{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:13:08Z","timestamp":1783732388315,"version":"3.55.0"},"reference-count":21,"publisher":"American Animal Hospital Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Meningioma is the most common primary brain tumor in dogs, and recurrence after treatment presents a significant clinical challenge. This retrospective study evaluated prognostic factors in 21 dogs with intracranial meningioma treated with surgical resection alone or with postoperative radiation therapy (RT). Recurrence rate, progression-free survival (PFS), median survival time (MST), and prognostic indicators were assessed. Of the 21 dogs, 13 received adjuvant RT. Local recurrence was noted in six dogs (28%). Overall MST was 845 days, and PFS was 771 days. By treatment group, MST was 886 days for surgery alone and 845 days with RT; PFS was 886 and 531 days, respectively, with no significant statistical difference. Grade 1 tumors and intact male status were associated with favorable outcomes (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). All grade 1 cases (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), treated with surgery alone, showed no recurrence, whereas all recurrences occurred in grade 2 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093) or unknown-grade tumors (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093), most receiving radiation. RT was well tolerated but did not show statistically proven efficacy. However, the benefit of postoperative RT could not be determined due to selection bias.\n                  <\/jats:p>","DOI":"10.5326\/jaaha-ms-7536","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:30:53Z","timestamp":1783729853000},"page":"176-182","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Outcomes of Canine Intracranial Meningioma With or Without Radiation"],"prefix":"10.5326","volume":"62","author":[{"given":"Akihiro","family":"Uno","sequence":"first","affiliation":[{"name":"From the Animal Medical Centre, Faculty of Applied Biological Sciences (A.U., Y.N.) and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Nozue","sequence":"additional","affiliation":[{"name":"From the Animal Medical Centre, Faculty of Applied Biological Sciences (A.U., Y.N.) and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (R.I., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mori","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Oncology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan (R.I., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3280","reference":[{"key":"i1547-3317-62-4-176-b1","series-title":"Compend Contin Educ Pract Vet","first-page":"241","article-title":"Central nervous system meningiomas","volume":"8","author":"Braund","year":"1986","unstructured":"Braund KG. Central nervous system meningiomas. Compend Contin Educ Pract Vet 1986;8:241\u20138."},{"key":"i1547-3317-62-4-176-b2","series-title":"Atlas of tumor pathology. 2nd series fascicle.","first-page":"169","author":"Rubinstein","year":"1972","unstructured":"Rubinstein LJ. Tumors of the central nervous system. In: Atlas of tumor pathology. 2nd series fascicle. Washington, DC: Armed Forces Institute of Pathology; 1972:169\u201375."},{"issue":"21","key":"i1547-3317-62-4-176-b3","series-title":"Future Oncol","first-page":"2161","article-title":"An overview of meningiomas","volume":"14","author":"Buerki","year":"2018","unstructured":"Buerki RA, Horbinski CM, Kruser T,  An overview of meningiomas. Future Oncol 2018;14(21):2161\u201377."},{"issue":"3","key":"i1547-3317-62-4-176-b4","series-title":"J Neuropathol Exp Neurol","first-page":"215","article-title":"The WHO classification of tumors of the nervous system","volume":"61","author":"Kleihues","year":"2002","unstructured":"Kleihues P, Louis DN, Scheithauer BW,  The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61(3):215\u201325."},{"issue":"5","key":"i1547-3317-62-4-176-b5","series-title":"J Vet Intern Med","first-page":"1143","article-title":"Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight","volume":"27","author":"Song","year":"2013","unstructured":"Song RB, Vite CH, Bradley CW,  Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. 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