201394."},{"key":"bib11","series-title":"Am J Surg","first-page":"71","article-title":"Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses","volume":"163","author":"Phillips\n              JD","year":"1992","unstructured":"Phillips\n              JD\n            , KimCS, FonkalsrudEW, et al.\n          Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses. Am J Surg1992;163:71\u20137."},{"key":"bib12","series-title":"Advances in Veterinary Dermatology","article-title":"Immunohistochemical characterization of canine acute graft-versus-host disease and erythema multiforme","volume":"Vol 3","author":"Affolter\n              V","year":"1998","unstructured":"Affolter\n              V\n            , MooreP, SandmaierB. Immunohistochemical characterization of canine acute graft-versus-host disease and erythema multiforme. In: KwochkaKW, WillemseT, von TscharnerC, eds. Advances in Veterinary Dermatology. Vol 3. Boston (MA): Butterworth-Heinemann; 1998."},{"key":"bib13","series-title":"J Small Anim Pract","first-page":"357","article-title":"Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog","volume":"45","author":"Nuttall\n              TJ","year":"2004","unstructured":"Nuttall\n              TJ\n            , MalhamT. Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog. J Small Anim Pract2004;45:357\u201361."},{"key":"bib14","series-title":"Vet Pathol","first-page":"321","article-title":"Clinical and microscopic characteristics of canine toxic epidermal necrolysis","volume":"52","author":"Banovic\n              F","year":"2015","unstructured":"Banovic\n              F\n            , OlivryT, BazzleL, et al.\n          Clinical and microscopic characteristics of canine toxic epidermal necrolysis. Vet Pathol2015;52:321\u201330."},{"key":"bib15","series-title":"Vet Pathol","first-page":"249","article-title":"Apoptosis as a mechanism for keratinocyte death in canine toxic epidermal necrolysis","volume":"54","author":"Banovic\n              F","year":"2017","unstructured":"Banovic\n              F\n            , DunstonS, LinderKE, et al.\n          Apoptosis as a mechanism for keratinocyte death in canine toxic epidermal necrolysis. Vet Pathol2017;54:249\u201353."},{"key":"bib16","series-title":"Skin Diseases of the Dog and Cat","first-page":"75","article-title":"Interface disease of the dermal-epidermal junction","volume":"67\u20138","author":"Gross\n              TL","year":"2005","unstructured":"Gross\n              TL\n            , IhrkePJ, WalderEJ, et al.\n          Interface disease of the dermal-epidermal junction. Skin Diseases of the Dog and Cat. 2nd ed.Oxford: Blackwell Science, Ltd. 2005:67\u20138; 75\u20139."},{"key":"bib17","series-title":"Today's Vet Pract","first-page":"32","article-title":"Diagnosis of immune-mediated hemolytic anemia","volume":"3","author":"Archer\n              TMA","year":"2013","unstructured":"Archer\n              TMA\n            \n          . Diagnosis of immune-mediated hemolytic anemia. Today's Vet Pract2013;3:32\u20136."},{"key":"bib18","series-title":"Vet Dermatol","first-page":"391","article-title":"Erythema multiforme associated with zonisamide in a dog","volume":"26","author":"Ackermann\n              AL","year":"2015","unstructured":"Ackermann\n              AL\n            , FrankLA, McEnteeMF, et al.\n          Erythema multiforme associated with zonisamide in a dog. Vet Dermatol2015;26:391\u20132, e389."},{"key":"bib19","series-title":"Vet Pathol","first-page":"647","article-title":"Parvovirus infection of keratinocytes as a cause of canine erythema multiforme","volume":"37","author":"Favrot\n              COT","year":"2000","unstructured":"Favrot\n              COT\n            , DunstonSM, Degorce-RubialesF, et al.\n          Parvovirus infection of keratinocytes as a cause of canine erythema multiforme. Vet Pathol2000;37:647\u20139."},{"key":"bib20","series-title":"J Vet Med Sci","first-page":"869","article-title":"Erythema multiforme possibly triggered by food substances in a dog","volume":"68","author":"Itoh\n              T","year":"2006","unstructured":"Itoh\n              T\n            , NibeK, KojimotoA, et al.\n          Erythema multiforme possibly triggered by food substances in a dog. J Vet Med Sci2006;68:869\u201371."},{"key":"bib21","series-title":"J Am Anim Hosp Assoc","first-page":"312","article-title":"Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs","volume":"42","author":"Trotman\n              TK","year":"2006","unstructured":"Trotman\n              TK\n            , PhillipsH, FordyceH, et al.\n          Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs. J Am Anim Hosp Assoc2006;42:312\u201320."},{"key":"bib22","series-title":"J Vet Intern Med","first-page":"504","article-title":"Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs","volume":"16","author":"Carr\n              AP","year":"2002","unstructured":"Carr\n              AP\n            , PancieraDL, KiddL. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs. J Vet Intern Med2002;16:504\u20139."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/56\/2\/article-p133.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/56\/2\/133\/2481886\/jaaha-ms-6896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/56\/2\/article-p133.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/56\/2\/article-p133.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:31:24Z","timestamp":1772325084000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/56\/2\/article-p133.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":44,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6896","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}