{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:46:33Z","timestamp":1775792793581,"version":"3.50.1"},"reference-count":53,"publisher":"Ubiquity Press, Ltd.","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TOHM"],"abstract":"<jats:p>Background: Orthostatic tremor (OT) is characterized by a lower extremity tremor causing unsteadiness while standing, urging patients to lean, walk, or sit to ease symptoms. This severely disrupts daily life and reduces quality of life (QoL), though the extent of QoL impairment remains largely unknown. The objective of this cohort study was to evaluate the effect of OT on daily functioning and well-being over time.\nMethods: In this prospective single-center and community based cohort study, OT patients annually completed self-report scales from 2018 to 2024, including the Dutch OT-questionnaire, Hospital Anxiety and Depression Scale (HADS), (instrumental) Activities of Daily Living, and the Short Form-36 (SF-36) to evaluate QoL.\nResults: Fifty-three OT patients participated in the study. OT patients showed reduced well-being compared to the general population based on outcomes from the SF-36 and HADS, with 30 out of 53 patients experiencing potential or suspected depression and\/or anxiety. Despite viewing OT as progressive, most patients saw no significant changes in overall well-being or daily functioning, although a significant difference was found between baseline and last follow-up for physical role limitation.\nDiscussion: Although OT patients report reduced well-being, both daily functioning and overall well-being remained stable over time, despite progressive symptoms. This is likely due to patients increased ability to adapt to OT symptoms. Additionally, a substantial portion had potential or suspected depression or anxiety.\nHighlights\nOrthostatic tremor (OT) patients report reduced quality of life, with worsened walking ability and increased weather sensitivity over time. Despite this, daily functioning and overall well-being remained stable throughout the study. A significant portion of patients also showed potential or suspected depression and\/or anxiety.<\/jats:p>","DOI":"10.5334\/tohm.1008","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:06:49Z","timestamp":1746623209000},"page":"22","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Orthostatic Tremor on Quality of Life &amp;ndash; a Cohort Study"],"prefix":"10.5334","volume":"15","author":[{"given":"Wietske A.","family":"Babeliowsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Swinnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-6052","authenticated-orcid":false,"given":"Jeroen","family":"Hoogland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob M. A.","family":"De Bie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-9098","authenticated-orcid":false,"given":"Anne-Fleur","family":"Van Rootselaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3285","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"issue":"1","key":"key20250507130643_B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mds.27121","article-title":"Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society","volume":"33","year":"2018","journal-title":"Mov Disord"},{"issue":"11","key":"key20250507130643_B2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/mus.880161117","article-title":"Orthostatic tremor: clinical and electrophysiologic characteristics","volume":"16","year":"1993","journal-title":"Muscle Nerve"},{"issue":"7","key":"key20250507130643_B3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/mds.20132","article-title":"Natural history and syndromic associations of orthostatic tremor: a review of 41 patients","volume":"19","year":"2004","journal-title":"Mov Disord"},{"key":"key20250507130643_B4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/B978-0-444-52014-2.00035-5","article-title":"Orthostatic tremor \u2013 a review","volume":"100","year":"2011","journal-title":"Handb Clin Neurol"},{"key":"key20250507130643_B5","first-page":"2","article-title":"Orthostatic tremor responds to bilateral thalamic deep brain stimulation","year":"2012","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"5","key":"key20250507130643_B6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1212\/WNL.0000000000002328","article-title":"Orthostatic tremor: Clinical, electrophysiologic, and treatment findings in 184 patients","volume":"86","year":"2016","journal-title":"Neurology"},{"issue":"8","key":"key20250507130643_B7","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1212\/WNL.37.8.1434","article-title":"EMG in orthostatic tremor","volume":"37","year":"1987","journal-title":"Neurology"},{"issue":"14","key":"key20250507130643_B8","article-title":"Teaching video neuroimages: orthostatic tremor: the helicopter sign","volume":"80","year":"2013","journal-title":"Neurology"},{"issue":"8970","key":"key20250507130643_B9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0140-6736(95)92190-7","article-title":"New clinical sign for orthostatic tremor","volume":"346","year":"1995","journal-title":"Lancet"},{"issue":"8","key":"key20250507130643_B10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1001\/archneur.1984.04050190086020","article-title":"Orthostatic tremor","volume":"41","year":"1984","journal-title":"Arch Neurol"},{"key":"key20250507130643_B11","first-page":"66","article-title":"Orthostatic tremor (shaky legs syndrome)","volume":"30","year":"1993","journal-title":"Clin Exp