{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:00:05Z","timestamp":1770912005047,"version":"3.50.1"},"reference-count":36,"publisher":"American Animal Hospital Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n It has been reported that hypertriglyceridemia can partially mediate between diabetes mellitus (DM) and pancreatitis in dogs, implying that another mediator, such as chronic hyperglycemia, might exist. Therefore, this study aimed to evaluate the relationship between hyperglycemia and serum canine pancreatic lipase immunoreactivity (cPLI) concentration in diabetic dogs. This retrospective cohort study included 26 client-owned diabetic dogs, divided according to their serum fructosamine levels (<500 \u03bcmol\/L = well-controlled DM group; \u2265500 \u03bcmol\/L = untreated or poorly controlled DM group). Five of the 26 DM dogs (19.2%) had serum cPLI concentrations consistent with pancreatitis, among which two showed ultrasonographic evidence of pancreatitis without clinical signs. The serum cPLI concentrations (median [interquartile range]) were significantly higher in the untreated or poorly controlled group (520 \u03bcg\/L [179.76\u20131000 \u03bcg\/L]) than in the well-controlled group (77 \u03bcg\/L [32.22\u2013244.6 \u03bcg\/L],\n P<\/jats:italic>\n = 0.0147). The serum fructosamine concentration was positively correlated with the serum cPLI concentration (r = 0.4816;\n P<\/jats:italic>\n = 0.0127). Multivariate analysis revealed serum triglyceride and fructosamine concentrations were associated with the serum cPLI concentration. In conclusion, this study suggests that chronic hyperglycemia may induce pancreatic inflammation in diabetic dogs; however, the clinical significance of increased cPLI concentration is unknown.\n <\/jats:p>","DOI":"10.5326\/jaaha-ms-7365","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T15:36:37Z","timestamp":1694705797000},"page":"241-248","source":"Crossref","is-referenced-by-count":5,"title":["Association between Hyperglycemia and Canine Serum Pancreatic Lipase Immunoreactivity Concentration in Diabetic Dogs"],"prefix":"10.5326","volume":"59","author":[{"given":"Joonseok","family":"Kim","sequence":"first","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon","family":"Chae","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dohee","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonhoi","family":"Koo","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijin","family":"Cha","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesik","family":"Yun","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhan-Pyo","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Teck","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-59-5-241-b1","series-title":"J Small Anim Pract","first-page":"50","article-title":"Diabetes mellitus and pancreatitis\u2013cause or effect?","volume":"56","author":"Davison","year":"2015","unstructured":"Davison\n L.\n \n \n Diabetes mellitus and pancreatitis\u2013cause or effect?\n \n J Small Anim Pract\n \n 2015;56:50\u20139."},{"issue":"1","key":"i1547-3317-59-5-241-b2","series-title":"Canine Genet Epidemiol","first-page":"19","article-title":"Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival","volume":"7","author":"Heeley","year":"2020","unstructured":"Heeley\n AM,\n \n \n O\u2019Neill\n DG,\n \n \n Davison\n LJ,\n \n \n \n Diabetes mellitus in dogs attending UK primary-care practices: frequency, risk factors and survival. 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