{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:01:19Z","timestamp":1770786079809,"version":"3.50.0"},"reference-count":30,"publisher":"American Animal Hospital Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>An 8 yr old spayed female domestic shorthair presented with a 1 wk history of anorexia and lethargy. Cytological examination of the liver using fine-needle aspiration revealed numerous adipocytes, confirming hepatic lipidosis. The cat was hospitalized for treatment; subsequently, the clinical signs and blood analysis results improved. On day 17, the nasoesophageal tube was removed because of recovery of appetite and vitality. However, owing to insufficient voluntary food intake, partial parenteral nutrition (PPN) was initiated using an amino acid solution with a low branched-chain amino acid (BCAA)\/aromatic amino acid (AAA) ratio and arginine deficiency. Within 24 hr of PPN administration, neurological signs were observed, including vocalization, panting, hyperactivity, and a subsequent comatose state. Although hepatic encephalopathy was considered, there was limited evidence of hepatic failure. The clinical course was most consistent with acute hyperammonemia secondary to arginine deficiency, although a contributing role of the low BCAA\/AAA ratio cannot be excluded. This case suggests that amino acid PPN with arginine deficiency and a low BCAA\/AAA ratio may contribute to neurological signs in cats, underscoring the importance of careful amino acid selection in nutritional formulations.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7508","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:53:18Z","timestamp":1770771198000},"page":"38-42","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Parenteral Amino Acid Composition on Hyperammonemia in a Cat with Hepatic Lipidosis"],"prefix":"10.5326","volume":"62","author":[{"given":"Jinyeong","family":"Park","sequence":"first","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Teck","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerim","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesik","family":"Yun","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon","family":"Chae","sequence":"additional","affiliation":[{"name":"From the Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3280","reference":[{"key":"i1547-3317-62-1-38-b1","series-title":"Annu Rev Nutr","first-page":"87","article-title":"Regulation of enzymes of the urea cycle and arginine metabolism","volume":"22","author":"Morris","year":"2002"},{"key":"i1547-3317-62-1-38-b2","series-title":"J Physiol","first-page":"471","article-title":"Arginine metabolism in cat kidney","volume":"491","author":"Levillain","year":"1996"},{"key":"i1547-3317-62-1-38-b3","series-title":"J Nutr","first-page":"146","article-title":"Deficiency of pyrroline-5-carboxylate synthase in the intestinal mucosa of the cat","volume":"115","author":"Rogers","year":"1985"},{"key":"i1547-3317-62-1-38-b4","series-title":"Ann Surg","first-page":"343","article-title":"Alterations in plasma and CSF amino acids, amines and metabolites in hepatic coma","volume":"187","author":"Smith","year":"1978"},{"key":"i1547-3317-62-1-38-b5","series-title":"Vet Clin North Am Small Anim Pract","first-page":"337","article-title":"Hepatic encephalopathy: clinical signs, pathogenesis, and treatment","volume":"25","author":"Paugh","year":"1995"},{"key":"i1547-3317-62-1-38-b6","year":"2014"},{"key":"i1547-3317-62-1-38-b7","series-title":"Vet Radiol Ultrasound","first-page":"447","article-title":"Brain magnetic resonance imaging characteristics in dogs and cats with congenital portosystemic shunts","volume":"46","author":"Torisu","year":"2005"},{"key":"i1547-3317-62-1-38-b8","series-title":"Brain Dev","first-page":"567","article-title":"Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: a case report","volume":"32","author":"Okanishi","year":"2010"},{"key":"i1547-3317-62-1-38-b9","series-title":"Curr Opin Clin Nutr Metab Care","first-page":"75","article-title":"Amino acid composition in parenteral nutrition: what is the evidence?","volume":"14","author":"Yarandi","year":"2011"},{"key":"i1547-3317-62-1-38-b10","series-title":"Vet Sci","first-page":"59","article-title":"The role of thiamine and effects of deficiency in dogs and cats","volume":"4","author":"Kritikos","year":"2017"},{"key":"i1547-3317-62-1-38-b11","series-title":"Vet Clin North Am Small Anim Pract\u00a0","first-page":"403","article-title":"Taurine deficiency syndrome in cats","volume":"19","author":"Hayes","year":"1989"},{"key":"i1547-3317-62-1-38-b12","series-title":"Rev Invest Clin","first-page":"513","article-title":"The BCAA\/AAA ratio of plasma amino acids in three different groups of