{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:57:20Z","timestamp":1774007840488,"version":"3.50.1"},"reference-count":90,"publisher":"Ubiquity Press, Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,13]]},"DOI":"10.5334\/gh.891","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T07:39:31Z","timestamp":1602574771000},"source":"Crossref","is-referenced-by-count":47,"title":["COVID-19: Implications for People with Chagas Disease"],"prefix":"10.5334","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-7507","authenticated-orcid":false,"given":"Ezequiel Jos\u00e9","family":"Zaidel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1481-8367","authenticated-orcid":false,"given":"Colin J.","family":"Forsyth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-7522","authenticated-orcid":false,"given":"Gabriel","family":"Novick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-8864","authenticated-orcid":false,"given":"Rachel","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-0042","authenticated-orcid":false,"given":"Antonio Luiz P.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-1075","authenticated-orcid":false,"given":"Maria-Jesus","family":"Pinazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-2099","authenticated-orcid":false,"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-3859","authenticated-orcid":false,"given":"Luis Eduardo","family":"Echeverr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-041X","authenticated-orcid":false,"given":"Maria Aparecida","family":"Shikanai-Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-8559","authenticated-orcid":false,"given":"Pierre","family":"Buekens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-301X","authenticated-orcid":false,"given":"Pablo","family":"Perel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-0329","authenticated-orcid":false,"given":"Sheba K.","family":"Meymandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-5679","authenticated-orcid":false,"given":"Kate","family":"Ralston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-4529","authenticated-orcid":false,"given":"Fausto","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-5456","authenticated-orcid":false,"given":"Sergio","family":"Sosa-Estani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3285","reference":[{"issue":"9723","key":"key20201013033928_B1","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","year":"2010","journal-title":"The Lancet"},{"key":"key20201013033928_B2","unstructured":"Johns Hopkins Coronavirus Resource Center. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) 2020 [updated and accessed September 4, 2020]. Available from: https:\/\/coronavirus.jhu.edu\/map.html."},{"issue":"6","key":"key20201013033928_B3","first-page":"33","volume":"90","author":"World Health Organization","year":"2015","journal-title":"Chagas disease in Latin America: An epidemiological update based on 2010 estimates Weekly Epidemiological Record"},{"key":"key20201013033928_B4","volume-title":"Fourth WHO Report on Neglected Tropical Diseases","author":"World Health Organization","year":"2017"},{"issue":"1","key":"key20201013033928_B5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5334\/gh.484","article-title":"WHF IASC Roadmap on Chagas Disease","volume":"15","year":"2020","journal-title":"Global Heart"},{"issue":"10","key":"key20201013033928_B6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2012.109","article-title":"Diagnosis and management of Chagas disease and cardiomyopathy","volume":"9","year":"2012","journal-title":"Nature Reviews Cardiology"},{"issue":"7","key":"key20201013033928_B7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","article-title":"SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS","volume":"39","year":"2009","journal-title":"European Journal of Clinical Investigation"},{"issue":"6","key":"key20201013033928_B8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/cvr\/cvaa078","article-title":"The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2","volume":"116","year":"2020","journal-title":"Cardiovascular Research"},{"issue":"5","key":"key20201013033928_B9","first-page":"475","article-title":"[Protective effect of benznidazole against parasite reactivation in patients chronically infected with Trypanosoma cruzi and treated with corticoids for associated diseases]","volume":"32","year":"1999","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"5","key":"key20201013033928_B10","first-page":"613","article-title":"[Trypanosoma cruzi high parasitemia in patient with systemic lupus erythematosus]","volume":"36","year":"2003","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"1","key":"key20201013033928_B11","first-page":"50","article-title":"[C-reactive protein and interleukin-6 serum levels increase as Chagas disease progresses towards cardiac failure]","volume":"59","year":"2006","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda"},{"key":"key20201013033928_B12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijcard.2015.07.040","article-title":"Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease","volume":"199","year":"2015","journal-title":"International