{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:13:05Z","timestamp":1783732385527,"version":"3.55.0"},"reference-count":20,"publisher":"American Animal Hospital Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This retrospective case series describes the clinical features, treatment, and course of disease in 17 cats diagnosed with primary immune thrombocytopenia (pITP). At the time of diagnosis, median age was 4.25 yr (range 7 mo to 16 yr), 15 cats (88.2%) had clinical bleeding, and median platelet count was 10,000\/\u03bcL (range 5000\u201350,000\/\u03bcL). All 17 cats were treated with corticosteroids; cyclosporine was additionally prescribed in 14 cats. The median duration of immunosuppressive therapy was 365 days (range 49\u20132086 days). Thirteen cats achieved a platelet count &gt; 100,000\/\u00b5L at a median of 15 days (range 2\u2013207 days) following diagnosis of pITP. Only one cat achieved a full remission. A relapse was documented in 10 cats (59%) at a median of 191 days (range 67\u20131022 days) after diagnosis and 48 days (range 15\u2013196 days) after immunosuppressive medication was reduced or discontinued. Median survival time was 1067 days (range 49\u20132516 days). No patient, clinicopathological, or treatment variables were identified to affect 3 and 6 mo survival. This study highlights that clinical bleeding is common in cats with pITP, and despite an initial positive response to therapy, it can be difficult to maintain remission.<\/jats:p>","DOI":"10.5326\/jaaha-ms-7525","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:17:25Z","timestamp":1776824245000},"page":"115-122","source":"Crossref","is-referenced-by-count":0,"title":["Primary Immune Thrombocytopenia in 17 Cats: A Case Series"],"prefix":"10.5326","volume":"62","author":[{"given":"Lindsay","family":"Courtney","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Schwarzman Animal Medical Center, New York, NY (L.C., E.A.);"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Woolcock","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN (A.W.); and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Ghali","sequence":"additional","affiliation":[{"name":"Department of Research, Schwarzman Animal Medical Center, New York, NY (H.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Appleman","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Schwarzman Animal Medical Center, New York, NY (L.C., E.A.);"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"issue":"5","key":"i1547-3317-62-3-115-b1","series-title":"J Vet Intern Med","first-page":"261","article-title":"Thrombocytopenia in cats: a retrospective study of 41 cases","volume":"7","author":"Jordan","year":"1993","unstructured":"Jordan HL, Grindem CB, Breitschwerdt EB. Thrombocytopenia in cats: a retrospective study of 41 cases. J Vet Intern Med 1993;7(5):261\u20135."},{"issue":"9","key":"i1547-3317-62-3-115-b2","series-title":"J Small Anim Pract","first-page":"531","article-title":"Prevalence and disease associations in feline thrombocytopenia: a retrospective study of 194 cases","volume":"59","author":"Ellis","year":"2018","unstructured":"Ellis J, Bell R, Barnes DC,  Prevalence and disease associations in feline thrombocytopenia: a retrospective study of 194 cases. J Small Anim Pract 2018;59(9):531\u20138."},{"issue":"3","key":"i1547-3317-62-3-115-b3","series-title":"Vet Clin Pathol","first-page":"137","article-title":"Prevalence of low automated platelet counts in cats: comparison with prevalence of thrombocytopenia based on blood smear estimation","volume":"30","author":"Norman","year":"2001","unstructured":"Norman EJ, Barron RC, Nash AS,  Prevalence of low automated platelet counts in cats: comparison with prevalence of thrombocytopenia based on blood smear estimation. Vet Clin Pathol 2001;30(3):137\u201340."},{"issue":"5","key":"i1547-3317-62-3-115-b4","series-title":"J Feline Med Surg","first-page":"495","article-title":"Presumed primary immune-mediated thrombocytopenia in four cats","volume":"10","author":"Bianco","year":"2008","unstructured":"Bianco D, Armstrong PJ, Washabau RJ. Presumed primary immune-mediated thrombocytopenia in four cats. J Feline Med Surg 2008;10(5):495\u2013500."},{"issue":"1","key":"i1547-3317-62-3-115-b5","series-title":"J Am Anim Hosp Assoc","first-page":"12","article-title":"Primary immune-mediated thrombocytopenia in cats","volume":"46","author":"Wondratschek","year":"2010","unstructured":"Wondratschek C, Weingart C, Kohn B. Primary immune-mediated thrombocytopenia in cats. J Am Anim Hosp Assoc 2010;46(1):12\u20139."},{"issue":"6","key":"i1547-3317-62-3-115-b6","series-title":"J Am Anim Hosp Assoc","first-page":"464","article-title":"Idiopathic thrombocytopenic purpura in a cat","volume":"35","author":"Garon","year":"1999","unstructured":"Garon CL, Scott MA, Selting KA,  Idiopathic thrombocytopenic purpura in a cat. J Am Anim Hosp Assoc 1999;35(6):464\u201370."