{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:58:54Z","timestamp":1790816334289,"version":"4.1.0"},"reference-count":54,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n The study objective was to evaluate sedative, hemodynamic, and echocardiographic effects of cats receiving single-dose, oral gabapentin. A prospective, double-blinded, placebo-controlled, crossover study was conducted with 10 client-owned cats. Vital parameters, physical exam, blood pressure, echocardiography, and sedation scoring were performed at each visit within 2 hr of receiving either a placebo or gabapentin capsule. Vital parameters, blood pressure recordings, and echocardiographic measurements were compared between baseline, gabapentin, and placebo; interobserver agreement for sedation scoring and correlation between variables were also evaluated. Seven of 10 cats exhibited mild sedation within 120 min after receiving gabapentin, and no adverse events occurred. Significant differences were detected with two-dimensional fractional shortening (\n P<\/jats:italic>\n = .022), left ventricular internal diameter in systole using M-mode (\n P<\/jats:italic>\n = .014), and left atrial volume (\n P<\/jats:italic>\n < .0001). Interobserver agreement for sedation scoring was near-perfect (\n \u03ba<\/jats:italic>\n = 0.84). No significant correlation was found for gabapentin dosage and sedation score. Single-dose oral gabapentin is well tolerated in healthy cats and produces a modest decrease in several echocardiographic parameters of systolic function; however, all affected variables remained within established reference ranges. These results suggest gabapentin may be an appropriate sedative to administer before echocardiography in cats necessitating mild sedation.\n <\/jats:p>","DOI":"10.5326\/jaaha-ms-7081","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T20:31:48Z","timestamp":1633379508000},"page":"278-284","source":"Crossref","is-referenced-by-count":20,"title":["Hemodynamic, Echocardiographic, and Sedative Effects of Oral Gabapentin in Healthy Cats"],"prefix":"10.5326","volume":"57","author":[{"given":"Meghan E.","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine F.","family":"Scollan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"6","key":"i1547-3317-57-6-278-b1","series-title":"J Vet Intern Med","first-page":"1996","article-title":"The pharmacokinetics of gabapentin in cats","volume":"32","year":"2018","unstructured":"Adrian\n D,\n \n \n Papich\n MG,\n \n \n Baynes\n R,\n \n \n .\n\t\t\t\t\tThe pharmacokinetics of gabapentin in cats.\n\t\t\t\t\tJ Vet Intern Med2018;\n\t\t\t\t\t32(\n\t\t\t\t\t6):\n\t\t\t\t\t1996\u2013\n\t\t\t\t\t2002."},{"issue":"7","key":"i1547-3317-57-6-278-b2","series-title":"Am J Vet Res","first-page":"817","article-title":"Pharmacokinetics of gabapentin in cats","volume":"71","year":"2010","unstructured":"Siao\n KT,\n \n \n Pypendop\n BH,\n \n \n Ilkiw\n JE.\n \n \n Pharmacokinetics of gabapentin in cats.\n\t\t\t\t\tAm J Vet Res2010;\n\t\t\t\t\t71(\n\t\t\t\t\t7):\n\t\t\t\t\t817\u2013\n\t\t\t\t\t21."},{"issue":"6","key":"i1547-3317-57-6-278-b3","series-title":"J Feline Med Surg","first-page":"535","article-title":"Use of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial","volume":"20","year":"2018","unstructured":"Pankratz\n KE,\n \n \n Ferris\n KK,\n \n \n Griffith\n EH,\n \n \n .\n\t\t\t\t\tUse of single-dose oral gabapentin to attenuate fear responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial.