{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:22:43Z","timestamp":1774426963081,"version":"3.50.1"},"reference-count":27,"publisher":"Ubiquity Press, Ltd.","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,28]]},"DOI":"10.5334\/tohm.600","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T12:42:55Z","timestamp":1622205775000},"source":"Crossref","is-referenced-by-count":6,"title":["Can Plasma \u03b1-Synuclein Help Us to Differentiate Parkinson\u2019s Disease from Essential Tremor?"],"prefix":"10.5334","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-0126","authenticated-orcid":false,"given":"Silvia M.","family":"Albillos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-8756","authenticated-orcid":false,"given":"Olimpio","family":"Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Solano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Trejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-1182","authenticated-orcid":false,"given":"Esther","family":"Cubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3285","reference":[{"issue":"22 Suppl","key":"key20210625081714_B1","first-page":"S106","article-title":"Biomarkers in Parkinson\u2019s disease: Advances and strategies","volume":"1","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"key":"key20210625081714_B2","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","year":"2007","journal-title":"Brain"},{"key":"key20210625081714_B3","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1212\/WNL.0000000000004609","article-title":"Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls","volume":"89","year":"2017","journal-title":"Neurology"},{"key":"key20210625081714_B4","first-page":"BC01","article-title":"Serological Analysis of Alpha-synuclein and NF-kappaB in Parkinson\u2019s Disease Patients","volume":"9","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"key20210625081714_B5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10072-019-03738-1","article-title":"Plasma alpha-synuclein levels in patients with Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"40","year":"2019","journal-title":"Neurological sciences: official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology"},{"key":"key20210625081714_B6","first-page":"189","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","year":"1975","journal-title":"J Psychiatr Res"},{"key":"key20210625081714_B7","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1002\/mds.21844","article-title":"Diagnostic procedures for Parkinson\u2019s disease dementia: recommendations from the movement disorder society task force","volume":"22","year":"2007","journal-title":"Mov Disord"},{"key":"key20210625081714_B8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: A clinico-pathological study of 100 cases","volume":"55","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20210625081714_B9","volume-title":"Members of the UPDRS Development Committee Recent Developments in Parkinson\u2019s Disease","year":"1987"},{"key":"key20210625081714_B10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/mds.21596","article-title":"The metric properties of a novel non-motor symptoms scale for Parkinson\u2019s disease: Results from an international pilot study","volume":"22","year":"2007","journal-title":"Mov Disord"},{"key":"key20210625081714_B11","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/mds.22007","article-title":"Parkinson\u2019s disease-cognitive rating scale: A new cognitive scale specific for Parkinson\u2019s disease","volume":"23","year":"2008","journal-title":"Mov Disord"},{"key":"key20210625081714_B12","first-page":"S7","article-title":"Criteria for the diagnosis of essential tremor","volume":"54","year":"2000","journal-title":"Neurology"},{"key":"key20210625081714_B13","unstructured":"Tape TG. Interpreting diagnostic tests. University of Nebraska Medical Center, 2008. (Accessed September 10, 2020, at http:\/\/gim.unmc.edu\/dxtests\/Default.htm)."},{"key":"key20210625081714_B14","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/ene.12256","article-title":"Is there a one-way street from essential tremor to Parkinson\u2019s disease? Possible biological ramifications","volume":"20","year":"2013","journal-title":"European journal of neurology"},{"key":"key20210625081714_B15","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/mds.22161","article-title":"Emergence of Parkinson\u2019s disease in essential tremor: A study of the clinical correlates in 53 patients","volume":"23","year":"2008","journal-title":"Mov Disord"},{"key":"key20210625081714_B16","first-page":"589","article-title":"Essential Tremor and Parkinson\u2019s Disease: Exploring the Relationship","volume":"8","year":"2018","journal-title":"Tremor and other hyperkinetic movements (New York, NY)"},{"key":"key20210625081714_B17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.parkreldis.2006.05.033","article-title":"Exploring the relationship between essential tremor and Parkinson\u2019s disease","volume":"13","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"key":"key20210625081714_B18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/mds.26919","article-title":"Essential pitfalls in \u201cessential\u201d tremor","volume":"32","year":"2017","journal-title":"Mov Disord"},{"key":"key20210625081714_B19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0404.2008.01056.x","article-title":"Distinguishing Parkinson\u2019s disease and essential tremor with transcranial sonography","volume":"119","year":"2009","journal-title":"Acta Neurol Scand"},{"key":"key20210625081714_B20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/bs.irn.2018.10.008","article-title":"Transcranial B-Mode Sonography in Movement Disorders","volume":"143","year":"2018","journal-title":"Int Rev Neurobiol"},{"key":"key20210625081714_B21","article-title":"Alphalpha-synuclein levels in blood plasma from LRRK2 mutation carriers","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key20210625081714_B22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00702-005-0427-9","article-title":"The plasma alpha-synuclein levels in patients with Parkinson\u2019s disease and multiple system atrophy","volume":"113","year":"2006","journal-title":"Journal of neural transmission (Vienna, Austria : 1996)"},{"key":"key20210625081714_B23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/00207454.2017.1394851","article-title":"Alpha-synuclein levels in patients with multiple system atrophy: A meta-analysis","volume":"128","year":"2018","journal-title":"Int J Neurosci"},{"key":"key20210625081714_B24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000112832","article-title":"Red blood cells are the major source of alpha-synuclein in blood","volume":"5","year":"2008","journal-title":"Neurodegener Dis"},{"key":"key20210625081714_B25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2010.06.009","article-title":"Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson\u2019s disease","volume":"480","year":"2010","journal-title":"Neurosci Lett"},{"key":"key20210625081714_B26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.beem.2013.05.011","article-title":"Heterophilic antibody interference in immunometric assays","volume":"27","year":"2013","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key20210625081714_B27","doi-asserted-by":"crossref","first-page":"33691","DOI":"10.1074\/jbc.M112.379792","article-title":"Novel one-step immunoassays to quantify alpha-synuclein: applications for biomarker development and high-throughput screening","volume":"287","year":"2012","journal-title":"J Biol Chem"}],"container-title":["Tremor and Other Hyperkinetic Movements"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/doi.org\/10.5334\/tohm.600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T08:10:44Z","timestamp":1699085444000},"score":1,"resource":{"primary":{"URL":"https:\/\/tremorjournal.org\/articles\/10.5334\/tohm.600\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,5,28]]}},"alternative-id":["10.5334\/tohm.600"],"URL":"https:\/\/doi.org\/10.5334\/tohm.600","relation":{},"ISSN":["2160-8288"],"issn-type":[{"value":"2160-8288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"20"}}