{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:30:35Z","timestamp":1787167835194,"version":"build-2736575974"},"reference-count":30,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ancylostoma caninum<\/jats:italic>\n                    is a nematode of the canine gastrointestinal tract commonly referred to as hookworm. This study involved eight privately owned adult greyhounds presenting with persistent\n                    <jats:italic>A. caninum<\/jats:italic>\n                    ova shedding despite previous deworming treatments. The dogs received a combination treatment protocol comprising topical moxidectin, followed by pyrantel\/febantel\/praziquantel within 24 hr. At 7\u201310 days posttreatment, a fecal examination monitored for parasite ova. Dogs remained on the monthly combination treatment protocol until they ceased shedding detectable ova. The dogs then received only the monthly topical moxidectin maintenance treatment. The dogs remained in the study for 5\u201314 mo with periodical fecal examinations performed. During the study, three dogs reverted to positive fecal ova status, with two being associated with client noncompliance. Reinstitution of the combination treatment protocol resulted in no detectable ova. Use of monthly doses of combination pyrantel, febantel and moxidectin appears to be an effective treatment for nonresponsive or persistent\n                    <jats:italic>A. caninum<\/jats:italic>\n                    ova shedding. Follow-up fecal examinations were important for verifying the presence or absence of ova shedding despite the use of anthelmintic treatment. Limitations of the current study include small sample size, inclusion of only privately owned greyhounds, and client compliance with fecal collection and animal care.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6904","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T17:03:11Z","timestamp":1552582991000},"page":"160-166","source":"Crossref","is-referenced-by-count":27,"title":["Combination Anthelmintic Treatment for Persistent Ancylostoma caninum Ova Shedding in Greyhounds"],"prefix":"10.5326","volume":"55","author":[{"given":"Lindie B.","family":"Hess","sequence":"first","affiliation":[{"name":"From the Department of Veterinary Preventive Medicine (L.B.H., A.M.), and Department of Veterinary Clinical Sciences (L.M.M., A.R., E.V.), College of Veterinary Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie M.","family":"Millward","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Preventive Medicine (L.B.H., A.M.), and Department of Veterinary Clinical Sciences (L.M.M., A.R., E.V.), College of Veterinary Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Rudinsky","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Preventive Medicine (L.B.H., A.M.), and Department of Veterinary Clinical Sciences (L.M.M., A.R., E.V.), College of Veterinary Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Vincent","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Preventive Medicine (L.B.H., A.M.), and Department of Veterinary Clinical Sciences (L.M.M., A.R., E.V.), College of Veterinary Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Marsh","sequence":"additional","affiliation":[{"name":"From the Department of Veterinary Preventive Medicine (L.B.H., A.M.), and Department of Veterinary Clinical Sciences (L.M.M., A.R., E.V.), College of Veterinary Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"5","key":"bib1","series-title":"J Parasit","first-page":"1041","article-title":"Morphological differentiation of eggs of Ancylostoma caninum, Ancylostoma tubaeforme, and Ancylostoma braziliense from dogs and cats in the United States","volume":"98","author":"Lucio-Forster\n              A","year":"2012","unstructured":"Lucio-Forster\n              A\n            , LiottaJ, YarosJ, et al.\n          Morphological differentiation of eggs of Ancylostoma caninum, Ancylostoma tubaeforme, and Ancylostoma braziliense from dogs and cats in the United States. J Parasit2012;98(5):1041\u201344."},{"key":"bib2","series-title":"The Biology of Nematodes","first-page":"521","article-title":"Chemical control of animal parasitic nematodes","author":"Conder\n              GA","year":"2002","unstructured":"Conder\n              GA\n            \n          . Chemical control of animal parasitic nematodes. In: D.L.Lee, ed. The Biology of Nematodes. 