{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:13:12Z","timestamp":1783732392057,"version":"3.55.0"},"reference-count":13,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Canine meningioma is the most common intradural extramedullary and primary spinal cord tumor. Previous studies suggest that postoperative radiation therapy can be effective for spinal meningiomas. Information on radiation-induced complications and prognosis remains limited. This case series evaluated treatment outcomes of surgical and radiation therapy in dogs with spinal meningiomas. Ten dogs were included. All underwent surgery, and histopathological examination confirmed meningioma. Among the four cases where surgical margins were assessed, three had incomplete resections. Postoperative radiation therapy was administered as an adjuvant treatment in nine dogs. One dog that did not receive postoperative radiation underwent radiation upon recurrence, observed at 99 days postsurgery. The radiation protocol consisted of fractionated irradiation (32\u201355 Gy\/12\u201321 fractions) delivered five times per week. During the observation period, nine of 10 dogs died, with a median survival time of 568 days (range: 165\u20131823 days). Local recurrence occurred in six dogs at 95, 99, 153, 367, 433, and 1086 days postoperatively, confirmed by magnetic resonance imaging. Among 10 dogs receiving radiation, one experienced worsening limb paralysis on day 1679, suspected as a radiation-induced complication. No clinically evident acute or late radiation-induced side effects were noted in the medical records of the remaining cases.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7498","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:17:25Z","timestamp":1776824245000},"page":"108-114","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes and Tolerability of Postoperative Radiotherapy in 10 Dogs with Spinal Meningiomas"],"prefix":"10.5326","volume":"62","author":[{"given":"Akihiro","family":"Uno","sequence":"first","affiliation":[{"name":"From the Faculty of Applied Biological Sciences, Animal Medical Center, Gifu University, Gifu, Japan (A.U.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Joint Department of Veterinary Medicine, Gifu University, Gifu, Japan (R.I., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mori","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Joint Department of Veterinary Medicine, Gifu University, Gifu, Japan (R.I., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-62-3-108-b1","series-title":"J Vet Intern Med","first-page":"639","article-title":"399 spinal tumors in dogs","volume":"21","author":"Johnson","year":"2007","unstructured":"Johnson KB, Manhart K, Vite C,  399 spinal tumors in dogs. J Vet Intern Med 2007;21:639\u201340."},{"issue":"4","key":"i1547-3317-62-3-108-b2","series-title":"J Small Anim Pract","first-page":"213","article-title":"A retrospective study of 29 spinal tumors in the dog and cat","volume":"21","author":"Luttgen","year":"1980","unstructured":"Luttgen PJ, Braund KG, Brawner WR Jr,  A retrospective study of 29 spinal tumors in the dog and cat. J Small Anim Pract 1980;21(4):213\u201326."},{"issue":"4","key":"i1547-3317-62-3-108-b3","series-title":"J Vet Intern Med","first-page":"946","article-title":"Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogs","volume":"22","author":"Petersen","year":"2008","unstructured":"Petersen SA, Sturges BK, Dickinson PJ,  Canine intraspinal meningiomas: imaging features, histopathologic classification, and long-term outcome in 34 dogs. J Vet Intern Med 2008;22(4):946\u201353."},{"issue":"4","key":"i1547-3317-62-3-108-b4","series-title":"J Am Anim Hosp Assoc","first-page":"307","article-title":"Spinal tumors in 37 dogs: clinical outcome and long-term survival (1987\u20131994)","volume":"33","author":"Levy","year":"1997","unstructured":"Levy MS, Kapatkin AS, Patnaik AK,  Spinal tumors in 37 dogs: clinical outcome and long-term survival (1987\u20131994). J Am Anim Hosp Assoc 1997;33(4):307\u201312."