{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:10:30Z","timestamp":1790712630814,"version":"4.1.0"},"reference-count":15,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two young dogs domiciled in Honolulu, Hawaii, were presented in November and December 2018 (respectively) for spinal hyperesthesia, hindlimb weakness, and proprioceptive ataxia. Both dogs had neurologic findings referable to spinal cord disease. Both dogs had a combination of lower motor neuron signs (reduced muscle mass, decreased withdrawal reflexes, low tail carriage) and long tract signs (conscious proprioceptive deficits, crossed extensor response, increased myotatic reflexes). Peripheral eosinophilia was present in the second case, but hematology and serum biochemistries were otherwise unremarkable. Plain radiographs and computed tomography scans \u00b1 contrast were unremarkable. Cerebrospinal fluid (CSF) from both patients demonstrated eosinophilic pleocytosis, and real-time polymerase chain reaction testing demonstrated\n                    <jats:italic>Angiostrongylus cantonensis<\/jats:italic>\n                    deoxyribonucleic acid in CSF, confirming a diagnosis of neuroangiostrongyliasis. Treatment included glucocorticoid therapy, \u00b1 anthelmintic (fenbendazole). Both dogs made a complete recovery. These are the first confirmed cases of autochthonous neuroangiostrongyliasis in canine patients in the United States and the first dogs anywhere to be diagnosed definitively with\n                    <jats:italic>A cantonensis<\/jats:italic>\n                    infection based on real-time polymerase chain reaction testing of CSF. A clinician examining a patient with severe spinal hyperesthesia and a combination of upper and lower motor signs should consider\n                    <jats:italic>A cantonensis<\/jats:italic>\n                    as a differential, especially in endemic areas.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-6989","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T17:54:41Z","timestamp":1606845281000},"page":"42-46","source":"Crossref","is-referenced-by-count":12,"title":["First Documented Cases of Canine Neuroangiostrongyliasis Due to Angiostrongylus cantonensis in Hawaii"],"prefix":"10.5326","volume":"57","author":[{"given":"Jenee","family":"Odani","sequence":"first","affiliation":[{"name":"From the University of Hawai\u2019iat M\u0101noa College of Tropical Agriculture and Human Resources, Honolulu, Hawaii (J.O., R.J.); Veterinary Emergency + Referral Center of Hawaii, Honolulu, Hawaii (E.S., W.C.); and Centre for Veterinary Education, University of Sydney, Sydney, Australia (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Sox","sequence":"additional","affiliation":[{"name":"From the University of Hawai\u2019iat M\u0101noa College of Tropical Agriculture and Human Resources, Honolulu, Hawaii (J.O., R.J.); Veterinary Emergency + Referral Center of Hawaii, Honolulu, Hawaii (E.S., W.C.); and Centre for Veterinary Education, University of Sydney, Sydney, Australia (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Coleman","sequence":"additional","affiliation":[{"name":"From the University of Hawai\u2019iat M\u0101noa College of Tropical Agriculture and Human Resources, Honolulu, Hawaii (J.O., R.J.); Veterinary Emergency + Referral Center of Hawaii, Honolulu, Hawaii (E.S., W.C.); and Centre for Veterinary Education, University of Sydney, Sydney, Australia (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Jha","sequence":"additional","affiliation":[{"name":"From the University of Hawai\u2019iat M\u0101noa College of Tropical Agriculture and Human Resources, Honolulu, Hawaii (J.O., R.J.); Veterinary Emergency + Referral Center of Hawaii, Honolulu, Hawaii (E.S., W.C.); and Centre for Veterinary Education, University of Sydney, Sydney, Australia (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[{"name":"From the University of Hawai\u2019iat M\u0101noa College of Tropical Agriculture and Human Resources, Honolulu, Hawaii (J.O., R.J.); Veterinary Emergency + Referral Center of Hawaii, Honolulu, Hawaii (E.S., W.C.); and Centre for Veterinary Education, University of Sydney, Sydney, Australia (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-57-1-42-b1","series-title":"J Vet Intern Med","first-page":"275","article-title":"Cerebrospinal fluid eosinophilia in dogs","volume":"23","year":"2009","unstructured":"Windsor\n              RC,\n            \n            \n              Sturges\n              BK,\n            \n            \n              Vernau\n              KM,\n            \n          \n          .\n\t\t\t\t\tCerebrospinal fluid eosinophilia in dogs.\n\t\t\t\t\tJ Vet Intern Med2009;\n\t\t\t\t\t23:\n\t\t\t\t\t275\u2013\n\t\t\t\t\t81."},{"key":"i1547-3317-57-1-42-b2","article-title":"Parasites \u2013 Angiostrongyliasis (also known as Angiostrongylus infection)","unstructured":"Centers for Disease Control and Prevention.\n\t\t\t\t\t\n          Parasites \u2013 Angiostrongyliasis (also known as Angiostrongylus infection).\n\t\t\t\t\tAvailable at: www.cdc.gov\/parasites\/angiostrongylus\/index.html. 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Hyg","first-page":"353","article-title":"Neuroangiostrongyliasis: the \u201csubarachnoid phase\u201d and its implications for anthelminthic therapy","volume":"98","year":"2018","unstructured":"Prociv\n              P,\n            \n            \n              Turner\n              M.\n            \n          \n          Neuroangiostrongyliasis: the \u201csubarachnoid phase\u201d and its implications for anthelminthic therapy.\n\t\t\t\t\tAm J Trop Med Hyg2018;\n\t\t\t\t\t98(\n\t\t\t\t\t2):\n\t\t\t\t\t353\u2013\n\t\t\t\t\t9."},{"issue":"5","key":"i1547-3317-57-1-42-b11","series-title":"Curr Opin Infect Dis","first-page":"399","article-title":"Angiostrongylus cantonensis in travelers: clinical manifestations, diagnosis and treatment","volume":"31","year":"2018","unstructured":"Ansdell\n              V,\n            \n            \n              Wattanagoon\n              Y.\n            \n          \n          \n            Angiostrongylus cantonensis in travelers: clinical 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marine: a case report and literature review","volume":"19","year":"2019","unstructured":"McAuliffe\n              L,\n            \n            \n              Ensign\n              SF,\n            \n            \n              Bavaro\n              M,\n            \n          \n          .\n\t\t\t\t\tSevere CNS angiostrongyliasis in a young marine: a case report and literature review.\n\t\t\t\t\tLancet Infect Dis2019;\n\t\t\t\t\t19(\n\t\t\t\t\t4):\n\t\t\t\t\te132\u2013\n\t\t\t\t\t42."},{"issue":"9","key":"i1547-3317-57-1-42-b14","series-title":"Parasitology","first-page":"1087","article-title":"Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen","volume":"143","year":"2016","unstructured":"Barratt\n              J,\n            \n            \n              Chan\n              D,\n            \n            \n              Sandaradura\n              I,\n            \n          \n          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Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/57\/1\/article-p42.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/57\/1\/42\/2693823\/i1547-3317-57-1-42.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/57\/1\/article-p42.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/57\/1\/article-p42.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:05:03Z","timestamp":1763741103000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/57\/1\/article-p42.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-6989","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}