{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:37:52Z","timestamp":1780393072053,"version":"3.54.1"},"reference-count":22,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"ABSTRACT<\/jats:title>\n A 4 yr old female neutered Labrador retriever was referred with a history of left hind-limb lameness and an acute, nonpainful, subcutaneous mass on the medial aspect of the left stifle. Stifle radiographs and fine needle aspirates of the soft tissue mass performed by the referring veterinarian confirmed the presence of predominantly highly granulated mast cells, consistent with a mast cell tumor. Computed tomography demonstrated a soft tissue mass centered on the left medial stifle, with associated joint effusion and polyostotic lytic lesions on the tibial plateau and distal patella. Ultrasound-guided aspirates of the liver, spleen, and popliteal lymph nodes were obtained to rule out further metastatic spread. Cytology of the joint fluid demonstrated a low number of well-differentiated mast cells. Surgical and oncological interventions were discussed, and full hind-limb amputation was elected. Histopathological analysis of the submitted tissues after amputation diagnosed a subcutaneous mast cell tumor with neoplastic cell infiltrate extending into sections of joint capsule and synovial membrane. Infiltration to the tibia and distal patella were suspected following the presence of mast cell clusters in both osteolytic lesions. No evidence of metastasis was identified in the popliteal lymph node. Postoperative monitoring of iliac lymph node size using ultrasound did not identify evidence of metastasis 12 mo postoperatively.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7278","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T15:36:50Z","timestamp":1694705810000},"page":"234-240","source":"Crossref","is-referenced-by-count":2,"title":["Tibial Plateau and Stifle Joint Invasion with a Subcutaneous Mast Cell Tumor"],"prefix":"10.5326","volume":"59","author":[{"given":"Monique","family":"Triglia","sequence":"first","affiliation":[{"name":"From Willows Veterinary Centre and Referral Service Ltd, Birmingham, United Kingdom (M.T., H.H., A.J.F., W.P.R.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollie","family":"Horton","sequence":"additional","affiliation":[{"name":"From Willows Veterinary Centre and Referral Service Ltd, Birmingham, United Kingdom (M.T., H.H., A.J.F., W.P.R.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Dobromylskyj","sequence":"additional","affiliation":[{"name":"Finn Pathologists, Harleston, United Kingdom. (M.D)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Jo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"From Willows Veterinary Centre and Referral Service Ltd, Birmingham, United Kingdom (M.T., H.H., A.J.F., W.P.R.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Peter","family":"Robinson","sequence":"additional","affiliation":[{"name":"From Willows Veterinary Centre and Referral Service Ltd, Birmingham, United Kingdom (M.T., H.H., A.J.F., W.P.R.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-59-5-234-b1","series-title":"Veterinary Surgical Oncology.","first-page":"61","author":"Ryan","year":"2012","unstructured":"Ryan\n S,\n \n \n Wouters\n EGH,\n \n \n van Nimwegen\n S,\n \n \n \n Skin and subcutaneous tumours. In: KudnigS,SeguinB, eds. 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Vet Med (Auckl)2014;5:49\u201358."},{"issue":"4","key":"i1547-3317-59-5-234-b4","series-title":"Cells","first-page":"618","article-title":"Diagnosis, prognosis and treatment of canine cutaneous and subcutaneous mast cell tumors","volume":"11","author":"De Nardi","year":"2022","unstructured":"De Nardi\n AB,\n \n \n Dos Santos Horta\n R,\n \n \n Fonseca-Alves\n CE,\n \n \n \n Diagnosis, prognosis and treatment of canine cutaneous and subcutaneous mast cell tumors. Cells2022;11(4):618."},{"issue":"2","key":"i1547-3317-59-5-234-b5","series-title":"Vet Comp Oncol","first-page":"130","article-title":"Cytological lymph node evaluation in dogs with mast cell tumors: association with grade and survival","volume":"7","author":"Krick","year":"2009","unstructured":"Krick\n EL,\n \n \n Billings\n AP,\n \n \n Shofer\n FS,\n \n \n \n Cytological lymph node evaluation in dogs with mast cell tumors: association with grade and survival. 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Semin Arthritis Rheum2006;36(1):32\u20136."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/59\/5\/article-p234.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/59\/5\/234\/3256025\/i1547-3317-59-5-234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/59\/5\/article-p234.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/59\/5\/article-p234.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:04:41Z","timestamp":1763741081000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/59\/5\/article-p234.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":22,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-7278","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}