\n\t\t\t\t\tJ Feline Med Surg2018;\n\t\t\t\t\t20(\n\t\t\t\t\t6):\n\t\t\t\t\t535\u2013\n\t\t\t\t\t43."},{"issue":"10","key":"i1547-3317-57-6-278-b4","series-title":"J Am Vet Med Assoc","first-page":"1175","article-title":"Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination","volume":"251","year":"2017","unstructured":"van Haaften\n K,\n \n \n Forsythe\n LRE,\n \n \n Stelow\n EA,\n \n \n .\n\t\t\t\t\tEffects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination.\n\t\t\t\t\tJ Am Vet Med Assoc2017;\n\t\t\t\t\t251(\n\t\t\t\t\t10):\n\t\t\t\t\t1175\u2013\n\t\t\t\t\t81."},{"key":"i1547-3317-57-6-278-b5","article-title":"Gabapentin and amantadine for chronic pain: is your dose right? 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Accessed March 30, 2019."},{"issue":"6","key":"i1547-3317-57-6-278-b6","series-title":"J Feline Med Surg","first-page":"530","article-title":"Effects of intramuscular sedation with alfaxalone and butorphanol on echocardiographic measurements in healthy cats","volume":"17","year":"2015","unstructured":"Ribas\n T,\n \n \n Bublot\n I,\n \n \n Junot\n S,\n \n \n .\n\t\t\t\t\tEffects of intramuscular sedation with alfaxalone and butorphanol on echocardiographic measurements in healthy cats.\n\t\t\t\t\tJ Feline Med Surg2015;\n\t\t\t\t\t17(\n\t\t\t\t\t6):\n\t\t\t\t\t530\u2013\n\t\t\t\t\t6."},{"issue":"10","key":"i1547-3317-57-6-278-b7","series-title":"J Feline Med Surg","first-page":"678","article-title":"Effects of sedation on echocardiographic variables of left atrial and left ventricular function in healthy cats","volume":"14","year":"2012","unstructured":"Ward\n JL,\n \n \n Schober\n KE,\n \n \n Fuentes\n VL,\n \n \n .\n\t\t\t\t\tEffects of sedation on echocardiographic variables of left 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\n Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.\n\t\t\t\t\tEpilepsy Res2007;\n\t\t\t\t\t73(\n\t\t\t\t\t2):\n\t\t\t\t\t137\u2013\n\t\t\t\t\t50."},{"issue":"12","key":"i1547-3317-57-6-278-b19","series-title":"J Clin Invest","first-page":"3306","article-title":"The L-type calcium channel in the heart: the beat goes on","volume":"115","year":"2005","unstructured":"Bodi\n I,\n \n \n Mikala\n G,\n \n \n Koch\n SE,\n \n \n .\n\t\t\t\t\tThe L-type calcium channel in the heart: the beat goes on.\n\t\t\t\t\tJ Clin Invest2005;\n\t\t\t\t\t115(\n\t\t\t\t\t12):\n\t\t\t\t\t3306\u2013\n\t\t\t\t\t17."},{"issue":"9","key":"i1547-3317-57-6-278-b20","series-title":"Proc Natl Acad Sci USA","first-page":"3628","article-title":"Pharmacological disruption of calcium channel trafficking by the \u03b12\u03b4ligand gabapentin","volume":"105","year":"2008","unstructured":"Hendrich\n J,\n \n \n Van Minh\n AT,\n \n \n Heblich\n F,\n \n \n .\n\t\t\t\t\tPharmacological disruption of calcium channel trafficking by the \u03b12\u03b4ligand gabapentin.\n\t\t\t\t\tProc Natl Acad Sci USA2008;\n\t\t\t\t\t105(\n\t\t\t\t\t9):\n\t\t\t\t\t3628\u2013\n\t\t\t\t\t33."},{"issue":"1","key":"i1547-3317-57-6-278-b21","series-title":"Am J Physiol Heart Circ Physiol","first-page":"117","article-title":"Targeted disruption of the voltage-dependent calcium channel \u03b12\/\u03b4-1-subunit","volume":"297","year":"2009","unstructured":"Fuller-Bicer\n GA,\n \n \n Varadi\n G,\n \n \n Koch\n SE,\n \n \n .\n\t\t\t\t\tTargeted disruption of the voltage-dependent calcium channel \u03b12\/\u03b4-1-subunit.