},{"issue":"3","key":"i1547-3317-62-3-115-b7","series-title":"J Small Anim Pract","first-page":"127","article-title":"Primary immune\u2010mediated thrombocytopenia in a cat","volume":"40","author":"Tasker","year":"1999","unstructured":"Tasker S, Mackin AJ, Day MJ. Primary immune\u2010mediated thrombocytopenia in a cat. J Small Anim Pract 1999;40(3):127\u201331."},{"key":"i1547-3317-62-3-115-b8","series-title":"J Am Anim Hosp Assoc","first-page":"585","article-title":"Autoimmune thrombocytopenia in a cat","volume":"15","author":"Joshi","year":"1979","unstructured":"Joshi BC, Raplee RG, Powell AL,  Autoimmune thrombocytopenia in a cat. J Am Anim Hosp Assoc 1979;15:585\u20138."},{"issue":"4","key":"i1547-3317-62-3-115-b9","series-title":"J Feline Med Surg","first-page":"254","article-title":"Platelet-bound antibodies detected by a flow cytometric assay in cats with thrombocytopenia","volume":"8","author":"Kohn","year":"2006","unstructured":"Kohn B, Linden T, Leibold W. Platelet-bound antibodies detected by a flow cytometric assay in cats with thrombocytopenia. J Feline Med Surg 2006;8(4):254\u201360."},{"key":"i1547-3317-62-3-115-b10","series-title":"Isr J Vet Med","first-page":"3","article-title":"Primary immune-mediated thrombocytopenia tentatively diagnosed in four cats","volume":"79","author":"Slon","year":"2024","unstructured":"Slon A, Aroch I. Primary immune-mediated thrombocytopenia tentatively diagnosed in four cats. Isr J Vet Med 2024;79:3\u201311."},{"issue":"4","key":"i1547-3317-62-3-115-b11","series-title":"J Vet Intern Med","first-page":"1958","article-title":"ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats","volume":"38","author":"LeVine","year":"2024","unstructured":"LeVine DN, Kidd L, Garden OA,  ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med 2024;38(4):1958\u201381."},{"issue":"2","key":"i1547-3317-62-3-115-b12","series-title":"J Vet Intern Med","first-page":"1022","article-title":"A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs","volume":"38","author":"Brooks","year":"2024","unstructured":"Brooks MB, Goggs R, Frye AH,  A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs. J Vet Intern Med 2024;38(2):1022\u201334."},{"issue":"3","key":"i1547-3317-62-3-115-b13","series-title":"J Vet Intern Med","first-page":"1041","article-title":"Development and implementation of a novel immune thrombocytopenia bleeding score for dogs","volume":"32","author":"Makielski","year":"2018","unstructured":"Makielski KM, Brooks MB, Wang C,  Development and implementation of a novel immune thrombocytopenia bleeding score for dogs. J Vet Intern Med 2018;32(3):1041\u201350."},{"issue":"4","key":"i1547-3317-62-3-115-b14","series-title":"J Vet Intern Med","first-page":"1982","article-title":"ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats","volume":"38","author":"LeVine","year":"2024","unstructured":"LeVine DN, Goggs R, Kohn B,  ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats. J Vet Intern Med 2024;38(4):1982\u20132007."},{"issue":"2","key":"i1547-3317-62-3-115-b15","series-title":"J Vet Intern Med","first-page":"1035","article-title":"Comparison of timing of relapse in dogs with nonassociative immune-mediated hemolytic anemia, thrombocytopenia, or polyarthritis","volume":"38","author":"Sparrow","year":"2024","unstructured":"Sparrow R, Swann JW, Glanemann B. Comparison of timing of relapse in dogs with nonassociative immune-mediated hemolytic anemia, thrombocytopenia, or polyarthritis. J Vet Intern Med 2024;38(2):1035\u201342."},{"issue":"3","key":"i1547-3317-62-3-115-b16","series-title":"J Am Vet Med Assoc","first-page":"346","article-title":"Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia","volume":"238","author":"O\u2018Marra","year":"2011","unstructured":"O\u2018Marra SK, Delaforcade AM, Shaw SP. Treatment and predictors of outcome in dogs with immune-mediated thrombocytopenia. J Am Vet Med Assoc 2011;238(3):346\u201352."},{"issue":"5","key":"i1547-3317-62-3-115-b17","series-title":"J Am Anim Hosp Assoc","first-page":"250","article-title":"Primary immune-mediated thrombocytopenia in 30 dogs (1997\u20132003)","volume":"44","author":"Putsche","year":"2008","unstructured":"Putsche JC, Kohn B. Primary immune-mediated thrombocytopenia in 30 dogs (1997\u20132003). J Am Anim Hosp Assoc 2008;44(5):250\u20137."},{"issue":"1","key":"i1547-3317-62-3-115-b18","series-title":"Acta Vet Scand","first-page":"54","article-title":"Immunomodulatory and immunosuppressive drug protocols in the treatment of canine primary immune thrombocytopenia, a scoping review","volume":"63","author":"Kristiansen","year":"2021","unstructured":"Kristiansen PS, Nielsen LN. Immunomodulatory and immunosuppressive drug protocols in the treatment of canine primary immune thrombocytopenia, a scoping review. 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