{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:03:44Z","timestamp":1772327024368,"version":"3.50.1"},"reference-count":14,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 10 yr old female spayed domestic shorthair was referred for an 11mo history of persistent total hypercalcemia and elevated ionized calcium with intermittent episodes of lethargy, vomiting, and diarrhea with a history of recurrent urinary tract infections and intermittently elevated kidney values. An abdominal ultrasound, thoracic radiographs, cervical ultrasound, and ionized calcium level, parathyroid hormone (PTH), and PTH-related peptide (PTHrp) levels were assessed. Results were consistent with chronic kidney disease, splenomegaly, diffuse thickening of small intestines, nodular lesions noted in the left thyroid and right parathyroid, and elevated ionized calcium, PTH, and elevated PTHrp levels. A left thyroidectomy and right cranial parathyroidectomy were performed. Hypocalcemia and anemia developed postoperatively, which were managed with calcium carbonate, calcitriol, and calcium gluconate and benign neglect of anemia. Histopathology was consistent with a left thyroid carcinoma and right cranial parathyroid adenoma. Thyroid carcinoma and parathyroid adenomas have not previously been reported to occur concurrently in domestic felines and should be considered when ionized calcium is elevated with both PTH and PTHrp levels increased in addition to ultrasonographic lesions.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7299","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T14:24:24Z","timestamp":1672410264000},"page":"32-35","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent Parathyroid Adenoma and Thyroid Carcinoma in a Domestic Shorthaired Feline"],"prefix":"10.5326","volume":"59","author":[{"given":"Abigail Elizabeth","family":"DeRouen","sequence":"first","affiliation":[{"name":"From BluePearl Specialty: BluePearl Veterinary Partners, LLC, Columbia, South Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-59-1-32-b1","series-title":"Textbook of veterinary surgery: small animal.","first-page":"43","article-title":"Fluid therapy","year":"2012","unstructured":"Silverstein,\n              D.\n            ,\n\t\t\t\t\t\tCampbell,J.\n          Fluid therapy.\n\t\t\t\t\tIn:TobiasKM,\n\t\t\t\t\t\tJohnstonSA,\n\t\t\t\t\teds.,Textbook of veterinary surgery: small animal.1st ed.\n\t\t\t\t\tSt. Louis:\n\t\t\t\t\tElsevier Saunders;\n\t\t\t\t\t2012:43\u201372."},{"key":"i1547-3317-59-1-32-b2","series-title":"Textbook of veterinary surgery: small animal.","first-page":"2043","article-title":"Thyroid and parathyroid glands","year":"2012","unstructured":"Seguin\n              B\n            \n            \n              Brownlee\n              L.\n            \n          \n          Thyroid and parathyroid glands.\n\t\t\t\t\tIn:TobiasKM,\n\t\t\t\t\t\tJohnstonSA,\n\t\t\t\t\teds.,Textbook of veterinary surgery: small animal.1st ed.\n\t\t\t\t\tSt. Louis:\n\t\t\t\t\tElsevier Saunders;\n\t\t\t\t\t2012:2043\u201358."},{"key":"i1547-3317-59-1-32-b3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1083","article-title":"Endocrine tumors","volume":"31","year":"2001","unstructured":"Lurye\n              JC\n            \n            \n              Behrend\n              EN.\n            \n          \n          Endocrine tumors.\n\t\t\t\t\tVet Clin North Am Small Anim Pract2001;31:1083\u2013110."