\n\t\t\t\t\tAm J Physiol Heart Circ Physiol2009;\n\t\t\t\t\t297(\n\t\t\t\t\t1):\n\t\t\t\t\t117\u2013\n\t\t\t\t\t24."},{"issue":"7","key":"i1547-3317-57-6-278-b22","series-title":"Biochim Biophys Acta","first-page":"1541","article-title":"The \u03b12\u03b4subunits of voltage-gated calcium 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entity?\n \n SM Emerg Med Crit Care\n \n 2017;\n\t\t\t\t\t1(\n\t\t\t\t\t2):\n\t\t\t\t\t1006."},{"issue":"6","key":"i1547-3317-57-6-278-b25","series-title":"Circulation","first-page":"e32","article-title":"Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association","volume":"134","year":"2016","unstructured":"Page\n RL,\n II\n \n \n O\u2019Bryant\n CL,\n \n \n Cheng\n D,\n \n \n .\n\t\t\t\t\tDrugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association.\n\t\t\t\t\tCirculation2016;\n\t\t\t\t\t134(\n\t\t\t\t\t6):\n\t\t\t\t\te32\u2013\n\t\t\t\t\t69."},{"issue":"12","key":"i1547-3317-57-6-278-b26","series-title":"Drug Saf","first-page":"1325","article-title":"Gabapentin and pregabalin and risk of atrial fibrillation in the elderly: a population-based cohort study in an electronic prescription database","volume":"41","year":"2018","unstructured":"Ortiz de Landaluce\n L,\n \n \n Carbonell\n P,\n 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responses in cage-trap confined community cats: a double-blind, placebo-controlled field trial.\n\t\t\t\t\tJ Feline Med Surg2018;\n\t\t\t\t\t20(\n\t\t\t\t\t6):\n\t\t\t\t\t535\u2013\n\t\t\t\t\t43."},{"issue":"10","key":"i1547-3317-57-6-278-b4","series-title":"J Am Vet Med Assoc","first-page":"1175","article-title":"Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination","volume":"251","year":"2017","unstructured":"van Haaften\n K,\n \n \n Forsythe\n LRE,\n \n \n Stelow\n EA,\n \n \n .\n\t\t\t\t\tEffects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination.\n\t\t\t\t\tJ Am Vet Med Assoc2017;\n\t\t\t\t\t251(\n\t\t\t\t\t10):\n\t\t\t\t\t1175\u2013\n\t\t\t\t\t81."},{"key":"i1547-3317-57-6-278-b5","article-title":"Gabapentin and amantadine for chronic pain: is your dose right? Today\u2019s Veterinary Practice","unstructured":"Grubb\n T.\n \n \n Gabapentin and amantadine for chronic pain: is your dose right? Today\u2019s Veterinary Practice.\n\t\t\t\t\tAvailable at: https:\/\/todaysveterinarypractice.com\/gabapentin-and-amantadine-for-chronic-pain\/. Accessed March 30, 2019."},{"issue":"6","key":"i1547-3317-57-6-278-b6","series-title":"J Feline Med Surg","first-page":"530","article-title":"Effects of intramuscular sedation with alfaxalone and butorphanol on echocardiographic measurements in healthy cats","volume":"17","year":"2015","unstructured":"Ribas\n T,\n \n \n Bublot\n I,\n \n \n Junot\n S,\n \n \n .\n\t\t\t\t\tEffects of intramuscular sedation with alfaxalone and butorphanol on echocardiographic measurements in healthy cats.\n\t\t\t\t\tJ Feline Med Surg2015;\n\t\t\t\t\t17(\n\t\t\t\t\t6):\n\t\t\t\t\t530\u2013\n\t\t\t\t\t6."},{"issue":"10","key":"i1547-3317-57-6-278-b7","series-title":"J Feline Med Surg","first-page":"678","article-title":"Effects of sedation on echocardiographic variables of left atrial and left ventricular function in healthy cats","volume":"14","year":"2012","unstructured":"Ward\n JL,\n \n \n Schober\n KE,\n \n \n Fuentes\n VL,\n \n \n .\n\t\t\t\t\tEffects of sedation on echocardiographic variables of left atrial and left ventricular function in healthy cats.