{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:13:10Z","timestamp":1763748790153,"version":"3.45.0"},"reference-count":24,"publisher":"American Animal Hospital Association","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A 6 mo old and a 7 mo old male intact Brittany were presented for progressive exercise intolerance, failure to grow, and dysphagia. Creatine kinase activity was markedly and persistently elevated in both dogs. Based on the neurological examination, clinical signs localized to the neuromuscular system. Electromyography revealed complex repetitive discharges in multiple muscle groups. Immunofluorescence of biopsies confirmed dystrophin-deficient muscular dystrophy. This is the first report describing dystrophin-deficient muscular dystrophy in the Brittany breed. Currently, no specific therapies are available for this form of myopathy. The presence of dystrophin deficiency in the two dogs suggests an inherited myopathy rather than a spontaneous mutation. The location of the dogs in the United States and Japan suggests a wide distribution of this dystrophy and should alert clinicians to the existence of this myopathy in the Brittany breed. A mutation in the\n                    <jats:italic>DMD<\/jats:italic>\n                    gene has not yet been identified.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-7255","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T14:16:09Z","timestamp":1667225769000},"page":"292-296","source":"Crossref","is-referenced-by-count":2,"title":["Dystrophin-Deficient Muscular Dystrophy in Two Male Juvenile Brittanys"],"prefix":"10.5326","volume":"58","author":[{"given":"Rebecca","family":"Stevens","sequence":"first","affiliation":[{"name":"From Burlington Emergency and Veterinary Specialists, Williston, Vermont (R.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kanazono","sequence":"additional","affiliation":[{"name":"Veterinary Specialists and Emergency Center, Saitama, Japan (S.K.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Petesch","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Matthew J. Ryan Veterinary Hospital, Philadelphia, Pennsylvania (S.P.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling T.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California (L.T.G., G.D.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Diane","family":"Shelton","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California (L.T.G., G.D.S.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-58-6-292-b1","series-title":"J Hered","first-page":"405","article-title":"Canine muscular dystrophy: confirmation of X-linked inheritance","volume":"79","year":"1988","unstructured":"Cooper\n              BJ,\n            \n            \n              Valentine\n              BA,\n            \n            \n              Wilson\n              S,\n            \n          \n          .\n\t\t\t\t\tCanine muscular dystrophy: confirmation of X-linked inheritance.\n\t\t\t\t\tJ Hered1988;\n\t\t\t\t\t79:\n\t\t\t\t\t405\u2013\n\t\t\t\t\t8."},{"key":"i1547-3317-58-6-292-b2","series-title":"J Vet Intern Med","first-page":"240","article-title":"Muscular dystrophy in female 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