Journal of Cardiology"},{"issue":"1","key":"key20201013033928_B13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccl.2016.08.013","article-title":"Chagas cardiomyopathy: Clinical presentation and management in the Americas","volume":"35","year":"2017","journal-title":"Cardiology Clinics"},{"issue":"12","key":"key20201013033928_B14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1586\/14779072.2015.1103648","article-title":"Developments in the management of Chagas cardiomyopathy","volume":"13","year":"2015","journal-title":"Expert Review of Cardiovascular Therapy"},{"issue":"10","key":"key20201013033928_B15","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/cvr\/cvaa106","article-title":"COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options","volume":"116","year":"2020","journal-title":"Cardiovascular Research"},{"issue":"5","key":"key20201013033928_B16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41577-020-0312-7","article-title":"COVID-19: Risk for cytokine targeting in chronic inflammatory diseases?","volume":"20","year":"2020","journal-title":"Nature Reviews Immunology"},{"issue":"1","key":"key20201013033928_B17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40249-020-00663-w","article-title":"CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: A cohort study of aging in Bambui, Brazil","volume":"9","year":"2020","journal-title":"Infectious diseases of poverty"},{"issue":"8","key":"key20201013033928_B18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/pim.12107","article-title":"Immunoregulatory networks in human Chagas disease","volume":"36","year":"2014","journal-title":"Parasite Immunology"},{"issue":"9","key":"key20201013033928_B19","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.hrthm.2020.05.001","article-title":"Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management","volume":"17","year":"2020","journal-title":"Heart Rhythm"},{"issue":"23","key":"key20201013033928_B20","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jacc.2020.04.031","article-title":"COVID-19 and thrombotic or thromboembolic disease: Implications for prevention, antithrombotic therapy, and follow-Up: JACC state-of-the-art review","volume":"75","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"key20201013033928_B21","article-title":"Altered hypercoagulability factors in patients with chronic Chagas disease: Potential biomarkers of therapeutic response","volume":"10","year":"2016","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"12","key":"key20201013033928_B22","first-page":"e169","article-title":"Chagas cardiomyopathy: An update of current clinical knowledge and management: A scientific statement From the American Heart Association","volume":"138","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"key20201013033928_B23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1590\/S0037-86822009000500002","article-title":"Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission","volume":"42","year":"2009","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"11","key":"key20201013033928_B24","article-title":"Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas","volume":"8","year":"2014","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"1","key":"key20201013033928_B25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijcard.2011.07.089","article-title":"Myocardial involvement in Chagas disease: Insights from cardiac magnetic resonance","volume":"165","year":"2013","journal-title":"International Journal of Cardiology"},{"issue":"4","key":"key20201013033928_B26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ehjci\/jex154","article-title":"Multimodality imaging evaluation of Chagas disease: An expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI)","volume":"19","year":"2018","journal-title":"European Heart Journal Cardiovascular Imaging"},{"key":"key20201013033928_B27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12968-015-0200-7","article-title":"Myocardial tissue characterization in Chagas\u2019 heart disease by cardiovascular magnetic resonance","volume":"17","year":"2015","journal-title":"Journal of Cardiovascular Magnetic Resonance"},{"issue":"2","key":"key20201013033928_B28","first-page":"213","article-title":"[Association between left ventricular wall motion abnormalities and ventricular arrhythmia in the indeterminate form of Chagas disease]","volume":"44","year":"2011","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"3","key":"key20201013033928_B29","first-page":"209","article-title":"Right ventricular Doppler echocardiographic study of indeterminate form of Chagas disease","volume":"104","year":"2015","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"key20201013033928_B30","article-title":"Use of tissue doppler imaging for the early detection of myocardial dysfunction in patients with the indeterminate form of Chagas