\n\t\t\t\t\tJ Feline Med Surg2012;\n\t\t\t\t\t14(\n\t\t\t\t\t10):\n\t\t\t\t\t678\u2013\n\t\t\t\t\t85."},{"issue":"2","key":"i1547-3317-57-6-278-b8","series-title":"Vet Anaesth Analg","first-page":"137","article-title":"Sedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats","volume":"39","year":"2012","unstructured":"Biermann\n K,\n \n \n Hungerb\u00fchler\n S,\n \n \n Mischke\n R,\n \n \n .\n\t\t\t\t\tSedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats.\n\t\t\t\t\tVet Anaesth Analg2012;\n\t\t\t\t\t39(\n\t\t\t\t\t2):\n\t\t\t\t\t137\u2013\n\t\t\t\t\t50."},{"issue":"9","key":"i1547-3317-57-6-278-b9","series-title":"J Am Vet Med Assoc","first-page":"1276","article-title":"Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats","volume":"221","year":"2002","unstructured":"Lamont\n LA,\n \n \n Bulmer\n BJ,\n \n \n Sisson\n DD,\n \n \n .\n\t\t\t\t\tDoppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats.\n\t\t\t\t\tJ Am Vet Med Assoc2002;\n\t\t\t\t\t221(\n\t\t\t\t\t9):\n\t\t\t\t\t1276\u2013\n\t\t\t\t\t81."},{"issue":"12","key":"i1547-3317-57-6-278-b10","series-title":"J Feline Med Surg","first-page":"1080","article-title":"Effects of oral trazodone on echocardiographic and hemodynamic variables in healthy cats","volume":"21","year":"2019","unstructured":"Fries\n RC,\n \n \n Kadotani\n S,\n \n \n Vitt\n JP,\n \n \n .\n\t\t\t\t\tEffects of oral trazodone on echocardiographic and hemodynamic variables in healthy cats.\n\t\t\t\t\tJ Feline Med Surg2019;\n\t\t\t\t\t21(\n\t\t\t\t\t12):\n\t\t\t\t\t1080\u2013\n\t\t\t\t\t5."},{"issue":"5","key":"i1547-3317-57-6-278-b11","series-title":"J Vet Intern Med","first-page":"1601","article-title":"Effect of body weight on echocardiographic measurements in 19,866 pure-bred cats with or without heart disease","volume":"30","year":"2016","unstructured":"H\u00e4ggstr\u00f6m\n J,\n \n \n Andersson\n \u00c5O,\n \n \n Falk\n T,\n \n \n .\n\t\t\t\t\tEffect of body weight on echocardiographic measurements in 19,866 pure-bred cats with or without heart disease.\n\t\t\t\t\tJ Vet Intern Med2016;\n\t\t\t\t\t30(\n\t\t\t\t\t5):\n\t\t\t\t\t1601\u2013\n\t\t\t\t\t11."},{"issue":"5","key":"i1547-3317-57-6-278-b12","series-title":"J Am Vet Med Assoc","first-page":"579","article-title":"Assessment of the effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life in osteoarthritic geriatric cats","volume":"253","year":"2018","unstructured":"Guedes\n A,\n \n \n Meadows\n J,\n \n \n Pypendop\n B,\n \n \n .\n\t\t\t\t\tAssessment of the effects of gabapentin on activity levels and owner-perceived mobility impairment and quality of life in osteoarthritic geriatric cats.\n\t\t\t\t\tJ Am Vet Med Assoc2018;\n\t\t\t\t\t253(\n\t\t\t\t\t5):\n\t\t\t\t\t579\u2013\n\t\t\t\t\t85."},{"issue":"2","key":"i1547-3317-57-6-278-b13","series-title":"J Am Anim Hosp Assoc","first-page":"70","article-title":"Effects of intramuscular alfaxalone\/acepromazine on echocardiographic, biochemical, and blood gas measurements in healthy cats","volume":"55","year":"2019","unstructured":"Kim\n B,\n \n \n Jang\n M,\n \n \n Sohn\n J,\n \n \n .\n\t\t\t\t\tEffects of intramuscular alfaxalone\/acepromazine on echocardiographic, biochemical, and blood gas measurements in healthy cats.\n\t\t\t\t\tJ Am Anim Hosp Assoc2019;\n\t\t\t\t\t55(\n\t\t\t\t\t2):\n\t\t\t\t\t70\u2013\n\t\t\t\t\t7."