{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:13:24Z","timestamp":1784632404692,"version":"3.55.0"},"reference-count":21,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA) has been uncommonly reported in dogs and is often associated with brachycephalic obstructive airway syndrome (BOAS). OSA independent from BOAS has been rarely reported. Treatment of OSA with ondansetron has only been reported in one dog and has not been reported in a breed commonly affected by BOAS. Here, we report the case of a pug with episodes of OSA despite appropriate treatment of BOAS. Administration of ondansetron led to a rapid and near-complete resolution of the clinical signs, with a follow-up of 3 mo. OSA independent of BOAS should be considered as a differential diagnosis in dogs that present for sleep-disordered breathing without exercise intolerance after appropriate treatment for BOAS. Use of certain serotonin antagonists may be useful as a treatment option for these cases.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7190","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:27:49Z","timestamp":1652707669000},"page":"152-155","source":"Crossref","is-referenced-by-count":4,"title":["Suspected Obstructive Sleep Apnea Successfully Treated with Ondansetron in a Pug"],"prefix":"10.5326","volume":"58","author":[{"given":"Erika","family":"Villedieu","sequence":"first","affiliation":[{"name":"From the Department of Soft Tissue Surgery, Willows Veterinary Centre and Referral Service, Solihull, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Robinson","sequence":"additional","affiliation":[{"name":"From the Department of Soft Tissue Surgery, Willows Veterinary Centre and Referral Service, Solihull, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Shales","sequence":"additional","affiliation":[{"name":"From the Department of Soft Tissue Surgery, Willows Veterinary Centre and Referral Service, Solihull, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"4","key":"i1547-3317-58-3-152-b1","series-title":"J Appl Physiol","first-page":"1344","article-title":"The English bulldog: a natural model of sleep-disordered breathing","volume":"63","year":"1987","unstructured":"Hendricks\n              JC,\n            \n            \n              Kline\n              LR,\n            \n            \n              Kovalski\n              RJ,\n            \n          \n          .\n\t\t\t\t\tThe English bulldog: a natural model of sleep-disordered breathing.\n\t\t\t\t\tJ Appl Physiol1987;\n\t\t\t\t\t63(\n\t\t\t\t\t4):\n\t\t\t\t\t1344\u2013\n\t\t\t\t\t50."},{"key":"i1547-3317-58-3-152-b2","series-title":"Am J Respir Crit Care Med","first-page":"1659","article-title":"The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog","volume":"160","year":"1999","unstructured":"Veasey\n              SC,\n            \n            \n              Fenik\n              P,\n            \n            \n              Panckeri\n              K,\n            \n          \n          .\n\t\t\t\t\tThe effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog.\n\t\t\t\t\tAm J Respir Crit Care Med1999;\n\t\t\t\t\t160:\n\t\t\t\t\t1659\u2013\n\t\t\t\t\t67."},{"issue":"2","key":"i1547-3317-58-3-152-b3","series-title":"Sleep","first-page":"155","article-title":"The effects of ondansetron on sleep-disordered breathing in the English bulldog","volume":"24","year":"2001","unstructured":"Veasey\n              SC,\n            \n            \n              Chachkes\n              J,\n            \n            \n              Fenik\n              P,\n            \n          \n          .\n\t\t\t\t\tThe effects of ondansetron on sleep-disordered breathing in the English bulldog.\n\t\t\t\t\tSleep2001;\n\t\t\t\t\t24(\n\t\t\t\t\t2):\n\t\t\t\t\t155\u2013\n\t\t\t\t\t60."},{"issue":"3","key":"i1547-3317-58-3-152-b4","series-title":"Chest","first-page":"767","article-title":"Upper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea","volume":"106","year":"1994","unstructured":"Okabe\n              S,\n            \n            \n              Hida\n              W,\n            \n            \n              Kikuchi\n              Y,\n            \n          \n          .\n\t\t\t\t\tUpper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea.\n\t\t\t\t\tChest1994;\n\t\t\t\t\t106(\n\t\t\t\t\t3):\n\t\t\t\t\t767\u2013\n\t\t\t\t\t73."},{"issue":"6","key":"i1547-3317-58-3-152-b5","series-title":"Am J Respir Crit Care Med","first-page":"1880","article-title":"Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls","volume":"153","year":"1996","unstructured":"Mezzanotte\n              WS,\n            \n            \n              Tangel\n              DJ,\n            \n            \n              White\n              DP.\n            \n          \n          Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls.\n\t\t\t\t\tAm J Respir Crit Care Med1996;\n\t\t\t\t\t153(\n\t\t\t\t\t6):\n\t\t\t\t\t1880\u2013\n\t\t\t\t\t7."