},{"issue":"3","key":"i1547-3317-62-3-108-b5","series-title":"J Am Anim Hosp Assoc","first-page":"245","article-title":"Outcome following treatment of vertebral tumors in 20 dogs (1986\u20131995)","volume":"36","author":"Dernell","year":"2000","unstructured":"Dernell WS, Van Vechten BJ, Straw R,  Outcome following treatment of vertebral tumors in 20 dogs (1986\u20131995). J Am Anim Hosp Assoc 2000;36(3):245\u201351."},{"issue":"6","key":"i1547-3317-62-3-108-b6","series-title":"J Am Vet Med Assoc","first-page":"720","article-title":"Spinal meningiomas in dogs: 13 cases (1972\u20131987)","volume":"191","author":"Fingeroth","year":"1987","unstructured":"Fingeroth JM, Prata RG, Patnaik AK. Spinal meningiomas in dogs: 13 cases (1972\u20131987). J Am Vet Med Assoc 1987;191(6):720\u20136."},{"key":"i1547-3317-62-3-108-b7","series-title":"Kleintierpraxis","first-page":"357","article-title":"Spinal cord canal tumors in dogs: 33 cases (retrospective study)","volume":"47","author":"Forterre","year":"2002","unstructured":"Forterre F, Kaiser S, Matiasek K,  Spinal cord canal tumors in dogs: 33 cases (retrospective study). Kleintierpraxis 2002;47:357\u201364."},{"issue":"3","key":"i1547-3317-62-3-108-b8","series-title":"Vet Comp Oncol","first-page":"344","article-title":"Canine spinal meningiomas and nerve sheath tumors in 34 dogs (2008\u20132016): distribution and long-term outcome based on histopathology and treatment modality","volume":"16","author":"Lacassagne","year":"2018","unstructured":"Lacassagne K, Hearon K, Berg J,  Canine spinal meningiomas and nerve sheath tumors in 34 dogs (2008\u20132016): distribution and long-term outcome based on histopathology and treatment modality. Vet Comp Oncol 2018;16(3):344\u201351."},{"issue":"3","key":"i1547-3317-62-3-108-b9","series-title":"Int J Radiat Oncol Biol Phys","first-page":"539","article-title":"Pathology of radiation injury to the canine spinal cord","volume":"23","author":"Powers","year":"1992","unstructured":"Powers BE, Beck ER, Gillette EL,  Pathology of radiation injury to the canine spinal cord. Int J Radiat Oncol Biol Phys 1992;23(3):539\u201349."},{"key":"i1547-3317-62-3-108-b10","series-title":"Vet Radiol Ultrasound","first-page":"789","article-title":"ACVR and ECVDI consensus statement: reporting elements for toxicity criteria of the veterinary radiation therapy oncology group v2.0","volume":"64","author":"Valerie","year":"2023","unstructured":"Valerie JP, Michele K, Ira K,  ACVR and ECVDI consensus statement: reporting elements for toxicity criteria of the veterinary radiation therapy oncology group v2.0. Vet Radiol Ultrasound 2023;64:789\u201397."},{"issue":"5","key":"i1547-3317-62-3-108-b11","series-title":"Vet Radiol Ultrasound","first-page":"547","article-title":"2024 guidelines for reporting radiation therapy in veterinary medicine","volume":"65","author":"Willows","year":"2024","unstructured":"Willows EL, Merhus C. 2024 guidelines for reporting radiation therapy in veterinary medicine. Vet Radiol Ultrasound 2024;65(5):547\u201355."},{"issue":"3","key":"i1547-3317-62-3-108-b12","series-title":"Vet Clin North Am Small Anim Pract","first-page":"559","article-title":"Update in veterinary radiation oncology: focus on stereotactic radiation therapy","volume":"54","author":"Michael","year":"2019","unstructured":"Michael WN, Tracy LG. Update in veterinary radiation oncology: focus on stereotactic radiation therapy. Vet Clin North Am Small Anim Pract 2019;54(3):559\u201375."},{"issue":"6","key":"i1547-3317-62-3-108-b13","series-title":"Strahlenther Onkol","first-page":"463","article-title":"New clinical data on human spinal cord re-irradiation tolerance","volume":"197","author":"Hiroshi","year":"2021","unstructured":"Hiroshi D, Keisuke Y, Ryoong-Jin O,  New clinical data on human spinal cord re-irradiation tolerance. 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