},{"issue":"2","key":"i1547-3317-57-6-278-b14","series-title":"Epilepsy Behav","first-page":"161","article-title":"Anxiety in patients with epilepsy: Systematic review and suggestions for clinical management","volume":"7","year":"2005","unstructured":"Beyenburg\n S,\n \n \n Mitchell\n AJ,\n \n \n Schmidt\n D,\n \n \n .\n\t\t\t\t\tAnxiety in patients with epilepsy: Systematic review and suggestions for clinical management.\n\t\t\t\t\tEpilepsy Behav2005;\n\t\t\t\t\t7(\n\t\t\t\t\t2):\n\t\t\t\t\t161\u2013\n\t\t\t\t\t71."},{"issue":"5","key":"i1547-3317-57-6-278-b15","series-title":"Can J Anesth","first-page":"432","article-title":"Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: A blinded randomized placebo-controlled trial","volume":"60","year":"2013","unstructured":"Clarke\n H,\n \n \n Kirkham\n KR,\n \n \n Orser\n BA,\n \n \n .\n\t\t\t\t\tGabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: A blinded randomized placebo-controlled trial.\n\t\t\t\t\tCan J Anesth2013;\n\t\t\t\t\t60(\n\t\t\t\t\t5):\n\t\t\t\t\t432\u2013\n\t\t\t\t\t43."},{"issue":"6","key":"i1547-3317-57-6-278-b16","series-title":"Anesth Analg","first-page":"1545","article-title":"Do surgical patients benefit from perioperative gabapentin\/pregabalin? A systematic review of efficacy and safety","volume":"104","year":"2007","unstructured":"Tiippana\n EM,\n \n \n Hamunen\n K,\n \n \n Kontinen\n VK,\n \n \n .\n\t\t\t\t\tDo surgical patients benefit from perioperative gabapentin\/pregabalin? A systematic review of efficacy and safety.\n\t\t\t\t\tAnesth Analg2007;\n\t\t\t\t\t104(\n\t\t\t\t\t6):\n\t\t\t\t\t1545\u2013\n\t\t\t\t\t56."},{"issue":"6","key":"i1547-3317-57-6-278-b17","series-title":"J Feline Med Surg","first-page":"507","article-title":"Long-term use of gabapentin for musculoskeletal disease and trauma in three cats","volume":"15","year":"2013","unstructured":"Lorenz\n ND,\n \n \n Comerford\n EJ,\n \n \n Iff\n I.\n \n \n Long-term use of gabapentin for musculoskeletal disease and trauma in three cats.\n\t\t\t\t\tJ Feline Med Surg2013;\n\t\t\t\t\t15(\n\t\t\t\t\t6):\n\t\t\t\t\t507\u2013\n\t\t\t\t\t12."},{"issue":"2","key":"i1547-3317-57-6-278-b18","series-title":"Epilepsy Res","first-page":"137","article-title":"Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery","volume":"73","year":"2007","unstructured":"Taylor\n CP,\n \n \n Angelotti\n T,\n \n \n Fauman\n E.\n \n \n Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.\n\t\t\t\t\tEpilepsy Res2007;\n\t\t\t\t\t73(\n\t\t\t\t\t2):\n\t\t\t\t\t137\u2013\n\t\t\t\t\t50."},{"issue":"12","key":"i1547-3317-57-6-278-b19","series-title":"J Clin Invest","first-page":"3306","article-title":"The L-type calcium channel in the heart: the beat goes on","volume":"115","year":"2005","unstructured":"Bodi\n I,\n \n \n Mikala\n G,\n \n \n Koch\n SE,\n \n \n .\n\t\t\t\t\tThe L-type calcium channel in the heart: the beat goes on.\n\t\t\t\t\tJ Clin Invest2005;\n\t\t\t\t\t115(\n\t\t\t\t\t12):\n\t\t\t\t\t3306\u2013\n\t\t\t\t\t17."},{"issue":"9","key":"i1547-3317-57-6-278-b20","series-title":"Proc Natl Acad Sci USA","first-page":"3628","article-title":"Pharmacological disruption of calcium channel trafficking by the \u03b12\u03b4ligand gabapentin","volume":"105","year":"2008","unstructured":"Hendrich\n J,\n \n \n Van Minh\n AT,\n \n \n Heblich\n F,\n \n \n .\n\t\t\t\t\tPharmacological disruption of calcium channel trafficking by the \u03b12\u03b4ligand gabapentin.\n\t\t\t\t\tProc Natl Acad Sci USA2008;\n\t\t\t\t\t105(\n\t\t\t\t\t9):\n\t\t\t\t\t3628\u2013\n\t\t\t\t\t33."