{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:17:56Z","timestamp":1763741876504,"version":"3.45.0"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acquired cardiomyopathies have been described in human patients with hypoadrenocorticism. Several mechanisms have been described to explain the cardiac effects of primary adrenal insufficiency, but, clinically, these manifestations may be underappreciated in dogs. In humans, there is an infrequently described, reversible dilated cardiomyopathy in patients with hypoadrenocorticism. Two dogs were presented to a single referral center for evaluation of weakness or collapse and were subsequently diagnosed with hypoadrenocorticism after a full diagnostic workup. Following the diagnosis of hypoadrenocorticism and administration of glucocorticoids and desoxycorticosterone pivalate, both dogs developed left-sided congestive heart failure and had systolic dysfunction diagnosed by echocardiogram. Both dogs were euthanized; one because of recurrent congestive heart failure and another because of a concern for poor long-term prognosis and decreased quality of life. The purpose of this case report is to document multiple cases of hypoadrenocorticism-associated systolic dysfunction and subsequent cardiogenic pulmonary edema in dogs.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7223","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T14:16:07Z","timestamp":1667225767000},"page":"297-302","source":"Crossref","is-referenced-by-count":1,"title":["Acquired Systolic Dysfunction and Subsequent Congestive Heart Failure Following Treatment of Hypoadrenocorticism in Two Dogs"],"prefix":"10.5326","volume":"58","author":[{"given":"Lindsey","family":"Jett","sequence":"first","affiliation":[{"name":"From Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, Pennsylvania (L.J., S.M.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaina","family":"Mooshian","sequence":"additional","affiliation":[{"name":"From Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, Pennsylvania (L.J., S.M.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Anderson","sequence":"additional","affiliation":[{"name":"Pittsburgh Veterinary Cardiology, Pittsburgh, Pennsylvania (E.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-58-6-297-b1","series-title":"Textbook of veterinary internal medicine.","first-page":"1488","article-title":"Hypoadrenocorticism","year":"2000","unstructured":"Reusch\n              CE.\n            \n          \n          Hypoadrenocorticism.\n\t\t\t\t\tIn:EttingerSJ,FeldmanEC,eds.Textbook of veterinary internal medicine.5th ed.\n\t\t\t\t\tPhiladelphia:\n\t\t\t\t\tWB Saunders;\n\t\t\t\t\t2000:\n\t\t\t\t\t1488\u2013\n\t\t\t\t\t99."},{"key":"i1547-3317-58-6-297-b2","series-title":"J Am Vet Med Assoc","first-page":"85","article-title":"Pretreatment clinical and laboratory findings in 225 dogs with hypoadrenocorticism","volume":"208","year":"1996","unstructured":"Peterson\n              ME,\n            \n            \n              Kintzer\n              PP,\n            \n            \n              Kass\n              PH.\n            \n          \n          Pretreatment clinical and laboratory findings in 225 dogs with hypoadrenocorticism.\n\t\t\t\t\tJ Am Vet Med Assoc1996;\n\t\t\t\t\t208:\n\t\t\t\t\t85\u2013\n\t\t\t\t\t91."},{"key":"i1547-3317-58-6-297-b3","series-title":"Rev Cardiovasc Med","first-page":"131","article-title":"Cardiac manifestations of adrenal insufficiency","volume":"17","year":"2016","unstructured":"Schumaecker\n              MM,\n            \n            \n              Larsen\n              TR,\n            \n            \n              Sane\n              DC.\n            \n          \n          Cardiac manifestations of adrenal insufficiency.\n\t\t\t\t\tRev Cardiovasc Med2016;\n\t\t\t\t\t17:\n\t\t\t\t\t131\u2013\n\t\t\t\t\t6."},{"key":"i1547-3317-58-6-297-b4","series-title":"J Pediatr Endocrinol Metab","first-page":"1191","article-title":"Reversible cardiomyopathy in paediatric Addison\u2019s disease\u2013a cautionary tale","volume":"16","year":"2003","unstructured":"Conwell\n              LS,\n            \n            \n              Gray\n              LM,\n            \n            \n              Delbridge\n              RG,\n            \n          \n          .\n\t\t\t\t\tReversible cardiomyopathy in paediatric Addison\u2019s disease\u2013a cautionary tale.\n\t\t\t\t\tJ Pediatr Endocrinol Metab2003;\n\t\t\t\t\t16:\n\t\t\t\t\t1191\u2013\n\t\t\t\t\t5."},{"key":"i1547-3317-58-6-297-b5","series-title":"Int J Cardiol","first-page":"e71","article-title":"Acute reversible cardiomyopathy with cardiogenic shock in a patient with Addisonian crisis: a case report","volume":"116","year":"2007","unstructured":"Wolff\n              B,\n            \n            \n              Machill\n              K,\n            \n            \n              Schulzki\n              I,\n            \n          \n          .