1st ed.London: Taylor & Francis; 2002:521\u20139."},{"key":"bib3","series-title":"Nematode Parasites of Vertebrates: Their Development and Transmission","first-page":"45","article-title":"The superfamily ancylostomatoidea","author":"Anderson\n              RC","year":"1992","unstructured":"Anderson\n              RC\n            \n          . The superfamily ancylostomatoidea. In: Nematode Parasites of Vertebrates: Their Development and Transmission. 1st ed.Oxon (United Kingdom): CABI Publishing; 1992:45\u20136."},{"issue":"2","key":"bib4","series-title":"Exp Parasitol","first-page":"303","article-title":"Ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs","volume":"54","author":"Schad\n              GA","year":"1982","unstructured":"Schad\n              GA\n            , PageMR. Ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs. Exp Parasitol1982;54(2):303\u20139."},{"issue":"3\u20134","key":"bib5","series-title":"Vet Parasitol","first-page":"167","article-title":"The detection of anthelmintic resistance in nematodes of veterinary importance","volume":"136","author":"Coles\n              GC","year":"2006","unstructured":"Coles\n              GC\n            , JacksonF, PomroyWE, et al.\n          The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol2006;136(3\u20134):167\u201385."},{"issue":"5","key":"bib6","series-title":"Vet Res","first-page":"491","article-title":"Anthelmintic resistance in nematodes of horses","volume":"33","author":"Kaplan\n              RM","year":"2002","unstructured":"Kaplan\n              RM\n            \n          . Anthelmintic resistance in nematodes of horses. Vet Res2002;33(5):491\u2013507."},{"issue":"3\u20134","key":"bib7","series-title":"Vet Parasitol","first-page":"284","article-title":"Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum","volume":"152","author":"Kopp\n              SR","year":"2008","unstructured":"Kopp\n              SR\n            , ColemanGT, MccarthyJS, et al.\n          Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum. Vet Parasitol2008;152(3\u20134):284\u201393."},{"issue":"3\u20134","key":"bib8","series-title":"Vet Parasitol","first-page":"299","article-title":"High-level pyrantel resistance in the hookworm Ancylostoma caninum","volume":"143","author":"Kopp\n              SR","year":"2007","unstructured":"Kopp\n              SR\n            , KotzeAC, McCarthyJS, et al.\n          High-level pyrantel resistance in the hookworm Ancylostoma caninum. Vet Parasitol2007;143(3\u20134):299\u2013304."},{"issue":"3\u20134","key":"bib9","series-title":"Vet Parasitol","first-page":"167","article-title":"Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance","volume":"210","author":"Bourguinat\n              C","year":"2015","unstructured":"Bourguinat\n              C\n            , LeeAC, LizundiaR, et al.\n          Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance. Vet Parasitol2015;210(3\u20134):167\u201378."},{"issue":"5","key":"bib10","series-title":"Am J Trop Med Hyg","first-page":"1201","article-title":"Praziquantel resistance in the zoonotic cestode Dipylidium caninum","volume":"99","author":"Chelladurai\n              JJ","year":"2018","unstructured":"Chelladurai\n              JJ\n            , KifleyohannesT, ScottJ, et al.\n          Praziquantel resistance in the zoonotic cestode Dipylidium caninum. Am J Trop Med Hyg2018;99(5)1201\u20135."},{"key":"bib11","series-title":"Veterinary Clinical Parasitology","article-title":"Fecal examination for the diagnosis of parasitism","volume":"4\u201312","author":"Zajac\n              AM","year":"2012","unstructured":"Zajac\n              AM\n            , ConboyGA. Fecal examination for the diagnosis of parasitism. In: Veterinary Clinical Parasitology. 8th ed.Chichester (United Kingdom): Wiley-Blackwell, 2012;4\u201312."},{"issue":"8","key":"bib12","series-title":"Am J Vet Res","first-page":"898","article-title":"Assessment of the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule system in dogs","volume":"71","author":"Boillat\n              CS","year":"2010","unstructured":"Boillat\n              CS\n            , GaschenFP, HosgoodGL. Assessment of the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule system in dogs. Am J Vet Res2010;71(8):898\u2013902."