Neurol"},{"issue":"2","key":"key20250507130643_B12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s00415-003-0980-9","article-title":"Quality of life in patients with orthostatic tremor","volume":"250","year":"2003","journal-title":"J Neurol"},{"issue":"8","key":"key20250507130643_B13","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/mds.27082","article-title":"Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry","volume":"32","year":"2017","journal-title":"Mov Disord"},{"issue":"14","key":"key20250507130643_B14","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/mds.23333","article-title":"Electrophysiological evaluation of thalamic DBS for orthostatic tremor","volume":"25","year":"2010","journal-title":"Mov Disord"},{"issue":"4","key":"key20250507130643_B15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1212\/CPJ.0000000000000730","article-title":"Deep brain stimulation for orthostatic tremor: A single-center case series","volume":"10","year":"2020","journal-title":"Neurol Clin Pract"},{"key":"key20250507130643_B16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.parkreldis.2022.10.001","article-title":"Deep brain stimulation and spinal cord stimulation for orthostatic tremor: A systematic review","volume":"104","year":"2022","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"key20250507130643_B17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2008.929","article-title":"Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial","volume":"301","year":"2009","journal-title":"JAMA"},{"issue":"3","key":"key20250507130643_B18","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/mds.26885","article-title":"What is quality of life and how do we measure it? Relevance to Parkinson\u2019s disease and movement disorders","volume":"32","year":"2017","journal-title":"Mov Disord"},{"issue":"1","key":"key20250507130643_B19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1008928321652","article-title":"Evaluation of a measurement strategy for Parkinson\u2019s disease: assessing patient health-related quality of life","volume":"9","year":"2000","journal-title":"Qual Life Res"},{"issue":"12","key":"key20250507130643_B20","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1468-1331.2005.01096.x","article-title":"Effects of dyskinesias in Parkinson\u2019s disease on quality of life and health-related costs: a prospective European study","volume":"12","year":"2005","journal-title":"Eur J Neurol"},{"key":"key20250507130643_B21","first-page":"747","article-title":"Health-Related Quality of Life Is Severely Affected in Primary Orthostatic Tremor","volume":"8","year":"2017","journal-title":"Front Neurol"},{"key":"key20250507130643_B22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.parkreldis.2018.06.014","article-title":"Measuring disease progression and disability in orthostatic tremor","volume":"55","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"issue":"6","key":"key20250507130643_B23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/mdc3.14035","article-title":"Deep Brain Stimulation for Orthostatic Tremor: An Observational Study","volume":"11","year":"2024","journal-title":"Mov Disord Clin Pract"},{"key":"key20250507130643_B24","unstructured":"Rootselaar van APE dHC, Buijink A.. Orthostatische Tremor, questionnaire OT 2014. Available from: https:\/\/orthostatischetremor.nl\/1%20OT%20enquete%2018-06.pdf] 2014."},{"issue":"6","key":"key20250507130643_B25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"5 Suppl","key":"key20250507130643_B26","first-page":"116","article-title":"12. Index of ADL","volume":"14","year":"1976","journal-title":"Med Care"},{"issue":"4","key":"key20250507130643_B27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jclinepi.2006.02.022","article-title":"Katz\u2019 ADL index assessed functional performance of Turkish, Moroccan, and Dutch elderly","volume":"60","year":"2007","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"key20250507130643_B28","first-page":"179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","year":"1969","journal-title":"Gerontologist"},{"issue":"2","key":"key20250507130643_B29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1207\/s15327558ijbm0302_2","article-title":"Psychometric qualities of the RAND 36-Item Health Survey 1.0: a multidimensional measure of general health status","volume":"3","year":"1996","journal-title":"Int J Behav Med"},{"issue":"2","key":"key20250507130643_B30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpsychores.2011.01.005","article-title":"Normative values for the hospital anxiety and depression scale (HADS) in the general German population","volume":"71","year":"2011","journal-title":"J Psychosom Res"},{"issue":"1","key":"key20250507130643_B31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1017\/S1092852918001633","article-title":"Demoralization in essential tremor: prevalence, clinical correlates, and dissociation from tremor severity","volume":"25","year":"2020","journal-title":"CNS Spectr"},{"key":"key20250507130643_B32","first-page":"9","article-title":"Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden","year":"2019","journal-title":"Tremor Other Hyperkinet Mov (NY)"},{"key":"key20250507130643_B33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.parkreldis.2018.02.031","article-title":"Self-report depressive symptoms are dissociated from tremor severity in essential tremor","volume":"50","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"key20250507130643_B34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/mds.20830","article-title":"Blinded placebo crossover