{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:32:34Z","timestamp":1784313154247,"version":"3.55.0"},"reference-count":21,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Anicteric gallbladder rupture has been rarely described in veterinary medicine, and, generally, it has been related to gallbladder wall necrosis secondary to gallbladder mucocele. A 5 yr old, male, neutered Labrador retriever presented for acute onset anorexia, lethargy, and vomiting. Cholecystitis was diagnosed based on the ultrasonographic findings and bactibilia, and, consequently, medical treatment was established. Despite improvement of the patient, a focal ultrasound of the hepatobiliary tract was performed 72 hr after admission for reassessment, revealing gallbladder wall thickening and abdominal effusion. Intracellular bacteria were present in nondegenerated neutrophils, and the effusion was categorized as septic exudate, compatible with septic peritonitis. Exploratory laparotomy confirmed an anicteric gallbladder rupture potentially secondary to cholecystitis and\/or previous cholecystocentesis. The patient was not icteric the day of the surgery, serum bilirubin was within normal limits, abdominal fluid bilirubin concentration was below that of serum, and no bile pigment was detected; however, bile acids were significantly higher in the abdominal effusion compared with the serum concentration. This case describes an anicteric gallbladder rupture in a dog with concomitant cholecystitis and raises the question about the sensitivity of bile acid evaluation as a tool for diagnosis of gallbladder rupture and bile peritonitis in dogs.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7079","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:27:47Z","timestamp":1652707667000},"page":"146-151","source":"Crossref","is-referenced-by-count":4,"title":["Anicteric Gallbladder Rupture with Elevated Bile Acids in Abdominal Effusion in a Dog with Cholecystitis"],"prefix":"10.5326","volume":"58","author":[{"given":"Mireia","family":"Pascual","sequence":"first","affiliation":[{"name":"From Dick White Referrals, Cambridgeshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Fauchon","sequence":"additional","affiliation":[{"name":"From Dick White Referrals, Cambridgeshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Monti","sequence":"additional","affiliation":[{"name":"From Dick White Referrals, Cambridgeshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Valls","sequence":"additional","affiliation":[{"name":"From Dick White Referrals, Cambridgeshire, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-58-3-146-b1","series-title":"BSAVA manual of canine and feline clinical pathology","first-page":"435","article-title":"Body cavity effusions","year":"2016","unstructured":"Dewhurst\n              E.\n            \n          \n          Body cavity effusions.\n\t\t\t\t\tIn:BSAVA manual of canine and feline clinical pathology.\n\t\t\t\t\t3rd ed.\n\t\t\t\t\tQuedgeley:\n\t\t\t\t\tVilliers & Risti\u0107;\n\t\t\t\t\t2016:\n\t\t\t\t\t435\u2013\n\t\t\t\t\t51."},{"key":"i1547-3317-58-3-146-b2","series-title":"Textbook of veterinary internal medicine.","year":"2017","unstructured":"Ettinger\n              SJ,\n            \n            \n              Feldman\n              EC,\n            \n            \n              Cote\n              E.\n            \n          \n          \n            Textbook of veterinary internal medicine.\n          \n          8th ed.\n\t\t\t\t\tSt. Louis:\n\t\t\t\t\tElsevier;\n\t\t\t\t\t2017."},{"key":"i1547-3317-58-3-146-b3","series-title":"Vet Surg","first-page":"90","article-title":"Surgical treatment of bile peritonitis in 24 dogs and 2 cats: a retrospective study (1987\u20131994)","volume":"26","year":"1997","unstructured":"Ludwig\n              LL,\n            \n            \n              McLoughlin\n              MA,\n            \n            \n              Graves\n              TK,\n            \n          \n          .