\n\t\t\t\t\tAcute reversible cardiomyopathy with cardiogenic shock in a patient with Addisonian crisis: a case report.\n\t\t\t\t\tInt J Cardiol2007;\n\t\t\t\t\t116:\n\t\t\t\t\te71\u2013\n\t\t\t\t\t3."},{"key":"i1547-3317-58-6-297-b6","series-title":"ASAIO J","first-page":"668","article-title":"A crisis of the heart: an acute reversible cardiomyopathy bridged to recovery in a patient with Addison\u2019s disease","volume":"59","year":"2013","unstructured":"Krishnamoorthy\n              A,\n            \n            \n              Mentz\n              RJ,\n            \n            \n              Hyland\n              KA,\n            \n          \n          .\n\t\t\t\t\tA crisis of the heart: an acute reversible cardiomyopathy bridged to recovery in a patient with Addison\u2019s disease.\n\t\t\t\t\tASAIO J2013;\n\t\t\t\t\t59:\n\t\t\t\t\t668\u2013\n\t\t\t\t\t70."},{"key":"i1547-3317-58-6-297-b7","series-title":"Case Rep Cardiol","first-page":"4362514","article-title":"Addison\u2019s disease and dilated cardiomyopathy: a case report and a review of the literature","volume":"2016","year":"2016","unstructured":"Mozolevska\n              V,\n            \n            \n              Schwartz\n              A,\n            \n            \n              Cheung\n              D,\n            \n          \n          .\n\t\t\t\t\tAddison\u2019s disease and dilated cardiomyopathy: a case report and a review of the literature.\n\t\t\t\t\tCase Rep Cardiol2016;\n\t\t\t\t\t2016:\n\t\t\t\t\t4362514."},{"key":"i1547-3317-58-6-297-b8","series-title":"Eur J Endocrinol","first-page":"425","article-title":"Regression of cardiac abnormalities after replacement therapy in Addison\u2019s disease","volume":"140","year":"1999","unstructured":"Fallo\n              F,\n            \n            \n              Betterle\n              C,\n            \n            \n              Budano\n              S,\n            \n          \n          .\n\t\t\t\t\tRegression of cardiac abnormalities after replacement therapy in Addison\u2019s disease.\n\t\t\t\t\tEur J Endocrinol1999;\n\t\t\t\t\t140:\n\t\t\t\t\t425\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-6-297-b9","series-title":"J Am Vet Med Assoc","first-page":"1732","article-title":"Prevalence of attenuated wavy fibers in the myocardium of dogs with dilated cardiomyopathy","volume":"212","year":"1998","unstructured":"Tidholm\n              A,\n            \n            \n              H\u00e4ggstr\u00f6m\n              J,\n            \n            \n              J\u00f6nsson\n              L.\n            \n          \n          Prevalence of attenuated wavy fibers in the myocardium of dogs with dilated cardiomyopathy.\n\t\t\t\t\tJ Am Vet Med Assoc1998;\n\t\t\t\t\t212:\n\t\t\t\t\t1732\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-6-297-b10","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1035","article-title":"The role of noncardiac disease in the development and precipitation of heart failure","volume":"21","year":"1991","unstructured":"Atkins\n              CE.\n            \n          \n          The role of noncardiac disease in the development and precipitation of heart failure.\n\t\t\t\t\tVet Clin North Am Small Anim Pract1991;\n\t\t\t\t\t21:\n\t\t\t\t\t1035\u2013\n\t\t\t\t\t80."},{"key":"i1547-3317-58-6-297-b11","series-title":"J Am Vet Med Assoc","first-page":"1390","article-title":"Diet-associated dilated cardiomyopathy in dogs: what do we know?","volume":"253","year":"2018","unstructured":"Freeman\n              LM,\n            \n            \n              Stern\n              JA,\n            \n            \n              Fries\n              R,\n            \n          \n          .\n\t\t\t\t\tDiet-associated dilated cardiomyopathy in dogs: what do we know?J Am Vet Med Assoc2018;\n\t\t\t\t\t253:\n\t\t\t\t\t1390\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-6-297-b12","series-title":"J Am Anim Hosp Assoc","first-page":"378","article-title":"Cardiogenic pulmonary edema in a dog following initiation of therapy for concurrent hypoadrenocorticism and hypothyroidism","volume":"52","year":"2016","unstructured":"Piak\n              J,\n            \n            \n              Kang\n              JH,\n            \n            \n              Chang\n              D,\n            \n          \n          .\n\t\t\t\t\tCardiogenic pulmonary edema in a dog following initiation of therapy for concurrent hypoadrenocorticism and hypothyroidism.\n\t\t\t\t\tJ Am Anim Hosp Assoc2016;\n\t\t\t\t\t52:\n\t\t\t\t\t378\u2013\n\t\t\t\t\t84."},{"key":"i1547-3317-58-6-297-b13","series-title":"Can Vet J","first-page":"828","article-title":"Improvement in myocardial dysfunction in a hypothyroid dog","volume":"50","year":"2009","unstructured":"Flood\n              J\n            \n            \n              Hoover\n              J.