},{"key":"i1547-3317-59-1-32-b4","series-title":"Vet Surg","first-page":"287","article-title":"Results of thyroidectomy in 101 cats with hyperthyroidism","volume":"35","year":"2006","unstructured":"Naan\n              EC\n            ,\n\t\t\t\t\t\tKirpenstejnJ,\n\t\t\t\t\t\tKooistraHS,\n\t\t\t\t\t\n          .\n\t\t\t\t\tResults of thyroidectomy in 101 cats with hyperthyroidism.\n\t\t\t\t\tVet Surg2006;35:287\u201393."},{"key":"i1547-3317-59-1-32-b5","series-title":"Can Vet J","first-page":"719","article-title":"The outcome for feline nonhypersecretory thyroid carcinoma after thyroidectomy","volume":"61","year":"2020","unstructured":"Oramas\n              A\n            ,\n\t\t\t\t\t\tBostenS,\n\t\t\t\t\t\tWavreilleV.\n          The outcome for feline nonhypersecretory thyroid carcinoma after thyroidectomy.\n\t\t\t\t\tCan Vet J2020;61:719\u201323."},{"key":"i1547-3317-59-1-32-b6","series-title":"Vet Med Res Rep","first-page":"85","article-title":"Diagnosis and management of feline hyperthyroidism: current perspectives","volume":"5","year":"2014","unstructured":"Vaske\n              HH\n            ,\n\t\t\t\t\t\tSchermerhornT,\n\t\t\t\t\t\tArmbrustL,\n\t\t\t\t\t\n          .\n\t\t\t\t\tDiagnosis and management of feline hyperthyroidism: current perspectives.\n\t\t\t\t\tVet Med Res Rep2014;5:85\u201396."},{"key":"i1547-3317-59-1-32-b7","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1065","article-title":"Hyperthyroidism in cats: considering the impact of treatment modality on quality of life for cats and their owners","volume":"50","year":"2020","unstructured":"Peterson\n              ME.\n            \n         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and parathyroid glands.\n\t\t\t\t\tIn:TobiasKM,\n\t\t\t\t\t\tJohnstonSA,\n\t\t\t\t\teds.,Textbook of veterinary surgery: small animal.1st ed.\n\t\t\t\t\tSt. Louis:\n\t\t\t\t\tElsevier Saunders;\n\t\t\t\t\t2012:2043\u201358."},{"key":"i1547-3317-59-1-32-b3","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1083","article-title":"Endocrine tumors","volume":"31","year":"2001","unstructured":"Lurye\n              JC\n            \n            \n              Behrend\n              EN.\n            \n          \n          Endocrine tumors.\n\t\t\t\t\tVet Clin North Am Small Anim Pract2001;31:1083\u2013110."},{"key":"i1547-3317-59-1-32-b4","series-title":"Vet Surg","first-page":"287","article-title":"Results of thyroidectomy in 101 cats with hyperthyroidism","volume":"35","year":"2006","unstructured":"Naan\n              EC\n            ,\n\t\t\t\t\t\tKirpenstejnJ,\n\t\t\t\t\t\tKooistraHS,\n\t\t\t\t\t\n          .\n\t\t\t\t\tResults of thyroidectomy in 101 cats with hyperthyroidism.\n\t\t\t\t\tVet Surg2006;35:287\u201393."},{"key":"i1547-3317-59-1-32-b5","series-title":"Can Vet J","first-page":"719","article-title":"The outcome for feline nonhypersecretory thyroid carcinoma after thyroidectomy","volume":"61","year":"2020","unstructured":"Oramas\n              A\n            ,\n\t\t\t\t\t\tBostenS,\n\t\t\t\t\t\tWavreilleV.\n          The outcome for feline nonhypersecretory thyroid carcinoma after thyroidectomy.\n\t\t\t\t\tCan Vet J2020;61:719\u201323."},{"key":"i1547-3317-59-1-32-b6","series-title":"Vet Med Res Rep","first-page":"85","article-title":"Diagnosis and management of feline hyperthyroidism: current perspectives","volume":"5","year":"2014","unstructured":"Vaske\n              HH\n            ,\n\t\t\t\t\t\tSchermerhornT,\n\t\t\t\t\t\tArmbrustL,\n\t\t\t\t\t\n          .\n\t\t\t\t\tDiagnosis and management of feline hyperthyroidism: current perspectives.\n\t\t\t\t\tVet Med Res 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