disease","volume":"53","year":"2020","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"6","key":"key20201013033928_B31","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/gutjnl-2020-320926","article-title":"Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms","volume":"69","year":"2020","journal-title":"Gut"},{"issue":"6","key":"key20201013033928_B32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gutjnl-2020-321013","article-title":"Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection","volume":"69","year":"2020","journal-title":"Gut"},{"issue":"19","key":"key20201013033928_B33","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1212\/WNL.0000000000009455","article-title":"Neurologic complications of coronavirus infections","volume":"94","year":"2020","journal-title":"Neurology"},{"key":"key20201013033928_B34","doi-asserted-by":"crossref","first-page":"105921","DOI":"10.1016\/j.clineuro.2020.105921","article-title":"Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review","volume":"194","year":"2020","journal-title":"Clinical Neurology and Neurosurgery"},{"issue":"1","key":"key20201013033928_B35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/1471-0528.12396","article-title":"Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis","volume":"121","year":"2014","journal-title":"BJOG"},{"issue":"6","key":"key20201013033928_B36","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/cid\/civ446","article-title":"Sustained domestic vector exposure is associated with increased Chagas cardiomyopathy risk but decreased parasitemia and congenital transmission risk among young women in Bolivia","volume":"61","year":"2015","journal-title":"Clinical Infectious Diseases"},{"issue":"10","key":"key20201013033928_B37","article-title":"Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women","volume":"13","year":"2019","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"7","key":"key20201013033928_B38","doi-asserted-by":"crossref","first-page":"e877","DOI":"10.1016\/S2214-109X(20)30206-0","article-title":"A call for action for COVID-19 surveillance and research during pregnancy","volume":"8","year":"2020","journal-title":"The Lancet Global health"},{"issue":"1","key":"key20201013033928_B39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1179\/136485907X154629","article-title":"Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV\/AIDS","volume":"101","year":"2007","journal-title":"Annals of Tropical Medicine and Parasitology"},{"issue":"5","key":"key20201013033928_B40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11912-020-00934-7","article-title":"COVID-19 and cancer: A comprehensive review","volume":"22","year":"2020","journal-title":"Current Oncology Reports"},{"issue":"6","key":"key20201013033928_B41","first-page":"525","article-title":"Viral screening before initiation of biologics in patients with inflammatory bowel disease during the COVID-19 outbreak","volume":"5","year":"2020","journal-title":"The Lancet Gastroenterology & Hepatology"},{"issue":"11","key":"key20201013033928_B42","article-title":"Estimating the burden of Chagas disease in the United States","volume":"10","year":"2016","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"2","key":"key20201013033928_B43","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijcard.2010.02.036","article-title":"Chagas disease and mortality in old age as an emerging issue: 10 year follow-up of the Bambu\u00ed population-based cohort study (Brazil)","volume":"145","year":"2010","journal-title":"International Journal of Cardiology"},{"key":"key20201013033928_B44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actatropica.2013.10.002","article-title":"Prevalence of Chagas disease in Brazil: A systematic review and meta-analysis","volume":"130","year":"2014","journal-title":"Acta Tropica"},{"issue":"10229","key":"key20201013033928_B45","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"key20201013033928_B46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1473-3099(20)30243-7","article-title":"Estimates of the severity of coronavirus disease 2019: A model-based analysis","volume":"20","year":"2020","journal-title":"The Lancet Infectious Diseases"},{"key":"key20201013033928_B47","unstructured":"Centers for Disease Control. CDC COVID Data Tracker 2020 [updated June 30, 2020]. Available from: https:\/\/www.cdc.gov\/covid-data-tracker\/index.html#demographics."},{"issue":"5","key":"key20201013033928_B48","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00392-020-01626-9","article-title":"Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China","volume":"109","year":"2020","journal-title":"Clinical Research in Cardiology"},{"issue":"11","key":"key20201013033928_B49","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","year":"2020","journal-title":"Jama"},{"issue":"4","key":"key20201013033928_B50","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s11357-020-00198-w","article-title":"COVID-19-associated cardiovascular morbidity in older adults: A position paper from the Italian Society of Cardiovascular Researches","volume":"42","year":"2020","journal-title":"GeroScience"},{"issue":"4","key":"key20201013033928_B51","article-title":"Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States","volume":"288","year":"2020","journal-title":"Journal of Internal