},{"issue":"1","key":"i1547-3317-57-6-278-b21","series-title":"Am J Physiol Heart Circ Physiol","first-page":"117","article-title":"Targeted disruption of the voltage-dependent calcium channel \u03b12\/\u03b4-1-subunit","volume":"297","year":"2009","unstructured":"Fuller-Bicer\n GA,\n \n \n Varadi\n G,\n \n \n Koch\n SE,\n \n \n .\n\t\t\t\t\tTargeted disruption of the voltage-dependent calcium channel \u03b12\/\u03b4-1-subunit.\n\t\t\t\t\tAm J Physiol Heart Circ Physiol2009;\n\t\t\t\t\t297(\n\t\t\t\t\t1):\n\t\t\t\t\t117\u2013\n\t\t\t\t\t24."},{"issue":"7","key":"i1547-3317-57-6-278-b22","series-title":"Biochim Biophys Acta","first-page":"1541","article-title":"The \u03b12\u03b4subunits of voltage-gated calcium channels","volume":"1828","year":"2013","unstructured":"Dolphin\n AC.\n \n \n The \u03b12\u03b4subunits of voltage-gated calcium channels.\n\t\t\t\t\tBiochim Biophys Acta2013;\n\t\t\t\t\t1828(\n\t\t\t\t\t7):\n\t\t\t\t\t1541\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-57-6-278-b23","series-title":"Syst Rev","first-page":"25","article-title":"Risk of heart failure and edema associated with the use of pregabalin: a systematic review","volume":"2","year":"2013","unstructured":"Ho\n JM,\n \n \n Tricco\n AC,\n \n \n Perrier\n L,\n \n \n .\n\t\t\t\t\tRisk of heart failure and edema associated with the use of pregabalin: a systematic review.\n\t\t\t\t\tSyst Rev2013;\n\t\t\t\t\t2:\n\t\t\t\t\t25."},{"issue":"2","key":"i1547-3317-57-6-278-b24","series-title":"SM Emerg Med Crit Care","first-page":"1006","article-title":"Pregabalin-induced heart failure: a new entity?","volume":"1","year":"2017","unstructured":"Lyu\n T,\n \n \n Wu\n H,\n \n \n Goh\n E.\n \n \n Pregabalin-induced heart failure: a new entity?\n \n SM Emerg Med Crit Care\n \n 2017;\n\t\t\t\t\t1(\n\t\t\t\t\t2):\n\t\t\t\t\t1006."},{"issue":"6","key":"i1547-3317-57-6-278-b25","series-title":"Circulation","first-page":"e32","article-title":"Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association","volume":"134","year":"2016","unstructured":"Page\n RL,\n II\n \n \n O\u2019Bryant\n CL,\n \n \n Cheng\n D,\n \n \n .\n\t\t\t\t\tDrugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association.\n\t\t\t\t\tCirculation2016;\n\t\t\t\t\t134(\n\t\t\t\t\t6):\n\t\t\t\t\te32\u2013\n\t\t\t\t\t69."},{"issue":"12","key":"i1547-3317-57-6-278-b26","series-title":"Drug Saf","first-page":"1325","article-title":"Gabapentin and pregabalin and risk of atrial fibrillation in the elderly: a population-based cohort study in an electronic prescription database","volume":"41","year":"2018","unstructured":"Ortiz de Landaluce\n L,\n \n \n Carbonell\n P,\n \n \n Asensio\n C,\n \n \n .\n\t\t\t\t\tGabapentin and pregabalin and risk of atrial fibrillation in the elderly: a population-based cohort study in an electronic prescription database.\n\t\t\t\t\tDrug Saf2018;\n\t\t\t\t\t41(\n\t\t\t\t\t12):\n\t\t\t\t\t1325\u2013\n\t\t\t\t\t31."},{"issue":"9","key":"i1547-3317-57-6-278-b27","series-title":"Am J Emerg Med","first-page":"2101.e1","article-title":"Complete atrioventricular block due to overdose of pregabalin","volume":"30","year":"2012","unstructured":"Aksakal\n E,\n \n \n Bakirci\n EM,\n \n \n Uzkeser\n M.\n \n \n Complete atrioventricular block due to overdose of pregabalin.\n\t\t\t\t\tAm J Emerg Med2012;\n\t\t\t\t\t30(\n\t\t\t\t\t9):\n\t\t\t\t\t2101.e1\u2013\n\t\t\t\t\t4."}],"container-title":["Journal of the American Animal Hospital 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