{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:06:30Z","timestamp":1791950790309,"version":"4.3.4"},"reference-count":15,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"ABSTRACT<\/jats:title>\n Only one report on the successful use of filgrastim (granulocyte colony-stimulating factor) in cats for severe neutropenia following azathioprine toxicity exists. Here, we report on a case in which a cat was prescribed methimazole but the medication was filled incorrectly with azathioprine tablets and the prescription label indicated a methimazole dosing regimen that was administered for three days before recognition of the error. On presentation, the cat\u2019s physical examinations were consistent with previous examinations before ingestion of azathioprine. A complete blood cell count revealed neutropenia and leukopenia. The cat later developed hyporexia, dehydration, and vomiting. Treatment included antinausea and appetite stimulant medications, filgrastim, and antibiotics. Filgrastim given as subcutaneous injections over the course of treatment increased neutrophil cell counts after suppression. The cat made a full recovery after responding to the treatment protocol. Based on the perceived response to filgrastim in this single feline case report, its use can be considered for the treatment of azathioprine-induced neutropenia in cats.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7409","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T15:13:14Z","timestamp":1714057994000},"page":"105-108","source":"Crossref","is-referenced-by-count":4,"title":["Filgrastim Use in the Treatment of Azathioprine-Induced Myelosuppression Toxicity After Prescription Error in the Feline"],"prefix":"10.5326","volume":"60","author":[{"given":"Leigh","family":"Klar","sequence":"first","affiliation":[{"name":"From Foxboro Animal Hospital, Foxboro, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"9","key":"i1547-3317-60-3-105-b1","series-title":"Aust Vet J","first-page":"415","article-title":"Hyperthyroid cats and their kidneys: a literature review","volume":"100","author":"Yu","year":"2022","unstructured":"Yu\n L,\n \n \n Lacorcia\n L,\n \n \n Johnstone\n T.\n \n \n Hyperthyroid cats and their kidneys: a literature review. Aust Vet J2022;100(9):415\u201332."},{"key":"i1547-3317-60-3-105-b2","series-title":"of treatment modality on quality of life for cats and their owners. Vet Clin Small Animal 2020;50;1065\u201384.","article-title":"Hyperthyroidism in cats: considering the impact","author":"Peterson,","unstructured":"Peterson,\n M.\n \n \n Hyperthyroidism in cats: considering the impact\n of treatment modality on quality of life for cats and their owners. Vet Clin Small Animal 2020;50;1065\u201384."},{"issue":"11","key":"i1547-3317-60-3-105-b3","series-title":"Acc Chem Res","first-page":"2706","article-title":"Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action","volume":"46","author":"Manna","year":"2013","unstructured":"Manna\n D,\n \n \n Roy\n G,\n \n \n Mugesh\n G.\n \n \n Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action. Acc Chem Res2013;46(11):2706\u201315."},{"key":"i1547-3317-60-3-105-b4","series-title":"Plumb\u2019s veterinary drug handbook.","author":"Budde","year":"2023","unstructured":"Budde\n J A,\n \n \n McCluskey\n D J.\n \n \n \n Plumb\u2019s veterinary drug handbook.\n \n 10th ed. Hoboken: Wiley-Blackwell; 2023."},{"issue":"3","key":"i1547-3317-60-3-105-b5","series-title":"Vet Clin North Am Small Anim Pract","first-page":"797","article-title":"Glucocorticoids, cyclosporine, azathioprine, chlorambucil, mycophenolate in dogs and cats: clinical uses, pharmacology, and side effects","volume":"52","author":"Viviano","year":"2022","unstructured":"Viviano\n KR.\n \n \n Glucocorticoids, cyclosporine, azathioprine, chlorambucil, mycophenolate in dogs and cats: clinical uses, pharmacology, and side effects. 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Proc Bayl Univ Med Cent2004;17:464\u20137."}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/60\/3\/article-p105.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jaaha\/article-pdf\/60\/3\/105\/3389989\/i1547-3317-60-3-105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/60\/3\/article-p105.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/60\/3\/article-p105.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:05:32Z","timestamp":1763741132000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/60\/3\/article-p105.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-7409","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}