},{"issue":"3","key":"bib13","series-title":"Acta Trop","first-page":"301","article-title":"Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of north west Australia","volume":"68","author":"Reynoldson\n              JA","year":"1997","unstructured":"Reynoldson\n              JA\n            , BehnkeJM, PallantLJ, et al.\n          Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of north west Australia. Acta Trop1997;68(3):301\u201312."},{"issue":"3","key":"bib14","series-title":"Animal Res Int","first-page":"540","article-title":"Comparative efficacy of ancylol, ivomec, mebendazole and piperazine against Ancylostoma caninum in experimentally infected pups","volume":"3","author":"Obiukwu\n              MO","year":"2006","unstructured":"Obiukwu\n              MO\n            , OnyaliIO. Comparative efficacy of ancylol, ivomec, mebendazole and piperazine against Ancylostoma caninum in experimentally infected pups. Animal Res Int2006;3(3)540\u20134."},{"key":"bib15","series-title":"Parasit Vectors","first-page":"12","article-title":"Protection of dogs against canine heartworm infection 28 days after four monthly treatments with Advantage Multi\u00ae for dogs","volume":"9","author":"Bowman\n              DD","year":"2016","unstructured":"Bowman\n              DD\n            , GrazetteAR, BaselC, et al.\n          Protection of dogs against canine heartworm infection 28 days after four monthly treatments with Advantage Multi\u00ae for dogs. Parasit Vectors2016;9:12\u20139."},{"issue":"5","key":"bib16","series-title":"J Vet Diagn Invest","first-page":"645","article-title":"Enzyme-linked immunosorbent assays for coproantigen detection of Ancylostoma caninum and Toxocara canis in dogs and Toxocara cati in cats","volume":"29","author":"Elsemore\n              DA","year":"2017","unstructured":"Elsemore\n              DA\n            , Geng, J, CoteJ, et al.\n          Enzyme-linked immunosorbent assays for coproantigen detection of Ancylostoma caninum and Toxocara canis in dogs and Toxocara cati in cats. J Vet Diagn Invest2017;29(5):645\u201353."},{"issue":"13\u201314","key":"bib17","series-title":"Int J Parasitol","first-page":"1377","article-title":"Utility of capsule endoscopy for evaluating anthelmintic efficacy in fully conscious dogs","volume":"41","author":"Lee\n              ACY","year":"2011","unstructured":"Lee\n              ACY\n            , EpeC, SimpsonKWet al.\n          Utility of capsule endoscopy for evaluating anthelmintic efficacy in fully conscious dogs. Int J Parasitol2011;41(13\u201314):1377\u201383."},{"issue":"1","key":"bib18","series-title":"Vet Immunol Immunopathol","first-page":"89","article-title":"Stress-mechanisms of immunosuppression","volume":"30","author":"Dohms\n              JE","year":"1991","unstructured":"Dohms\n              JE\n            , MetzA. Stress-mechanisms of immunosuppression. Vet Immunol Immunopathol1991;30(1):89\u2013109."},{"issue":"Suppl 2","key":"bib19","series-title":"Parasit Vectors","first-page":"S5","article-title":"Moxidectin: a review of chemistry, pharmacokinetics and use in horses","volume":"2","author":"Cobb\n              R","year":"2009","unstructured":"Cobb\n              R\n            , BoeckhA. Moxidectin: a review of chemistry, pharmacokinetics and use in horses. Parasit Vectors2009;2(Suppl 2):S5\u2013S13."},{"issue":"3","key":"bib20","series-title":"J Parasitol","first-page":"390","article-title":"Temperature-induced separation of larvae of Uncinaria stenocephala from a mixed fecal culture containing Ancylostoma caninum","volume":"71","author":"Hill\n              RL\n              Jr","year":"1985","unstructured":"Hill\n              RL\n              Jr\n            , RobersonEL. Temperature-induced separation of larvae of Uncinaria stenocephala from a mixed fecal culture containing Ancylostoma caninum. J Parasitol1985;71(3):390\u20131."},{"issue":"6","key":"bib21","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1341","article-title":"Hookworms of dogs and cats","volume":"17","author":"Kalkofen\n              UP","year":"1987","unstructured":"Kalkofen\n              UP\n            \n          . Hookworms of dogs and cats. Vet Clin North Am Small Anim Pract1987;17(6):1341\u201354."