Medicine"},{"issue":"6","key":"key20201013033928_B52","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1590\/S0037-86822009000600002","article-title":"Chagas\u2019 disease and ageing: The coexistence of other chronic diseases with Chagas\u2019 disease in elderly patients","volume":"42","year":"2009","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"key20201013033928_B53","article-title":"Cardiovascular comorbidities in patients with chronic Chagas disease","year":"2018","journal-title":"AME Medical Journal"},{"issue":"5","key":"key20201013033928_B54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1365-3156.2012.02965.x","article-title":"Metabolic, mental health, behavioural and socioeconomic characteristics of migrants with Chagas disease in a non-endemic country","volume":"17","year":"2012","journal-title":"Tropical Medicine & International Health"},{"issue":"13","key":"key20201013033928_B55","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention","volume":"323","year":"2020","journal-title":"Jama"},{"issue":"18","key":"key20201013033928_B56","first-page":"1775","article-title":"Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy","volume":"323","year":"2020","journal-title":"Jama"},{"key":"key20201013033928_B57","unstructured":"Centers for Disease Control. Provisional death counts for coronavirus disease 2019 (COVID-19): Race and Hispanic origin 2020 [updated June 24, 2020]. Available from: https:\/\/www.cdc.gov\/nchs\/nvss\/vsrr\/covid_weekly\/index.htm#Race_Hispanic."},{"key":"key20201013033928_B58","unstructured":"Batista A, Antunes B, Faveret G, Peres I, Marchesi J, Cunha JP, et al. An\u00e1lise socioecon\u00f4mica da taxa de letalidade da COVID-19 no Brasil. Nucleo de Operacoes e Inteligencia em Saude (NOIS); 2020 May 27, 2020. Contract No.: Nota Tecnica 11. Available from: https:\/\/www.sites.google.com\/view\/nois-pucrio\/publica%C3%A7%C3%B5es?authuser=0#h.ijqa5msfttoq"},{"issue":"8","key":"key20201013033928_B59","doi-asserted-by":"crossref","first-page":"E1018","DOI":"10.1016\/S2214-109X(20)30285-0","article-title":"Ethnic and regional variations in hospital mortality from COVID-19 in Brazil: A cross-sectional observational study","volume":"8","year":"2020","journal-title":"The Lancet Global Health"},{"issue":"11","key":"key20201013033928_B60","first-page":"1224","article-title":"The impact of socioeconomic conditions on chronic Chagas disease progression","volume":"62","year":"2009","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda"},{"key":"key20201013033928_B61","unstructured":"United Nations. World Economic Situation and Prospects as of mid-2020. New York, NY; 2020. Available from: https:\/\/www.un.org\/development\/desa\/dpad\/wp-content\/uploads\/sites\/45\/publication\/WESP2020_MYU_Report.pdf."},{"issue":"3","key":"key20201013033928_B62","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/ehjqcco\/qcaa046","article-title":"Admission of patients with STEMI since the outbreak of the COVID-19 pandemic: A survey by the European Society of Cardiology","volume":"6","year":"2020","journal-title":"European Heart Journal \u2013 Quality of Care and Clinical Outcomes"},{"issue":"5","key":"key20201013033928_B63","article-title":"Secondary impact of the COVID-19 pandemic on patients with heart failure","volume":"13","year":"2020","journal-title":"Circulation: Heart Failure"},{"key":"key20201013033928_B64","doi-asserted-by":"crossref","first-page":"104395","DOI":"10.1016\/j.jcv.2020.104395","article-title":"Characterisation of COVID-19 pandemic in paediatric age group: A systematic review and meta-analysis","volume":"128","year":"2020","journal-title":"Journal of Clinical Virology"},{"issue":"3","key":"key20201013033928_B65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00281-020-00796-y","article-title":"Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases","volume":"42","year":"2020","journal-title":"Seminars in Immunopathology"},{"key":"key20201013033928_B66","unstructured":"Pan American Health Organization. Guidelines for the diagnosis and treatment of Chagas disease. Washington, DC; 2019. Available from: https:\/\/iris.paho.org\/handle\/10665.2\/49653"},{"issue":"Suppl1","key":"key20201013033928_B67","first-page":"311","article-title":"Ergosterol biosynthesis and drug development for Chagas disease","volume":"104","year":"2009","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"issue":"18","key":"key20201013033928_B68","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.298.18.2171","article-title":"Evaluation and treatment of Chagas disease in the United States: A systematic review","volume":"298","year":"2007","journal-title":"Jama"},{"issue":"4","key":"key20201013033928_B69","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/jac\/dkx505","article-title":"Benznidazole treatment safety: The M\u00e9decins Sans Fronti\u00e8res experience in a large cohort of Bolivian patients with Chagas\u2019 disease\u2014Authors\u2019 response","volume":"73","year":"2018","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"11","key":"key20201013033928_B70","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1128\/AAC.00537-10","article-title":"Tolerance of benznidazole in treatment of