\n\t\t\t\t\tSurgical treatment of bile peritonitis in 24 dogs and 2 cats: a retrospective study (1987\u20131994).\n\t\t\t\t\tVet Surg1997;\n\t\t\t\t\t26:\n\t\t\t\t\t90\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-3-146-b4","series-title":"J Am Vet Med Assoc","first-page":"1412","article-title":"Anicteric gallbladder rupture in dogs: 5 cases","volume":"247","year":"2015","unstructured":"Guess\n              CG,\n            \n            \n              Harkin\n              KR,\n            \n            \n              Biller\n              DS.\n            \n          \n          Anicteric gallbladder rupture in dogs: 5 cases.\n\t\t\t\t\tJ Am Vet Med Assoc2015;\n\t\t\t\t\t247:\n\t\t\t\t\t1412\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-3-146-b5","series-title":"J Vet Intern Med","first-page":"195","article-title":"Gallbladder mucocele: variables associated with outcome and the utility of ultrasonography to identify gallbladder rupture in 219 dogs (2007\u20132016)","volume":"32","year":"2018","unstructured":"Jaffey\n              JA,\n            \n            \n              Graham\n              A,\n            \n            \n              VanEerde\n              E,\n            \n          \n          .\n\t\t\t\t\tGallbladder mucocele: variables associated with outcome and the utility of ultrasonography to identify gallbladder rupture in 219 dogs (2007\u20132016).\n\t\t\t\t\tJ Vet Intern Med2018;\n\t\t\t\t\t32:\n\t\t\t\t\t195\u2013\n\t\t\t\t\t200."},{"key":"i1547-3317-58-3-146-b6","series-title":"Vet Radiol Ultrasound","first-page":"270","article-title":"Ultrasound corner gallbladder wall thickness","volume":"34","year":"1993","unstructured":"Spaulding\n              KA.\n            \n          \n          Ultrasound corner gallbladder wall thickness.\n\t\t\t\t\tVet Radiol Ultrasound1993;\n\t\t\t\t\t34:\n\t\t\t\t\t270\u2013\n\t\t\t\t\t2."},{"key":"i1547-3317-58-3-146-b7","series-title":"J Vet Intern Med","first-page":"1046","article-title":"Bacterial cholangitis, cholecystitis, or both in dogs","volume":"30","year":"2016","unstructured":"Tamborini\n              A,\n            \n            \n              Jahns\n              H,\n            \n            \n              McAllister\n              H,\n            \n          \n          .\n\t\t\t\t\tBacterial cholangitis, cholecystitis, or both in dogs.\n\t\t\t\t\tJ Vet Intern Med2016;\n\t\t\t\t\t30:\n\t\t\t\t\t1046\u2013\n\t\t\t\t\t55."},{"key":"i1547-3317-58-3-146-b8","series-title":"Vet Clin North Am Small Anim Pract","first-page":"395","article-title":"Summary of the World Small Animal Veterinary Association Standardization Committee guide to classification of liver disease in dogs and cats","volume":"39","year":"2009","unstructured":"Cullen\n              JM.\n            \n          \n          Summary of the World Small Animal Veterinary Association Standardization Committee guide to classification of liver disease in dogs and cats.\n\t\t\t\t\tVet Clin North Am Small Anim Pract2009;\n\t\t\t\t\t39:\n\t\t\t\t\t395\u2013\n\t\t\t\t\t418."},{"key":"i1547-3317-58-3-146-b9","series-title":"J Small Anim Pract","first-page":"325","article-title":"Bacterial cholangitis\/cholangiohepatitis with or without concurrent cholecystitis in four fogs","volume":"47","year":"2007","unstructured":"O\u2019Neill\n              EJ,\n            \n            \n              Day\n              MJ,\n            \n            \n              Hall\n              EJ,\n            \n          \n          .\n\t\t\t\t\tBacterial cholangitis\/cholangiohepatitis with or without concurrent cholecystitis in four fogs.\n\t\t\t\t\tJ Small Anim Pract2007;\n\t\t\t\t\t47:\n\t\t\t\t\t325\u2013\n\t\t\t\t\t35."