{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:17:38Z","timestamp":1763741858037,"version":"3.45.0"},"reference-count":29,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"ABSTRACT<\/jats:title>\n A 10 yr old female spayed Pomeranian presented with a history of dyspnea and coughing and was diagnosed with a cranial mediastinal mass presumed to be a thymoma. Surgical removal was elected and occurred without intraoperative complications. Histopathology revealed the lesion to be a cholesterol granuloma. The patient developed a brief period of increased respiratory difficulty 3 days postoperatively. Thoracic radiographs showed mild pleural effusion and the patient improved with supportive care. Five months postoperatively, repeat thoracic radiographs revealed no evidence of recurrence or respiratory pathology. This case report describes a cholesterol granuloma in a unique location and reviews the pathogenesis\/pathophysiology of this type of mass.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7186","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:27:23Z","timestamp":1652707643000},"page":"129-136","source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol Granuloma of the Cranial Mediastinum in a Dog"],"prefix":"10.5326","volume":"58","author":[{"given":"Anastacia Marie","family":"Davis","sequence":"first","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Lahmers","sequence":"additional","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brie","family":"Trusiano","sequence":"additional","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Romeiser","sequence":"additional","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Tuohy","sequence":"additional","affiliation":[{"name":"From the Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-58-3-129-b1","series-title":"J Small Anim Pract","first-page":"25","article-title":"Aural cholesterol granuloma in a dog","volume":"36","year":"1995","unstructured":"Cox\n CL\n \n \n Payne-Johnson\n CE.\n \n \n Aural cholesterol granuloma in a dog.\n\t\t\t\t\tJ Small Anim Pract1995;\n\t\t\t\t\t36:\n\t\t\t\t\t25\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-3-129-b2","series-title":"Ann Otol Rhinol Laryngol","first-page":"79","article-title":"Clinicopathological consultation. Ear cholesteatoma versus cholesterol granuloma","volume":"106","year":"1997","unstructured":"Ferlito\n A,\n \n \n Devaney\n KO,\n \n \n Rinaldo\n A,\n \n \n .\n\t\t\t\t\tClinicopathological consultation. 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Invest2013;\n\t\t\t\t\t25:\n\t\t\t\t\t515\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-3-129-b5","series-title":"Vet Radiol Ultrasound","first-page":"650","article-title":"Imaging diagnosis-MRI characteristics of a fourth ventricular cholesterol granuloma in a dog","volume":"53","year":"2012","unstructured":"Lovett\n MC,\n \n \n Fenner\n WR,\n \n \n Watson\n AT,\n \n \n .\n\t\t\t\t\tImaging diagnosis-MRI characteristics of a fourth ventricular cholesterol granuloma in a dog.\n\t\t\t\t\tVet Radiol Ultrasound2012;\n\t\t\t\t\t53:\n\t\t\t\t\t650\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-3-129-b6","series-title":"Can Vet J","first-page":"72","article-title":"Cholesterol granuloma associated with otitis media and leptomeningitis in a cat due to a Streptococcus canis infection","volume":"54","year":"2013","unstructured":"Van der Heyden\n S,\n \n \n Butaye\n P,\n \n \n Roels\n S.\n \n \n Cholesterol granuloma associated with otitis media and leptomeningitis in a cat due to a Streptococcus 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imaging findings.\n\t\t\t\t\tJ Thorac Oncol2007;\n\t\t\t\t\t2:\n\t\t\t\t\t1054\u2013\n\t\t\t\t\t6."},{"key":"i1547-3317-58-3-129-b11","series-title":"Pathol Int","first-page":"356","article-title":"Cholesteroloma: a rare thymic pseudotumor","volume":"66","year":"2016","unstructured":"Ghigna\n MR,\n \n \n Dorfmuller\n P,\n \n \n Fadel\n E,\n \n \n .\n\t\t\t\t\tCholesteroloma: a rare thymic pseudotumor.\n\t\t\t\t\tPathol Int2016;\n\t\t\t\t\t66:\n\t\t\t\t\t356\u2013\n\t\t\t\t\t7."},{"key":"i1547-3317-58-3-129-b12","series-title":"J Jpn Assoc Chest Surg","first-page":"58","article-title":"A case of cholesterol granuloma in the thymus","year":"2017","unstructured":"Kawai\n T,\n \n \n Uehara\n H,\n \n \n Matsutani\n N,\n \n \n .\n\t\t\t\t\tA case of cholesterol granuloma in the thymus.\n\t\t\t\t\tJ Jpn Assoc Chest Surg2017:\n\t\t\t\t\t58\u2013\n\t\t\t\t\t62."},{"key":"i1547-3317-58-3-129-b13","series-title":"J Jpn Assoc Chest Surg","first-page":"99","article-title":"A resected case of 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Surg","first-page":"101","article-title":"A case report of cholesterol granuloma in the mediastinal region","year":"2008","unstructured":"Shindo\n K\n \n \n Kato\n M.\n \n \n A case report of cholesterol granuloma in the mediastinal region.