Chagas\u2019 disease in adults","volume":"54","year":"2010","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"8","key":"key20201013033928_B71","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/cid\/ciw477","article-title":"Safety profile of Nifurtimox for treatment of Chagas disease in the United States","volume":"63","year":"2016","journal-title":"Clinical Infectious Diseases"},{"issue":"5","key":"key20201013033928_B72","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41569-020-0360-5","article-title":"COVID-19 and the cardiovascular system","volume":"17","year":"2020","journal-title":"Nature Reviews Cardiology"},{"issue":"5","key":"key20201013033928_B73","first-page":"537","article-title":"The heart in COVID-19: Primary target or secondary bystander?","volume":"5","year":"2020","journal-title":"JACC: Basic to Translational Science"},{"issue":"6","key":"key20201013033928_B74","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1592\/phco.27.6.874","article-title":"Pharmacogenetics of beta-blockers","volume":"27","year":"2007","journal-title":"Pharmacotherapy"},{"issue":"1","key":"key20201013033928_B75","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13046-018-0967-0","article-title":"Increasing intratumor C\/EBP-\u03b2 LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer","volume":"37","year":"2018","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"issue":"3","key":"key20201013033928_B76","first-page":"271","article-title":"Hidroxicloroquina. Mensajes desde la cardiolog\u00eda en tiempos de pandemia por coronavirus [Hydroxychloroquine: Cardiology\u2019s viewpoint in times of coronavirus pandemic]","volume":"80","year":"2020","journal-title":"Medicina (B Aires"},{"key":"key20201013033928_B77","unstructured":"University of California-San Francisco. Interactions with Amiodarone and Antiretrovirals. 2019. Available from: http:\/\/arv.ucsf.edu\/insite?page=ar-00-02&post=8&param=116."},{"issue":"3","key":"key20201013033928_B78","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00228-012-1397-0","article-title":"ACE inhibitors and ribavirin-associated cough: A common undefined predisposing factor?","volume":"69","year":"2013","journal-title":"European Journal of Clinical Pharmacology"},{"key":"key20201013033928_B79","unstructured":"DrugBank. Ivermectin 2020 [updated June 30, 2020]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB00602."},{"key":"key20201013033928_B80","unstructured":"DrugBank. Umifenovir 2020 [updated June 12, 2020]. Available from: https:\/\/www.drugbank.ca\/drugs\/DB13609."},{"issue":"6","key":"key20201013033928_B81","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2165\/11599820-000000000-00000","article-title":"Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1\u03b2 monoclonal antibody","volume":"51","year":"2012","journal-title":"Clinical Pharmacokinetics"},{"key":"key20201013033928_B82","article-title":"ILARIS (canakinumab) Full Prescribing Information 2012","author":"Novartis Pharmaceuticals Corporation"},{"key":"key20201013033928_B83","article-title":"GAMIFANTTM (emapalumab-lzsg) injection, for intravenous use","author":"Patheon Italia","year":"2018"},{"key":"key20201013033928_B84","article-title":"SYLVANT. Full Prescribing Information 2014","author":"Janssen Biotech"},{"issue":"2","key":"key20201013033928_B85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2165\/00003088-199630020-00004","article-title":"Clinically significant drug interactions with cyclosporin","volume":"30","year":"1996","journal-title":"Clinical Pharmacokinetics"},{"issue":"17","key":"key20201013033928_B86","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/ajhp\/57.17.1579","article-title":"Cyclosporine\u2013drug interactions and the influence of patient age","volume":"57","year":"2000","journal-title":"American Journal of Health-System Pharmacy"},{"key":"key20201013033928_B87","article-title":"RAPAMUNE","author":"Pfizer Inc","year":"2017"},{"key":"key20201013033928_B88","article-title":"PREZCOBIX (darunavir and cobicistat) tablets, for oral use","author":"Janssen Pharmaceutical Companies","year":"2019"},{"issue":"1","key":"key20201013033928_B89","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacc.2020.05.001","article-title":"Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19","volume":"76","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"5","key":"key20201013033928_B90","first-page":"306","article-title":"Prevention strategies of cardioembolic ischemic stroke in Chagas\u2019 disease","volume":"91","year":"2008","journal-title":"Arquivos Brasileiros de Cardiologia"}],"container-title":["Global Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/doi.org\/10.5334\/gh.891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T09:23:36Z","timestamp":1657531416000},"score":1,"resource":{"primary":{"URL":"https:\/\/globalheartjournal.com\/articles\/10.5334\/gh.891\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,10,13]]}},"alternative-id":["10.5334\/gh.891"],"URL":"https:\/\/doi.org\/10.5334\/gh.891","relation":{},"ISSN":["2211-8179"],"issn-type":[{"value":"2211-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"69"}}