{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:17:45Z","timestamp":1763741865823,"version":"3.45.0"},"reference-count":18,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 9 yr old castrated male miniature schnauzer was diagnosed histopathologically with a mucosal histiocytic sarcoma of the urinary bladder apex, biopsied at the time of surgical cystotomy. Sequential adjuvant chemotherapy, including both lomustine (discontinued because of adverse effects) and then doxorubicin, were employed. A response to both agents was documented. Ultimately, a complete response was achieved following completion of the doxorubicin protocol. A complete response persisted 768 days following diagnosis at last follow-up. Histiocytic sarcoma of the urinary bladder remains a rare diagnosis in veterinary medicine. Only one previous case report is currently published. This case contrasts with the previous case report, which reported a survival of only 2 mo.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7100","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:27:49Z","timestamp":1652707669000},"page":"156-159","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged Survival Following Treatment of Histiocytic Sarcoma of the Canine Urinary Bladder"],"prefix":"10.5326","volume":"58","author":[{"given":"Steve","family":"Patten","sequence":"first","affiliation":[{"name":"From the Oncology Department (S.P.), Toronto Veterinary Emergency and Referral Hospital, Scarborough, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"From the Diagnostic Imaging Department (S.M.), Toronto Veterinary Emergency and Referral Hospital, Scarborough, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"issue":"1","key":"i1547-3317-58-3-156-b1","series-title":"ILAR J","first-page":"100","article-title":"Urinary bladder cancer in dogs, a naturally occurring model for cancer biology and drug development","volume":"55","year":"2014","unstructured":"Knapp\n              DW,\n            \n            \n              Ramos-Vara\n              JA,\n            \n            \n              Moore\n              GE,\n            \n          \n          .\n\t\t\t\t\tUrinary bladder cancer in dogs, a naturally occurring model for cancer biology and drug development.\n\t\t\t\t\tILAR J2014;\n\t\t\t\t\t55(\n\t\t\t\t\t1):\n\t\t\t\t\t100\u2013\n\t\t\t\t\t18."},{"issue":"2","key":"i1547-3317-58-3-156-b2","series-title":"J Comp Pathol","first-page":"113","article-title":"Pathology of canine bladder and urethral cancer and correlation with tumour progression and 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Tierheilkd","first-page":"565","article-title":"Primary malignant lymphoma of the urinary bladder in a dog: longterm remission following treatment with radiation and chemotherapy","volume":"150","year":"2008","unstructured":"Kessler\n              M,\n            \n            \n              Kandel-Tschiederer\n              B,\n            \n            \n              Pfleghaar\n              S,\n            \n          \n          .\n\t\t\t\t\tPrimary malignant lymphoma of the urinary bladder in a dog: longterm remission following treatment with radiation and chemotherapy.\n\t\t\t\t\tSchweiz Arch Tierheilkd2008;\n\t\t\t\t\t150(\n\t\t\t\t\t11):\n\t\t\t\t\t565\u2013\n\t\t\t\t\t9."},{"issue":"12","key":"i1547-3317-58-3-156-b10","series-title":"J Small Anim Pract","first-page":"665","article-title":"Histiocytic sarcoma of the urinary bladder in a dog","volume":"52","year":"2011","unstructured":"Amores-Fuster\n              I,\n            \n            \n              Elliott\n         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breed predisposition?","volume":"58","year":"2017","unstructured":"Lenz\n              JA,\n            \n            \n              Furrow\n              E,\n            \n            \n              Craig\n              LE,\n            \n          \n          .\n\t\t\t\t\tHistiocytic sarcoma in 14 miniature schnauzers - a new breed predisposition?J Small Anim Pract2017;\n\t\t\t\t\t58(\n\t\t\t\t\t8):\n\t\t\t\t\t461\u2013\n\t\t\t\t\t7."},{"issue":"1","key":"i1547-3317-58-3-156-b14","series-title":"Vet Radiol Ultrasound","first-page":"79","article-title":"Ultrasonographic findings related to prognosis in canine transitional cell carcinoma","volume":"55","year":"2014","unstructured":"Hanazono\n              K,\n            \n            \n              Fukumoto\n              S,\n            \n            \n              Endo\n              Y,\n            \n          \n          .\n\t\t\t\t\tUltrasonographic findings related to prognosis in canine transitional cell carcinoma.\n\t\t\t\t\tVet Radiol Ultrasound2014;\n\t\t\t\t\t55(\n\t\t\t\t\t1):\n\t\t\t\t\t79\u2013\n\t\t\t\t\t84."},{"issue":"1","key":"i1547-3317-58-3-156-b15","series-title":"J Vet Intern Med","first-page":"121","article-title":"CCNU for the treatment of dogs with histiocytic sarcoma","volume":"21","year":"2007","unstructured":"Skorupski\n              KA,\n            \n            \n              Clifford\n              CA,\n            \n            \n              Paoloni\n              MC,\n            \n          \n          .\n\t\t\t\t\tCCNU for the treatment of dogs with histiocytic sarcoma.\n\t\t\t\t\tJ Vet Intern Med2007;\n\t\t\t\t\t21(\n\t\t\t\t\t1):\n\t\t\t\t\t121\u2013\n\t\t\t\t\t6."},{"issue":"2","key":"i1547-3317-58-3-156-b16","series-title":"Vet Comp Oncol","first-page":"139","article-title":"Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy","volume":"7","year":"2009","unstructured":"Skorupski\n            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histiocytic sarcoma.\n\t\t\t\t\tJ Small Anim Pract2015;\n\t\t\t\t\t56(\n\t\t\t\t\t7):\n\t\t\t\t\t425\u2013\n\t\t\t\t\t9."},{"issue":"4","key":"i1547-3317-58-3-156-b18","series-title":"Vet Comp Oncol","first-page":"1171","article-title":"Clinical prognostic factors in canine histiocytic sarcoma","volume":"15","year":"2017","unstructured":"Dervisis\n              NG,\n            \n            \n              Kiupel\n              M,\n            \n            \n              Qin\n              Q,\n            \n          \n          .\n\t\t\t\t\tClinical prognostic factors in canine histiocytic sarcoma.\n\t\t\t\t\tVet Comp Oncol2017;\n\t\t\t\t\t15(\n\t\t\t\t\t4):\n\t\t\t\t\t1171\u2013\n\t\t\t\t\t80."}],"container-title":["Journal of the American Animal Hospital 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