},{"key":"i1547-3317-58-3-146-b10","series-title":"J Am Vet Med Assoc","first-page":"359","article-title":"Clinical, ultrasonographic, and laboratory findings associated with gallbladder disease and rupture in dogs: 45 cases (1997\u20132007)","volume":"234","year":"2009","unstructured":"Crews\n              LJ,\n            \n            \n              Feeney\n              DA,\n            \n            \n              Jessen\n              CR,\n            \n          \n          .\n\t\t\t\t\tClinical, ultrasonographic, and laboratory findings associated with gallbladder disease and rupture in dogs: 45 cases (1997\u20132007).\n\t\t\t\t\tJ Am Vet Med Assoc2009;\n\t\t\t\t\t234:\n\t\t\t\t\t359\u2013\n\t\t\t\t\t66."},{"key":"i1547-3317-58-3-146-b11","series-title":"J Vet Intern Med","first-page":"1451","article-title":"Association between gallbladder ultrasound findings and bacterial culture of bile in 70 cats and 202 dogs","volume":"31","year":"2017","unstructured":"Smith\n              RP,\n            \n            \n              Gookin\n              JL,\n            \n            \n              Smolski\n              W,\n            \n          \n          .\n\t\t\t\t\tAssociation between gallbladder ultrasound findings and bacterial culture of bile in 70 cats and 202 dogs.\n\t\t\t\t\tJ Vet Intern Med2017;\n\t\t\t\t\t31:\n\t\t\t\t\t1451\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-3-146-b12","series-title":"Vet Radiol Ultrasound","first-page":"611","article-title":"Evaluation of contrast-enhanced ultrasonography as a method for detecting gallbladder necrosis or rupture in dogs","volume":"57","year":"2016","unstructured":"Bargellini\n              P,\n            \n            \n              Orlandi\n              R,\n            \n            \n              Paloni\n              C,\n            \n          \n          .\n\t\t\t\t\tEvaluation of contrast-enhanced ultrasonography as a method for detecting gallbladder necrosis or rupture in dogs.\n\t\t\t\t\tVet Radiol Ultrasound2016;\n\t\t\t\t\t57:\n\t\t\t\t\t611\u2013\n\t\t\t\t\t20."},{"key":"i1547-3317-58-3-146-b13","series-title":"J Clin Ultrasound","first-page":"270","article-title":"Role of sonography in the diagnosis of gallbladder perforation","volume":"30","year":"2002","unstructured":"Sood\n              BP,\n            \n            \n              Kalra\n              N,\n            \n            \n              Gupta\n              S,\n            \n          \n          .\n\t\t\t\t\tRole of sonography in the diagnosis of gallbladder perforation.\n\t\t\t\t\tJ Clin Ultrasound2002;\n\t\t\t\t\t30:\n\t\t\t\t\t270\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-3-146-b14","series-title":"World J Gastroenterol","first-page":"7832","article-title":"Diagnosis and treatment of gallbladder perforation","volume":"12","year":"2006","unstructured":"Derici\n              H,\n            \n            \n              Kara\n              C,\n            \n            \n              Bozdag\n              AD,\n            \n          \n          .\n\t\t\t\t\tDiagnosis and treatment of gallbladder perforation.\n\t\t\t\t\tWorld J Gastroenterol2006;\n\t\t\t\t\t12:\n\t\t\t\t\t7832\u2013\n\t\t\t\t\t6."},{"key":"i1547-3317-58-3-146-b15","series-title":"Vet Rec Case Rep","first-page":"e000481","article-title":"CT findings of gall bladder rupture in two dogs with gall bladder mucocele","volume":"5","year":"2017","unstructured":"Gordon\n              CR,\n            \n            \n              Fernandez\n              N,\n            \n            \n              Schwarz\n              T.\n            \n          \n          CT findings of gall bladder rupture in two dogs with gall bladder mucocele.\n\t\t\t\t\tVet Rec Case Rep2017;\n\t\t\t\t\t5:\n\t\t\t\t\te000481."