cirrhotics","volume":"44","author":"Campollo","year":"1992"},{"key":"i1547-3317-62-1-38-b13","series-title":"Am J Vet Res","first-page":"696","article-title":"Plasma amino acid analysis in dogs with experimentally induced hepatocellular and obstructive jaundice","volume":"48","author":"Rutgers","year":"1987"},{"key":"i1547-3317-62-1-38-b14","series-title":"J Hepatol","first-page":"756","article-title":"Hyperammonemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma","volume":"25","author":"Leweling","year":"1996"},{"key":"i1547-3317-62-1-38-b15","series-title":"J Anim Sci Biotechnol\u00a0","first-page":"19","article-title":"Amino acid nutrition and metabolism in domestic cats and dogs","volume":"14","author":"Li","year":"2023"},{"key":"i1547-3317-62-1-38-b1","series-title":"Annu Rev Nutr","first-page":"87","article-title":"Regulation of enzymes of the urea cycle and arginine metabolism","volume":"22","author":"Morris","year":"2002"},{"key":"i1547-3317-62-1-38-b2","series-title":"J Physiol","first-page":"471","article-title":"Arginine metabolism in cat kidney","volume":"491","author":"Levillain","year":"1996"},{"key":"i1547-3317-62-1-38-b3","series-title":"J Nutr","first-page":"146","article-title":"Deficiency of pyrroline-5-carboxylate synthase in the intestinal mucosa of the cat","volume":"115","author":"Rogers","year":"1985"},{"key":"i1547-3317-62-1-38-b4","series-title":"Ann Surg","first-page":"343","article-title":"Alterations in plasma and CSF amino acids, amines and metabolites in hepatic coma","volume":"187","author":"Smith","year":"1978"},{"key":"i1547-3317-62-1-38-b5","series-title":"Vet Clin North Am Small Anim Pract","first-page":"337","article-title":"Hepatic encephalopathy: clinical signs, pathogenesis, and treatment","volume":"25","author":"Paugh","year":"1995"},{"key":"i1547-3317-62-1-38-b6","year":"2014"},{"key":"i1547-3317-62-1-38-b7","series-title":"Vet Radiol Ultrasound","first-page":"447","article-title":"Brain magnetic resonance imaging characteristics in dogs and cats with congenital portosystemic shunts","volume":"46","author":"Torisu","year":"2005"},{"key":"i1547-3317-62-1-38-b8","series-title":"Brain Dev","first-page":"567","article-title":"Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: a case report","volume":"32","author":"Okanishi","year":"2010"},{"key":"i1547-3317-62-1-38-b9","series-title":"Curr Opin Clin Nutr Metab Care","first-page":"75","article-title":"Amino acid composition in parenteral nutrition: what is the evidence?","volume":"14","author":"Yarandi","year":"2011"},{"key":"i1547-3317-62-1-38-b10","series-title":"Vet Sci","first-page":"59","article-title":"The role of thiamine and effects of deficiency in dogs and cats","volume":"4","author":"Kritikos","year":"2017"},{"key":"i1547-3317-62-1-38-b11","series-title":"Vet Clin North Am Small Anim Pract\u00a0","first-page":"403","article-title":"Taurine deficiency syndrome in cats","volume":"19","author":"Hayes","year":"1989"},{"key":"i1547-3317-62-1-38-b12","series-title":"Rev Invest Clin","first-page":"513","article-title":"The BCAA\/AAA ratio of plasma amino acids in three different groups of cirrhotics","volume":"44","author":"Campollo","year":"1992"},{"key":"i1547-3317-62-1-38-b13","series-title":"Am J Vet Res","first-page":"696","article-title":"Plasma amino acid analysis in dogs with experimentally induced hepatocellular and obstructive jaundice","volume":"48","author":"Rutgers","year":"1987"},{"key":"i1547-3317-62-1-38-b14","series-title":"J Hepatol","first-page":"756","article-title":"Hyperammonemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma","volume":"25","author":"Leweling","year":"1996"},{"key":"i1547-3317-62-1-38-b15","series-title":"J Anim Sci Biotechnol\u00a0","first-page":"19","article-title":"Amino acid nutrition and metabolism in domestic cats and dogs","volume":"14","author":"Li","year":"2023"}],"container-title":["Journal of the American Animal Hospital Association"],"original-title":[],"link":[{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/62\/1\/article-p38.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/62\/1\/article-p38.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jaaha.kglmeridian.com\/downloadpdf\/journals\/aaha\/62\/1\/article-p38.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:53:24Z","timestamp":1770771204000},"score":1,"resource":{"primary":{"URL":"https:\/\/jaaha.kglmeridian.com\/view\/journals\/aaha\/62\/1\/article-p38.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":30,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.5326\/jaaha-ms-7508","relation":{},"ISSN":["1547-3317","0587-2871"],"issn-type":[{"value":"1547-3317","type":"electronic"},{"value":"0587-2871","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}