},{"issue":"2","key":"i1547-3317-58-3-152-b6","series-title":"Am J Respir Crit Care Med","first-page":"776","article-title":"The effects of serotonin antagonists in an animal model of sleep-disordered","volume":"153","year":"1996","unstructured":"Veasey\n              SC,\n            \n            \n              Veasey\n              SC,\n            \n            \n              Panckeri\n              KA,\n            \n          \n          .\n\t\t\t\t\tThe effects of serotonin antagonists in an animal model of sleep-disordered.\n\t\t\t\t\tAm J Respir Crit Care Med1996;\n\t\t\t\t\t153(\n\t\t\t\t\t2):\n\t\t\t\t\t776\u2013\n\t\t\t\t\t86."},{"issue":"2","key":"i1547-3317-58-3-152-b7","series-title":"Sleep","first-page":"131","article-title":"Serotonin 5-HT3-receptor antagonist GR 38032F suppresses leep apneas in rats","volume":"21","year":"1998","unstructured":"Radulovacki\n              M,\n            \n            \n              Trbovic\n              SM,\n            \n            \n              Carley\n              DW.\n            \n          \n          Serotonin 5-HT3-receptor antagonist GR 38032F suppresses leep apneas in rats.\n\t\t\t\t\tSleep1998;\n\t\t\t\t\t21(\n\t\t\t\t\t2):\n\t\t\t\t\t131\u2013\n\t\t\t\t\t6."},{"issue":"12","key":"i1547-3317-58-3-152-b8","series-title":"Am J Respir Crit Care Med","first-page":"1824","article-title":"Mirtazapine, a mixed-profile serotonin agonist\/antagonist, suppresses sleep apnea in the rat","volume":"160","year":"1999","unstructured":"Carley\n              DW\n            \n            \n              Radulovacki\n              M.\n            \n          \n          Mirtazapine, a mixed-profile serotonin agonist\/antagonist, suppresses sleep apnea in the rat.\n\t\t\t\t\tAm J Respir Crit Care Med1999;\n\t\t\t\t\t160(\n\t\t\t\t\t12):\n\t\t\t\t\t1824\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-58-3-152-b9","series-title":"Am J Respir Med","first-page":"21","article-title":"Serotonin agonists and antagonists in obstructive sleep apnea","volume":"2","year":"2003","unstructured":"Veasey\n              SC.\n            \n          \n          Serotonin agonists and antagonists in obstructive sleep apnea.\n\t\t\t\t\tAm J Respir Med2003;\n\t\t\t\t\t2:\n\t\t\t\t\t21\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-58-3-152-b10","series-title":"Clin Case Rep","first-page":"872","article-title":"Obstructive sleep apnea in a Chihuahua successfully managed with ondansetron","volume":"7","year":"2019","unstructured":"Kopke\n              MA,\n            \n            \n              Wightman\n              P,\n            \n            \n              Ruaux\n              CG.\n            \n          \n          Obstructive sleep apnea in a Chihuahua successfully managed with ondansetron.\n\t\t\t\t\tClin Case Rep2019;\n\t\t\t\t\t7:\n\t\t\t\t\t872\u2013\n\t\t\t\t\t6."},{"key":"i1547-3317-58-3-152-b11","series-title":"J Small Anim Pract","first-page":"137","article-title":"Long-term results of upper respiratory syndrome surgery and gastrointestinal tract medical treatment in 51 brachycephalic dogs","volume":"47","year":"2006","unstructured":"Poncet\n              CM,\n            \n            \n              Dupre\n              GP,\n            \n            \n              Freiche\n              VG,\n            \n          \n          .\n\t\t\t\t\tLong-term results of upper respiratory syndrome surgery and gastrointestinal tract medical treatment in 51 brachycephalic dogs.\n\t\t\t\t\tJ Small Anim Pract2006;\n\t\t\t\t\t47:\n\t\t\t\t\t137\u2013\n\t\t\t\t\t42."},{"key":"i1547-3317-58-3-152-b12","series-title":"Vet Surg","first-page":"488","article-title":"Validation of exercise testing and laryngeal auscultation for grading brachycephalic obstructive airway syndrome in pugs, French bulldogs, and English bulldogs by using whole-body barometric plethysmography","volume":"48","year":"2019","unstructured":"Riggs\n              J,\n            \n            \n              Liu\n              N,\n            \n            \n              Sutton\n              DR,\n            \n          \n          .\n\t\t\t\t\tValidation of exercise testing and laryngeal auscultation for grading brachycephalic obstructive airway syndrome in pugs, French bulldogs, and English bulldogs by using whole-body barometric plethysmography.\n\t\t\t\t\tVet Surg2019;\n\t\t\t\t\t48:\n\t\t\t\t\t488\u2013\n\t\t\t\t\t96."},{"issue":"2","key":"i1547-3317-58-3-152-b13","series-title":"Vet Surg","first-page":"165","article-title":"A novel approach to brachycephalic syndrome. 1. Evaluation of anatomical intranasal airway obstruction","volume":"45","year":"2016","unstructured":"Oechtering\n              GU,\n            \n            \n              Pohl\n              S,\n            \n            \n              Schlueter\n              C,\n            \n          \n          .\n\t\t\t\t\tA novel approach to brachycephalic syndrome. 