study of gabapentin in primary orthostatic tremor","volume":"21","year":"2006","journal-title":"Mov Disord"},{"issue":"7","key":"key20250507130643_B35","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/mds.20392","article-title":"Gabapentin can improve postural stability and quality of life in primary orthostatic tremor","volume":"20","year":"2005","journal-title":"Mov Disord"},{"issue":"13","key":"key20250507130643_B36","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/mds.23881","article-title":"Levetiracetam in primary orthostatic tremor: a double-blind placebo-controlled crossover study","volume":"26","year":"2011","journal-title":"Mov Disord"},{"key":"key20250507130643_B37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.parkreldis.2022.07.011","article-title":"Perampanel as a treatment option for orthostatic tremor","volume":"102","year":"2022","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"key20250507130643_B38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/jnnp.72.1.47","article-title":"Impact of thalamic deep brain stimulation on disability and health-related quality of life in patients with essential tremor","volume":"72","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"key20250507130643_B39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3233\/JPD-160790","article-title":"The Effects of Physical Activity in Parkinson\u2019s Disease: A Review","volume":"6","year":"2016","journal-title":"J Parkinsons Dis"},{"issue":"3","key":"key20250507130643_B40","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jnnp.69.3.308","article-title":"What contributes to quality of life in patients with Parkinson\u2019s disease?","volume":"69","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"key20250507130643_B41","article-title":"Depression in Parkinson\u2019s Disease: A Narrative Review","volume":"14","year":"2022","journal-title":"Cureus"},{"issue":"6","key":"key20250507130643_B42","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/mds.1201","article-title":"Fatigue in Parkinson\u2019s disease: a nine-year follow-up","volume":"16","year":"2001","journal-title":"Mov Disord"},{"issue":"4","key":"key20250507130643_B43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1212\/WNL.0b013e31827f07be","article-title":"Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy","volume":"80","year":"2013","journal-title":"Neurology"},{"issue":"12","key":"key20250507130643_B44","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1212\/WNL.41.12.1982","article-title":"Is essential tremor benign?","volume":"41","year":"1991","journal-title":"Neurology"},{"issue":"6","key":"key20250507130643_B45","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00484-024-02658-w","article-title":"Evidence of heat sensitivity in people with Parkinson\u2019s disease","volume":"68","year":"2024","journal-title":"Int J Biometeorol"},{"issue":"4","key":"key20250507130643_B46","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0894-1130(00)80019-8","article-title":"The effect of temperature on hand function in patients with tremor","volume":"13","year":"2000","journal-title":"J Hand Ther"},{"key":"key20250507130643_B47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jns.2015.12.031","article-title":"Cognitive and neuropsychiatric features of orthostatic tremor: A case-control comparison","volume":"361","year":"2016","journal-title":"J Neurol Sci"},{"key":"key20250507130643_B48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5334\/tohm.324","article-title":"Orthostatic Tremor: An Update on a Rare Entity","volume":"6","year":"2016","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"29","key":"key20250507130643_B49","article-title":"Resting state functional MRI reveals abnormal network connectivity in orthostatic tremor","volume":"95","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"key20250507130643_B50","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1001\/archneur.56.12.1497","article-title":"Resetting of orthostatic tremor associated with cerebellar cortical atrophy by transcranial magnetic stimulation","volume":"56","year":"1999","journal-title":"Arch Neurol"},{"issue":"Pt 1","key":"key20250507130643_B51","first-page":"199","article-title":"The cerebral oscillatory network of parkinsonian resting tremor","volume":"126","year":"2003","journal-title":"Brain"},{"issue":"7","key":"key20250507130643_B52","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1007\/s10072-022-06037-4","article-title":"Essential tremor and cognitive impairment: who, how, and why","volume":"43","year":"2022","journal-title":"Neurol Sci"},{"issue":"10","key":"key20250507130643_B53","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/mds.28142","article-title":"Development and Validation of the Orthostatic Tremor Severity and Disability Scale (OT-10)","volume":"35","year":"2020","journal-title":"Mov Disord"}],"container-title":["Tremor and Other Hyperkinetic Movements"],"original-title":[],"link":[{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2006","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/download\/1008\/2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T13:49:58Z","timestamp":1746625798000},"score":1,"resource":{"primary":{"URL":"https:\/\/account.tremorjournal.org\/index.php\/up-j-tohm\/article\/view\/1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":53,"URL":"https:\/\/doi.org\/10.5334\/tohm.1008","relation":{},"ISSN":["2160-8288"],"issn-type":[{"value":"2160-8288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]}}}