\n\t\t\t\t\tJ Jpn Assoc Chest Surg2008:\n\t\t\t\t\t101\u2013\n\t\t\t\t\t5."},{"key":"i1547-3317-58-3-129-b19","series-title":"Virchows Arch","first-page":"609","article-title":"Primary thymic cholesteroloma: a clinicopathological correlation of four cases of an unusual benign lesion","volume":"467","year":"2015","unstructured":"Weissferdt\n A,\n \n \n Kalhor\n N,\n \n \n Moran\n C.\n \n \n Primary thymic cholesteroloma: a clinicopathological correlation of four cases of an unusual benign lesion.\n\t\t\t\t\tVirchows Arch2015;\n\t\t\t\t\t467:\n\t\t\t\t\t609\u2013\n\t\t\t\t\t11."},{"year":"2014","series-title":"Piermattei\u2019s atlas of surgical approaches to the bones and joints of the dog and cat.","key":"i1547-3317-58-3-129-b20","unstructured":"Johnson\n KA,\n \n \n ed.\n \n Piermattei\u2019s atlas of surgical approaches to the bones and joints of the dog and cat.\n \n 5th ed.\n\t\t\t\t\tSt. Louis:\n\t\t\t\t\tElsevier;\n\t\t\t\t\t2014."},{"key":"i1547-3317-58-3-129-b21","series-title":"Vet Pathol","first-page":"547","article-title":"Cholesterol granuloma associated with otitis media and destruction of the tympanic bulla in a dog","volume":"44","year":"2007","unstructured":"Fliegner\n RA,\n \n \n Jubb\n KV,\n \n \n Lording\n PM.\n \n \n Cholesterol granuloma associated with otitis media and destruction of the tympanic bulla in a dog.\n\t\t\t\t\tVet Pathol2007;\n\t\t\t\t\t44:\n\t\t\t\t\t547\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-58-3-129-b22","series-title":"J Vet Intern Med","first-page":"1241","article-title":"Cerebral cholesterol granuloma in a cat","volume":"20","year":"2006","unstructured":"Fluehmann\n G,\n \n \n Konar\n M,\n \n \n Jaggy\n A,\n \n \n 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Otolaryngol2017;\n\t\t\t\t\t2017:\n\t\t\t\t\t4793786."},{"key":"i1547-3317-58-3-129-b25","series-title":"J Small Anim Pract","first-page":"188","article-title":"Cholesterol granuloma as long-term complication of total ear canal ablation in a dog","volume":"53","year":"2012","unstructured":"Riedinger\n B,\n \n \n Albaric\n O,\n \n \n Gauthier\n O.\n \n \n Cholesterol granuloma as long-term complication of total ear canal ablation in a dog.\n\t\t\t\t\tJ Small Anim Pract2012;\n\t\t\t\t\t53:\n\t\t\t\t\t188\u2013\n\t\t\t\t\t191."},{"key":"i1547-3317-58-3-129-b26","series-title":"Laryngoscope","first-page":"2037","article-title":"Otitis media with perforation of the tympanic membrane: a longitudinal experimental study","volume":"90","year":"1980","unstructured":"Goycoolea\n MV,\n \n \n Paparella\n MM,\n \n \n Juhn\n SK,\n \n \n .\n\t\t\t\t\tOtitis media with perforation of the tympanic membrane: a longitudinal experimental study.\n\t\t\t\t\tLaryngoscope1980;\n\t\t\t\t\t90:\n\t\t\t\t\t2037\u2013\n\t\t\t\t\t45."},{"key":"i1547-3317-58-3-129-b27","series-title":"J Laryngol Otol","first-page":"491","article-title":"Experimental cholesterol granuloma. Histopathological and histochemical studies","volume":"96","year":"1982","unstructured":"Hiraide\n F,\n \n \n Inouye\n T,\n \n \n Miyakogawa\n N.\n \n \n Experimental cholesterol granuloma. Histopathological and histochemical studies.\n\t\t\t\t\tJ Laryngol Otol1982;\n\t\t\t\t\t96:\n\t\t\t\t\t491\u2013\n\t\t\t\t\t501."},{"key":"i1547-3317-58-3-129-b28","series-title":"Acta Otolaryngol","first-page":"444","article-title":"Experimental evidence suggestive of early intervention in mucoid otitis media","volume":"129","year":"2009","unstructured":"Hueb\n MM\n \n \n Goycoolea\n MV.\n \n \n Experimental evidence suggestive of early intervention in mucoid otitis media.\n\t\t\t\t\tActa Otolaryngol2009;\n\t\t\t\t\t129:\n\t\t\t\t\t444\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-3-129-b29","series-title":"Am J Primatol","first-page":"349","article-title":"Xanthogranuloma of the choroid plexus in the fat tailed dwarf lemur (Cheirogaleus medius)","volume":"38","year":"1996","unstructured":"Lee\n JT,\n \n \n Miller\n CA,\n \n \n McDonald\n CT,\n \n \n .\n\t\t\t\t\tXanthogranuloma of the choroid plexus in the fat tailed dwarf lemur (Cheirogaleus medius).\n\t\t\t\t\tAm J Primatol1996;\n\t\t\t\t\t38:\n\t\t\t\t\t349\u2013\n\t\t\t\t\t55."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/58\/3\/article-p129.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/58\/3\/129\/3064335\/i1547-3317-58-3-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/58\/3\/article-p129.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/58\/3\/article-p129.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:05:40Z","timestamp":1763741140000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/58\/3\/article-p129.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":29,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-7186","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"type":"electronic","value":"1547-3317"},{"type":"print","value":"0587-2871"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}