1. Evaluation of anatomical intranasal airway obstruction.\n\t\t\t\t\tVet Surg2016;\n\t\t\t\t\t45(\n\t\t\t\t\t2):\n\t\t\t\t\t165\u2013\n\t\t\t\t\t72."},{"issue":"2","key":"i1547-3317-58-3-152-b14","series-title":"Vet Surg","first-page":"173","article-title":"A novel approach to brachycephalic syndrome. 2. Laser-assisted turbinectomy (LATE)","volume":"45","year":"2016","unstructured":"Oechtering\n              GU,\n            \n            \n              Pohl\n              S,\n            \n            \n              Schlueter\n              C,\n            \n          \n          .\n\t\t\t\t\tA novel approach to brachycephalic syndrome. 2. Laser-assisted turbinectomy (LATE).\n\t\t\t\t\tVet Surg2016;\n\t\t\t\t\t45(\n\t\t\t\t\t2):\n\t\t\t\t\t173\u2013\n\t\t\t\t\t81."},{"key":"i1547-3317-58-3-152-b15","series-title":"Vet Radiol","first-page":"497","article-title":"Sleep-disordered breathing in the Cavalier King Charles spaniel: a case series","volume":"48","year":"2019","unstructured":"Hinchliffe\n              TA,\n            \n            \n              Liu\n              N,\n            \n            \n              Ladlow\n              J.\n            \n          \n          Sleep-disordered breathing in the Cavalier King Charles spaniel: a case series.\n\t\t\t\t\tVet Radiol2019;\n\t\t\t\t\t48:\n\t\t\t\t\t497\u2013\n\t\t\t\t\t504."},{"key":"i1547-3317-58-3-152-b16","series-title":"The international classification of sleep disorders\u2013diagnostic and coding manual.","year":"2005","unstructured":"American Academy of Sleep Medicine.\n          \n          \n            The international classification of sleep disorders\u2013diagnostic and coding manual.\n          2nd ed.\n\t\t\t\t\tWestchester (IL):\n\t\t\t\t\tAmerican Academy of Sleep Medicine;\n\t\t\t\t\t2005."},{"key":"i1547-3317-58-3-152-b17","series-title":"Sleep Disord","first-page":"798487","article-title":"Complex sleep apnea syndrome","volume":"2014","year":"2014","unstructured":"Khan\n              M\n            \n            \n              Franco\n              R.\n            \n          \n          Complex sleep apnea syndrome.\n\t\t\t\t\tSleep Disord2014;\n\t\t\t\t\t2014:\n\t\t\t\t\t798487."},{"key":"i1547-3317-58-3-152-b18","series-title":"J Vet Intern Med","first-page":"815","article-title":"Signalment, clinical presentation, concurrent diseases, and diagnostic findings in 28 dogs with dynamic pharyngeal collapse (2008\u20132013)","volume":"29","year":"2015","unstructured":"Rubin\n              JA,\n            \n            \n              Holt\n              DE,\n            \n            \n              Reetz\n              JA,\n            \n          \n          .\n\t\t\t\t\tSignalment, clinical presentation, concurrent diseases, and diagnostic findings in 28 dogs with dynamic pharyngeal collapse (2008\u20132013).\n\t\t\t\t\tJ Vet Intern Med2015;\n\t\t\t\t\t29:\n\t\t\t\t\t815\u2013\n\t\t\t\t\t21."},{"issue":"7","key":"i1547-3317-58-3-152-b19","series-title":"Sleep","first-page":"982","article-title":"Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome","volume":"33","year":"2010","unstructured":"Prasad\n              B,\n            \n            \n              Radulovacki\n              M,\n            \n            \n              Olopade\n              C,\n            \n          \n          .\n\t\t\t\t\tProspective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome.\n\t\t\t\t\tSleep2010;\n\t\t\t\t\t33(\n\t\t\t\t\t7):\n\t\t\t\t\t982\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-58-3-152-b20","series-title":"Vet Radiol Ultrasound","first-page":"529","article-title":"The prevalence of dynamic pharyngeal collapse is high in brachycephalic dogs undergoing videofluoroscopy","volume":"59","year":"2018","unstructured":"Pollard\n              RE,\n            \n            \n              Johnson\n              LR,\n            \n            \n              Marks\n              SL.\n            \n          \n          The prevalence of dynamic pharyngeal collapse is high in brachycephalic dogs undergoing videofluoroscopy.\n\t\t\t\t\tVet Radiol Ultrasound2018;\n\t\t\t\t\t59:\n\t\t\t\t\t529\u2013\n\t\t\t\t\t34."},{"issue":"1","key":"i1547-3317-58-3-152-b21","series-title":"J Vet Med Sci","first-page":"64","article-title":"Pharyngeal contraction secondary to its collapse in dogs with brachycephalic airway syndrome","volume":"82","year":"2020","unstructured":"Hara\n              Y,\n            \n            \n              Teshima\n              K,\n            \n            \n              Seki\n              M,\n            \n          \n          .\n\t\t\t\t\tPharyngeal contraction secondary to its collapse in dogs with brachycephalic airway syndrome.\n\t\t\t\t\tJ Vet Med Sci2020;\n\t\t\t\t\t82(\n\t\t\t\t\t1):\n\t\t\t\t\t64\u2013\n\t\t\t\t\t7."}],"container-title":["Journal of the American Animal Hospital 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