},{"issue":"1","key":"bib22","series-title":"Vet J","first-page":"11","article-title":"Modes of action of anthelmintic drugs","volume":"154","author":"Martin\n              RJ","year":"1997","unstructured":"Martin\n              RJ\n            \n          . Modes of action of anthelmintic drugs. Vet J1997;154(1):11\u201334."},{"issue":"7","key":"bib23","series-title":"Biopharm Drug Dispos","first-page":"263","article-title":"Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs","volume":"23","author":"Vanapalli\n              SR","year":"2002","unstructured":"Vanapalli\n              SR\n            , HungYP, FleckensteinL, et al.\n          Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs. Biopharm Drug Dispos2002;23(7):263\u201372."},{"issue":"4","key":"bib24","series-title":"Vet Clin Path","first-page":"433","article-title":"Prevalence of dog erythrocyte antigens in retired racing Greyhounds","volume":"39","author":"Iazbik\n              C","year":"2010","unstructured":"Iazbik\n              C\n            , O\u2019DonnellM, MarinLet al. Prevalence of dog erythrocyte antigens in retired racing Greyhounds. Vet Clin Path2010;39(4);433\u20135."},{"issue":"2","key":"bib25","series-title":"J Vet Pharmacol Ther","first-page":"99","article-title":"Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions","volume":"24","author":"Craven\n              J","year":"2001","unstructured":"Craven\n              J\n            , Bj\u00f8rnH, HennessyD, et al.\n          Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions. J Vet Pharmacol Ther2001;24(2):99\u2013104."},{"issue":"1","key":"bib26","series-title":"Vet J","first-page":"47","article-title":"Breed differences on the plasma availability of moxidectin administered pour-on to calves","volume":"164","author":"Sallovitz\n              J","year":"2002","unstructured":"Sallovitz\n              J\n            , LifschitzA, ImperialeF, et al.\n          Breed differences on the plasma availability of moxidectin administered pour-on to calves. Vet J2002;164(1):47\u201353."},{"issue":"1","key":"bib27","series-title":"Clin Tech Small Anim Pract","first-page":"38","article-title":"Anesthesia of the sighthound","volume":"14","author":"Court\n              MH","year":"1999","unstructured":"Court\n              MH\n            \n          . Anesthesia of the sighthound. Clin Tech Small Anim Pract1999;14(1):38\u201343."},{"issue":"2","key":"bib28","series-title":"J Vet Pharmacol Ther","first-page":"102","article-title":"Comparative pharmacokinetics of amikacin in greyhound and beagle dogs","volume":"31","author":"KuKanich\n              B","year":"2008","unstructured":"KuKanich\n              B\n            , CoetzeeJF. Comparative pharmacokinetics of amikacin in greyhound and beagle dogs. J Vet Pharmacol Ther2008;31(2):102\u20137."},{"issue":"3","key":"bib29","series-title":"Vet Anaesth Analg","first-page":"242","article-title":"The disposition and behavioral effects of methadone in greyhounds","volume":"35","author":"KuKanich\n              B","year":"2008","unstructured":"KuKanich\n              B\n            , Borum, S. The disposition and behavioral effects of methadone in greyhounds. Vet Anaesth Analg2008;35(3):242\u20138."},{"issue":"4","key":"bib30","series-title":"Vet Parasitol","first-page":"377","article-title":"Helminth infections of British dogs: Prevalence in racing greyhounds","volume":"1","author":"Jacobs\n              DE","year":"1976","unstructured":"Jacobs\n              DE\n            , ProleJH. Helminth infections of British dogs: Prevalence in racing greyhounds. Vet Parasitol1976;1(4):377\u201387."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/3\/article-p160.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/55\/3\/160\/2473573\/jaaha-ms-6904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/3\/article-p160.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/55\/3\/article-p160.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:03:14Z","timestamp":1763740994000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/55\/3\/article-p160.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":30,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6904","relation":{},"ISSN":["0587-2871","1547-3317"],"issn-type":[{"value":"0587-2871","type":"print"},{"value":"1547-3317","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}