},{"key":"i1547-3317-58-3-146-b16","series-title":"Abdom Imaging","first-page":"239","article-title":"Gallbladder perforation: comparison of US findings with CT","volume":"19","year":"1994","unstructured":"Kim\n              PN,\n            \n            \n              Lee\n              KS,\n            \n            \n              Kim\n              IY,\n            \n          \n          .\n\t\t\t\t\tGallbladder perforation: comparison of US findings with CT.\n\t\t\t\t\tAbdom Imaging1994;\n\t\t\t\t\t19:\n\t\t\t\t\t239\u2013\n\t\t\t\t\t42."},{"key":"i1547-3317-58-3-146-b17","series-title":"J Small Anim Pract","first-page":"58","article-title":"Presumptive migrating gall bladder mucocele in two dogs with gall bladder rupture","volume":"60","year":"2019","unstructured":"Burchell\n              RK,\n            \n            \n              Thornton\n              L,\n            \n            \n              Lim\n              CK,\n            \n          \n          .\n\t\t\t\t\tPresumptive migrating gall bladder mucocele in two dogs with gall bladder rupture.\n\t\t\t\t\tJ Small Anim Pract2019;\n\t\t\t\t\t60:\n\t\t\t\t\t58\u2013\n\t\t\t\t\t61."},{"key":"i1547-3317-58-3-146-b18","series-title":"Scand J Clin Lab Invest","first-page":"543","article-title":"Bile constituents in ascitic fluid","volume":"48","year":"1988","unstructured":"Hedenborg\n              G,\n            \n            \n              J\u00f6nsson\n              G,\n            \n            \n              Norman\n              A,\n            \n            \n              Wis\u00e9n\n              O.\n            \n          \n          Bile constituents in ascitic fluid.\n\t\t\t\t\tScand J Clin Lab Invest1988;\n\t\t\t\t\t48:\n\t\t\t\t\t543\u2013\n\t\t\t\t\t52."},{"key":"i1547-3317-58-3-146-b19","series-title":"Vet Clin Pathol","first-page":"114","article-title":"Three cases of canine bile peritonitis with mucinous material in abdominal fluid as the prominent cytologic finding","volume":"32","year":"2003","unstructured":"Owens\n              SD,\n            \n            \n              Gosset\n              R,\n            \n            \n              McElhaney\n              R,\n            \n          \n          .\n\t\t\t\t\tThree cases of canine bile peritonitis with mucinous material in abdominal fluid as the prominent cytologic finding.\n\t\t\t\t\tVet Clin Pathol2003;\n\t\t\t\t\t32:\n\t\t\t\t\t114\u2013\n\t\t\t\t\t20."},{"key":"i1547-3317-58-3-146-b20","series-title":"J Vet Intern Med","first-page":"123","article-title":"Cytological findings of 140 bile samples from dogs and cats and associated clinical pathological data","volume":"30","year":"2016","unstructured":"Peters\n              LM,\n            \n            \n              Glanemann\n              B,\n            \n            \n              Garden\n              OA,\n            \n          \n          .\n\t\t\t\t\tCytological findings of 140 bile samples from dogs and cats and associated clinical pathological data.\n\t\t\t\t\tJ Vet Intern Med2016;\n\t\t\t\t\t30:\n\t\t\t\t\t123\u2013\n\t\t\t\t\t31."},{"key":"i1547-3317-58-3-146-b21","series-title":"J Small Anim Pract","first-page":"389","article-title":"Percutaneous ultrasound-guided cholecystocentesis: complications and association of ultrasonographic findings with bile culture results","volume":"58","year":"2017","unstructured":"Schiborra\n              F,\n            \n            \n              McConnell\n              JF,\n            \n            \n              Maddox\n              TW.\n            \n          \n          Percutaneous ultrasound-guided cholecystocentesis: complications and association of ultrasonographic findings with bile culture results.\n\t\t\t\t\tJ Small Anim Pract2017;\n\t\t\t\t\t58:\n\t\t\t\t\t389\u2013\n\t\t\t\t\t94."}],"container-title":["Journal of the American Animal Hospital 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