\n            \n          \n          Improvement in myocardial dysfunction in a hypothyroid dog.\n\t\t\t\t\tCan Vet J2009;\n\t\t\t\t\t50:\n\t\t\t\t\t828\u2013\n\t\t\t\t\t34."},{"key":"i1547-3317-58-6-297-b14","series-title":"Intensive Care Med","first-page":"138","article-title":"Hemodynamic changes in acute adrenal insufficiency","volume":"20","year":"1994","unstructured":"Bouachour\n              G,\n            \n            \n              Tirot\n              P,\n            \n            \n              Varache\n              N,\n            \n          \n          .\n\t\t\t\t\tHemodynamic changes in acute adrenal insufficiency.\n\t\t\t\t\tIntensive Care Med1994;\n\t\t\t\t\t20:\n\t\t\t\t\t138\u2013\n\t\t\t\t\t41."},{"key":"i1547-3317-58-6-297-b15","series-title":"Perspect Biol Med","first-page":"135","article-title":"Cardiovascular failure in experimental adrenal insufficiency: a historical revival","volume":"27","year":"1983","unstructured":"Cleghorn\n              RA.\n            \n          \n          Cardiovascular failure in experimental adrenal insufficiency: a historical revival.\n\t\t\t\t\tPerspect Biol Med1983;\n\t\t\t\t\t27:\n\t\t\t\t\t135\u2013\n\t\t\t\t\t55."},{"key":"i1547-3317-58-6-297-b16","series-title":"J Paediatr Child Health","first-page":"280","article-title":"Fludrocortisone induced heart failure in Addison\u2019s disease","volume":"30","year":"1994","unstructured":"Willis\n              FR,\n            \n            \n              Byrne\n              GC,\n            \n            \n              Jones\n              TW.\n            \n          \n          Fludrocortisone induced heart failure in Addison\u2019s disease.\n\t\t\t\t\tJ Paediatr Child Health1994;\n\t\t\t\t\t30:\n\t\t\t\t\t280\u2013\n\t\t\t\t\t1."},{"key":"i1547-3317-58-6-297-b17","series-title":"J R Soc Med","first-page":"433","article-title":"Heart failure with fludrocortisone in Addison\u2019s disease","volume":"91","year":"1998","unstructured":"Bhattacharyya\n              A\n            \n            \n              Tymms\n              DJ.\n            \n          \n          Heart failure with fludrocortisone in Addison\u2019s disease.\n\t\t\t\t\tJ R Soc Med1998;\n\t\t\t\t\t91:\n\t\t\t\t\t433\u2013\n\t\t\t\t\t4."},{"key":"i1547-3317-58-6-297-b18","series-title":"Vet Pathol","first-page":"1","article-title":"Histologic characterization of canine dilated cardiomyopathy","volume":"42","year":"2005","unstructured":"Tidholm\n              A\n            \n            \n              Jonsson\n              L.\n            \n          \n          Histologic characterization of canine dilated cardiomyopathy.\n\t\t\t\t\tVet Pathol2005;\n\t\t\t\t\t42:\n\t\t\t\t\t1\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-6-297-b19","series-title":"J Vet Med Sci","first-page":"985","article-title":"Ultrasonographic adrenal gland measurements in clinically normal small breed dogs and comparison with pituitary-dependent hyperadrenocorticism","volume":"73","year":"2011","unstructured":"Choi\n              J,\n            \n            \n              Kim\n              H,\n            \n            \n              Yoon\n              J.\n            \n          \n          Ultrasonographic adrenal gland measurements in clinically normal small breed dogs and comparison with pituitary-dependent hyperadrenocorticism.\n\t\t\t\t\tJ Vet Med Sci2011;\n\t\t\t\t\t73:\n\t\t\t\t\t985\u2013\n\t\t\t\t\t9."},{"key":"i1547-3317-58-6-297-b20","series-title":"J Vet Intern Med","first-page":"311","article-title":"Allometric scaling of M-Mode cardiac measurements in normal adult dogs","volume":"18","year":"2004","unstructured":"Cornell\n              CC,\n            \n            \n              Kittleson\n              MD,\n            \n            \n              Della Torre\n              P,\n            \n            .\n\t\t\t\t\t\n          Allometric scaling of M-Mode cardiac measurements in normal adult dogs.\n\t\t\t\t\tJ Vet Intern Med2004;\n\t\t\t\t\t18:\n\t\t\t\t\t311\u2013\n\t\t\t\t\t21."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/58\/6\/article-p297.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/58\/6\/297\/3137345\/i1547-3317-58-6-297.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/58\/6\/article-p297.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/58\/6\/article-p297.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:06:13Z","timestamp":1763741173000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/58\/6\/article-p297.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":20,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-7223","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"type":"electronic","value":"1547-3317"},{"type":"print","value":"0587-2871"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}